EBSD and reconstruction of pre-transformation microstructures, examples and complexities in steels

Abbasi, M.,Kim, D.I.,Nelson, T.W.,Abbasi, M. Elsevier 2014 Materials characterization Vol.95 No.-

Electron backscattered diffraction has provided a quantitative tool to study micro/nano-structures in large scales. A recent application of electron backscattered diffraction is the reconstruction of pre-transformed phases in polymorphic systems, especially when there is no retained pre-transformed phase at room temperature. This capability has been demonstrated by various researchers utilizing different approaches towards grain structure and orientation recovery. However, parameters affecting reconstruction have not been investigated systematically. Factors such as post-transformed microstructures (morphology and crystallography), lattice strain (deformation), pattern and sample quality are among the affecting factors. Two-dimensional datasets of different steels have been reconstructed along with a limited 3-dimensional dataset in the current paper. Preliminary results intended for large-scale automatic reconstructions have been presented. They indicate that the successfulness of reconstruction is strongly dependent on the post-transformed microstructure. Factors such as morphology, grain size, variant selection, and deformation play roles. Few examples of reconstruction complexity at prior austenite boundaries leading to uncertain results are presented. Lastly, reconstructions are discussed in terms of meaningfulness and if they correctly represent pre-transformed grains and orientations.

Application of Transmitted Kikuchi Diffraction in Studying Nano-oxide and Ultrafine Metallic Grains

Abbasi, Majid,Kim, Dong-Ik,Guim, Hwan-Uk,Hosseini, Morteza,Danesh-Manesh, Habib,Abbasi, Mehrdad AMERICAN CHEMICAL SOCIETY 2015 ACS NANO Vol.9 No.11

Thin film graphene oxide membrane: Challenges and gas separation potential

Fateme Abbasi,Javad Karimi-Sabet,Cyrus Ghotbi,Zeinab Abbasi 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.5

Graphene oxide membranes were prepared by vacuum and pressurized ultrafiltration methods on the 12% modified Polyacrylonitrile (12mPAN) substrate to specify challenges, salient features, future directions, and potential of GO membrane for separation fields using characterization techniques and gas separation test (studied gases are CO2, He and N2), which is an efficient tool for better understanding of GO membrane behavior. GO membrane structure was examined over a wide range of parameters, such as pore size range of substrate and its surface properties, pH of GO dispersion, GO content, synthesis pressure, operating pressure and temperature. The results show that the GO content does not hold a linear relationship with the permeance and selectivity. Film thickness, aggregates, synthesis pressure defects and interlayer spacing have significant effects on the gas separation performance of GO membranes which originate from the synthesis method and its conditions.

Application of the GTN model to predict the forming limit diagram of IF-Steel

Mahmoud Abbasi,Mohammad A. Shafaat,Mostafa Ketabch,Davoud F. Haghshenas,Mohammad Abbasi 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.2

Forming limit diagrams (FLDs) are extensively used in industries, particularly the auto industry. The establishment of these diagrams using a predictive approach can lead to reduction in both cost and time. In the present work, Gurson-Tvergaard-Needleman (GTN), a porosity-based model, was used to predict the FLD of an interstitial-free steel via finite element simulation. Optimum values of the GTN model were obtained by applying a response surface methodology (RSM) based on central composite design. Results show that RSM is a good method for an appropriate determination of the GTN model parameters, such as initial void volume fraction, effective void volume fraction, critical void volume fraction, and final void volume fraction. Furthermore, the experimental FLD of the specimen steel was considerably predicted using the obtained GTN model parameters.

ON EIGENSHARPNESS AND ALMOST EIGENSHARPNESS OF LEXICOGRAPHIC PRODUCTS OF SOME GRAPHS

Abbasi, Ahmad,Taleshani, Mona Gholamnia Korean Mathematical Society 2022 대한수학회보 Vol.59 No.3

The minimum number of complete bipartite subgraphs needed to partition the edges of a graph G is denoted by b(G). A known lower bound on b(G) states that b(G) ≥ max{p(G), q(G)}, where p(G) and q(G) are the numbers of positive and negative eigenvalues of the adjacency matrix of G, respectively. When equality is attained, G is said to be eigensharp and when b(G) = max{p(G), q(G)} + 1, G is called an almost eigensharp graph. In this paper, we investigate the eigensharpness and almost eigensharpness of lexicographic products of some graphs.

Mass composition of ultrahigh-energy cosmic rays with the Telescope Array Surface Detector data

Abbasi, R. U.,Abe, M.,Abu-Zayyad, T.,Allen, M.,Azuma, R.,Barcikowski, E.,Belz, J. W.,Bergman, D. R.,Blake, S. A.,Cady, R.,Cheon, B. G.,Chiba, J.,Chikawa, M.,di Matteo, A.,Fujii, T.,Fujita, K.,Fukushim American Physical Society 2019 Physical review. D Vol.99 No.2

New formulated "DOX-MTX-loaded Nanoparticles" Down-regulate HER2 Gene Expression and Improve the Clinical Outcome in OSCCs Model in Rat: the Effect of IV and Oral Modalities

Abbasi, Mehran Mesgari,Monfaredan, Amir,Hamishehkar, Hamed,Jahanban-Esfahlan, Rana Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Background: Oral squamous cell carcinoma (OSCC) remains as one of the most difficult malignancies to control because of its high propensity for local invasion and cervical lymph node dissemination. In this study, we evaluate the efficacy of our novel pH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in affecting HER2 expression profile in OSCC model in rat. Results: DOX-MTX- nanoparticle complexes caused significant decrease in mRNA level of HER2 compared to untreated cancers (p<0.05) and this finding was more pronounced with the IV mode (p<0.000). Surprisingly, HER2 mRNA was not affected in DOX treated as compared to the control group (p>0.05). On the other hand, in the DOX-MTX NP treated group, fewer tumors characterized with advanced stage and decreased HER2 paralleled improved clinical outcome (P<0.05). Moreover, the effectiveness of the oral route in the group treated with nanodrug accounted for the enhanced bioavailability of nanoparticulated DOX-MTX compared to free DOX. Furthermore, there was no significant difference in mRNA level of HER2 (p>0.05). Conclusions: Influence of HER2 gene expression is a new feature and mechanism of action observed only in dual action DOX-MTX-NPs treated groups. Down-regulation of HER2 mRNA as a promising marker and prognosticator of OSCC adds to the cytotoxic benefits of DOX in its new formulation. Both oral and IV application of this nanodrug could be used, with no preferences in term of their safety or toxicity. As HER2 is expressed abundantly by a wide spectrum of tumors, i DOX-MTX NPs may be useful for a wide-spectrum of lesions. However, molecular mechanisms underlying HER2 down regulation induced by DOX-MTX NPs remain to be addressed.

DOX-MTX-NPs Augment p53 mRNA Expression in OSCC Model in Rat: Effects of IV and Oral Routes

Abbasi, Mehran Mesgari,Khiavi, Monir Moradzadeh,Monfaredan, Amir,Hamishehkar, Hamed,Seidi, Khaled,Jahanban-Esfahlan, Rana Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy worldwide. Cancer development and progression require inactivation of tumor suppressor genes and activation of proto-oncogenes. The well recognized mechanism of action demonstrated for chemotherapeutic agents is induction of apoptosis via reactivation of p53. In this context, we evaluate the efficacy of IV and oral routes of our novel PH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in affecting p53 profile in an OSCC rat model. Methods: In this study, 120 male rats were divided into 8 groups of 15 animals each. The new formulated DOX-MTX NP and free doxorubicin were IV and orally given to rats with 4-nitroquinoline-1-oxide induced OSCC. Results: Results showed that both DOX and DOX-MTX-NP caused significant increase in mRNA levels of P53 compared to the untreated group (p<0.000). With both DOX and DOX-MTX NP, the IV mode was more effective than the oral (gavage) route (p<0.000). Surprisingly, in oral mode, p53 mRNA was not affected in DOX treated groups (p>0.05), Nonetheless, both IV and oral administration of MTX-DOX NP showed superior activity (~3 fold) over free DOX in reactivation of p53 in OSCC (p<0.000). The effectiveness of oral route in group treated with nanodrug accounts for the enhanced bioavailability of nanoparticulated DOX-MTX compared to free DOX. Moreover, in treated groups, tumor stage was markedly related to the amount of p53 mRNA (p<0.05). Conclusion: Both oral and IV application of our novel nanodrug possesses superior activity over free DOX-in up-regulation of p53 in a OSCC model and this increase in p53 level associated with less aggressive tumors in our study. Although, impressive results obtained with IV form of nanodrug (-21 fold increase in p53 mRNA level) but both forms of nanodrug are effective in OSCC, with less toxicity normal cells.

ARTINIANNESS OF LOCAL COHOMOLOGY MODULES

Abbasi, Ahmad,Shekalgourabi, Hajar Roshan,Hassanzadeh-lelekaami, Dawood The Honam Mathematical Society 2016 호남수학학술지 Vol.38 No.2

In this paper we investigate the Artinianness of certain local cohomology modules $H^i_I(N)$ where N is a minimax module over a commutative Noetherian ring R and I is an ideal of R. Also, we characterize the set of attached prime ideals of $H^n_I(N)$, where n is the dimension of N.

Synthesis, <i>in vitro</i> and <i>in silico</i> studies of novel potent urease inhibitors: <i>N</i>-[4-({5-[(3-Un/substituted-anilino-3-oxopropyl)sulfanyl]-1,3,4-oxadiazol-2-yl}methyl)-1,3-thiazol-2-yl]benzamides

Abbasi, Muhammad Athar,Hassan, Mubashir,Aziz-ur-Rehman, Mubashir,Siddiqui, Sabahat Zahra,Raza, Hussain,Shah, Syed Adnan Ali,Seo, Sung-Yum Elsevier 2018 Bioorganic & medicinal chemistry Vol.26 No.13

<P><B>Abstract</B></P> <P>The present article describes the synthesis, <I>in vitro</I> urease inhibition and <I>in silico</I> molecular docking studies of a novel series of bi-heterocyclic bi-amides. The synthesis of title compounds was initiated by benzoylation, with benzoyl chloride (<B>1</B>), of the key starter ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate (<B>2</B>) in weak basic aqueous medium followed by hydrazide formation, <B>4</B>, and cyclization with CS<SUB>2</SUB> to reach the parent bi-heterocyclic nucleophile, <I>N</I>-{4-[(5-sulfanyl-1,3,4-oxadiazol-2-yl)methyl]-1,3-thiazol-2-yl}benzamide (<B>5</B>). Various electrophiles, <B>8a–l</B>, were synthesized by a two-step process and these were finally coupled with <B>5</B> to yield the targeted bi-heterocyclic bi-amide molecules, <B>9a–l</B>. The structures of the newly synthesized products were corroborated by IR, <SUP>1</SUP>H NMR, <SUP>13</SUP>C NMR, EI-MS and elemental analysis. The <I>in vitro</I> screening of these molecules against urease explored that most of the compounds exhibit potent inhibitory potential against this enzyme. The compound <B>9j</B>, with IC<SUB>50</SUB> value of 2.58 ± 0.02 µM, exhibited most promising inhibitory activity among the series, relative to standard thiourea having IC<SUB>50</SUB> value of 21.11 ± 0.12 µM. <I>In silico</I> studies fully augmented the experimental enzyme inhibition results. Chemo-informatics analysis showed that synthesized compounds (<B>9a–l</B>) mostly obeyed the Lipinski's rule. Molecular docking study suggested that ligand <B>9j</B> exhibited good binding energy value (−7.10 kcal/mol) and binds within the active region of target protein. So, on the basis of present investigation, it was inferred that <B>9j</B> may serve as a novel scaffold for designing more potent urease inhibitors.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>