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DMBA로 유발한 Mouse 피부암에 대한 Astaxanthin이 함유된 난황의 항암효과
이상호,박철우,이영춘,최의성,김무남,하영래,Lee, Sang-Ho,Park, Cheol-U,Lee, Yeong-Chun,Choe, Ui-Seong,Kim, Mu-Nam,Ha, Yeong-Rae 한국환경성돌연변이발암원학회 1998 한국환경성돌연변이·발암원학회지 Vol.18 No.1
Anticarcinogenic activity of astaxanthin-containing egg yolks (designate AEY) was investigated for 7,12-dimethylbenz[a]anthracene (DMBA)-induced two stage mouse epidermal carcinogenesis. Female ICR mouse (6-7 weeks of age) were house in a humidity-and-temperature-controlled facility and subjected to feed and water ad libitum. AEY (10 mg/0.2 ml acetone) was painted on the back of mice 7 days, 3 days and 5 min before DMBA treatment (50 nmole/0.2 ml acetone). One week later after DMBA treatment, 6 ${\mu}g$ tetradecanoyl 12-phorbol 13-O-acetate (TPA) dissolved in 0.2 ml acetone was applied on the mouse twice weekly over a period of 22 weeks. No sample was given to control mice. Control egg yolk (CEY) and astaxanthin-containing oil (designate AO) from Phaffia rhodozyma were used as positive controls. Mouse treated with AEY exhibited 10 tumors per mouse whereas control mouse exhibited 15 tumors per mouse, the fact that 33% reduction of tumor per mouse by AEY treatment. Tumor incidence was also reduced to 15% by AEY treatment when compared to that of control group. Such effects were also seen in CEY and AO treatment groups, but leaser extent. AO gave reduction of food intake and body weights relative to those of AEY and CEY, indicating toxicity of AO. These results suggest that AEY exhibits anticarcinogenic activity for DMBA-induced mouse epidermal carcinogenesis.
삼백초 Hexane 분획물의 Heterocyclic Amine 돌연변이성 조정효과
이상호,박철우,박경아,이영춘,김무남,하영래,Lee, Sang-Ho,Park, Cheol-U,Park, Gyeong-A,Lee, Yeong-Chun,Kim, Mu-Nam,Ha, Yeong-Rae 한국환경성돌연변이발암원학회 1998 한국환경성돌연변이·발암원학회지 Vol.18 No.1
Antimutagenic activity of Saururus chinesis (Lour.) Bail was investigated for food-borne mutagens using S. typhimurium TA98. Methanol extract from Saururus Chinesis (Lour.) Bail was fractionated into hexane, chloroform, ethylacetate and butanol fractions, followed by determination of antimutagenic activity for food-borne mutagenic heterogenic amines (HCA). The hexane fraction exhibited a strong antimutagenic activity for 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), 2-amino-3,8-dimethylimidazo[4,5-f] quinoxaline (MeIQ), 2-amino-3,4-dimethyl-3H-imidazo[4,5-f]quinoline (MeIQx), 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), 3-amino-1-methyl-5H-pyroid[4,3-b]indole acetate (Trp-2-A); however its fraction rather enhanced the bacterial mutagenicity of 2-amino-3,4,8-trimethyl-3H-imidazo[4,5-f]quinozaline (4,8-diMeIQx) and 2-amino-3,7,8-trimethyl-3H-imidazo[4,5-f]quinoxline (7,8-diMeIQx). Active principle in the fraction was found to be two major compounds (${\gamma}$-crene B and epi-bicyclosesquiphellandrane) and 6 minor compounds (${\delta}$-caryophyllene, ${\gamma}$-elemene, ${\beta}$-cabebene, ${\delta}$-cadinene, ${\delta}$-selinene, and patchoulene). Modulation effect for the mutagenic activity of the food-borne mutagenic HCA by the fraction might be derived from a cumulative effect of each individual compounds. Hence, this hexane fraction might be use to reduce the production of mutagenic HCA during cooking process of protein-rich foods.
치료된 증식당뇨망막병증에서 신생혈관녹내장 발생의 예측인자
이지현(Ji Hyun Lee),김은영(Eun Yeong Kim),김태경(Tai Kyong Kim),신혜영(Hye Young Shin),김수영(Su Young Kim),이영춘(Young Chun Lee),이미연(Mee Yon Lee) 대한안과학회 2017 대한안과학회지 Vol.58 No.4
목적: 증식당뇨망막병증 환자에서 신생혈관녹내장으로의 진행에 유의한 인자에 대해 분석하고자 한다. 대상과 방법: 2014년 3월부터 2016년 3월까지 본원에 내원하여 증식당뇨망막병증을 처음 진단 받은 환자 52명의 의무기록을 후향적으로 분석하여 당뇨유병기간, 당화혈색소, 고혈압, 고지혈증, 신장 질환 등의 만성 질환 여부, 인슐린 치료 여부, 혈액 요소질소, 혈액 크레아티닌, 사구체 여과율, 소변 알부민, 투석 여부, 초진 시 교정 시력, 초진 시 안저 소견에서의 견인성 막, 유리체 출혈, 망막앞출혈 여부 등을 각 군에서 비교하여 신생혈관녹내장 발생의 예측인자에 대하여 알아보았다. 결과: 총 52명이 포함되었으며, 홍채신생혈관만 발생한 환자는 12명(23.08%), 신생혈관녹내장까지 발생한 환자는 4명(7.69%)이었다. 당뇨유병기간은 홍채신생혈관 발생군은 10.88 ± 7.14년, 신생혈관녹내장 발생군에서는 11.75 ± 8.61로 홍채신생혈관이 발생하지 않은 대조군의 8.30 ± 5.25년에 비하여 유의하게 길었다(p-value 0.41, 0.032). 당화혈색소는 홍채신생혈관 발생군은 9.59 ± 2.23이었으며 대조군에서는 9.27 ± 2.54로 서로 유의한 차이를 보이지 않았으나(p=0.721), 신생혈관녹내장 발생군에서는 11.55 ± 0.21로 대조군에 비하여 유의하게 높았다(p-value 0.048). 결론: 증식당뇨망막병증 환자에서 오랜 당뇨유병기간 및 높은 당화혈색소 수치는 신생혈관녹내장으로의 진행에 있어 유의한 영향을 미치며 환자의 예후 예측 및 예방에 유용하게 이용될 수 있을 것이다. Purpose: To evaluate the factors that are significant in progression to neovascular glaucoma in patients with proliferative diabetic retinopathy. Methods: In this retrospective analysis, we reviewed the medical records of 52 patients who were first diagnosed with proliferative diabetic retinopathy from March 2014 to March 2016. We compared diabetes mellitus period, HbA1c, chronic diseases such as hypertension, hyperlipidemia, and kidney disease, insulin treatments, blood urea nitrogen, blood creatinine, glomerular filtration rate, urine albumin, dialysis, corrected visual acuity at the first visit, traction membrane sign of the retina at the first visit, vitreous hemorrhage and preretinal hemorrhage in each group and then investigated the prognostic factors of neovascular glaucoma. Results: A total of 52 patients were included in the investigation, 12 patients (23.08%) were diagnosed with iris neovascularization and 4 patients (7.69%) developed neovascular glaucoma. The patients without iris neovascularization were defined as Group I, those with iris neovascularization as Group II, and those with neovascular glaucoma as Group III. The diabetes mellitus period was significantly longer in Group II (10.88 ± 7.14 years) and in Group III (11.75 ± 8.61 years) than Group I (8.30 ± 5.25 years) (p-value 0.41, 0.032, respectively). The HbA1c level was 9.59 ± 2.23 in Group II and 9.27 ± 2.54 in Group I. There was no significant difference between the two groups (p = 0.721). However, HbA1c was significantly higher in Group III (11.55 ± 0.21) than Group I (p-value 0.048). Conclusions: A long diabetes mellitus period and high HbA1c level have a significant effect on the progression to neovascular glaucoma in patients with proliferative diabetic retinopathy. This information could be useful for predicting and preventing the prognosis of patients.
범망막광응고술을 시행한 증식당뇨망막병증에서 임상적으로 유의한 황반부종을 유발하는 전신 위험인자
김소희(So Hee Kim),김은영(Eun Yeong Kim),김태경(Tai Kyong Kim),신혜영(Hye-Young Shin),김수영(Su Young Kim),이영춘(Young Chun Lee),이미연(Mee Yon Lee) 대한안과학회 2017 대한안과학회지 Vol.58 No.6
목적: 증식당뇨망막병증 환자에서, 첫 범망막광응고술 시행 후 1년 안에 치료가 필요한 당뇨망막병증의 합병증이 발생할 확률과 전신 위험인자의 상관관계를 분석하고자 한다. 대상과 방법: 2010년 1월부터 2016년 12월까지 처음 진단되어 본원에서 범망막광응고술을 시행한 증식당뇨망막병증 환자의 기록을 후향적으로 분석하였다. 전체 대상자 총 171안을 임상적으로 유의한 황반부종(85안)군과 임상적으로 유의한 황반부종이 없는 군(86안) 으로 분류하였다. 임상적으로 유의한 황반부종과 당화혈색소(HbA1c), 당뇨유병기간, 혈압, 체질량지수(body mass index, BMI), 이상 지질혈증, 추정사구체여과율(excreted glomerular filtration rate, eGFR) 및 성별의 상관관계를 분석했다. 결과: 총 171명의 환자 중 단변수분석에서 당뇨유병기간, 총 콜레스테롤수치, 저밀도지단백(low density lipoprotein), HbA1c 및 eGFR 이 임상적으로 유의한 황반부종(clinically significant macula edema, CSME) 군에서 통계적으로 유의하게 높았다(p<0.05). 고밀도지 단백(high density lipoprotein), 중성지방(triglycerides), BMI, 수축기 및 이완기 혈압은 유의한 상관관계가 없었다. 다변량분석을 통해 높은 총 콜레스테롤수치 및 HbA1c 수치가 임상적으로 유의한 황반부종을 유발하는 위험인자임이 밝혀졌다. 결론: 콜레스테롤수치 및 HbA1c 수치가 임상적으로 유의한 황반부종(CSME)의 발생에 유의한 영향을 미치는 인자이며 환자의 예후를 예측하고 설명하는 부분에 있어 유용하게 이용될 수 있다. Purpose: We investigated systemic risk factors for clinically significant macula edema (CSME) within 1 year after pan-retinal photocoagulation in patients with proliferative diabetic retinopathy. Methods: A retrospective chart review was performed on 171 patients who received pan-retinal photocoagulation at our hospital from January 2010 to December 2016. The patients were divided into Group Ⅰ with CSME (85 eyes) and Group Ⅱ without CSME (86 eyes). The associations between presence of CSME and glycated hemoglobin (HbA1c), duration of diabetes, systolic and diastolic blood pressure (BP), body mass index (BMI), lipid status, sex, and estimated glomerular filtration rate (eGFR) were evaluated. Results: In the present study of 171 patients, there was no significant difference in age and gender distribution between the two groups. Duration of diabetes, total serum cholesterol, serum low density lipoprotein, HbA1c, and eGFR were significantly higher in patients with CSME (p < 0.05). Serum high-density lipoprotein, triglycerides, BMI, and systolic and diastolic BP showed no correlation with CSME. Multiple logistic regression analysis showed that total serum cholesterol and HbA1c values had significantly high odds of developing CSME. Conclusions: HbA1c, total serum cholesterol, and eGFR are important risk factors associated with CSME in patients with proliferative diabetic retinopathy secondary to pan-retinal photocoagulation. Thus, early detection of these risk factors and their control have significant roles in preventing the development and progression of maculopathy and thereby preventing severe visual loss. J Korean Ophthalmol Soc 2017;58(6):670-675