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      • KCI등재

        안면홍조를 호소하는 뇌경색 환자 한방치료 치험 1례

        황규상,장철용,이수영,김준현,우찬,신용진,신선호,Hwang, Gyu-sang,Jang, Chul-yong,Lee, Su-yeong,Kim, June-hyun,Woo, Chan,Shin, Yong-jeen,Shin, Sun-ho 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.5

        Methods: A stroke patient with hot flashes was treated for 4 weeks with acupuncture, herbal acupuncture, and herbal medicine. We then evaluated the frequency, intensity, and score (frequency×intensity) of the hot flashes, as well as the Pittsburgh Sleep Quality Index (PSQI), which shows subjective sleep quality. Results: After 4 weeks of traditional Korean medicine (TKM) treatment, the patient showed reductions in the frequency of hot flashes from a score of 7 to 4, the intensity of hot flashes from a score of 4 to 2, the scoring (frequency×intensity) of hot flashes from 28 to 4, and the PSQI from 13 to 4. Conclusions: This study validated the effect of TKM as a treatment for hot flashes in patients with stroke.

      • KCI등재

        자하거 약침 단독치료로 호전된 다발성 경화증 치험 1례

        황규상,유근정,이수영,이준영,김두리,홍가경,신선호,신용진,Hwang, Gyu-sang,Yu, Keun-jeong,Lee, Su-yeong,Lee, Jun-yeong,Kim, Du-ri,Hong, Ka-kyung,Shin, Sun-ho,Shin, Yong-jeen 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.2

        Objectives: This case report describes the effect of Hominis placenta pharmacopuncture (HPP) on multiple sclerosis. Methods: A multiple sclerosis patient with gait disturbances, tremors, spasms of both lower limbs, and diplopia was treated with only HPP for two weeks. To evaluate the effects of HPP on the balance ability of the patient, the Functional System (FS) scale, Expanded Disability Statue Scale (EDSS), visual analog scale (VAS), manual muscle test (MMT), and Berg Balance Scale (BBS) were used. Results: The HPP treatment reduced the patient's gait disturbance, tremors, spasms of the lower limbs, and diplopia. According to the FS scale, the patient's cerebellar and optic functions were enhanced. In addition, the patient's performance on the EDSS improved from 4.0 to 3.0.3. As shown by the MMT, the lower extremities showed a mild improvement (from F+ to G.4). Furthermore, the VAS showed a considerable improvement, decreasing from 9 to 6.5 post-treatment. The patient's performance on the BBS, which denotes balance ability, showed a considerable improvement, increasing from 38 to 49. Conclusion: Treatment with only HPP could help to ameliorate the symptoms of multiple sclerosis.

      • KCI등재

        H<sub>2</sub>O<sub>2</sub>로 유발된 C6 신경교세포 사멸에 대한 총명공진단의 보호 효과

        황규상,신용진,Hwang, Gyu-sang,Shin, Yong-jeen 대한한방내과학회 2020 大韓韓方內科學會誌 Vol.41 No.1

        Objectives: This study was conducted to identify the protective effects of Chongmyunggongjin-dan (CMGJD) on Hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced apoptosis mechanisms in C6 glial cells. Method: We used CMGJD after distilled water extraction, filtration, and lyophilization. The ROS scavenging effect was examined by fluorescence microscopy. Expression levels of proteins related to ROS generation were investigated by western blotting. Functional changes in organelles related to Reactive oxygen species (ROS) generation were investigated by immunoblotting and by verifying expression level of relevant enzymes. Results: The CMGJD extract protected the cells against H<sub>2</sub>O<sub>2</sub>-induced morphological changes and DNA fragmentation, inhibited the increase of Heme_oxygenase-1(HO<sup>-1</sup>) and the decrease in catalase, protected against the loss of mitochondrial membrane potential, inhibited disturbances of lysosomal function, and induced an increase in peroxisomes. Conclusion: CMGJD was confirmed to have a protective effect on H<sub>2</sub>O<sub>2</sub>-induced C6 glial cell death possibly by blocking the pathways causing damage to subcellular organelles, such as mitochondria, lysosomes, and peroxisomes. We assume that CMGJD will be effective for the prevention and treatment of ischemic stroke in a clinical environment.

      • KCI등재
      • KCI등재

        척추기저동맥박리에 의한 소뇌경색 환자 한방치험 1례

        이수영,황규상,김두리,윤종민,문병순,Lee, Su-yeong,Hwang, Gyu-sang,Kim, Du-ri,Yun, Jong-min,Moon, Byung-soon 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.5

        Objective: This study is a report on a case of cerebellar infarction with vertebrobasilar artery dissection which was improved by Korean medicine. Methods: A 63-year-old man diagnosed with cerebellar infarction with vertebrobasilar artery dissection was admitted to hospital for 86 days and treated with Korean medicine (acupuncture and herbal medicine) and rehabilitation treatment. Clinical symptoms were assessed with a Modified Barthel index, functional independent measurement, Berg balance scale, manual muscle test, and a visual analogue scale. Result: After treatment, the clinical symptoms were improved, and the evaluation index scores (modified Barthel index, functional independent measurement, Berg balance scale) increased. Conclusion: Korean medicine may be a meaningful treatment for patients with cerebellar infarction with vertebrobasilar artery dissection.

      • KCI등재

        만성기 비골신경 마비의 한방치료 증례보고

        유근정,황규상,이준영,이언정,Yu, Keun-jeong,Hwang, Gyu-sang,Lee, Jun-yeong,Lee, Un-jung 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.5

        Objective: This case report describes the effects of Korean medicine treatment on chronic peroneal nerve palsy. Methods: One patient with peroneal nerve palsy was treated 6 months after onset with various Korean medicine treatments, such as acupuncture, cupping, herbal medicine (Bojungikki-tang and Palmijihwang-tang), and Hominis Placental pharmacopuncture for 14 days. The Manual Muscle Test (MMT), range of motion (ROM) of the ankle, and a numerical rating scale (NRS) were used to evaluate the effectiveness of treatment. Results: After 14 days of treatment, the scores for all 3 scales were improved. The MMT grade increased from 1-3 to 4-4+. The ankle ROM was restored to a nearly normal range. The NRS showed a considerable improvement, decreasing from 7 to 2. No side effects were noted. Conclusions: Korean medicine may be effective for the treatment of chronic peroneal nerve palsy, but further studies are needed.

      • KCI등재

        뇌졸중 환자에게 유치도뇨관 삽입 이후 발생한 다제내성 녹농균 요로감염 한방치험 1례

        장철용,김효린,황규상,유근정,이수영,김준현,김민수,신용진,신선호,Jang, Chul-yong,Kim, Hyo-rin,Hwang, Gyu-sang,Yu, Keun-jeong,Lee, Su-yeong,Kim, June-hyun,Kim, Min-soo,Shin, Yong-jeen,Shin, Sun-ho 대한한방내과학회 2016 大韓韓方內科學會誌 Vol.37 No.6

        This case study reports on the effect of Korean medicine on a catheter-associated urinary tract infection (CAUTI) caused by multidrug-resistant Pseudomonas aeruginosa. An 83-year-old man diagnosed with stroke had dysuria, and it was found that an indwelling urinary catheter led to CAUTI. From laboratory tests, we identified multidrug-resistant Pseudomonas aeruginosa and applied Korean medicine to him. After herbal medication with acupuncture and moxibustion, we studied a urinalysis and urine culture again for follow-up. We found meaningful improvement in bacteriuria and bacterial identification. This case suggests that Korean medicine could have a beneficial effect on urinary tract infections caused by multidrug-resistant Pseudomonas aeruginosa.

      • KCI등재

        투자펀드에서의 관계인거래에 대한 미국의 규제와 시사점

        박삼철(Park, Sam-Cheol),이규림(Lee, Kyu-Rim),황규상(Hwang, Kyu-Sang) 한국증권법학회 2015 증권법연구 Vol.16 No.1

        투자펀드제도는 자금 제공자와 자금 운용자의 분리라는 특성으로 인해 자산운용회사가 자신이나 그 관계인의 이익을 위해 펀드재산을 남용하는 이익상충 문제를 내포하고 있다. 이러한 문제는 펀드와 그 관계인 간의 거래, 즉 관계인거래를 통해 현실화되는 것이 일반적이다. 따라서 관계인거래로부터 펀드투자자의 이익을 보호하는 것은 펀드규제의 핵심이라고 할 수 있다. 미국의 펀드규제법인 투자회사법은 펀드 관계인거래를 관계인의 거래상의 지위와 거래양태를 기준으로 유형화하여 매우 구체적이고 체계적으로 규제하고 있다. 또한, 관계인에 의한 남용 소지가 없는 거래에 대해서는 다양한 방식으로 예외를 허용함으로써 펀드투자자 이익 보호라는 규제목적과 함께 펀드운용의 효율성도 적절히 배려하고 있다. 규제목적에 맞는 정치한 법규와 이를 합리적·탄력적으로 적용하는 감독당국의 노력에 힘입어 미국의 관계인거래 규제는 펀드투자자의 이익 보호와 펀드산업의 명성 유지에 필수적인 역할을 하고 있다. 우리 자본시장법상 펀드 관계인거래 규제는 관계인에 의한 펀드재산 남용 방지라는 규제목적과 이러한 목적에 맞게 잘 정비되어 있는 미국의 입법례에 비추어 볼때 규제체계와 규제내용에 대한 전반적인 개선이 요망된다. 무엇보다 우리 자본시장법은 펀드의 관계인을 합리적 근거 없이 ‘자산운용회사의 대주주등’과 ‘자산운용 회사등’으로 구분하여 전자만 펀드의 이해관계인으로 정의하고 나아가 후자와 펀드간의 거래는 불건전영업행위의 한 유형으로 규제하는 것은 규제체계상 문제가 있으므로 정비가 필요하다. 관계인거래의 규제방식도 현재와 같이 단순히 ‘거래’를 금지할 것이 아니라 관계인의 거래상의 지위와 거래양태 등을 고려하여 유형화하여 구체적인 규정을 둠으로써 규제 실효성을 제고할 필요가 있다. 그리고 자본시장법상 관계인거래의 예외가 지나치게 좁아 과잉규제의 소지가 있으므로 관계인에 의한 남용행위는 엄격하게 금지하되 공정하고 건설적인 거래는 허용함으로써 펀드투자자 보호와 펀드운용 효율성 제고의 조화를 도모할 필요가 있다. 마지막으로, 증권펀드 외의 펀드, 즉 부동산펀드 등에 대해서는 펀드의 특성을 고려하여 그에 적합한 별도의 규제를 정하는 것을 검토해볼 필요가 있다. Investment funds, due to the nature of separation of investor and investment manager, inevitably face conflict of interest issues because the manager may potentially abuse the fund for the benefit of itself or its related parties. Such issues rise to the surface when there are transactions between the investment fund and its related parties. Consequently, one of the most important goals of investment fund regulation is to protect investors from risks stemming from affiliates transactions. The US has very specific and systematic investment fund regulations concerning affiliates transactions, which categorize the issues depending on the status of the affiliates and type of transaction. In addition, US regulations allow various exemptions and exceptions for types of transactions that are unlikely to be abused by the affiliates, securing the balance between the regulatory purpose of protection of the investors and the efficiency of investment management. Thanks to such flexible application of the regulations by the US regulator focusing on the regulatory purposes based on fine-tuned regulatory provisions, US regulation concerning affiliates transactions has played an important role in maintaining and improving the reputation of the investment fund business and protecting investors. On the contrary, the regulations around affiliates transactions under the Financial Services and Capital Markets Act of Korea (“FSMCA”) require overall reassessment, based on the study of the well-established regulatory system of the US which is well designed to the point of prohibition of abuse of the fund by the affiliates. Most of all, it is hard to find any reasonable ground for the different categorization of ‘major shareholders, etc. of asset management company’ and ‘asset management company, etc.’ and giving different treatment to those two categories ? the former is regulated as affiliates transaction and the latter is regulated as unsound business practice. Thus, such regulation structure under FSCMA without sound grounds needs to be revisited. In terms of how to regulate affiliates transactions, it is necessary to improve the effectiveness of the regulation by building up more reasonably categorized provisions to cover various status of affiliates and types of transactions, instead of simply prohibiting the ‘transaction’ as stipulated in the current FSCMA. In addition, as there are only narrow exceptions available in the FSCMA, which may be excessively restrictive, it is necessary to achieve balance between investor protection and the efficiency of investment management by allowing fair and constructive transactions while prohibiting abuse by affiliates. Finally, it is recommendable to consider setting up a separate set of regulations for investment funds that do not invest mainly in securities, as such funds (e.g. real estate funds, etc.) that have a totally different character and nature.

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