임신성 피부질환의 한약 치료에 대한 국내 연구 동향

홍가경,강수진,김선경,김송백 대한한방부인과학회 2020 大韓韓方婦人科學會誌 Vol.33 No.1

Objectives: The purpose of this study is to investigate the domestic study trends on dermatosis gravidarum treated with herbal medicine. Methods: We searched for studies of dermatosis gravidarum treated with herbal medicine published until September 2019, through 6 Korean web databases. After searching studies, we analyzed selected studies. Results: As a result, eight studies were included in this study, all of which were case reports. Three studies used herbal medicine alone, three studies used herbal medicine with acupuncture, and two studies used herbal medicine with other treatment. In all of eight studies, herbal medicine treatment was effective for dermatosis gravidarum. Conclusion: This study shows that herbal medicine could be helpful in treating dermatosis gravidarum. However, in order to consolidate the foundation of herbal medicine treatment for dermatosis gravidarum, more case reports and high-quality clinical researches are needed.

LPS로 유도된 염증모델에 대한 청포축어탕의 억제 효과

홍가경 ( Ka-kyung Hong ),이수형 ( Soo-hyung Lee ),정현태 ( Hyun-tae Jung ),김송백 ( Song-baek Kim ) 대한한방부인과학회 2021 大韓韓方婦人科學會誌 Vol.34 No.4

Objective: This study was performed to investigate the inhibitory effect of Cheongpochukeo-tang (CCT) on lipopolysaccharide (LPS)-induced inflammation model. Methods: RAW 264.7 cells were pre-treated with CCT and incubated with LPS (500 ng/ml) after 1 hour. Cell viability was measured by MTT assay to figure out cytotoxicity of CCT. The production of nitric oxide and mRNA expression of pro-inflammatory cytokine were measured. And the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB) were examined to figure out molecular mechanisms of CCT’s anti-inflammatory effects. In addition, mice survival rate and cytokine levels of serum were observed after treated with CCT. And mice liver tissues were observed and their cytokines levels in liver tissue were measured. Results: CCT did not have cytotoxic effect in RAW 264.7 cells. It inhibited LPS-induced nitric oxide (NO) production, but showed an increase in NO by itself at 2 mg/ml concentration. CCT inhibited mRNA expression of IL-1β, IL-6, TNF-α in a dose dependant and the activaton of MAPKs and NF-κB. In addition, CCT reduced mortality in the LPS-induced mouse model and inhibited production of cytokines in mouse serum and liver tissue. Conclusion: The results suggest that CCT could reduce LPS-induced inflammation by inhibiting MAPKs and NF-κB activaton, NO production, and pro-inflammatory cytokines secretion. Thereby, CCT could be effective medicine for the inflammatory disease.

AMH 수치가 상승된 희발월경 환자 증례보고

홍가경 ( Ka-kyunghong ),강수진 ( Su-jinkang ),김선경 ( Sun-kyungkim ),김송백 ( Song-baekki ) 대한한방부인과학회 2018 大韓韓方婦人科學會誌 Vol.31 No.3

Objectives: In recent studies, increased AMH level has been suggested as objective surrogate marker for diagnosis PCOS, one of the major causes of oligomenorrhea. The purpose of this study is to report the clinical effect of Korean medicine treatment on oligomenorrhea patient with increased Anti-mullerian hormone level, who can be diagnosed who can be ruled out PCOS. Methods : A 27 year old woman with oligomenorrhea was enrolled in this study. We measured serum hormone levels and ruled out PCOS. The patient received Korean medicine treatment for 3 months, we assessed the result of treatment through observation of the menstrual cycle and follow-up measurements of serum hormone levels. Results : 1. The patient had menstrual cycle regularly. 2. Increesed serum AMH level of the patient decreesed from 12.16 ng/ml to 8.51 ng/ml. 3. The other serum hormone levels such as testosterone, LH/FSH ratio decreased Conclusion: This case shows that Korean medicine treatment could have a beneficial effect on menstrual cycle and decrease the increased serum hormone levels of ruled out PCOS patient.

갱년기 안면홍조에 대한 매선치료 : 체계적 문헌고찰

송미화,홍가경,최창민,Song, Mi-Hwa,Hong, Ka-Kyung,Choi, Chang-Min 대한한방부인과학회 2017 大韓韓方婦人科學會誌 Vol.18 No.4

Objectives: The purpose of this systematic review was to overview and evaluate the effectiveness of acupoint catgut embedding for climacteric hot flush. Methods: We searched articles from CNKI, Pubmed CENTRAL, Koreantk, Oasis online databases. After searching the articles, we performed quality assessment using Cochrane risk of bias (RoB) tools. Results: Among the 20 articles were searched, one radomized controlled clinical trial (RCT) was selected. 1 Study showed that Acupoint catgut embedding treatment has significant effect on climacteric hot flush in terms of the effectiveness rate. Conclusions: This study found encouraging but limited evidence of aupoint catgut embedding theragpy for climacteric hot flush.

단삼 물 추출물의 LPS로 유도된 RAW 264.7 세포와 생쥐 염증모델에서의 항염증 효과

김건희,홍가경,조한백,최창민,김송백 대한한방부인과학회 2019 大韓韓方婦人科學會誌 Vol.32 No.2

Objectives: This study was performed to identify the anti-inflammatory effects of Salvia miltiorrhizae radix Water extract (SMW) on lipopolysaccharide (LPS) induced inflammation. Methods: RAW 264.7 cells were treated with 500 ng/ml of LPS. SMW (0.1, 0.25, 0.5 mg/ml) was treated 1 h prior to LPS. Cell viability was measured by MTT assay. Levels of nitric oxide (NO) were measured with Griess reagent and pro-inflammatory cytokines were measured by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR). We also examined molecular mechanisms such as mitogen-activated protein kinases (MAPKs) and nuclear factor-kappa B (NF-κB) activation by western blot. In addition, we observed mice survival rate after LPS and examined their cytokine levels of serum and liver tissue. Results: SMW itself did not have cytotoxic effects in RAW 264.7 cells less than 0.5 mg/ml. SMW treatment inhibited the production of NO, and interleukin (IL)-1β which is pro-inflammatory cytokine. And SMW treatment inhibited the LPS-induced activation of MAPKs such as extracellular signal-regulated kinase1/2 (ERK1/2), p38 kinases (p38), c-Jun NH2-terminal kinase (JNK) and NF-κB. In addition, it also showed reducing the level of IL-1β on the serum and liver tissue of mice. Also, death of LPS-induced mice was inhibited by SMW. Conclusions: The result suggests that treatment of SMW could reduce the LPS-induced inflammation. Thereby, SMW could be used as a protective agent against inflammation. Also, this study could give a clinical basis that SMW could be a drug or agent to prevent inflammatory diseases.

황련해독탕 약침 치료를 병행한 임신 중 좌골신경통을 동반한 요통 환자의 증례보고

김선경,강수진,홍가경,최창민 대한한방부인과학회 2019 大韓韓方婦人科學會誌 Vol.32 No.2

Objectives: This study was to report clinical effect and safety of Traditional Korean Medical Treatment including Hwangryunhaedok-tang Pharmacopuncture for pregnant woman with low back pain with sciatica. Methods: The patient who suffered from sudden low back pain with sciatica was treated with Hwangryunhaedok-tang Pharmacopuncture, acupuncture, moxibustion, herbal medication and cupping therapy during admission. Visual Analog Score (VAS), Oswestry Disability Index (ODI), McGill pain questionnaire-short form (SF-MPQ) were checked to measure the outcome. Results: After treatment, Visual Analog Score (VAS), Oswestry disability index (ODI), McGill pain questionnaire-short form (SF-MPQ) were considerably improved in this case. Conclusions: The results indicate that Traditional Korean Medical Treatment including Hwangryunhaedok-tang Pharmacopuncture is the effective therapy for low back pain with sciatica during pregnancy.

갱년기 안면홍조에 대한 매선치료 : 체계적 문헌고찰

송미화 ( Mi-hwa Song ),홍가경 ( Ka-kyung Hong ),최창민 ( Chang-min Choi ) 대한한방부인과학회 2017 大韓韓方婦人科學會誌 Vol.30 No.2

Objectives: The purpose of this systematic review was to overview and evaluate the effectiveness of acupoint catgut embedding for climacteric hot flush. Methods: We searched articles from CNKI, Pubmed CENTRAL, Koreantk, Oasis online databases. After searching the articles, we performed quality assessment using Cochrane risk of bias (RoB) tools. Results: Among the 20 articles were searched, one radomized controlled clinical trial (RCT) was selected. 1 Study showed that Acupoint catgut embedding treatment has significant effect on climacteric hot flush in terms of the effectiveness rate. Conclusions: This study found encouraging but limited evidence of aupoint catgut embedding theragpy for climacteric hot flush.

유방암 환자의 항암화학요법 후 한방병원 입원치료에 대한 일개 한방병원 환자 특성 및 치료 고찰

강수진,김선경,양금진,홍가경,조한백 대한한방부인과학회 2020 大韓韓方婦人科學會誌 Vol.33 No.2

Objectives: The purpose of this study is to analyse current status and treatment of the Korean medicine hospital after chemotherapy in patients with breast cancer. Methods: We investigated the medical records of 21 patients who admitted to Korean medicine hospital after chemotherapy in patients with breast cacner from March 1, 2017 to December 31, 2019. We searched medical records retrospectively and analyzed current status and treatment of Korean medicine hospital. Results: The average age of 21 participants was 52.81±8.38 years and 40s and 50s accounted for 85.6% of the total. After receiving chemotherapy, the average time to hospitalization was 1.87±3.13days and average hospital stay was 9.78±4.14 days. The subjects were classified as 28.6% of stage I, 52.4% of stage Ⅱ, 9.5% of stage Ⅲ, and 9.5% of stage Ⅳ. The analysis according to the presence of metastasis was 57.1% without metastasis, 33.3% with axillary lymph node metastasis, and 9.5% with distant metastasis. The main symptoms complained when hospitalized by 21 subjects were nausea (54.2%), fatigue (54.2%), and anorexia (50.8%) in over 50%, pantalgia (47.5%), and insomnia (47.5%), dizziness (44.1%), cold sweating (42.4%), lower extremity pain (40.7%), 37.5~37.9℃ fever (39.0%), headache (37.3%), hot flush (37.3%), pruritus (30.5%) are 30% or more. Korean medicine treatment was performed in 87.4% of all hospitalizations and Gwakhyangjunggi-san-gami was the most administered prescription. Extracts of Korean medicine was performed in 100.0% of all patients and Eunkyo-san was most administered extracts medicine. Acupuncture, moxibustion, and cupping treatments were performed in all 21 study subjects. Other treatments was performed at a frequency of hyperthermia (90.5%), lymph massage (23.8%), air compression therapy (23.8%), and Interference current therapy (19.0%) Conclusion: Korean traditional medicine can be used as a countermeasure for side effects after chemotherapy in breast cancer patients.

자하거 약침 단독치료로 호전된 다발성 경화증 치험 1례

황규상,유근정,이수영,이준영,김두리,홍가경,신선호,신용진,Hwang, Gyu-sang,Yu, Keun-jeong,Lee, Su-yeong,Lee, Jun-yeong,Kim, Du-ri,Hong, Ka-kyung,Shin, Sun-ho,Shin, Yong-jeen 대한한방내과학회 2017 大韓韓方內科學會誌 Vol.38 No.2

Objectives: This case report describes the effect of Hominis placenta pharmacopuncture (HPP) on multiple sclerosis. Methods: A multiple sclerosis patient with gait disturbances, tremors, spasms of both lower limbs, and diplopia was treated with only HPP for two weeks. To evaluate the effects of HPP on the balance ability of the patient, the Functional System (FS) scale, Expanded Disability Statue Scale (EDSS), visual analog scale (VAS), manual muscle test (MMT), and Berg Balance Scale (BBS) were used. Results: The HPP treatment reduced the patient's gait disturbance, tremors, spasms of the lower limbs, and diplopia. According to the FS scale, the patient's cerebellar and optic functions were enhanced. In addition, the patient's performance on the EDSS improved from 4.0 to 3.0.3. As shown by the MMT, the lower extremities showed a mild improvement (from F+ to G.4). Furthermore, the VAS showed a considerable improvement, decreasing from 9 to 6.5 post-treatment. The patient's performance on the BBS, which denotes balance ability, showed a considerable improvement, increasing from 38 to 49. Conclusion: Treatment with only HPP could help to ameliorate the symptoms of multiple sclerosis.