왕실의 議藥

홍세영(Seyoung Hong) 한국의사학회 2010 한국의사학회지 Vol.23 No.1

Seungjeongwon Ilgi[『承政院日記』], the Diaries of Royal Secretariat of the Joeson Dynasty is the most massive compilation of records in Korean history. Medical records in Seungjeongwon Ilgi have been studied but the procedures of clinical discussion[議藥] have not yet been studied. In this paper, main agents of clinical discussion, formation of participant doctor system, particularity of clinical discussion in Royal Court and problems derived from it will be discussed. Main agents of clinical discussion were court doctors[內醫], royal doctors[御醫] and participant doctors[議藥同參]. The king himself decided ultimately as a matter of form. Head of the Medical Dpt. of the Palace[藥房都提調] was in charge of attending to king, but head of the court doctor[首醫] led the actual discussion of deciding treatment. The Medical Dpt. of the Palace[內醫院] was divided into three sectors-court doctor division, acupuncture doctor division and participant doctor division. Palace doctors payed a great attention to avoid serious error. This tendency led them occasionally to passive management. Sometimes aggressive treatment is needed in the course of treating disease, but palace doctors tended to choose slow and gradual methods. It induced minor conflict between palace doctors and participant doctors from outside palace, because doctors from outside palace subordinated effectiveness. Their opinion had not been always recognized by court doctors. However, their role was meaningful because they provided flexibility to the rigidity of clinical discussion in the palace. It is important to evaluate clinical records in Seungjeongwon Ilgi[『承政院日記』]. If we have broader eye on the clinical procedure in the palace, we can estimate the value of the contents more objectively and accurately.

단백질 나노입자를 이용한 약물전달 시스템

홍세영(Seyoung Hong),박희호(Hee Ho Park) 한국생물공학회 2020 KSBB Journal Vol.35 No.1

Nanoparticles have various advantages as drug carriers, so they have been widely used to deliver various chemical and biomolecule drugs, such as anti-cancer drugs and therapeutic proteins. Among nanoparticles, protein nanoparticles are non-cytotoxic and biodegradable, with high potential as drug carriers. Protein nanoparticles can be synthesized using proteins such as silk protein fibroin, albumin, gelatin, gliadin, legumin, 30Kc19 protein derived from silkworm hemolymph, and are manufactured using methods such as emulsion/solvent extension, desolvation, electrospray technology, complexification, and etc. The characterization parameters of protein nanoparticles are particle size, particle morphology and structure, surface charge, drug loading and release, which vary the drug delivery efficiency according to these parameters. Thus, the synthesis of protein nanoparticles using various materials and manufacturing techniques is being actively studied to improve drug delivery efficiency.

연어 중심 어휘 지도가 유아의 말하기 능력에 미치는 효과

홍세영(Hong, Seyoung),김낙복(Kim, Nahk-Bohk) 한국영어교과교육학회 2012 영어교과교육 Vol.11 No.2

The purpose of this study was to investigate the effects of the collocational approach on improving the speaking ability of kindergarteners. Specifically, this study compares the effectiveness of collocation learning to an individual word memorization as a way to improve speaking abilities. Surveys measuring speaking ability, listening comprehension and interest were administered after five weeks of treatment to identify differences in effectiveness between the two methods. The results of this study are as follows. First, collocational learning has more influence on the improvement of learners’ speaking ability. This shows that learning a variety of collocations is more effective for speaking than learning individual vocabulary words. Second, collocational learning has a greater positive influence on improving learners’ listening comprehension. The study reveals the collocational approach is more effective as kindergartners expressed their understanding through role-playing, drawing pictures, and other expressive activities. Third, collocational learning enhanced students’ interest in English. Thus, collocational lesson plans with visual, physical, aural and verbal activities seem to motivate kindergarteners to be more interested in English. In spite of time limitations, overall, this study implies that the collocational approach is more effective in improving kindergarteners’ speaking, listening comprehension, and interest in learning English.

초등학생의 학교적응 영향요인 분석

김진미(Kim, Jinmi),홍세영(Hong, Seyoung) 학습자중심교과교육학회 2019 학습자중심교과교육연구 Vol.19 No.6

본 연구는 초등학교 1학년의 학교적응에 영향을 미치는 변인을 탐색하는데 목적이 있다. 이를 통해 아동이 처음 접하는 공교육기관인 학교에서 성공적인 발달단계의 과업을 성취하고, 사회집단에 적응할 수 있는 기초 토대가 되는 학교적응을 높이 기 위한 시사점을 도출하고자 하였다. 선행연구에서 학교적응에 유의한 영향변인으로 보고되는 학생 개인과 가정 변인과 함께 교사 변인을 투입하여 이들이 학교적응에 미치는 영향력을 탐색하였다. 이를 위해 한국아동패널 8차년도(2015) 자료를 바 탕으로 위계적 회귀분석을 실시하여 분석하였다. 본 연구에서 도출된 주요 분석결과는 다음과 같다. 첫째, 아동의 성별과 학업수행 능력은 학교적응에 유의한 영향을 미치는 것으로 나타났다. 여아이며 학업수행능력이 높을수록 학교적응이 높았다. 둘째, 가정 변인 중 부모의 학교생활 관심 정도만 통계적으로 유의한 영향을 미쳤다. 즉 교사가 인식하는 부모의 학교생활 관심이 높을수록 아동의 학교적응도는 높았다. 셋째, 교사의 연령과 교사의 업무스트레스는 부적으로, 교수효능감과 교직만족도는 정적으로 영향을 미치는 것으로 나타났다. 즉 교사의 연령이 어리고 교사가 지각하는 업무 스트레스가 적으며, 교수효능감과 교직 만족도가 높을수록 아동의 학교적응은 높았다. 넷째, 학교적응 하위 영역별로 영향을 미치는 변인들이 조금씩 상이하게 나타났으나 학업수행능력, 부모의 학교생활 관 심 정도, 교사 연령은 모든 하위 영역에 통계적으로 유의한 영향을 미쳤다. 이러한 결과를 바탕으로 학생들의 특성과 교사의 근무조건을 고려하여 아동의 학교적응을 높이기 위한 지원방안을 제시하였다. The purpose of the study is to examine the factors that would affect the first grade students school adjustment in elementary school. Through this investigation, it aims to draw the implications for encouraging successful elementary students early adjustment to school where they establish the foundation for the social adjustment. Based on the literature review, this study examined the impact of students personal factors, household factors and teachers characteristic factors, specifically focusing on impact of teachers characteristic on students school adjustment. The results of the study are as follows. First, students gender, academic achievement were significant factors. Girls display higher school adjustment than boys and academic achievement positively influences school adjustment. Second, among household factors, only parents school involvement turned out to be the significant factor on school adjustment while the other variables like the social or economic backgrounds were not. Third, teachers characteristics such as age, work stress, teaching efficacy, and teachers job satisfaction significantly affect the school adjustment. The younger teachers are, the better students adjust to school. Teachers job satisfaction was positive factor while work stress negatively influences students school adjustment. These findings suggest the necessity of the strategies for improving the intensive care considering students characteristics as well as the teachers work condition.

암 치료를 위한 항체치료제에 대한 고찰: 면역항암제

유한진(HanJin Yu),홍세영(Seyoung Hong),권미지(Miji Kwon),이지현(Jihyeon Lee),박희호(Hee Ho Park),임광석(Kwang Suk Lim) 한국생물공학회 2020 KSBB Journal Vol.35 No.2

Recently, biopharmaceutical drugs take a big part in the pharmaceutical market with the development of genetic engineering. Therapeutic antibodies, one of the representative biopharmaceuticals, have strong therapeutic efficacy in various diseases such as autoimmune disease, rheumatism and cancer. Antibodies are widely used as targeted delivery systems, diagnostics and therapeutics because of their high specific recognition ability. In addition, the market for therapeutic antibodies is expanding further with the development of new biologic drugs such as biosimilar and biobetter. In particular, cancer immunotherapy has shown excellent efficacy for the treatment of cancer by regulating the immune response. In recent years, antibody-drug conjugates (ADCs), immune checkpoint inhibitors and therapeutic antibodies have been developed by many researchers and pharmaceutical companies and approved by U.S. food and drug administration as a potential strategy for the treatment of cancer. Although cancer immunotherapy has a strong therapeutic efficacy, there are still limitations to overcome such as for the treatment of solid tumor, immunogenicity and resistance. To solve these problems, new biomarkers, bispecific antibodies and combinatorial therapy with chemotherapy are being investigated. In this review, we describe the mechanism of immune response with respect to antibody therapeutics, characteristics of target cancers and discuss the potentials of cancer immunotherapy.

학교준비도, 학업수행능력, 자아존중감, 학교적응 간 구조적 관계 분석

김진미 ( Kim Jin-mi ),홍세영 ( Hong Seyoung ) 인하대학교 교육연구소 2019 교육문화연구 Vol.25 No.3

본 연구는 아동의 학교준비도가 취학 이후 아동의 학업수행능력, 자아존중감이 학교적응에 미치는 영향을 구조적으로 탐색하는 데 목적이 있다. 이를 위해 한국아동패널 자료를 바탕으로 구조방정식 모형을 적용하여 분석하였다. 본 연구에서 도출된 주요 분석결과는 다음과 같다. 첫째, 학교준비도, 학업수행능력, 자아존중감, 학교적응 간 구조적관계모형이 본 연구 자료에 적합한지 살펴본 결과, 모형의 적합도 지수는 전반적으로 양호한 것으로 나타나 제시된 모형이 자료에 잘 부합함을 확인하였다. 둘째, 연구에서 설정한 변인 간의 관계에 대한 결과를 경로별로 구체적으로 살펴본 결과, 학교준비도는 학업수행능력과 자아존중감에 각 β=.262, β=.125로 정적인 영향을 주었으며, 학교적응에도 β=.059로 정적인 영향을 주었다. 셋째, 학업수행능력과 자아존중감은 학교적응에 각 β=.621, β=.055로 영향을 미쳤다. 넷째, 학교준비도가 학업수행능력과 자아존중감을 매개로 학교적응에 미치는 효과를 검증하기 위해 Bootstrapping 방법을 실시한 결과, 학교준비도가 학업수행능력과 자아존중감을 매개로 학교적응에 이르는 경로가 통계적으로 유의하게 나타났다. 본 연구결과를 바탕으로 초기 학업결손을 미연에 방지할 수 있는 기제로서의 학교준비도의 중요성을 인식하고, 이를 제고하기 위한 방안을 모색해야 할 필요성을 제시하였다. 또한 취학 이후 학교적응을 높이기 위해 학업수행능력과 자아존중감의 증진 방안에 대해서 논하였다. The purpose of this study was to investigate the structural relationships among children’s school readiness, academic achievement, self-esteem, and school adjustment. Based on literature review, the structural model between school readiness. academic achievement, self-esteem, and school adjustment as well as the scale of each concepts were established. This study analyzed data from the 7th(2014) and 8th(2015) Panel Study on Korean Children(PSKC) by Korea Institute of Child Care and Education, employing structure equation modeling. The results of the study were as follows. First, children’s school readiness had a positively significant effect on academic achievement, self-esteem, and school adjustment. It showed that children with higher level of school readiness were more likely to reveal higher academic achievement, self-esteem, and school adjustment. Also, this study examined that school readiness influences the later school adjustment mediated by academic achievement and self-esteem. Based on these findings, implications for enhancing children’s school readiness especially focusing on reducing the educational inequality of preschool level were suggested.

CAMPUS Asia 시범사업의 성과 및 집행과정 분석

변기용 ( Byun Kiyong ),전재은 ( Jon Jae-eun ),홍세영 ( Hong Seyoung ),박예진 ( Park Ye-jin ) 안암교육학회 2016 한국교육학연구 Vol.22 No.3

본 연구의 목적은 2012년부터 2015년까지 4년간 시행된 CAMPUS Asia 시범사업의 성과와 집행과정을 다양한 이해관계자의 시각에서 분석하고 이를 바탕으로 본 사업의 설계 및운영에 대한 실천적인 시사점을 도출하는 데 있다. 이를 위해 본 연구는 정책집행 분석을 위한 통합적 접근방식을 사용하였고, 시범사업 기간 동안 수집한 문헌자료, 설문 및 면담조사 등 다양한 자료를 활용하였다. 분석 결과, CAMPUS Asia 시범사업은 참여 학생의 발달측면 그리고 정부 및 대학 차원의 교류 협력 기반 조성 측면에서 상당한 성과를 거둔 반면, 여러 한계점도 드러낸 것을 확인하였다. 다음으로 이러한 CAMPUS Asia 시범사업의 성과및 한계에 영향을 미친 맥락적 요인을 정부 차원, 참여 사업단 차원, 학생 차원으로 구분하여 분석하였다. 이러한 결과를 바탕으로 향후 CAMPUS Asia 본사업의 효과를 극대화하기위한 다양한 방안들, 예를 들어, 사업의 궁극적 목표에 대한 명확한 설정, 정부 차원의 국가별 학사제도 차이 및 학점인정 문제 해결, 사업의 차별성 확립, 사업단별 교육과정 강화, 공동 비교과 프로그램 운영, 특화된 진로모델 개발 등을 제언하였다. The purpose of this study is to examine the outcomes and implementation process from various stakeholders`` perspectives related to the CAMPUS Asia (Collective Action for Mobility Program of University Student in Asia) pilot project, and thereby provide practical suggestions for it. The pilot projet of the CAMPUS Asia lasted four years from 2012 to 2015. A hybrid approach was used to analyze its implementation process, and diverse sources of data such as documents, surveys, and interviews were employed for analysis. Findings showed the accomplishments of the CAMPUS Asia pilot project for promoting participants`` development and building the foundation for international cooperation at the governmental and institutional levels, while various limitations were also identified. In addition, analysis was conducted to identify the contextual factors that influenced the outcomes and limitations of the CAMPUS Asia pilot project at the governmental, institutional, and student levels. Based on these findings, multiple suggestions to maximize the effect of the CAMPUS Asia pilot project were provided, for example, to set up the ultimate goals of the project clearly, for governments to coordinate different academic systems by country and address the issue of credit transfer, to establish the uniqueness of the project, to strengthen the curriculum of each consortium, to co-manage the extra-curricular activities, and to develop the specialized career paths.

항암제 개발: 토포아이소머라제, HSP90, mTOR 및 티로신키나제 억제제

최경철(Kyoungcheol Choi),이성호(Seongho Lee),권미지(Miji Kwon),홍세영(Seyoung Hong),박희호(Hee Ho Park),임광석(Kwang Suk Lim) 한국생물공학회 2021 KSBB Journal Vol.36 No.2

Chemical anticancer drugs that have been used for a long time for the treatment of cancer have high anticancer effects and many side effects. The side effects of anticancer drugs have also affected normal cells because they induce the death of cancer cells by inhibiting or blocking essential mechanisms for cell survival. Recently, inhibitory drugs that inhibit specific mechanisms of cancer cells are receiving a lot of attention as anticancer drugs. Inhibitory drugs have less effect on normal cells by inhibiting the activity of target proteins that are overexpressed in cancer cells. Representative anticancer inhibitors among many inhibitory drugs are mTOR inhibitors, topoisomerase inhibitors, heat shock protein 90 (HSP90) inhibitors and tyrosine kinase inhibitors. For each of these inhibitor family, new candidate inhibitor drugs are continuously being developed and clinical trials are underway. In this review, we will examine the drug mechanism of each inhibitor drug, and describe the approved drugs and drugs in clinical trials.