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- 저자 : 조정애(Cho, Jung-Ae) (검색결과 5 건)
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백혈병 미세잔존질환 정량검출을 위한 실시간 역전사중합효소연쇄반응법의 유용성
조정애 ( Jeung Ai Cho ),김다운 ( Da Woon Kim ),정성두 ( Seong Du Jeong ),천지선 ( Ji Seon Cheon ),나경아 ( Gyeong Ah Na ),김혜란 ( Hye Ran Kim ),김진각 ( Jin Gak Kim ),김인환 ( In Hwan Kim ),김수현 ( Soo Hyun Kim ),신명근 ( Myung 대한임상검사과학회 2009 대한임상검사과학회지(KJCLS) Vol.41 No.1
Chromosomal rearrangements are major pathology in hematological malignancies. The detection of minimal residual disease (MRD) for these gene rearrangements helps in monitoring treatment outcomes and predicting prognosis of patients. Recently, quantification of these gene transcripts based on real-timequantitative polymerase chain reaction (RQ-PCR) has been used as MRD detection. The purpose of this study is to ensure the usefulness of the RQ-PCR technique for detecting MRD in hamatological malignancy patients. The patients had been diagnosed to AML1-ETO positive AML, PML-RARa positive AML and BCR-ABL positive MPN at Chonnam National University Hwasun Hospital from Jan. 2006 to Aug. 2008. The fusion transcript was quntified by RQ-PCR and analyzed in comparison to conventional cytogenetics, FISH and RT-PCR. The fusion gene transcript was quantified by RQ-PCR in 57 samples from 14 patients with AML1-ETO positive AML, 79 samples from 27 patients with PML-RARa positive AML and 108 samples from 36 patients with CML. At diagnosis, the quantitative fusion transcripts for AM1-ETO, PML-RARa and BCR-ABL showed the range of 0.485552651~10.82233683 (mean 3.782217131, SD 2.998052348), 0.005300395~0.29267494 (mean 0.056901315, SD 0.080131381) and 0.1293929~12.94826849 (mean 1.701935665, SD 2.200913158). The increase of AML1-ETO fusion gene transcripts preceded morphologic relapse in two patients. Quantification of fusion gene transcripts by RQ-PCR could detected MRD in samples which were negative by in cytogenetic analysis or FISH. Our findings indicated that quantitative analysis of AML1-ETO, PML-RARa and BCR-ABL transcripts by RQ-PCR might be a useful tool for the monitoring of minimal residual disease in hematological malignancies.
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논문 1 : 백혈병 미세잔존질환 정량검출을 위한 실시간 역전사중합효소연쇄반응법의 유용성
조정애 ( Jeung Ai Cho ),김다운 ( Da Woon Kim ),정성두 ( Seong Du Jeong ),천지선 ( Ji Seon Cheon ),나경아 ( Gyeong Ah Na ),김진각 ( Jin Gak Kim ),김인환 ( In Hwan Kim ),김수현 ( Soo Hyun Kim ),신명근 ( Myung Geun Shin ) 대한임상병리사협회 2008 임상혈액검사학회 발표자료집 Vol.10 No.1
Background : Chromosomal rearrangements are major pathology inhematological malignancy. The detection of minimal residual disease(MRD) for these gene rearrangements helps in monitoring treatment outcomes and predicting prognosis. patients. Recently, quantification of these gene transcripts based on real-time quantitative polymerase chain reaction (RQ-PCR) has been used as MRD detection. The purpose of this study is to ensure the usefulness of the RQ-PCR technique for detecting MRD in hematological malignancy patients. Methods : The patients had been diagnosed to AML1-ETO positive AML, PML-RARa positive AML and BCR-ABL positive MPN (CML) at Chonnam National University Hwasun Hospital (CNUHH, Hwasun, Korea) from Jan. 2006 to Aug. 2008. The fusion transcript was quantified by RQ-PCR and analyzed in comparison to conventional cytogenetics, FISH and RT-PCR. Results : The fusion gene transcript was quantified by RQ-PCR in 57 samples from 14 patients with AML1-ETO positive AML, 79 samples from 27 patients with PML-RARa positive AML and 108 samples from 36 patients with CML. At diagnosis, the quantitative fusion transcripts for AM1-ETO, PML-RARa and BCR-ABL showed the range of 0.485552651 ~ 10.82233683 (mean 3.782217131, SD 2.998052348), 0.005300395 ~ 0.29267494 (mean 0.056901315, SD 0.080131381) and 0.1293929 ~ 12.94826849 (mean 1.701935665, SD 2.200913158). The increase of AML1-ETO fusion gene transcripts preceded morphologic relapse in two patients. Quantification of fusion gene transcripts by RQ-PCR could detected MRD in samples which were negative by in cytogenetics analysis or FISH. Conclusions : Our findings indicated that quantitative analysis of AML1-ETO, PML-RARa and BCR-ABL transcripts by RQ-PCR might be a useful tool for the monitoring of minimal residual disease in hematological malignancy.
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조정애(Cho, Jung-Ae),김정선(Kim, Jeong-Seon) 한국산학기술학회 2016 한국산학기술학회논문지 Vol.17 No.4
본 연구의 목적은 간호대학생들의 학과만족도 향상을 위한 재학생들의 교육프로그램 개발 및 학교 적응프로그램 개발을 위한 기초자료를 제공하고자 시도되었다. 연구대상자는 B·U 시 소재 4개 간호대학에 재학 중인 학생 235명으로, 자아 탄력성, 간호전문직관, 학과만족 정도를 설문지로 측정하였다. 자료수집기간은 2015년 10월 16일부터 11월 25까지이었다. 수집된 자료는 Spss 18.0을 이용하여 t-test, ANOVA로 분석하였으며, 사후검정은 Scheffé test, Pearson's correlation coefficient, Stepwise multiple regression을 실시하였다. 연구 결과, 간호학생의 학과 만족도에 미치는 영향을 파악한 결과 전체적 영향 요인은 25.3%였으며, 가장 높은 관련요인은 간호전문직관으로 19.9%로 가장 설명력이 높았다. 그 다음으로 자아탄력성을 추가하였을 때 24.4%, 교우관계를 추가 하였을 때 25.3%의 설명력을 나타났다. 본 연구의 결과를 토대로 학과만족도를 높이 기 위해서는 간호전문직관을 향상 시킬 수 있는 교육전략을 개발하여 적용하는 것이 필요하다고 제언한다. The purpose of this study was to provide basic information for the development of an educational program and a school adaptation program both of which aim to improve the nursing college students' satisfaction with their department. The participants were 235 nursing students at four different colleges located in B·U City. A questionnaire survey was conducted on those students to determine their ego-resiliency, view of the nursing profession, and satisfaction with the nursing department. The data were collected from October 16th to November 25th, 2015. The collected data were analyzed using a t-test and ANOVA in accordance with SPSS 18.0. A post-test was then conducted through a Scheff? test, Pearson's correlation coefficient, and the stepwise multiple regression. These findings can be summarized as follows. All factors affecting nursing the students' satisfaction with their department had an explanatory power of 25.3%. Of those factors, the view of the nursing profession was highest in the explanatory power, or 19.9%. That power increased to 24.4% when ego-resiliency was added as another factor. This also increased to 25.3% when peer relations were added. Based on the study results, this study suggests that it is necessary to develop and apply an educational strategy to improve the nursing profession for the nursing department
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건강한 독거노인의 자서전적 기억 구체성과 돌봄 서비스 종사자의 공감반응과의 관련성
박수동(Su Dong Park),김태희(Tae Hui Kim),박상미(Sang Mi Park),이규원(Kyu Won Lee),조정애(Jeong Ae Cho) 대한노인정신의학회 2020 노인정신의학 Vol.24 No.2
Objective: This study aimed to investigate relation between empathic response of care workers and specificity of autobiographic memory of the elderly living alone. Methods: An interview of autobiographical memory was conducted on 66 physically and mentally healthy elderly people living alone in the community. The transcript was used to evaluate the empathic responses of the care workers and to classify the specificity of the autobiographical memory into four categories: episodic, categoric, semantic, and error. Logistic regression was used for investigation relation between empathic response of care workers and specificity of autobiographic memory of the elderly living alone. Results: More than half of the elderly reported specific autobiographical memories, and the interviewers showed a high level of empathic response when the elderly reported specific memories. Episodic and categoric autobiographical memory had a high empathic response of interviewer, and semantic memory or error type memory had a low empathic response. Empathy enhancement program experience showed not significantly association with empathic response of interviewer. Conclusion: Further research is needed on interview techniques that can easily and conveniently talk about specific autobiographical memories
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