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대한간학회지 제8차 춘계학술대회 초록집 : 포스터 발표 ; 만성 간질환 환자에서 간섬유화의 정도와 혈청 히아루론산치를 이용한 간섬유화의 예측
조병식 ( Jo Byeong Sig ),남순우 ( Nam Sun U ),장정원 ( Jang Jeong Won ),배시현 ( Bae Si Hyeon ),최종영 ( Choe Jong Yeong ),윤승규 ( Yun Seung Gyu ),안병민 ( An Byeong Min ),최상욱 ( Choe Sang Ug ),이창돈 ( Lee Chang Don ),정규원 ( 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
대한간학회지 제8차 춘계학술대회 초록집 : 포스터 전시 ; 수술적 절제술로 증명한 간내 국소 결절성 과증식 1예
김성용 ( Kim Seong Yong ),김미경 ( Kim Mi Gyeong ),조병식 ( Jo Byeong Sig ),장정원 ( Jang Jeong Won ),배시현 ( Bae Si Hyeon ),최종영 ( Choe Jong Yeong ),윤승규 ( Yun Seung Gyu ),박두호 ( Park Du Ho ),정은선 ( Jeong Eun Seon ),김 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.2(S)
만성 간질환 환자에서 간섬유화의 정도와 혈청 히알루론산치를 이용한 간섬유화의 예측
김창욱 ( Kim Chang Ug ),윤승규 ( Yun Seung Gyu ),조병식 ( Jo Byeong Sig ),신주엽 ( Sin Ju Yeob ),장정원 ( Jang Jeong Won ),최종영 ( Choe Jong Yeong ),한남익 ( Han Nam Ig ),이창돈 ( Lee Chang Don ),정규원 ( Jeong Gyu Won ),선희식 ( 대한소화기학회 2003 대한소화기학회지 Vol.42 No.6
Backgrounds/Aims: The extent of hepatic fibrosis is important in chronic liver disease. Liver biopsy is essential for diagnosis of fibrosis. However, biopsy is invasive and may not represent the whole liver state. Serum hyaluronic acid (HA), a major component of connective tissues, was introduced as a useful non-invasive index of hepatic fibrosis. The aim of this study was to evaluate the relationship among HA, the degree of fibrosis, several hematologic and biochemical parameters in patients with chronic liver diseases or post state liver transplantation (PSLT). Methods: Total 102 cases were divided into 4 groups: 57 chronic hepatitis (CH), 12 cirrhosis, 21 hepatocellular carcinoma (HCC), 12 PSLT. HA was measured by enzyme-linked binding protein assay and evaluated in relation the degree of fibrosis, several hematologic and biochemical parameters. Results: Among four groups, HCC showed the highest HA and HA of HCC significantly higher than that of CH. The degree of fibrosis were correlated with HA. HA was correlated with age, platelet count and albumin but, not with ALT and PT. There is no significant relation between HA and the presence of acute rejection in liver transplantation. Conclusions: In chronic liver diseases, HA is a useful non-invasive index of hepatic fibrosis and disease severity. (Korean J Gastroenterol 2003;42:510-518)