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Rapamycin이 T 림프구의 세포주기 조절에 미치는 영향
이정삼(Jeong Sam Lee),한철(Chul Han),최수진나(Soo Jin Na Choi),정상영(Sang Young Chung) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.73 No.1
Purpose: Rapamycin (RPM) and its analogues are known for their potent immunosuppressant and anti-proliferative properties, which stem from their ability to modulate the signal transduction pathways involved in cell cycle progression from the G1 to S phase. Thus, RPM has been shown to inhibit the proliferation of a number of non-immune cell types, including hepatocytes, vascular smooth cells and fibroblasts. In addition to its effects on proliferation, RPM may also play a role in the regulation of apoptosis under certain circumstances. Methods: The effects of RPM on the activation, proliferation and expression of cytotoxic effector molecules were examined on Molt-4 human T-lymphocyte by determining its effects on apoptosis, cell viability, reactive oxygen species (ROS) production and mitochondrial dysfunction. Cells were cultured in the presence or absence of RPM, and then analyzed by Flow cytometry after staining with PI (propidium iodide). Results: The viability of Molt-4 T cells dose- and time-dependently decreased on the addition of RPM. Conclusion: RPM induced cytotoxicity was characterized by G2/M phase cell cycle arrest. In addition, a pharmacological scavenging study of ROS, including H₂O₂, revealed the cytotoxicity was mainly induced by the generation of ROS, which might modulate the expression of Bak protein and mitochondrial dysfunction.
자가미세유화시스템을 이용한 매스틱의 헬리코박터파일로리 대한 In vitro 및 In vivo 활성 연구
김수지(Su Ji Kim),정상영(Sang-Young Jeong),길영식(Young Sig Gil),신병철(Byung-Cheol Shin),황성주(Sung-Joo Hwang),조선행(Sun Hang Cho) 대한약학회 2011 약학회지 Vol.55 No.1
Mastic is a bleed resin formed in pistacia lentiscus tree extract form the anacatdiaceae family. Mastic is used as a food ingredient in the Mediteraanean resin, and has been used by local inhabitants as a traditional medicine for relief of upper abdominal discomfort, dyspepsiaand peptic ulcer. Clinically, mastic has been effective in the treatment of benign gastric and duodenal, ulcers, giving symptomatic relief and endoscopically proven healing. In this study, to enhance activiteies of poorly water soluble Mastic with oils, surfactants and cosurfactants and then the mixure was microemulsified in aqueous media under condition of gentle agitation and digestive motility that would be encountered in the gastrointestinal tract. Formulation development and screening were based on phase diagrams and characteristics of resultant microemulsion. For optimum mastic formulation, microemulsions with various ratio (w/w%) of mastics, oils, surfactants and cosurfactants were prepared and their solubility was evaluated by monitoring particles size in their buffer through visual asessment and electrophoretic light scattering spectrophotomerter (ELS). In vitro activity of self microemulsified mastic (SME mastic) was determined by minimum ingibition concentration (MIC) test against a panel of Helicobacter pylori (H.pylori) clinical strains. Additionally, in vivo activity of SME masitc was investigated us mouse infected by CH275 of H. pylori. The mean diameter of SME mastic was less then 100 nm in water and SME mastic was showed similar antiboisis effect compared to tometronidazole, clarithromycin and omeproazole. Consequently, SME mastic would be effective system to exterminate H. pylori. If mastic were dose with combined treatment, mastic might augur well for effect of H. pylori eradication as good remedy.
우관제(Kwan-Je Woo),정상영(Sang-Young Jeong),김용원(Yong-Won Kim) 한국철도학회 2015 한국철도학회 학술발표대회논문집 Vol.2015 No.10
차량이 노후화 됨에 따라 차량 안전성에 관련된 요소들의 특성이 변화하는 경향이 있다. 특히 타고오름탈선에 관련된 1차 스프링, 2차 스프링의 강성은 차량 노후화에 따라 강성이 커져 탈선의 위험성이 증가하게 된다. 또한 도시철도차량 안전기준에 관한 규칙발효 이전에 제작된 전동차는 윤중비 관리가 이루어지지 않아 수 십 %의 윤중비가 측정을 통해 확인되었다. 본 논문에서는 차량의 노후화에 따른 현수장치 특성 변경 및 도시철도차량 안전기준에 관한 규칙 발효 이전에 설계/제작된 차량의 실제 윤중비로 인한 타고오름탈선의 위험성에 대해 연구하였다 As the operation time of the train increases, the characteristics of the parts which have effect on the safety of the trains change. Especially, the stiffness of the primary and secondary springs has a tendency to increase with the aging so the possibility of the wheel climbing derailment increases. And the trains which designed and built before the domestic regulation which specifies the limit values of the wheel load ratio became effective, the measured wheel load ratio are as high as 20%~30%. In this paper the possibility of the wheel climbing derailment was studied with the changes of the characteristics of the suspension and wheel off-load ratio of the degraded trains.