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최흥식(Heung Seek Choi),전영명(Young Myoung Chun),이원상(Won Sang Lee) 대한두경부종양학회 1996 대한두경부 종양학회지 Vol.12 No.1
The primary treatment of the nasopharyngeal carcinoma is at this time, mainly based on radiotherapy. In most studies for patient treated with radiotherapy, overall 5-year survival rate is in the range of 35 to 55%. Obviously, these therapeutic results may be influenced by various factors such as clinical stages, histopathological types and radiation techniques, etc. Though the radiotherapy had a good therapeutic result, there is a limitation to apply the radiotherapy only in cases of the advanced nasopharyngeal carcinoma. Anatomical complexity of the skull base and difficulties in complete surgical intervention were the trouble of the surgery but in the case of radiation failure, there is no adequate choice of other curative modalities. So it is appropriate to investigate whether surgical resection may improve the outcome of treatment of nasopharyngeal carcinoma. The purpose of this papaer is to report our surgical experience of the nasopharyngeal carcinoma, then to take into consideration of the new model of treatment strategy of nasopharyngeal carcinoma.
윤정선(Jung Sun Youn),전영명(Young Myoung Chun),이원상(Won Sang Lee) 대한두경부종양학회 1993 대한두경부 종양학회지 Vol.9 No.2
The primary treatment of the nasopharyngeal carcinoma is, at this time, mainly based on radiotherapy. In most studies for patient treated with radiotherapy, overall 5-year survival rate is in the range of 35 to 55%. Obviously, these therapeutic results may be influenced by various factors such as clinical stages, histopathological types and radiation techniques, etc. Though the radiotherapy had a good therapeutic result, there is a limitation to apply the radiotherapy only in cases of the advanced nasopharyngeal carcinoma. Anatomical complexity of the skull base and difficulties in complete surgical intervention were the trouble of the surgery but in the case of radiation failure, there is no adequate cholice of other curative modalities. So it is appropriate to investigate whether surgical resection may improve the results of treatment of nasopharyngeal carcinoma. The purpose of this paper is to report the surgical experience with nasopharyngeal carcinoma, then to take into consideration of the new model of treatment strategy of nasopharyngeal carcinoma.
"Mandibular Swing 접근법"에 의한 인두후벽암 치험 1례
전영명,고중화,이진석 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1
Traditionally, enbloc resection of the primary tumor with its lymphatics is the surgical procedure of choice for many oral and oropharyngeal malignancies. However, the operative fields reached by conventional approaches are too limited and narrow to remove extensive tumors, especially posterior pharyngeal tumor. The mandibular swing approach has greatly assisted tumor ablation and reconstruction of these areas. The authors essayed a mandibular swing approach for the ablation of a huge posterior pharyngeal wall carcinoma.
이비인후과 영역의 급성염증성질환 치료에 대한 Azithromycin의 임상연구
박기현,전영명,이정권,김광문 대한화학요법학회 1992 대한화학요법학회지 Vol.10 No.2
Azithromycin is a novel aszlide antibiotic with a spectrum of activity broadly similar to that of crythromycin. However, it show substantially better potency in vitro against Hemophilus influenzae, Neisseria gonorrheae, Mycoplasma hominis and Citrobacter diversus than erythromycin. Acitivity in vitro against Streptococcus pneumoniae, Legionella, Branhamella group A and D Streptococcus, and Staphylococcus aureus in essentially similar to that of erythromycin. The objective of this study is to determine the efficacy, safety and toleration of azithromycin in the treatment of patients with acute otitis media, acute sinusitis and acute tonsillitis. We analysed 30 patients who were treated with azithromycin through the open-noncomparative study. Azthromycin was administered orally once daily at a dose of 500㎎ on day 1 followed by 250 ㎎/day on day 2-5. Azithromycin appeared to be an effective safe and simplified treatment for acute infectious diseases in Ent field.
엄주현,전영명,박기현 아주대학교 의과학연구소 1996 아주의학 Vol.1 No.1
Human epidermis is a continuously dividing tissue, in which the keratinocytes gradually differentiate and mature while moving from the basal cell compartment to the upper cell layers. However, cholesteatoma is characterized by the presence of squamous epithelium invading the middle ear. This epithelium is believed to have hyperproliferative properties. Using immunohistochemical techniques, we investigated the reaction pattern of monoclonal antibody to PCNA and cytokeratin 16 as proliferating markers, and of monoclonal antibody to cytokeratin 13 and DBA as basal cell markers in the cholesteatoma to determine whether the number of proliferating cells is increased, and whether proliferating cells are found beyond the basal cell layer in cholesteatoma. The results were as follows: 1) When the tissues were stained with the proliferating markers PC10 and K8.12, the normal epithelium of ear canal showed focal staining in the basal cell layer, whereas epithelium of cholesteatoma showed dense, diffuse staining not only in the basal cell layer but also in the suprabasal cell layer. 2) When the tissues were stained with the basal cell markers KS-1A3 and DBA, both epithelium of the normal ear canal and of cholesteatoma showed staining in only a single basal cell layer. These results suggest that increased epidermal cell proliferation in cholesteatoma may be due to increased proliferative activity in suprabasal keratinocytes as well as in the basal compartment.