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비만 생쥐모델의 폐약(肺弱)을 유발하기 위한 Bleomycin의 농도 결정 연구
고영미 ( Young-mee Koh ),장순우 ( Soon-woo Jang ),안택원 ( Taek-won Ahn ) 대전대학교 한의학연구소 2020 혜화의학회지 Vol.29 No.1
Objectives : The objectives of this study is to develop a mouse model similar to Taeeum-type by inducing Lung fibrosis with bleomycin, and to determine adequate concentration of bleomycin. Methods : The subjects were divided into six groups: normal, obesity induced group, and bleomycin administered 0.015U, 0.03U, 0.06U, and 0.09U(U/100g bw) concentrations respectively. Each concentration of bleomycin was dissolved in distilled water, and administered through Intra-Nazal-Trachea injection method. Food intake and body weight were measured at regular time weekly. At the end of the experiment, blood was gathered by cardiac puncture for biochemical examinations, organs were removed for histological examinations, and weigh and mRNA genes was analyzed. Result : Mice administered with bleomycin at 0.015U and 0.03U showed body and fat weight gain, and increased blood total cholesterol, LDL-cholesterol, glucose, and free fatty acid level. Fat related genes also showed higher level than the control group. Obesity was most strongly induced in the mice administered with 0.03U of bleomycin. On the other hand, when bleomycin was administered at concentrations above 0.06U, a model of obesity mouse was not created due to rapid emphysema inflammation and weakness. Conclusions : Mice were most vulnerable to obesity when bleomycin was administered at a concentration of 0.3 to cause liver damage. Bleomycin concentration over 0.06U did not cause obesity-induced mice, due to severe damage in liver.
유성진,김자현,장순우,전형준,김병권,박종태 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.4
목적 근로자를 대상으로 직무스트레스와 감정표현불능성향과의 상관성에 대하여 연구하였다 방법 서울과 경기도 안산지역의 2개 대학병원에 건강검진을 위해 내원한 근로자중 생산직 근로자521명을 대상으로 하였다 한글판 Karasek 직무스트레스 설문(Korean version of the Karasek's Job Content Questionnaire JCQ)을 통해 직무스트레스를 평가하고 한글판 토론토 감정표현불능증 적도 설문(Korean Version of Toronto Alexithymia Scale TAS-20K)으로 감정표현불능 성향을 조사하였다 개별 JCQ 척도의 중앙값을 기준으로 이분하였고 직무긴장도 (Karasek 직무 긴장모델에 의해 정신적 직무요구와 직무재량도로 직무긴장도 평가 높음/중간/낮음) 직업불안정성 (높음/낮음) 직무불만족도(높음/낮음) 3가지 척도로 직무스트레스를 평가하였다 JCQ 척도와 감정표현불능 성향(total TAS score ≥52)과의 상관성을 알아보기 위해 보정하지 않은 비차비(crude odds ratios)와 보정비차비(adjusted odds ratios)를 계산하였다 결과 보정하지 않은 비차비 계산시 직무긴장도가 낮은 집단보다 높은 집단(crude OR 3.05 95% CI 1.35-6.87)에서 직업불안정성이 높은 집단(2.98 1.69-5.27)에서 직무불만족도가 높은 집단(2.93 1.69-5.09)에서 감정표현불능 성향이 유의하게 높게 나타났다 다중로지스틱회귀모형에 의한 보정비차비 계산시 직무긴장도가 낮은 집단보다 높은 집단(adjusted OR 2.26 95% CI 0.93-5.44)에서 감정표현불능 성향이 크게 나타났으나 유의하지는 않았고 직업불안정성이 높은 집단(2.26 1.21-4.22)에서 직무불만족도가 높은 집단(1.99 1.06-3.74)에서 감정표현불능 성향이 유의하게 높게 나타났다 결론 직무스트레스와 감정표현불능 성향 사이에 유의한 상관성이 있는 것으로 나타났다 Objectives We evaluated the association between job stress and alexithymic traits in Korean workers Methods Workers(n=521) who visited two university hospitals for medical check-ups were recruited for this study Job stress was evaluated using the Korean version of Karasek's Job Content Questionnaire(JCQ) and alexithymic traits were assessed using the Korean version of the Toronto Alexithymia Scale(TAS-20K) Crude and adjusted odds ratios(ORs) of job stress scales (job strain, job insecurity and job dissatisfaction) with alexithymic traits(total TAS score ≥ 52) were calculated Results High job strain compared with low strain had a high but insignificant association with alexithymic traits(adjusted OR, 2.26 95% CI, 0.93-5.44) High job insecurity(adjusted OR 2.26, 95% CI 1.21-4.22) and high job dissatisfaction (adjusted OR 1.99 95% CI 1.06-3.74) had significant associations with alexithymic traits Conclusions This study suggests that job stress is associated with alexithymic traits in workers.