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이문숙(Moon Sook Lee),노임환(Im Hwan Roe),이만용(Man Yong Lee),이재현(Jai Hyun Lee),남승우(Seung Woo Nam),이명인(Myung In Lee),김미례(Mi Rae Kim),신지현(Ji Hyun Shin),명나혜(Na Hye Myong) 대한소화기학회 2001 대한소화기학회지 Vol.37 No.6
Background/Aims: Antrum has been proposed for the best biopsy site to diagnose Helicobacter pylori (H. pylori) infection. The aim of this study was to determine the best biopsy site for maximum diagnostic yield. Methods: H. pylori infection was determined by rapid urease test and histology from the biopsy specimens obtained from 992 patients (652 gastritis, 130 gastric ulcer, 148 duodenal ulcer, and 62 gastric adenocarcinoma). Three biopsy specimens were obtained from each of three biopsy sites (the antral greater curvature, mid-body greater curvature, and fundus). Results: H. pylori positivity was significantly higher in mid-body than in antrum or fundus (52.8% vs. 40.0%, 40.3%). The diagnostic yield from the mid-body alone was not significantly different from those of any combinations of other two biopsy sites. The results of rapid urease test were very similar to those of histologic diagnosis. H. pylori positivity in the patients with gastric ulcer and gastric cancer was significantly higher in mid-body than in antrum (55.4%, 45.2% vs. 26.9%, 27.4%). In duodenal ulcer patients, the positivity was significantly higher in mid-body than in antrum or in fundus (68.9% vs. 54.7%, 56.2%). Conclusions: The greater curvature of mid-body, not the antrum, is the best site to diagnose H. pylori infection irrespective of the kinds of gastroduodenal diseases. (Korean J Gastroenterol 2001;37:406-411)
박현종(Hyun Jong Park),남승우(Seung Woo Nam),노임환(Im Hwan Roe),이문숙(Moon Sook Lee),유 권(Yoo Kweon),이재현(Jai Hyun Lee),명나혜(Na Hye Myong) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.1
Ingestion of foreign bodies occurs commonly in young children and emotionally disturbed individuals. Predisposing factors include decreased palatal sensitivity by dentures, excessive alcohol intake or drug use. Despite the incredible number and variety of objects, most ingested foreign bodies pass through the gastrointestinal tract, but the cases fewer than 1% result in perforation. The clinical manifestations of perforation include peritonitis, abscess, inflammatory mass, fistula, obstruction, and hemorrhage. Because most symptoms mimic the other common intraabdominal conditions, and many patients can not recall the ingested materials, preoperative diagnosis is difficult. The greastest number of perforations occur in appendix, the ileocecal region and Meckel`s diverticula. The remainders are scattered throughout the gastrointestinal tract, with a slightly higher incidence in the sigmoid colon. We present here a case of colonic perforation by an ingested chicken bone presenting as an intraabdominal inflammatory mass. The diagnosis was confirmed by laparoscopic surgery. (Korean J Gastroenterol 2001; 38:53-56)
신용운(Yong Woon Shin),이명인(Myung In Lee),남승우(Seung Woo Nam),노임환(Im Hwan Roe),이만용(Man Yong Lee),이재현(Jai Hyun Lee),신기철(Ki Chui Shin),김정택(Jung Taik Kim),김어진(Eo Jin Kim) 대한소화기학회 2001 대한소화기학회지 Vol.37 No.5
Intraductal papillary mucinous tumor (IPMT) of the pancreas and mucin-hypersecreting bile duct tumor are characterized by intraductal papillary epithelial growth and hypersecretion of thick mucin. They show unique clinical, radiological and pathologic features. Mucin producing tumors may coexist in the bile duct and the pancreatic duct because they have the same embryologic origin. However, the case of double primary mucin producing tumors coexistent in the bile duct and the pancreatic duct is very rare in the literature. We reported a case of mucin-hypersecreting tumor of the pancreas and the bile duct with inflammatory choledocho-pancreatic fistula. The possibility of malignant invasion into the bile duct from IPMT of the pancreas was easily excluded because coexistent tumors were benign neoplasms and pancreaticobiliary fistula tract was formed by inflammation. We could not decide exactly whether the biliary intraductal lesion was a displaced pancreatic lesion or another primary biliary lesion, but benign histologic findings of both tumors suggested the likelihood of double primary neoplasms. (Korean J Gastroenterol 2001;37:384-388)
장기간 홍삼복방제 투여가 혈중 지질 및 체지방 변화에 미치는 영향
김성수(Sung-Soo Kim),박호윤(Ho-Yoon Park),변용현(Yong-Hyun Byun),황부근(Bu-Geun Hwang),이재현(Jae-Hyun Lee),심영제(Young-Jae Shim),박채규(Chae-Kyu Park),박명한(Myung-Han Park),양재원(Jai-Won Yang) 고려인삼학회 2002 Journal of Ginseng Research Vol.26 No.2
장기간의 홍삼복방제 투여가 혈중지질 및 체지방에 미치는 영향을 알아보고자 체지방율이 30% 이상인 여학생 28명을 대상으로 위약군(placebo group, n=7명), 홍삼복방제투여군 (red-ginseng product administration group, n=7명), 운동군(exercise group, n=7명), 운동 및 홍삼복방제투여군(exercise<br/> and red-ginseng product administration group, n=7명) 등 네 집단으로 분류하여 12주간의 실험기간에 따른 TC, TG, HDL-C, LDL-C, 체중 및 체지방의 변화를 관찰하여 분석한 결과 다음과 같은 결론을 얻었다. TC, TG, LDL-C의 경우 실험 12주후 위약군을 제외한 모든 집단에서 유의한[홍삼복방제투여군(p<.001), 운동군(p<.01), 운동 및 홍삼복방제투여군(p<.001)] 감소를 보였다. HDL-C의경우실험 12주후 위약군을 제외한 모든 집단에서 유의하게[홍삼복방제투여군(p<.05), 운동군(p<.01), 운동 및<br/> 홍삼복방제투여군(p<.001)] 증가하였다. 체중, 체지방율, 체지방량의경우실험 12주후 위약군을 제외한 모든 집단에서 유의한[홍삼복방제투여군(p<.001), 운동군(p<.001),운동 및홍삼복방제투여군(p<.001)] 감소를 보였다. 제지방량의 경우 실험 12주후 위약군을 제외한 모든 집단에서 유의하게[홍삼복방제투여군(p<.05), 운동군(p<.001), 운동 및 홍삼복방제투여군(p<.001)] 증가하였다. This study was done in order to evaluate the effects on the blood lipid profiles, the body weight and body fat in 28 healthy female volunteers who had over 30% body fat by the long term intake of red ginseng product. Subjects were divided into four groups (placebo group n=7, red ginseng product group; n=7, exercise group; n=7, exercise & red ginseng product group; n=7). Blood sampling and measuring of the body fat were taken by pre-treatment, 3 weeks, and after 12 weeks.Statistical techniques for data analysis were applied one-way ANOVA and repeated measures ANOVA. The 5% level of significance was used as the critical level for this study. In summary of results, total<br/> cholesterol, triglyceride and low density lipoproprotein cholesterol were reduced in three groups (red ginseng product group, p<0.001; exercise group, p<0.01; exercise & red ginseng product group, p<0.001) except placebo group. HDL-C was improved in three groups (red ginseng product group, p<0.05; exercise group, p<0.01; exercise & red ginseng product group, p<0.001) except placebo group. Body weight, percent body fat and body fat mass were reduced in three groups (red ginseng product group, p<0.01; exercise group, p<0.01; exercise & red ginseng product group, p<0.001) except placebo group. Finally, lean body mass was improved in three groups (red ginseng product group, p<0.05; exercise group, p<0.01; exercise & red ginseng product group, p<0.001) except placebo group.<br/> Key words : Red ginseng, blood lipid, body fat, total cholesterol, triglyceride, low density lipoprotein cholesterol (LDLC), high density lipoprotein cholesterol (HDL-C)
CA 19-9의 현저한 상승을 보인 간내담관낭선종 1예
김병하,임창영,신현덕,송일한,신정우,기명주,김정택,노임환,이재현 대한소화기학회 2001 대한소화기학회지 Vol.37 No.3
Hepatobiliary cystadenoma is a rare but distinct neoplasm with malignant potential. The differential diagnosis includes other cystic neoplasms, primary or metastatic, and nonneoplastic cysts including infective conditions. A 38-year-old woman was admitted because of abrupt epigastric pain. Abdominal imaging studies revealed about 15×10 cm sized multiloculated cystic lesion in left lobe of the liver. Both serum and cystic fluid level of CA 19-9 were raised above 2,400 U/mL. Laparotomy and left lobectomy were performed. A 15×10 cm sized cystic mass was noted in left lobe of the liver. About 1,800 mL of serous fluid was obtained from this multiloculated cystic mass. Microscopic findings revealed a cystadenoma lined by a single layer of columnar epithelium containing some intracellular mucin pools and hemorrhagic infarct without evidence of cellular atypism or mitosis. We report a case of intrahepatic biliary cystadenoma with markedly elevated CA 19-9 with the review of literatures.