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이경종,고령은,이현,정병호,엄상원,김호중,권오정 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Background: In patients who have suspected progression of lung cancer after systemic treatment, it is very important to confirm disease progression or mutational re-evaluation for making treatment decision. We investigated the role of rebiopsy by EBUS-TBNA for patients with progressed lung cancer. Methods: We searched EBUS-TBNA registry and found 114 patients who underwent EBUS-TBNA as a rebiopsy procedure between May 2012 and April 2016. Pathologic and mutation success was defined as cases who had tumor cells or detection of any mutations in the EBUS samples. Results: Among 114 patients, 36 patients (31.6%) were for the confirmation of disease progression and 78 patients (68.4%) for molecular and mutational analysis. Overall, Pathologic success rate to acquire tumor tissues by EBUS-TBNA was 82.5%. Mutational success rate including T790M, ROS, cMET, ALK FISH was 82.7%. The failure of mutation analysis resulted from insufficient tissues (n=3), no malignant cells (n=7), EGFR mutation detection failure (n=1), respectively. Success rate for T790M mutation was 85.4% among 48 patients who had EGFR-TKI treatment failure and EGFR T709M mutation was detected in 56.1%. T790M with Exon 19 mutation, Exon 21 mutation was found in 15 patients (36.6%) and 8 patients (19.5%). There was no significant difference between exon 19 and exon 21 mutation for T790M mutation (p=0.093). Mutational discrepancy rate between primary and rebiopsy samples was 5.3%. Conclusion: EBUS-TBNA for rebiopsy was feasible in patients who were necessary to confirm the disease progression or mutational status.
이경종,한근식,윤수진,이연경,김찬호,김정림,이윤환,Lee, Kyung-Jong,Han, Geun-Shik,Yoon, Soo-Jin,Lee, Yeon-Kyung,Kim, Chan-Ho,Kim, Jeong-Lim,Lee, Yun-Hwan 대한예방의학회 2002 예방의학회지 Vol.35 No.4
Objectives : To develop a physical functioning instrument for older adults living in the community. Methods : A representative sample of 979 people aged 65 years or over were interviewed in-person. Of these, 199 people also completed a detailed in-hospital examination. The scale items were selected based on the frequency of endorsement, along with the item-total and inter-item correlations. The associations of the scale with their physical performance and clinical examination were analyzed to evaluate the criterion-related validity. Construct validity was assessed using factor analysis, and internal consistency through Cronbach's alpha and item-total correlations. Test-retest reliability was measured by agreement between the household survey and the repeat survey at the in-hospital examination. Results : Initially, 23 items on the level of difficulty, ranging from no difficulty to an inability to complete a task, with the specific mobility and self-care tasks were included. Those with a high frequency of endorsement and a low inter-item or item-total correlations were excluded, resulting in a 10-item Physical Functioning (PT) scale. Equal weights were given to each item and a summated score was calculated. Significant associations were found between the PF scores and the physical performance, surrey and clinical data. The scale revealed a 2-factor (mobility and self-care) structure. Cronbach's alpha was 0.92 and the item-total correlations were in the 0.63 to 0.78 range. Pearson's correlations for the test-retest ranged between 0.56 and 0.61. Conclusions : The newly developed Physical Functioning (PF) scale showed good psychometric properties in older people. Further work, however, is needed to improve its sensitivity to discriminate higher levels of functioning, in addition to assessing its predictive value in detecting changes in health.