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증례 : Ciprofloxacin에 의해 유발된 중증 면역성혈소판감소증 1예
안성기 ( Sung Ki Ahn ),손현영 ( Hyun Young Son ),김자영 ( Ja Young Kim ),오형철 ( Hyoung Chul Oh ),전재범 ( Jae Bum Jun ),윤재필 ( Jae Pil Yun ),최성준 ( Seong Jun Choi ) 대한내과학회 2005 대한내과학회지 Vol.69 No.-
저자들은 60세 남자 환자에서 ciprofloxacin 투여 12일 후, 매우 심한 비출혈을 동반하고 혈소판 수혈에도 호전되지 않는 혈소판 감소증이 발생하였고, 스테로이드와 면역글로불린 치료로 혈소판 수치의 급격히 호전을 보인 ciprofloxacin에 의한 면역성 혈소판 감소증 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Ciprofloxacin is generally considered to be a safe drug with infrequent hematological side effects such as thrombocytopenia. Here, we report a case of severe immune thrombocytopenia associated with the use of ciprofloxacin. A 64-year-old man developed generalized purpura and severe epistaxis associated with severe thrombocytpenia that occurred after the use of ciprofloxacin. Thrombocy-topenia persisted in spite of repeated platelet transfusion. After discontinuation of ciprofloxacin and the use of corticosteroid and immunoglobulin, his platelet count rapidly recovered to normal value and his bleeding symptoms disappeared. (Korean J Med 69:S943-S947, 2005)
박정제,김재원,안성기,전시영,Park Jung Je,Kim Jae Won,Ahn Seong Ki,Jeon Sea Young 대한기관식도과학회 2004 大韓氣管食道科學會誌 Vol.10 No.2
Pemphigus vulgaris is a rin, chronic intraepidermal bullous disease with potentially fatal outcome. Oral lesions precede skin lesions in at least $70\%$ of cases, and in cutaneous disease, concomitant oral lesions are encountered in $90\%$ of patients. This disorder involve the skin and mucous membranes, especially the oral and pharyngeal mucosa, but may also involve the nasal, oropharyngeal, laryngeal and esophageal mucosa. Oral lesions are initially vesicobullous but rapidly rupture, leaving a painful erosion that shows little tendency to heal. Pemphigus vulgaris affecting the oral mucosa is still diagnosed only after considerable delay, because oral ulceration in common, and clinicians believed the lesions to be caused by more common conditions such as recurrent aphthous stomatitis rather than a rare disorder such as pemphigus vulgaris. The definitive diagnosis of pemphigus vulgaris should be undertaken as early as possible, so that treatment can be started at an earl·y stage. Because of the presence of nonspecific oral ulcer, high degree of suspicion is often required to ultimately make the diagnosis of pemphigus vulgaris and then we report a case of pemphigus vulgaris with a literature review.
김지연 ( Chi Yeon Kim ),박상영 ( Sang Young Park ),안성기 ( Seong Ki Ahn ),오지원 ( Chee Won Oh ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.4
Melanoacanthoma, a rare benign variant of seborrheic keratosis, was first introduced by Mishima and Pinkus in 1960. It is a slow-growing, painless, pigmented plaque with a verrucous surface and a diameter ranging from a few millimeters to 10 cm. It tends to develop during middle-age with an equal sex incidence, and the lesion usually presents on the head, trunk, and especially the lip. It also has a histopathologic finding of mixed neoplasm composed of melanocytes scattered throughout keratinocytic lobules, and is characterized by hyperkeratosis, parakeratosis, acanthosis, papillomatosis and pseudo-horn cysts in the epidermis. We report a case of melanoacanthoma occurring in a 52-year-old female, who presented with an easily bleeding mass on her right external auditory canal, an extremely uncommon site. (Korean J Dermatol 2007;45(4):369~372)
국소진행된 하인두암에서 선행 항암화학요법과 방사선치료의 효과
김재원(Jae-Won Kim),손희영(Hee Young Son),전시영(Sea Yuong Jeon),박정제(Jung Je Park),안성기(Seong Ki Ahn,),강기문(Ki Mun Kang),김진평(Jin Pyeong Kim) 대한두경부종양학회 2008 대한두경부 종양학회지 Vol.24 No.1
Purpose :Hypopharyngeal carcinoma is usually diagnosed as an advanced disease after an asymptomatic beginning, and it is related to a high frequency of lymph node metastases. An eventual negative outcome may occur not only because of possible locoregional failures but also for frequent distant metastases. Thus, the efficacy of induction chemotherapy followed by radiation therapy, with regards to the response, survival rate and compli-cations for locally advanced hypopharyngeal carcinoma patients, was examined. Methods and Materials :Since July 1998 to February 2001, 18 patients having locally advanced hypopha-ryngeal carcinoma were treated with induction chemotherapy followed by radiation therapy, and the results were retrospectively analyzed. The regimen of the induction chemotherapy was the 5-flurouracil(5-FU, 1,000mg/m 2 daily for 5 consecutive days) and cisplatin(100mg/m 2 on day 1) combination at 3-week intervals for 2 cycles. The total radiation dose for the primary tumor and metastatic lymph nodes was 68.4-72.0Gy(median:70.2Gy) Results :The 3-year overall survival rate and disease free survival rate were 31.3% and 22.2%, respectively. In 6 patients(33.3%), preservation of the larynx for over 3 years was possible. After the induction chemotherapy and radiotherapy, a complete response was noted in 14 patients(77.8%), and a partial response in 4 patients (22.2%), with an overall response rate of 100%. Conclusion :Induction chemotherapy followed by radiation therapy is an effective treatment and larynx pre-servation rate was 33% in patients with locally advanced hypopharyngeal carcinoma in our report.
민영숙,안성기,송진규,이수곤 대한건축학회 2000 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.20 No.2
Contrary to reinforced concrete frames, beams or girders in steel frames are neither hinged nor fixed at their ends. Instead, they are usually restrained by the columns to which they are attached. Many studies have been . performed to include the effect of connection rigidity. Here in this paper, Kim's modified slope-deflection equation based on the Kinney's fixity factor and the power model proposed by Richard and Abbot were utilized to analyze semi-rigid frame. After Kinney's definition, fixity factor ranges from 0.0 to 1.0. This definition makes moment-rotation relation clearer. Meanwhile the accuracy of the pourer model for nonlinear behavior of semi-rigid frame is rather less clear. But it is simple, because it uses only three parameters. Stress analysis results by the finite element method, in which the stiffness matrix was modified to reflect Kim's modified slope-deflection method, coincided well with those of some references. Finally, a simplified stress analysis for semi-rigid steel frame was suggested through an example.