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정규원(Kyu Won Chung),선희식(Hee Sik Sun),정진우(Jin Woo Jeong),심규식(Kyu Sik Shim),채현석(Hyun Suk Chae),강숙영(Sook Young Kang),한석원(Sun Won Han),박영민(Yong Min Park),주상용(Sang Yong Ju),심상인(Sang In Shim) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
Chronic pancreatitis is mainly caused by chronic alcohol abuse and increases in incidence. The disease is characterized as epigastric pain radiating to back which is precipitated by alcohol inges- tion, and there may be nausea, vomiting, constipation, and mild jaundice with dark urine. The complications of chronic pancreatitis are diabetes mellitus, steatorrhea, pancreatic calcifica- tion, biliary obstruction, pseudocyst, peptic ulcer, abscess, carcinoma of pancreas, ascites and GI bleeding, etc. Since Riedel reported the case of common bile duct obstruction in chronic pancreatitis in 1892, there have been reported allmost 100 cases of common bile duct obstruction in pancreatitis. We report 2 cases of common bile duct obstruction caused by chronic pancreatitis without above complications.
Phalloidin 으로 유발되는 간세포막 변형에 대한 트립신 효과
정규원(Kyu Won Chung),이영석(Young Sok Lee),서정민(Jeong Min Suh),심규식(Kyu Sik Shim),양진모(Jin Mo Yang),안병민(Byung Min Ahn),김재광(Jae Kwang Kim),한남익(Nam Ik Han),김환묵(hwan Mook Kim),오구택(Goo Taeg Oh) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.2
N/A Phalloidin, a bicyclic heptapeptide isolated from the mushroom Amanita phalloides, was reported as a membrane specific toxin inducing membrane protrusions in the isolated hepatocyte. The molecular basis of this injury most likely lies in the interaction of phalloirlin with the protein filaments of the plasma rnembrane. Trypsin was reported as one of the agents which preuent membrane protrusions of hepatocyte, from phalloidin. However, the exact mechanism of trypsin to the phalloidin action is still obscure. This study was designed to investigate the ultrastructures of isolated hepatoryte treated by phalloidin and trypsin, as a part of study to elucidate the mechanism of trypsin antagonisrn to phalloidin. In our experiments, multiple protrusions on the surface of isolated rat hepatocytes were observed, whereas trypsinized hepatocytes showed mild degree membrane protrusions along with hepatocyte aggregation after 20 min incubation with 10 ug/ml of phalloidin. The total number of aggregated cells were increased with gradual increase in trypsin concentration. These trypsin effects were disappeared spontaneously after twice washing of trypsinized heptocytes with Hank's balanced salt solution (HBSS) or treatment with soy bean trypsin inhibitor. Without trypsin, both Tween 80 trcated hepatocytes and hepatocyte ghosts were not aggregated but showed membrane protrusions with phalloidin. However, electron microscopy revealed mild membrane deformity on trypsin and phalloidin treated cells that was determined as normal under light microscopy. In conclusion, these results suggest that certain memmbrane structures in isolated rat liver cell, to which trypsin is reversely reartive, are required to recognze or to uptake phalloidin. These trypsin altered membrane structures lead to aggregation of hepatocytes upon reaction to phalloidin. And more studies should be performed to evaluate the mechanism of trypsin especially in regard to the hepatocyte aggregation.
정규원(Kyu Won Chung),김부성(Boo Sung Kim),심규식(Kyu Sik Shim),양진모(Jin Mo Yang),안병민(Byung Min Ahn),이봉수(Bong Soo Lee),김진일(Jin Il Kim),김병욱(Byung Wook Kim),이영길(Young Gil Lee),황호원(Ho Won Hwang) 대한소화기학회 1993 대한소화기학회지 Vol.25 No.3
Fatal cases of mushroom poisonings are mostly caused by Amanita species in Korea. Arnanita mushrooms induce severe liver damage by cyclopeptide toxins which are thermostable. Human victims of acute Amanita poisoning usually undergo typical three phases. The gastrointesti nal symptoms of colicky abdominal pain, vomiting, watery diarrheaa begin 6-12 hr after ingestion of mushrooms. In most cases, gastrointestinal symptoms regress spontaneously and then clinical signs of severe hepatic injury develop. The histopathological findings of acute liver injuries are acute hemorrhagic necrosis of parenchyma, coagulative necrosis, vacuolated degeneration, micro-vesicular fat droplets, and yellow atrophy in the literature. However, the ultrastructural findings on human victim have been rarely reported. In Korea, total number of reported human victims of Amanita poisoing in the literature was belov 60 and there was no precise description on the subspecies of genus Amanita except only one in 1987. Recently, we experienced two cases of mushroom poisonings by Amanita virosa. Thus we report the clinical findings of the patients with the histological feature of liver injury using light and electron microscopy.
서정민(Jeong Min Suh),심규식(Kyu Sik Shim),양영상(Young Sang Yang),윤승규(Seung Kew Yoon),한준열(Joon Yeol Han),안병민(Byung Min Ahn),이창돈(Chang Don Lee),정규원(Kyu Won Chung),선희식(Hee Sik Sun),박두호(Doo Ho Park),김부성(Boo Sung 대한내과학회 1996 대한내과학회지 Vol.50 No.2
N/A Objectives: Primary biliary cirrhosis(PBC) is a relatively common autoimmune liver disease in western country. But it is rare in Asia. Only 11 cases of PBC has been reported so far in Korea. We have experienced 7 cases of PRC recently. The aim of the present study is to assess the clinical characteristics of PHC in Korea. Methods: We ana1yzed 18 cases of PBC for the distribution of age and sex, initial symptoms and signs, associated disorders, frequency of autoantibodies, and pathologic stage. Results: Of 18 patients, the ratio of male to female was 1: 3.5 and the average age was 52.8 years old. Pruritus(77.8%) was the most frequent clinical symptom followed by jaundice(61.1%), chronic fatigue(44.4%), xerostomia and xerophthalmia(22.2%), and general weakness(16.7%). Associated disorders were Sjogres`s syndrome(22.2%), Behcet`s syndrome, (5.6%), bronchial asthma(5.6%), pleural effusion (5.6%), and bicuspid valve stenosis (5.6%), Detected autoantibodies were antimitochondrial antibody(100%), fluorescent antinuclear antibody(50%), rheumatoid factor(44.4%), and smooth muscle antibody(5.6%). The pathologic stages based on morphologic findings were stage 1(16.7%), stage 1-2(11.1%), stage 2 (27.8%), stage 2-3(22.2%), stage 3(16.7%), and stage 3-4(5.6%). Conclusion: The clinical characteristics of PBC in Korea are similar to those of western country`s cases. But the male to female ratio in Korea is higher than in western countires
송춘익(Choon Eck Song),심규식(Kyu Sik Shim),구완서(Wan Suk Koo),박동준(dong JUne Park),김철민(chul Min Kim),하현권(Hyun Kwon Ha),허미경(Mi Kyung Hur),강문원(Moon Won Kang) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
This is a report of two cases of adenocarcinoma in ileum of the small intestine. Ileal adenocar- cinoma has been noted at its rarity, etiology, distribution, and poor prognosis. Recently we experi- enced two interesting cases. One dveloped in 25 year-old rnan, and the other in 42 year old man, vho had treated by segmental resection and chemotherapy, was followed by development of gastric carcinoma after 8 year-survival.
중년여성의 12주간 수영참여가 건강체력, 혈중지질 및 스트레스호르몬에 미치는 영향
이보애(Lee, Bo-Ae),심규식(Shim, Kyu-Sik),김종원(Kim, Jong-Won) 한국체육과학회 2021 한국체육과학회지 Vol.30 No.4
In this study, swimming was performed for 12 weeks, 3 times a week, once for 60 minutes for normal middle-aged women living in P city. Health physical fitness, blood lipid and stress hormone were measured and analyzed using SPSS Ver.21.0 statistical program. The result was as follows. 1. Within the group, muscle endurance, flexibility, and lean mass significantly increased and body fat percentage significantly decreased in the exercise group. There was no significant difference in muscle strength, muscular endurance, flexibility, cardiorespiratory endurance, body fat percentage, and lean mass in the control group. There was no significant difference in all items between groups. 2. Within the group, there were no significant differences in all items in the exercise group. In the control group, only high-density lipoprotein cholesterol showed a significant decrease, and there was no significant difference in total cholesterol, triglyceride, and low-density lipoprotein cholesterol. 3. Within the group, there was no significant difference in both the exercise group and the control group, and there was no significant difference in all items between groups. Summarizing the above results, regular swimming exercise had a significant effect on health, but did not significantly effect on blood lipids and stress hormones. Regular and continuous aerobic exercise, such as swimming, proper personal fitness level, has a positive effect on preventing the increase of blood lipids and stress hormones. In the future, it is expected that many follow-up studies on changes in blood lipids and stress hormones will be studied for safe and systematic exercise intensity setting.
만성 B형 간염에 대한 인터페론 알파 - 2a의 치료효과
윤승규(Seung Kew Yoon),조현미(Hyun Mi Cho),박영민(Young Min Park),심규식(Kyu Sik Shim),이창돈(Chang Don Lee),백남종(Nam Jong Baeg),차상복(Sang Bok Cha),박두호(Doo Ho Park),김부성(Boo Sung Kim) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.1
N/A To evaluate the effect of recombinant interferon alfa-2a in chronic hepatitis B, we randomly assigned 47 patients with chronic hepatitis B to four groups: HBeAg(+)/anti-Hbe( ) group I (n=9), treated with 3 MU of interferon alfa-2a every day for 6 months; HBeAg(+)/anti-Hbe ( ) group II(n=10), treated with 3MU of IFN alfa-2a every day for 1 month followed by every other day for 5 months; HBeAg( )/anti-Hbe(+) group lII(n=8), treated with IFN alfa-2a per every other day for 6 months; untreated(control) group IV(n=20). At the end of the treatment (6th month), the normalization of serum ALT was 6/9(66.7%) in group I, 7/10(70.0%) in group LI, 2/8(25.0%) in group III and 7/20(35.0%) in untreated group, but there was no significant difference between the treated group with IFN and untreated group. The seroconversion of HBeAg was 2/9(22.2%) in group I, 3/10(30.0%) in group II and 2/ 20(10.0%) in untreated group. Hepatitis B virus DNA was negative in 25.0% in group I, 20.0% in group II, 28.6% in group III and 5.0% in untreated group, however significant difference was not noted between treated groups and untreated group. Seroconversion of HBsAg was ob- served in the one patient who belonged to group II. Paired t-test in the comparison of biochemical tests before and after treatment of IFN in group I, -II and -tII revealed that serum ALT level significantly decreased in group I (p<0. 05), serum albumin level was significantly increased in group I, -II, and -lII(p<0,05, p<0.01), serum alkaline phosphatase and significantly decreased in group I (p<0.05). All patients with IFN alfa-2a complained of transient flu-like symptom, but not serious and there was no other side effect to withdrawal treatment. These results suggest that IFN alfa-2a in chronic hepatitis B does not have a powerful anti- viral effect but seems to be relatively effective and tolerable.(Korean J Gastroenterol 1994;26: 109 118)
김부성(Boo Sung Kim),박두호(Doo Ho Park),서정민(Jeong Min Suh),심규식(Kyu Sik Shim),안병민(Byung Min Ahn),양영상(Young Sang Yang) 대한소화기학회 1994 대한소화기학회지 Vol.26 No.1
Solid and papillary epithelial neoplasm of the pancreas is a rare tumor of low malignant po- tential. It tends to occur chiefly in young women. The origin of the tumor is still uncertain, although the studies from immunochemical staining suggest an origin from exocrine or endo- crine pancreas. The tumor is apparently curable by surgical excision in most cases, so it is very important to make a correct diagnosis before surgery. We present here a case of solid and papillary epithelial neoplasm of the pancreas occurred in 51-year-old woman, and a review of literatures.(Korean J Gastroenterol 1994; 26: 214-217)