제4차 산업혁명을 넘어선 육군의 장기전략 -육군비전 2050-

송윤선,정민섭,이경록 한국방위산업진흥회 2020 國防과 技術 Vol.- No.496

Inhibition of Angiogenesis by Propolis

송윤선,박은희,KyungJaJung,진창배 대한약학회 2002 Archives of Pharmacal Research Vol.25 No.4

(Received May 9, 2002) Propolis, obtained from honeybee hives, has been used in Oriental folk medicine as an antiinflammatory, anti-carcinogenic, and immunomodulatory agent. There is considerable evidence suggesting that angiogenesis and chronic inflammation are codependent. Blockage of angiogenesis results in an anti-inflammatory effect. Ethanol (EEP) and ether extracts of propolis (REP), and caffeic acid phenethyl ester (CAPE), an active component of propolis, were examined for their anti-angiogenic activities using the chick embryo chorioallantoic membrane (CAM), and the calf pulmonary arterial endothelial (CPAE) cell proliferation, assays. The presence of EEP, REP and CAPE inhibited angiogenesis in the CAM assay and the proliferation of CPAE cells. The results suggest that anti-angiogenic activities of EEP, REP and CAPE are also responsible for their anti-inflammatory effect.

한반도 군정 사례의 미래 안정화작전 시사점 분석

송윤선 육군사관학교 화랑대연구소 2020 한국군사학논집 Vol.76 No.1

The purpose of this study is to get the implication of the cases of Military Government in Korean Peninsular for Stability Operations that may be in Korean Peninsula in the future. This study reviews 3 historical cases since 1945, focusing on how the Military Governments had been proceeded in Korean Peninsular. The cases are the Military Government in South Korea from 1945 to 1948, the Military Government in North Korea in 1950, and the Military Government in the restored area north of 38 line of South Korea from 1951 to 1954. The study indicates that a constant pattern in its process and the conflicts between Korean Authority and the US Forces Command in the past Military Governments may take place again in Stability Operations in the future in Korean Peninsular. 본 연구는 과거 한반도에서의 군사적 점령지역에 대한 군정(안정화작전)이 어떻게 전개되었는지 역사적 사례를 고찰하여 국가적, 전략적 차원에서의 작전 수행 절차와 이를 위한 대비 방향에 대한 시사점을 얻는데 연구 목적을 두고 있다. 이를 위해 우리나라에서 있었던 해방 직후 한반도에 진주한 미군에 의한 안정화작전과 6·25 전쟁시 유엔군 점령 지역에서의 안정화작전 사례를 분석하고자 한다. 과거 미군에 의한 한반도에서의 안정화작전 사례 연구는 오늘날 급변사태나 전면전시 북한지역에 대한 안정화작전 수행간 한국적 특수성으로 인해 발생할 수 있는 다양한 현상들을 추론하고 이에 대한 대비 방향 등을 모색하는데 도움을 줄 것이다.

Low-Dose Fluoroscopy Protocol for Diagnostic Cerebral Angiography

송윤선,한성식,Kim Byung Jun,Oh Seong Heum,Kim Jin Su,Kim Tae Il,Lee Deok Hee 대한신경중재치료의학회 2020 Neurointervention Vol.15 No.2

Purpose: We applied a low-dose fluoroscopic protocol in routine diagnostic cerebral angiography and evaluated the feasibility of the protocol.Materials and Methods: We retrospectively reviewed a total of 60 patients who underwent diagnostic cerebral angiography for various neurovascular diseases from September to November 2019. Routine protocols were used for patients in the first phase and low-dose protocols in the second phase. We compared radiation dose, fluoroscopy time, and complications between groups.Results: Age, diseases, and operators were not significantly different between the two groups. The mean fluoroscopy dose significantly decreased by 52% in the low-dose group (3.09 vs. 6.38 Gy·cm² ); however, the total dose was not significantly different between the two groups (34.07 vs. 33.70 Gy·cm² ). The total fluoroscopic time was slightly longer in the low-dose group, but the difference was not statistically significant (12.2. vs. 12.5 minutes). In all patients, angiography was successfully performed without complications.Conclusion: The low-dose fluoroscopy protocol is feasible to apply for diagnostic cerebral angiography in that this protocol could significantly reduce the fluoroscopic dose.

International Survey on Criteria for Training and Accreditation in Interventional Neuroradiology

송윤선,Kim Minjae,Michael Söderman,서대철,René van den Berg 대한신경중재치료의학회 2020 Neurointervention Vol.15 No.2

Purpose: With the rapid expansion of the field of interventional neuroradiology (INR) and the diverse background of aspiring neuro-interventionists, there is an ever increasing need to establish consensus criteria for training and accreditation in INR.Materials and Methods: We performed a survey to explore the current state of criteria for training and accreditation in INR. The questionnaire consisting of 11 questions was emailed to the members of World Federation of Interventional and Therapeutic Neuroradiology (WFITN) worldwide. It was focused on the training charter, training program, qualifying examination, and education after training program as perceived by practitioners in each country.Results: A total of 52 WFITN members in 19 countries responded to the questionnaire. There was a huge variation internationally and nationally due to the unique situation and challenges in each country and institution. Criteria for training and accreditation in INR were well established in some countries of Europe, North America, and Asia but not specified in other countries.Conclusion: It is critical to establish consensus criteria for training and accreditation in INR in order to ensure safe practice and continued expansion and development of INR as a specialty.

Cigarette Smoking Preferentially Affects Intracranial Vessels in Young Males: A Propensity-Score Matching Analysis

송윤선,Lee Dongwhane,서대철,Joong-goo Kim,김재균,Minkyu Han,Liu Hairi,Lingbo Zhao,Eun Hye Kim,Sung Chul Jung,Dong-geun Lee,구현정,Min-ju Kim,Seunghee Baek,황선문,Bum Joon Kim,Yeon-Jung Kim,조홍준,김상준,Sang-Beom Jeon,Jon 대한신경중재치료의학회 2019 Neurointervention Vol.14 No.1

Purpose: Cigarette smoking (CS) is one of the major risk factors of cerebral atherosclerotic disease, however, its level of contribution to extracranial and intracranial atherosclerotic stenosis (ECAS and ICAS) was not fully revealed yet. The purpose of our study was to assess the association of CS to cerebral atherosclerosis along with other risk factors. Materials and Method:s All consecutive patients who were angiographically confirmed with severe symptomatic cerebral atherosclerotic disease between January 2002 and December 2012 were included in this study. Multivariate logistic regression analyses were performed to identify risk factors for ECAS and ICAS. Thereafter, CS group were compared to non-CS group in the entire study population and in a propensity-score matched population with two different age-subgroups. Results: Of 1709 enrolled patients, 794 (46.5%) had extracranial (EC) lesions and the other 915 (53.5%) had intracranial (IC) lesions. CS group had more EC lesions (55.8% vs. 35.3%, P<0.001) whereas young age group (<50 years) had more IC lesion (84.5% vs. 47.6%, P<0.001). In multivariate analysis, seven variables including CS, male, old age, coronary heart disease, higher erythrocyte sedimentation rate, multiple lesions, and anterior lesion were independently associated with ECAS. In the propensity-score matched CS group had significant more EC lesion compared to non-CS group (65.7% vs. 47.9%) only in the old age subgroup. Conclusion: In contrast to a significant association between CS and severe symptomatic ECAS shown in old population, young patients did not show this association and showed relatively higher preference of ICAS.

Clinical Manifestation and Radiologic Patterns of Spontaneous Cervicocephalic Dissection According to the Anatomic Location: A Single-Center Analysis in Korean Patients

송윤선,Park Sang Ik,Budianto Pepi,Kwon Boseong,Suh Dae Chul 대한신경중재치료의학회 2022 Neurointervention Vol.17 No.2

Purpose Spontaneous cervicocephalic dissection (SCAD) is an important cause of stroke and shows various lesion locations and clinical features. The purpose of this study was to analyze the location of SCAD and its clinical and radiologic patterns in Korean patients. Materials and Methods Patients with SCAD who were evaluated between 2013 and 2018 at a tertiary center in Korea were reviewed. We classified and compared the morphological (aneurysm or steno-occlusion) and presenting (hemorrhage or infarction) patterns according to the lesion locations (anterior circulation [AC] vs. posterior circulation [PC]; intradural [ID] vs. extradural [ED]). Results A total of 166 patients were included in this study. The SCAD most commonly occurred in the PC-ID location (65.1%), followed by AC-ID (13.3%), AC-ED (13.3%), and PC-ED (8.4%). Aneurysm and steno-occlusion patterns were observed in 66.9% and 57.8% of the cases, respectively. The aneurysm pattern was significantly more common in the PC-ID location (78.7%) than in other locations. As for the presenting pattern, cerebral infarction was the most common pattern (39.8%), and intracranial hemorrhage was observed only in the ID location (7.2%). Conclusion In Korean patients, PC-ID, especially ID vertebral artery, was the most common location of SCAD, and most cases were accompanied by an aneurysm. It also suggested that these location trends differ by population or ethnicity.

오염 지중환경 특성화와 자연저감평가를 위한 말단전자수용과정(TEAPs) 분석 및 평가기술 소개

송윤선,김한석,권만재 한국지하수토양환경학회 2020 지하수토양환경 Vol.25 No.특별호

Monitoring and assessing terminal electron accepting processes (TEAPs) are one of the most important steps to remediatecontaminated sites via various in-situ techniques. TEAPs are a part of the microbial respiration reactions. Microorganismsgain energy from these reactions and reduces pollutants. Monitoring TEAPs enables us to predict degradability ofcontaminants and degradation rates. In many countries, TEAPs have been used for characterization of field sites andmanagement of groundwater wells. For instance, US Environmental Protection Agency (EPA) provided strategies forgroundwater quality and well management by applying TEAPs monitoring. Denmark has also constructed TEAPs map oflocal unit area to develop effective groundwater managing system, particularly to predict and assess nitrogencontamination. In case of Korea, although detailed soil survey and groundwater contamination assessment have beenemployed, site investigation guidelines using TEAPs have not been established yet. To better define TEAPs in subsurfaceenvironments, multiple indicators including ion concentrations, isotope compositions and contaminant degradationbyproducts must be assessed. Furthermore, dissolved hydrogen concentrations are regarded as significant evidence ofTEAPs occurring in subsurface environment. This review study introduces optimal sampling techniques of groundwaterand dissolved hydrogen, and further discuss how to assess TEAPs in contaminated subsurface environments according toseveral contamination scenarios.

Alpha Stent for Coiling of Unruptured, Wide-Necked, Distal Internal Carotid Artery Aneurysms: Safety and Effectiveness at 6 Months

송윤선,신재준,김중구,이상훈,조수희,박중철,최충곤,이덕희 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.2

Objective: The Alpha stent (CGBio), a new intracranial stent featuring a re-sheathable mesh design with improved wall apposition at the curved segment, was clinically evaluated. We report the 6-month follow-up results from a prospective, singlecenter study in which the stent was used for coiling of wide-necked distal internal carotid artery (ICA) aneurysms. Materials and Methods: Between April 2016 and 2018, 50 patients (mean age, 56.5 years, 45 females [90%]) with 54 unruptured distal ICA aneurysms (average diameter: 5.6 ± 1.7 mm) were enrolled. The primary endpoint for effectiveness was successful coil embolization with the Alpha stent, and subsequent complete or near-complete occlusion at the 6-month magnetic resonance angiography assessment. The primary safety endpoint was the absence of serious adverse events (SAEs) up to 6 months from the procedure. Results: The primary effectiveness endpoint was observed in 94.4% (51/54) aneurysms. In one patient with technical failure, the stent could not be deployed because of parent artery tortuosity; therefore, a different type of stent was used. Of the 53 aneurysms treated with the Alpha stent, complete occlusion was achieved in 64.1% (34/53) cases, and near-complete occlusion was achieved in 32.0% (17/53) cases by the 6-month follow-up. Two cases (3.7%) required retreatment because of major recurrence. In 4% (2/50) patients, SAEs, i.e., retinal artery thromboembolism and corona radiata lacunar infarction, were reported after the procedure. Conclusion: For endovascular treatment of unruptured, wide-necked, distal ICA aneurysms, coil embolization using the newly developed Alpha stent showed excellent procedural and mid-term clinical follow-up results in terms of effectiveness and safety.

병역환경 변화에 따른 병력충원정책 연구

송윤선,이웅 한국정책개발학회 2020 정책개발연구 Vol.20 No.1

The purpose of this research is to suggest the innovative policy development of the recruitment policy of the ROK, based on the analysis about the environment of military service system in the future. To achieve the purpose, this research firstly investigated how other countries had developed and transformed their military service system on the basis of cross-sectional and longitudinal study. Secondly, this research examined the general determinants of the military service system and the environment that influence on the recruitment policy of the ROK in the future. Lastly, each scenario, which we considered as alternatives for the upcoming demographic cliff, was developed and suggested. With the result of research, future oriented innovative ideas such as human resource management, weapon system building, and e.t.c. were suggested in order to prepare for the newly rising environmental change in the future. 본 연구는 인구절벽을 비롯한 미래의 병역 환경 속에서 향후 미래의 한국군이 소요 병역자원을 효과적으로 확보하기 위한 병력 충원 방안과 정책 혁신방안을 제시하고자 하였다. 이를 위하여 먼저 병역제도의 전반에 관한 이론적고찰을 통해 오늘날 세계의 병역제도가 역사적으로 어떤 과정을 거쳐 변화해왔는지를 살펴보았으며, 병역제도 시행에 영향을 미치는 제 요인들을 검토하였다. 또한, 미래 한국의 병역환경을 전망하고 여기에 적합한 우리 군의 병력충원 모델을 설정하여 미래 시점에서 실제 어떻게 적용할 수 있을지를 시나리오별로 제시하였다. 그리하여 이를 바탕으로 미래의 새로운 환경변화에 능동적으로 대응하기 위한 인력운영, 전력발전 등에 관한 미래지향적 정책 혁신방안을 제시하였다.