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사람의 난관 상피세포에서 인슐린유사 성장인자 - II 의 발현
노재숙(Jae Sook Roh),성노현(Ro Hyun Sung),신중식(Joong Sik Shin),유중배(Jung Bae Yoo),황윤영(Youn Yeung Hwang) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.9
연구목적 : 인슐린유사성장인자-II가 여성의 자궁이나 난소조직의 주기적인 변화에 관여하는 것은 잘 알려져 있으나, 난관 상피세포의 주기적인 변화와도 관련이 있는지는 명확치 않다. 본 연구는 난관 상피세포에서 IGF-II가 발현되는지를 알아보고, 발현되는 경우 생식주기에 따른 차이를 보이는지 비교하였다. 연구대상 및 방법 : 다양한 부인과 질환으로 개복수술을 받았던 월경주기가 규칙적인 16명의 가임기 여성과 4명의 폐경기 여성에서 난관조직을 얻어 IGF-II에 대한 면역조직염색을 시행하였다. 연구결과: IGF-II는 주로 난관 상피세포에서 강하게 발현되었고 기질세포와 근육층에서는 약하게 발현되었다. 상피세포 중에서 섬모가 있는 세포와 없는 세포간에 차이는 없었다. 난관 상피세포에서 IGF-II의 발현정도는 생식주기에 따른 차이를 보여, 증식기 중,후기와 분비기 초,중기가 증식기 초기 및 분비기 후기와 비교하여 강하게 발현되고 폐경기에서는 발현되지 않았다. 결 론 : 본 연구결과 가임기 여성의 난관 상피세포에 IGF-II가 발현된다는 것을 알 수 있었다. 이는 IGF-II가 직, 간접적으로 난관 기능에 관여한다는 것을 의미하며, 또한 주기에 따른 발현 정도의 차이는 IGF-II가 난소에서 분비되는 스테로이드 호르몬의 영향을 받는다는 것을 의미한다. Objective : The involvement of IGF-II in reproductive tissues, especially uterine and ovarian, there is very little information is available concerning their presence in human tubal epithelium. To elucidate this, the present study was undertaken to determine the pattern of expression and cyclic changes of IGF-II in human tubal epithelium during various reproductive stages including postmenopause. Methods : Tube samples from 16 normally cycling women, as well as from 4 postmenopausal women were obtained. The expression pattern of IGF-II was examined using immunohistochemistry. Results : The primary site of immunoreactivity for IGF-II in fallopian tube tissue was in the epithelial lining of the tubes, with substantially lower intensity in the stromal cells and smooth muscle layer. The immunostaining was associated with both cilicated and nonciliated tubal epithelial cells without substantial differences in their intensity. Immunostaining intensity of IGF-II in tubal epithelial cells was cycle-dependent and considerably higher in mid-late proliferative and early-mid secretory compared to early proliferative and late secretory phases of the menstrual cycle, with no immunostaining in the postmenopausal period. Conclusion : This study demonstrates the presence of IGF-II in the human fallopian tube during various stages of the menstrual cycle. These data suggest an autocrine or paracrine role for the IGF-II in fallopian tube function, and their cyclic dependency further implies ovarian steroidal regulation.
증례 : 소화기 ; 내시경 절제술로 치료한 팽대부 주위 신경절세포 부신경절종 1예
채희복 ( Hee Bok Chae ),박선미 ( Seon Mee Park ),성노현 ( Ro Hyun Sung ),전원중 ( Won Joong Jeon ),서의근 ( Eui Keun Seo ),주혜진 ( Hye Jin Joo ),조영심 ( Young Shim Cho ) 대한내과학회 2010 대한내과학회지 Vol.79 No.5
Gangliocytic paraganglioma is a rare tumor that is usually seen in the duodenum. This neoplasm generally behaves in a benign fashion, although instances of recurrence and lymph node metastasis have been described. We experienced a case of incidentally found gangliocytic paraganglioma treated with endoscopic resection. A 61-year-old man was referred because of submucosal tumor adjacent to the major papilla. Endoscopic biopsy revealed paraganglioma. Abdominal CT showed that there was no evidence of a duodenal mass or lymphadenopathy. This tumor was resected endoscopically by electrosurgical snare polypectomy. The excised tumor measured 1.0 cm in diameter. Histopathological examination revealed a benign gangliocytic paraganglioma and the resection margins were free of tumor. At the 6-month follow-up, the patient was still asymptomatic and no residual tumor was detected at the resection site. (Korean J Med 79:543-548, 2010)
임신중기 태반조기박리 임부에서 기대요법에 의한 생존분만
하민숙 ( Min Sook Ha ),황태기 ( Tae Gi Hwang ),이상경 ( Sang Kyeong Lee ),이인하 ( In Ha Lee ),박연진 ( Yeon Jin Park ),지일운 ( Ill Woon Ji ),정은환 ( Eun Hwan Jeong ),김학순 ( Hak Soon Kim ),성노현 ( Ro Hyun Sung ) 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.9
Prognosis of placental abruption depends on gestational age and the status of the mother and the fetus, and perinatal mortality was almost entirely attributable to prematurity. A midtrimester women with placental abruption was successfully treated by expe
최재홍 ( Jae Hong Choi ),임정묵 ( Joung Muk Leem ),최희복 ( Hee Bok Chae ),윤세진 ( Sei Jin Youn ),성노현 ( Ro Hyun Sung ) 대한소화기학회 2002 대한소화기학회 춘계학술대회 Vol.2002 No.-
〈목적〉 과민성 장 증후군의 병인에 대한 설명은 다양하며 아직 명확하지 않다. 그 중 일부의 과민성 장 증후군 환자들에서는 장관의 염증과 연관되어 생길 수 있으며, 비만세포가 과민성 장 증후군의 병인과 연관이 있다고 추측되지만 아직 그 결과가 다양하고, 아직까지 국내에서는 이에 대한 보고가 없는 상태이다. 따라서 본 연구의 목적은 비만세포가 과민성 장 증후군 환자의 대장에서 다른 대조군의 대장과 차이가 있는지를 확인해 보기 위한 것이다. 〈방법〉 생검
최재홍 ( Jae Hong Choi ),나병규 ( Byung Kyu Nah ),임정묵 ( Jung Muk Leem ),배상석 ( Sang Seok Bae ),최기원 ( Ki Won Choi ),채희복 ( Hee Bok Chae ),박선미 ( Seon Mee Park ),윤세진 ( Sei Jin Youn ),성노현 ( Ro Hyun Sung ) 대한소화기기능성질환·운동학회 2004 Journal of Neurogastroenterology and Motility (JNM Vol.10 No.1
목적: 과민성 장 증후군은 임상적으로 매우 흔한 질환이지만 아직까지 그 원인이나 기전이 명확하게 밝혀지지 못한 상황이다. 비만세포는 장관 신경과 평활근의 기능을 변화시키는 중요한 매개체를 가지며 장관 신경과 근육과도 상호작용을 하여 과민성 장 증후군의 병인에 작용할 수 있다고 생각한다. 이에 저자들은 비만세포가 과민성 대장 증후군 환자의 대장 점막에서 정상 및 염증성 질환 환자에 비해서 차이가 있는지 알아보고, 과민성 장 증후군의 아형에 따라서도 차이가 있는지를 알아보고자 하였다. 대상 및 방법: 대상 환자는 충북대학교 병원 내과에서 진료 받은 환자들 중 Rome II 진단 기준에 합당한 환자들을 대상으로 하였으며 과민성 장 증후군 환자는 16명, 정상 대조군 8명, 염증성 대조군은 5명이었다. 모든 환자는 대장내시경 검사를 시행하였고, 맹장, 상행, 하행 결장과 직장 부위에서 생검을 하였다. 비만세포는 트립타제에 대한 항체를 이용한 면역 염색법으로 관찰하였고, H&E 염색을 통하여 중성구, 림프구, 형질세포와 호산구의 수를 측정하여 차이를 비교하였다. 결과: 비만세포수는 하행 결장에서만 과민성 장 증후군(15.2±4.0)에서 정상 대조군(10.9±2.7)과 염증성 대조군(11.0±2.9)보다 유의하게( p=0.02) 높았으며, 다른 부위에서는 유의한 차이가 없었다. 비만세포를 제외하고는 과민성 장 증후군에서 다른 염증세포의 침윤이 증가해 있지는 않았다. 과민성 장 증후군의 증상의 유형에 따라서도 차이가 있어 맹장 부위에서의 비만세포수가 변비형(21.3±3.4)과 통증형(22.7±2.5)이 설사형(14.6±4.2)보다 유의하게 높게 나타났다( p<0.05). 결론: 과민성 장 증후군에서 다른 염증성 및 정상 대조군과 비교하여 하행 결장의 점막에서 비만세포의 수가 유의하게 높았고, 과민성 장 증후군의 증상별 아형에 따른 비교에서는 변비형과 통증형이 설사형 보다 맹장 부분에서 유의하게 높게 관찰되었다. 과민성 장 증후군에서 비만세포가 병인에 관여하며 증상의 아형별에 따라서 그 관여정도가 차이가 존재할수 있음을 시사한다. Backgr ound/Aims: Irritable bowel syndrome (IBS) is ubiquitous but the pathophysiology remains poorly established. There has been increasing interest in the role of mast cells (MC) as they release variable mediators and have receptors for neurotransmitters. The aim of this study was to determine whether MC were increased in the colonic mucosa of IBS patients compared to controls. Methods: Biopsy was done from the cecum, ascending colon, descending colon and rectum of 29 patients: 16 IBS, 8 normal, and 5 inflammatory controls. Tissue was stained immunohistochemically with a monoclonal antibody for human mast cell tryptase for MC, and H&E stain for other inflammatory cells. Results: MC count of IBS patients at the descending colon (15.2±4.0) was significantly higher than that of either normal controls (10.9±2.7) or inflammatory controls (11.0±2.9). In a group of patients with IBS, MC count at the cecum was significantly higher in the constipation-predominant subtype (21.3±3.4) and the pain-predominant subtype (22.7±2.5) than the diarrheapredominant subtype (14.7±4.2). Conclusions: Patients with IBS have higher MC count than controls, and MC count in constipation-predominant IBS patients was significantly higher than diarrhea-predominant IBS patients. These findings suggest that MC might play an important role in IBS. (Kor J Neur ogastr oenter ol Motil 2004;1:57-62)
괴상형 간세포암 : 수술적으로 절제한 괴상형 간세포암종 증례
이신영 ( Shin Young Lee ),채희복 ( Hee Bok Chae ),류동희 ( Dong Hee Ryu ),배일헌 ( Il Hun Bae ),성노현 ( Ro Hyun Sung ) 대한간암연구회 2009 대한간암학회지 Vol.9 No.-
A 59-year-old male patient visited ER complaining of persistent pain in his right upper quadrant abdomen. He had suffered from end stage renal disease secondary to long-term hypertension and had been under the maintenance hemodialysis for 13 years. Half a month ago, he recognized a mass at his epigastric area. He did not have any history of liver disease in his lifetime. Physical exams revealed that he had a tender and hard mass on his right upper quadrant and epigastric area. Total bilirubin was 0.6 mg/dL, AST/ALT was 59/75 IU/L, and AFP was 105,740 ng/mL. Computed tomography showed the huge liver mass in the left lobe and its size was estimated about 16cm. The regional lymph node was also found in the porta hepatis area. He received complete resection of the hepatoma and was discharged. We concerned about high probability of recurrence because of the pre-operative AFP level and vascular invasion in the pathologic specimen.
수술로 절제한 상피하 양성 십이지장 종양: 단일 기관의 증례들
박선미 ( Seon Mee Park ),김지훈 ( Ji Hoon Kim ),류동희 ( Dong Hee Ryu ),장이찬 ( Lee Chan Jang ),강성이 ( Sung Yi Kang ),성노현 ( Ro Hyun Sung ),최재운 ( Jae Woon Choi ) 대한췌장담도학회 2014 대한췌담도학회지 Vol.19 No.1
Background/Aims: The incidence of duodenal tumors has increased by health surveillance. However, preoperative diagnosis of subepithelial duodenal tumors remains difficult because of the wide variety of pathologies and the location of the tumors. We analyzed endoscopic, radiological, and pathological features of subepithelial benign duodenal tumors (BDTs), which were treated by surgical resection. Methods: Five patients with subepithelial BDTs treated by surgical resection were analyzed retrospectively. We compared the preoperative and postoperative diagnosis and evaluated the clinical presentations, endoscopic and radiological findings, surgical treatments, pathological results, and outcomes of these patients. Results: All the patients underwent successful surgical resection. There were two cases of gastrointestinal stromal tumors (GISTs) treated with segmental duodenectomy, one case of carcinoid tumor treated with antrectomy, one case of gangliocytic paraganglioma treated with ampullectomy, and a lipoma removed by mass excision. The two GISTs were in the duodenal third and fourth segment close to the pancreas, and it was difficult to exclude pancreatic tumors by imaging studies. All the patients remained healthy for more than three years. Conclusions: Subepithelial BDTs are rare and difficult to diagnosis. Awareness and preoperative diagnosis of subepithelial BDTs can lead to minimally invasive treatment, including endoscopic or local surgical resection. Korean J Pancreatobiliary 2014;19(1):18-25
이신영 ( Shin Young Lee ),주혜진 ( Hye Jin Joo ),조영심 ( Young Shim Cho ),전원중 ( Won Joong Jeon ),채희복 ( Hee Bok Chae ),박선미 ( Seon Mee Park ),윤세진 ( Sei Jin Youn ),성노현 ( Ro Hyun Sung ) 대한소화기학회 2009 대한소화기학회지 Vol.54 No.6
Acute cholangitis usually develops in congenital hepatic fibrosis (CHF), accompanied by cystic dilated bile ducts. However, it can also develop in simple CHF and may lead to critical course. A 30-year old man presented with recurrent acute cholangitis without bile duct dilatation. He visited the hospital for febrile sense and abdominal pain in the right upper quadrant. He had been admitted several times for hepatosplenomegaly and cholangitis since childhood and received a liver biopsy 15 years ago. Abdominal computed tomography (CT) and endoscopic retrograde cholangiopancreatography (ERCP) revealed hepatosplenomegaly and a mildly dilated bile duct without stones or biliary cysts. His condition improved after conservative treatment. However, during a two-month follow up period, the patient experienced three episodes of acute cholangitis. A liver biopsy was performed and showed periportal fibrosis and intrahepatic ductular dysplasia, characteristics of congenital hepatic fibrosis. The periportal fibrosis and the infiltration of inflammatory cells were aggravated compared to 15 years ago. There was no evidence of hepatic cirrhosis. He was diagnosed with congenital hepatic fibrosis with recurrent acute cholangitis without intrahepatic duct dilatation, and conservatively treated with antibiotics. (Korean J Gastroenterol 2009;54:404-408)