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치료적 절제술 후 문합부에서 재발한 대장의 반지세포암 1예
서유진 ( Yu Jin Suh ),차재명 ( Jae Myung Cha ),이정일 ( Joung Il Lee ),주광로 ( Kwang Ro Joo ),정성원 ( Sung Won Jung ),신현필 ( Hyun Phil Shin ),김수웅 ( Soo Woong Kim ) 대한장연구학회 2010 Intestinal Research Vol.8 No.1
A primary signet ring cell cancer (SRCC) is a rare form of an adenocarcinoma of the large intestine. The prognosis of SRCC of the colon has been reported to be worse than classic adenocarcinoma of the colon; however, there is no difference in the post-operative surveillance for SRCC. We report a case of SRCC of the colon with negative resection margins that recurred at the anastomosis site 26 months after curative resection. A 55-year-old male presented to the hospital with abdominal pain. The initial colonoscopy and abdominal computed tomography revealed SRCC of the proximal ascending colon. He underwent extensive curative surgical resection and adjuvant chemotherapy for 8 months. However, 26 months post-operatively, the cancer recurred at the anastomosis site without peritoneal dissemination. Physicians should be aware that SRCC may have different recurrence patterns compared with classic adenocarcinoma, and may need more vigorous surveillance, even after curative surgery. (Intest Res 2010;8:58-62)
만성 특발성 두드러기 환자에서 갑상선에 대한 자가항체의 의의
서유진(Yu Jin Suh),정철권(Cheol Kweon Jeung),이수진(Soo Jin Lee),김선신(Sun Sin Kim),이수걸(Soo Keol Lee),남동호(Dong Ho Nahm),박해심(Hae Sim Park) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.3
N/A Background:and objectives: Chronic idiopathic urticaria refers to recurrent hives of more than six weeks duration and in approximately 80% of cases, the etiology is unknown. Recently, involvement of an autoimmune mechanism in the pathogenesis of chronic idiopathic urticaria has been suggested. Thyroid autoimmunity has been reported in patients with chronic idiopathic urticaria and treatment with thyroxine in selected cases induced clinical remission. Materials and methods We studied 99 patients with chronic idiopathic urticaria to evaluate the clinical significance of anti-thyroid auto-antibodies including anti-thyroglobulin and anti-microsomal antibodies. Thirty-four normal volunteers were selected as controls. The prevalence of these two auto-antibodies as well as laboratory findings and clinical features between these two groups were compared. Results: Thyroid auto-antibodies were positive in 24% of patients compared to 8.7% of control patients and the duration of the disease was significantly longer in the patients with thyroid auto-antibodies than in those without thyroid auto-antibodies, respectively(p<0.05). There was no significant difference in age, positive rate of ANA and total eosinophil count. Administration of thyroxine to five patients with refractory urticaria resulted in improvement in three patients. Conclusion: Thyroid autoimmunity is associated with chronic idiopathic urticaria in some patients. Administration of thyroxine resulted in improvement of symptoms in some of these patients. Therefore, we recommend routine testing of thyroid auto-antibodies in patients with retractable chronic idiopathic urticaria.
Cefteram pivoxil을 생산하는 제약회사 직원들에서 직업성천식의 유병률 및 특이 IgE 감작률
서유진 ( Yu Jin Suh ),이영목 ( Young Mok Lee ),최정희 ( Jeong Hee Choi ),서창희 ( Chang Hee Suh ),남동호 ( Dong Ho Nahm ),박해심 ( Hae Sim Park ) 대한내과학회 2003 대한내과학회지 Vol.64 No.3
Background: Cephalosporins are well-Known agents that may cause occupational asthma and there have been a few reports suggesting that the pathogenesis may be IgE-mediated. After investigation of one worker with occupational asthma due to cefteram pivoxil
의료인에서 발생한 췌장 추출물 흡입에 의한 직업성 천식
이수진(Soo Jin Lee),김희연(Hee Yeon Kim),서유진(Yu Jin Suh),김선신(Sun Sin Kim),이수걸(Soo Keol Lee),남동호(Dong Ho Nahm),박해심(Hae Sim Park) 대한천식알레르기학회 2000 천식 및 알레르기 Vol.20 No.2
N/A Background and objective : Porcine pancreatic extracts (PPE) are composed of a-amylase, lipase, and protease which are common components of digestives. PPE are known to cause occupational asthma in pharmaceutical workers, but there has been no report of PPE-induced occupational asthma in medical personnel. The aims of this study were to document the rate of sensitization to PPE and the prevalence of PPE-induced occupational asthma in nurses exposed to PPE and to identify possible immunological pathogenic mechanisms. Subjects and method: A clinical questionnaire on bronchial asthma and allergic rhinitis was distributed among 56 nurses working in the medical ward of Ajou University Hospital. Then, allergy skin prick tests were done with PPE and a battery of eight common inhalant allergens. The determination of specific IgE antibodies to PPE, α-amylase, and lipase was performed by ELISA. The nurses with respiratory symptoms and positive skin tests to PPE underwent methacholine inhalation test and bronchial provocation test with PPE. Results. Of the 56 nurses, five (8.9%) had symptoms suggestive of bronchial asthma, and six (10.7%) had nasal symptoms suggestive of allergic rhinitis. Of these nurses, four (7.1%) had positive results on bronchial provocation test with PPE and proved to have PPE-induced occupational asthma. The prevalences of specific IgE to PPE and a-amylase were significantly higher in patients with positive skin tests (p<0.05). The prevalence of specific IgE to lipase was not significantly different between skin test positive and negative groups (p) 0.05). The prevalences of specific IgE to PPE and a-amylase were significantly higher in patients with respiratory symptoms(p<0.05), and four subjects with PPE-induced asthma had high specific IgE antibody to a-amylase, while specific IgE to lipase values were not significantly different between patients with respiratory symptoms and those without symptoms (p>0.05). Conclusion : These results support the view that inhalation of a-amylase within PPE powder may induce occupational asthma by IgE mediated reaction in exposed medical personnel.
Cefaclor에 의한 아나필락시스 환자에서 cefaclor 특이 IgE 항체 측정
최정희 ( Jeong Hee Choi ),서유진 ( Yu Jin Suh ),신유섭 ( Yu Seob Shin ),서창희 ( Chang Hee Suh ),남동호 ( Dong Ho Nahm ),박해심 ( Hae Sim Park ) 대한천식알레르기학회 2003 천식 및 알레르기 Vol.23 No.2
Cephalosporines are the most important ?lactams inducing IgE-mediated reactions such as urticaria, angioedema and anaphylaxis. There have been a few reports that describes assays of serum specific IgE for cephalosporins. We experienced a case of cefaclor-
정신건강복지센터 실습 교육이 간호대학생의 정신질환에 대한 차별행동, 태도, 사회적 거리감에 미치는 효과
한은경(Eun-Kyoung Han),서유진(Yu-Jin Suh) 학습자중심교과교육학회 2020 학습자중심교과교육연구 Vol.20 No.2
본 연구는 간호대학생의 정신건강복지센터 실습 교육이 정신질환자에 대한 차별행동 및 태도, 사회적 거리감에 미치는 효과를 알아보기 위해 실시하였다. 연구 대상자는 간호학과 3학년에 재학 중인 학생 48명이며, 자료수집기간은 2017년 10월 30일부터 2017년 12월 22일까지였다. 단일군 전-후 원시실험설계로 SPSS/Win 22.0 프로그램을 이용하여 일반적 특성은 빈도와 백분율을 구하였고, 정신건강복지센터 실습 전·후의 정신질환자에 대한 차별 행동, 태도 및 사회적 거리감의 사전사후 평균 차이는 Paired t-test로 분석하였다. 본 연구 결과 정신질환에 대한 차별행동은 유의미한 차이가 나타나지 않았으며(t=1.571, p=.123), 정신질환자에 대한 태도의 하위영역 가운데 낙관성과(t=-2.534, p=.015), 사회적 거리감에서 유의미한 차이가 나타났다(t=13.606, p<.001). 본 연구의 결과를 통하여 간호대학생의 정신질환자에 대한 차별행동 및 태도, 사회적 거리감을 줄일 수 있는 다양한 교육 프로그램 개발 및 검증을 제언하다. The purpose of this study was to evaluate discrimination, attitude, social distance toward mental illness in nursing students after clinical practice of mental health welfare center. A quasi-experimental study with one group pretest-posttest design. The 48 nursing students participated in this study from October 30 to December 22. Data were analyzed using descriptive statistics, paired t-test with the SPSS/Win 22.0 program. There were not significant differences in discrimination behavior toward mental illness. In the areas of the attitudes toward people with mental illness, scores of optimism (t=-2.534, p=.015) and social distance (t=13.606, p<.001) were significantly different before and after the clinical practice of mental health welfare center. The results of this study, we suggest the development and verification of various educational programs to reduce discrimination behaviors, attitudes, and social distance toward mental illnesses of nursing students.