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RISS 인기검색어
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- 저자 : 백희경 ( Hee Kyung Baek ) (검색결과 4 건)
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백희경,김미혜,양웅모,Hee Kyung Baek,Mi Hye Kim,Woong Mo Yang 대한융합한의학회 2022 대한융합한의학회지 Vol.4 No.1
Objectives : The purpose of this study was to investigate the anti-inflammatory effects of the aqueous extract of the steamed radix of Rehmanniae glutinosa (SRG) on periodontitis in ligature-induced rat model. Methods: To induce the periodontitis, ligature was placed around the lower first molar in rats. Rats were divided into 4 groups (n = 7), NL (non-ligatured and vehicle-treated), L (ligatured and vehicle-treated), SRG1 (ligatured and 1 mg/kg SRG-treated) and SRG100 (ligatured and 100 mg/kg SRG-treated). Vehicle or SRG solution was applied daily for 14 days and then all experimental rats were sacrificed. To examine the effect of SRG solution on periodontitis, the level of alveolar bone loss, cementum regeneration, gingival tissue degradation, and osteoclast cell numbers were analyzed. Results: Alveolar bone loss was inhibited in ligature-induced periodontitis rats treated with SRG treatment. Histopathological cementum was recovered in SRG1 and SRG100 groups. SRG extract inhibited gingival tissue degradation induced by ligature. In addition, the numbers of osteoclast cells were decreased by treatment SRG in periodontitis rats. Conclusion: Taken together, these results suggest that SRG have inhibitory effects against periodontitis. Therefore, the steamed radix of Rehmanniae glutinosa has may be a potential alternative for periodontitis.
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김혜인 ( Hye In Kim ),백희경 ( Hee Kyung Baek ),정진규 ( Jin Kyu Jung ),조용민 ( Yong Min Jo ),이상엽 ( Sang Yeob Lee ),이성원 ( Sung Won Lee ),정원태 ( Won Tae Chung ) 대한류마티스학회 2009 대한류마티스학회지 Vol.16 No.2
Objective: To assess the 10-year cumulative survival outcome of polymyositis (PM) and dermatomyositis (DM) as well as the factors associated with the the outcome. Methods: Eighty five patients with PM and twenty one patients with DM were diagnosed at our university medical center between 1997 and 2007. Thirty six patients with PM and 13 patients with DM were followed up until death or until the end of January, 2008. Gender, age, AST, ALT, CPK, LDH, ESR, CRP, aldolase, drugs of therapy, combined ILD, and cancer, and duration of remission after therapy were assessed as prognostic factors of death by the Kaplan-Meier curve and Cox regression model. Results: The respective 10-year survival rate for PM and DM was 80.8% (95% confidence interval (CI): 73.3∼87.2) and 55.9% (95% CI: 40.7∼71.1), respectively. The median survival for PM and DM was 11.3 years (95% CI: 9.8∼12.9) and 7.0 years (95% CI: 3.6∼10.5), respectively. Compared to DM patients, the subjects with PM had a 167.26 fold (95% CI: 7.59∼3683.19) combined ILD adjusted risk of mortality (p<0.05) and no other individual factor reached significance as a predictor of death. However, cancer had a hazard ratio (HR) of 17.00 (95% CI: 1.06∼281.79) and 2.45 (95% CI: 0.78∼12.45) for death in the PM and DM group, respectively. Conclusion: According to an analysis of the survival and its prognostic factors in patients with PM and DM, ILD is a risk factor for mortality in PM and cancer was risk factor for mortality in both PM and DM.
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증례 : 소화기 ; 뇌종양의 증상 발현으로 진단된 경화형 간세포암 1예
김상옥 ( Sang Ock Kim ),백희경 ( Hee Kyung Baek ),김도경 ( Do Kyong Kim ),신봉철 ( Bong Chul Shin ),정진숙 ( Jin Sook Jeong ),한상영 ( Sang Young Han ),이성욱 ( Sung Wook Lee ) 대한내과학회 2009 대한내과학회지 Vol.77 No.5S
최근 간암 치료의 발전으로 생존기간이 늘어나면서 뇌전이의 예가 점점 늘어나고 있다. 하지만 간암이 진단되기 이전에 간암의 뇌전이로 인해 신경학적인 증상이 먼저 발생하는 경우도 있다. 이렇게 전이성 뇌종양 진단 이후에 간암이 진단될 경우에 있어, 치료방침에 대한 연구가 확립되어 있지는 않다. 또한 간암의 조직학적 아형에 따른 호발되는 전이 부나 임상양상 및 예후 등에 대한 보고도 있지 않은 상태이다. 향후 간세포암의 뇌 전이에 있어 조직학적 아형에 따른 다양한 임상결과 및 치료결과에 대한 보고가 치료방침을 결정하는데 있어 좋은 자료가 될 것으로 생각하며, 따라서 본원에서 경험한 경화형 간세포암의 뇌 전이에 대한 임상 예를 보고하는 바이다. Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide, especially in far eastern countries. Extrahepatic metastases develop in 64% of patients with HCC. Lung, regional lymph node, bone, and adrenal gland are common sites of HCC metastasis, while metastases to the brain and skull are rare. Recently, the survival rate of HCC has increased with the development of new treatment modalities, and this has led to a higher frequency of HCC brain metastasis. However, no reports have mentioned the relationship between the subtype of HCC and clinical course. We report a case of scirrhous type HCC, presenting with the manifestations of an intracranial mass lesion with no symptoms or signs suggestive of HCC. We excised the intracranial metastatic mass and then treated the patient with palliative chemotherapy and radiotherapy. The patient survived for over 10 months. (Korean J Med 77:S1142-S1147, 2009)
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복막투석 환자에서 gadolinium 사용 후 발생한 콩팥성 전신성 섬유증 1예
구태형 ( Tae Hyoung Koo ),이동현 ( Dong Hyun Lee ),백희경 ( Hee Kyung Baek ),김도경 ( Do Kyong Kim ),김보경 ( Bo Kyung Kim ),홍숙희 ( Suk Hee Hong ),안원석 ( Won Suk An ) 대한내과학회 2010 대한내과학회지 Vol.78 No.4
콩팥성 전신성 섬유증은 급성 또는 만성 신부전 환자에서 gadolinium조영제를 사용하였을 경우에 생기는 질환으로 상하지 말단의 부종 후 딱딱해짐, 관절운동 장애 및 전신증상을 일으키는 질환으로 전세계적으로 증례들이 보고되고 있다. 저자들은 복막투석 환자에서 gadolinium을 사용한 자기 공명영상 촬영 후 하지부종 및 통증을 동반한 nephrogenic systemic fibrosis 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Nephrogenic systemic fibrosis is a systemic illness that only affects patients with kidney failure. Exposure to gadolinium-based contrast agents has been associated with the subsequent development of nephrogenic systemic fibrosis in patients with decreased renal function. Nephrogenic systemic fibrosis is characterized by skin induration after swelling and limited joint movement through a loss in flexibility that preferentially affects the extremities. A 58-year-old man in peritoneal dialysis developed swelling and stiffness of the lower limbs following gadolinium exposure for brain magnetic resonance imaging. This patient was diagnosed with nephrogenic systemic fibrosis by CD34 immunoreactivity of subcutaneous fibroblasts in a skin biopsy. We report, for the first time in Korea, that nephrogenic systemic fibrosis developed after gadolinium exposure in a peritoneal dialysis patient. (Korean J Med 78:507-511, 2010)
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