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당뇨병 환자의 피부병변 및 조갑변화에 관한 임상적 고찰
백혜승(Hae Seung Paik),양홍윤(Hong Yoon Yang),김중환(Joong Hwan Kim) 대한피부과학회 1994 대한피부과학회지 Vol.32 No.5
Background : Desmosomes are adhesive intercellular junctions that. for mean important component of the junction complexes of epithelial cells. They provide intercellular links between the intermediate filament cytoskeletons of adjacent cells and are has involved in maintaining the stritctural integrity of tissues. Objective : Calcium and retinioids ar:e major regulators of epidermal d fferentiation and their role on keratin proteins are well known. However, their effects on desmosom moleucles are unknown. To address this question we initiated a stdy of the effects of these epidermal differentiation regulators on desmosomal components, i.e., demoplikin, desmoglein, and pemphigus a atigens. Methods : We used monoclorial antibodies against desmoplakin(DF) and desmoglein(DG), and sera from patients with pemphigus vulgaris (PV), pemphigus foliaceus (DF) and paraneoplastic pemphigus (PNP) t,o study the effects of calcium and retinoic acids, which are major regulators of epidermal different,ation, on desmosomat protein formation in human cultured keratinoeytes. We performed immunofluorescence, immunoglotting and immunoprecipitation study using human keratinocytes cultured in high calcium media with or without retinoic acid and in low alcium media with or without retinoic acid. Results : 1. In low calcium (0.15mM) rnedia, PV antigen and DG were produced in a small amount and it appeared that these desmosomal proteins were located in cytosol. Thereas in high calcium (1,8mM) media production of these desmcsomal proteins was increased and they were assembled at, the desmosomal structures located in cell-cell contact margins. 2. PF antigen, which was idntical to the DG, were not producecio expressed in cultured kerati-nocytes even when cultured in high calcium media, 3. PNF antigen and DP were produced in cultured keratinocytes grow in both high and low calcium media but, their production was increased in high calcium media and only in high ealcium media they were assembled at the desninsomai structures. 4. Retinoic acids induced looiening of cell-cell contacts of culture keratinocytes and decreased t,he production of desmosomal grotein Conclusion : Our results suggests calcium is a major regulat,or of the production and assembly of desmosomal proteins including pemphigusantigens, but PF sera and minoclonal antibodies against DG show different, antigen binding characteristics. It appears that rtinvic acids inhibit production of desmosomal proteins. (Kor J Dermatol 1994;32(5):820 831)
김중환,양홍윤,소순남,백혜승,황유정,김지현,김영태,김재홍 ( Joong Hwan Kim,Hong Yoon Yang,Soon Nam Soh,Hae Seung Paik,Yoo Jung Hwang,Ji Hyun Kim,Young Tae Kim,Jae Hong Kim ) 대한피부과학회 1991 大韓皮膚科學會誌 Vol.29 No.6
N/A In view of high prevalence of penicillinase producing Neisseria gonorrhoeae(PPNG) and chromosomally mediated resistant Neisseria gonorrhoaea(CMRNG) among circulating N. gonorrhoeae and emergence of spectinomycin resistant strains in Korea, more effort is needed to seek new effective treatment regimens for gonorrhea. The objective of this trial was to establish the efficacy of enoxacin, one of new fluoroquinolones, in the treatment of uncomplicated male gonorrhea. A total of 112 male uncomplicated gonorrheal patients were treated with one of the two dose regimens at the VD Clinic, Choong-Ku Public Health Center, in Seoul, between January and August, 1990. The patients were divided randomly into two groups and assigned to one of the two different dose regimens of enoxacin: 300㎎, PO(group A) and 600㎎, PO(group B). One of 47 patients treated with enoxacin, 300㎎, PO, failed(2.1%) and two of 46 patients treated with enoxacin, 600㎎, PO, failed (4.3%) to recover. A single dose regimen of enoxacin, 300㎎, PO is exellent, sa?e and relatively inexpensive in the treatment of male uncomplicated gonococcal urethritis in Korea.