흰 생쥐의 태아기 저단백식이가 생장후의 운동능력 및 젓산형성에 미치는 영향

백광세,홍성일,이중우,김인교,강두희 최신의학사 1975 最新醫學 Vol.18 No.10

The effect of maternal protein deficiency during gestation and lactation on the physical performance and lactate formation of the child mice was studied. Thirthy female mice were devided into two groups consisting of 15 each, one group was maintained with balanced and the other with low protein diet. The former, the control group, was fed balanced diet containing 20% casein and the latter, experimental group was fed low protein diet containing 5% casein during the periods of gestation, delivery and lactation. 30 male mice weaned from each group (Total 60 mice) were fed with balanced diet until the experiment. 15 mice from each group (total 30 mice) was used for single acute experiment and the other half were trained under severe training program. 8 weeks after weaning, the maximal running time was recorded on a small animal treadmill with a speed of 34.3m/min and 19° slope. 3 minutes after the maximal running, the mouse was sacrificed immediately by decaptitation and the blood was collected. The lactic and pyruvic acid in the blood were determined by the method of Barker and Summerson (1941), and Friedman and Haugen (1942) respectively. The results were summarized as follows; 1. Newly born young mice from low protein group during gestation and lactation gained less weight than balanced diet group until 8 weeks after weaning. 2. The maximal running time of the low protein diet group was longer than control group significantly (P<0.05). The control group ran for an average of 7.23±1.46 min compared to 11.53±1.28 min of experimental group and the maximal work done of experimental group was also higher than control, 4238±470 gm-m and 2698±544 gm-m respectively. 3. The lactate concentration and lactate/pyruvate ratio in blood of the control group was higher then the experimental group. 4. The maximal running time and the maximal work of both groups after severe training program became insignificant, although the experimental group showed a longer maximal time.

군사훈련이 신체적성에 미치는 영향

백광세,김광수,김형철 공군본부 의무감실 1972 항공의학 Vol.20 No.1-2

공군 조종사를 위한 신체적성 운동

백광세,이원규,이종관,최용국 공군본부 의무감실 1970 항공의학 Vol.18 No.1-2

우리나라 마라톤選手의 體力現況 및 體力管理

白光世 대한의학협회 1969 대한의학협회지 Vol.12 No.1

인삼추출물이 생체 세포막 및 artificial lipid monolayer에 미치는 영향

백광세,이철영,이경남,송선옥,강두희,Paik, Kwang-Sei,Lee, Chul-Young,Lee, Kyung-Nam,Song, Sun-Ok,Kang, Doo-Hee 대한생리학회 1976 대한생리학회지 Vol.10 No.1

The Present study was conducted to investigate the effects of Ginseng extract on the tension-area curve for stearic acid monolayer. At the same time, the effects of Ginseng extract on osmotic and mechanical fragility of human red cells and histamine release from rabbit leukocytes were studied, The results are summarized as follows. 1. The Ginseng alcohol extract was found to expand liquid expanded phase of stearic acid monolayer, thus it is speculated that this agent may be acting as a surface active substance. 2. Osmotic hemolysis was inhibited by the Ginseng alcohol extract and the same effect was also observed in the presence of Ginseng saponin. However, the Ginseng alcohol extract was found to decrease hematocrit ratio of the RBC suspension, therefore, the inhibition of the osmotic hemolysis by this agent may be secondary effect to the reduced cell volume. 3. The mechanical hemolysis was also inhibited by the Ginseng alcohol extract but the inhibition was independent of changes in hematocrit ratio. 4. Histamine release from rabbit leukocytes was significantly increased in vitro in the presence of the Ginseng alcohol extract.(p<0.05)

말초신경 자극시 자극의 강도, 빈도 및 기간의 변화가 동통반응에 미치는 영향

백광세,임중우,김인교,이승일,강두희,Paik, Kwang-Sea,Leem, Joong-Woo,Kim, In-Kyo,Lee, Seung-Il,Kang, Doo-Hee 대한생리학회 1985 대한생리학회지 Vol.19 No.2

Previously, we had reported that the electrical stimulation of peripheral nerve with stimlatory parameters of 20 V strength and 2 Hz frequency for 60 min resulted in reducing the pain reaction. The present study was performed to evaluate if the pain reaction was affected by the peripheral nerve stimulation with different stimulatory parameters in the decerebrated cat. The flexion reflex was used as an index of the pain reaction. The reflex was elicited by stimulating the sural nerve (stimulus strength of 20 $V\;\times\;0.5$msec) and recorded as a compound action potential from the motor nerve innervated to the posterior biceps femoris muscle. The common perneal nerve was selected as a peripheral nerve on which the electrical stimulation of various intensities and frequencies was applied. The results are summarized as follows : 1) The peripheral nerve stimulation with 100 mV strength, regardless of frequencies, did not affect the pain reaction induced by the sural nerve stimulation. 2) When the stimulus of 1V intensity and slow frequency (2 Hz) was applied to the peripheral nerve for 30 min or 60 min, the pain reaction was significantly reduced comparing to the control. However, this reduced pain reaction by the peripheral nerve stimulation was not reversed by the injection of naloxone (0.02 mg/kg) 3) High frequency stimulus (60 Hz) of 1V intensity for 30 or 60 min did not show any effects of affecting the pain reaction. These results suggest that the stimulus of relatively high intensity (at least 1V) and low frequency (2 Hz) is needed to elicite the analgesic effect by the peripheral nerve stimulation. By the 1V stimulus, $A\delta$ nerve fiber is activated. Therefore, an $A\delta$ or smaller nerve fibers must be activated for showing analgesia by the peripheral nerve stimulation. However, the mechanism of analgesia by the $A\delta$ nerve activation alone was not related to the endogeneous morphine system since the reduced pain reaction by the $A\delta$ fiber activation alone was not reversed by the treatment of naloxone.

한냉자극(寒冷刺戟)에 대한 한국해녀의 혈관계 반응(血管系反應)에 관한 연구

백광세,김진경,한대석,강복순,홍석기,Paik, K.S.,Kim, C.K.,Han, D.S.,Kang, B.S.,Hong, S.K. 대한생리학회 1969 대한생리학회지 Vol.3 No.1

Experiments on thermoregulatory responses to cold immersion stimulus were carried out in September, 1968 (summer studies) and February, 1969 (winter studies). Eight each of ama and control subject were selected at random from a same community in Yong-Do Island, Pusan. The results obtained are summarized as follows: 1) The rate of fall in muscle temperature of forearm during a 30 min-immersion in $6^{\circ}C$ water bath was significantly slower in the ama in winter and was about the same in the two groups in summer. However, the magnitude of change in the skin temperature and the heat fluxes observed during immersion period was not significantly different either between groups or between seasons. 2) Both finger blood flow and skin temperature during one hr-immersion in $6^{\circ}C$ water bath decreased significantly in the ama as compared to the control. The magnitude of cold-induced vasodilatation during immersion period was significantly greater in the control in winter. However, the time of onset and blood flow at onset showed no significant relation between groups. 3) The magnitude of reactive hyperemia after a 5 min-arterial occlusion in both air and $15^{\circ}C$ water bath was significantly lower in the ana than in the control. In control subjects, post-occluded blood flow in water was significantly greater than in air, while in the ama it decreased to 1/2 of control values. The time required for the return of blood flow to resting values in the air was faster in the ama than in the control but was the same in water in the two groups. 4) The results suggest that vasoconstrictor tone increased in the ama in winter, indicating the development of vascular adaptation as a part of cold acclimatization.

흰생쥐에 있어서 성장기의 신체훈련이 신체발육 및 운동능력에 미치는 영향

백광세,Paik, Kwang-Sae 대한생리학회 1977 대한생리학회지 Vol.11 No.1

The object of the present study is to examine the effect of physical training during early growth of life on body weight gain and physical performance. Early weaned (2 weeks after birth) male mice were divided into control and training group-and experimental period was divided into growing period (from 1st week to 6th weeks after weaning) and adult period (from 7th weeks to 9th weeks after weaning). Physical training was. given on a small animal treadmill with a speed of 34.3m/min and $19^{\circ}C$ slope and both groups of body weight gain and maximal running time on the treadmill were determined. The results obtained are summarized as follows; 1. Body weight gain was lesser in training group than control group and the difference was. statistically significant at 1, 2.5, 5.7 weeks of training period. 2. Maximal running time of training group was found to be longer than that of control group at 6th (p<0.01), 8th (p<0.001) and 9th weeks. (p<0.01). From the above results, it may be concluded that if physical training is started in early growth of life, there might be an improvement of physical performance.

레일 결함 탐상 초음파 탐촉자의 내마모 소재 연구

백광세(Baek Kwang-Se),김용현(Kim Yong-Hyun),권세곤(Kwon Se-gon),박상준(Park Sang-Jun),김기복(Kim Ki-Bok) 한국방재학회 2018 한국방재학회논문집 Vol.18 No.2

레일 결함 검출 방법으로서 비파괴 초음파 검사기술이 사용되고 있으나 초음파 탐촉자가 레일 표면에 직접 접촉하여 검측을 수행하기 때문에 초음파 탐촉자의 마모로 인한 손실과 파손이 발생한다. 본 연구에서는 레일 검사용 초음파 탐촉자에 필요한 내마모 소재를 개발하기 위하여 수행되었다. PMMA (Poly(methyl methacrylate)) 소재를 기반으로 다양한 첨가제를 중합하여 마모 소재를 제작한 다음 내마모 시험, 충격 시험, 초음파 시험을 수행하여 적절한 내마모 소재의 제작조건을 분석하였다. 최종적으로 레일 결함 검사 초음파 탐촉자용 내마모 소재는 Taber 마모값이 165 mg loss, Izod 충격 에너지가 2.35 kJ/㎡인 소재로 선정되었다. As a method for detecting the rail defects, the nondestructive ultrasonic testing technique has been used. Since the ultrasonic transducer should be direct contacted to the surface of rail, damage and failure of the ultrasonic transducer are occurring due to its wear from the rail. This study was conducted to develop the wear-resistant material of ultrasonic transducer for inspecting the rail. The PMMA (Poly(methyl methacrylate))-based wear-resistant materials were fabricated by polymerization method. Various additives to PMMA were used. Four kinds of PMMA-based wear-resistant materials were fabricated and their characteristics such as abrasion, impact and ultrasound were measured and compared. Finally, as an wear-resistant material of ultrasonic transducer for inspecting the rail defect, the material of which Taber abraion and Izod impact energy were 165 mg loss and 2.35 kJ/㎡ Izod was selected.

말초신경자극이 동통반응에 미치는 영향

백광세(Paik, Kwang-Se),정진모(Chung, Jin-Mo),남택상(Nam, Taick-Sang),강두희(Kang, Doo-Hee) 대한생리학회 1981 대한생리학회지 Vol.15 No.2

Experiments were conducted in ischemic decerebrate cats to study the effects of electroacupuncture and electrical stimulation of peripheral nerve on pain reaction. Flexion reflex was used as an index of pain. The reflex was elicited by stimulating the sural nerve(20 V, 0.5 msec duration) and recorded as a compound action potential from the nerve innervated to the semitendinosus muscle. Electroacupuncture was performed, using a 23-gauge hyperdermic needle, on the tsusanli point in the lateral upper tibia of the ipsilateral hindlimb. The common peroneal nerve was selected as a peripheral nerve which may be associated with electroacupuncture action, as it runs through the tissue portion under the tsusanli point. Both for electroacupuncture and the stimulation of common peroneal nerve a stimulus of 20 V-intensity, 2 msec-duration and 2 Hz-frequency was applied for 60 min. The results are summerized as follows: 1) The electroacupuncture markedly depressed the flexion reflex; this effect was eliminated by systemic application of naloxone (0.02~0.12 mg/kg), a specific narcotic antagonist. 2) Similarly, the electrical stimulation of the common peroneal nerve significantly depressed the flexion reflex, the effect being reversed by naloxone. 3) When most of the afferent nerves excluding sural nerve in the ipsilateral hindlimb were cut, the effect of electroacupuncture on the flexion reflex was not observed. Whereas direct stimulation of the common peroneal nerve at the proximal end from the cut resulted in a significant reduction of the flexion reflex, again the effect was reversible by naloxone application. 4) Transection of the spinal cord at the thoracic 12 did not eliminate the effect of peripheral nerve stimulation on the flexion reflex and its reversal by naloxone, although the effect was significantly less than that in the animal with spinal cord intact. These results suggest that: 1) the analgesic effect of an electroacupuncture is directly mediated by the nervous system and involves morphine-like substances in CNS, 2) the site of analgesic action of electroacupuncture resides mainly in the brainstem and in part in the spinal cord.