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볼테라 시리즈 입력을 이용한 냉연 산세 라인 산농도 모델 추정
박찬은(Chan Eun Park),송주만(Ju-man Song),박태수(Tae Su Park),노일환(Il-Hwan Noh),박형국(Hyoung-Kuk Park),최승갑(Seung Gab Choi),박부견(PooGyeon Park) 제어로봇시스템학회 2015 제어·로봇·시스템학회 논문지 Vol.21 No.12
This paper deals with estimating the acid concentration of pickling process using the Volterra inputs. To estimate the acid concentration, the whole pickling process is represented by the grey box model consists of the white box dealing with known system and the black box dealing with unknown system. Because there is a possibility of nonlinear term in the unknown system, the Volterra series are used to estimate the acid concentration. For the white box modeling, the acid tank solution level and concentration equations are used, and for the black box modeling, the acid concentration is estimated using the Volterra Least Mean Squares (LMS) algorithm and Least Squares (LS) algorithm. The LMS algorithm has the advantage of the simple structure and the low computation, and the LS algorithm has the advantage of lowest error. The simulation results compared to the measured data are included.
오매 추출물에 함유된 Ursolic Acid에 의한 Helicobacter pylori의 Urease 활성억제
박찬엘 ( Chan El Park ),박창호 ( Chang Ho Park ) 한국화학공학회 2013 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.51 No.5
전통식물한약재에 대한 데이터베이스, 한국식물자원에 대한 문헌 및 선행연구 결과에 근거해 선정한 6가지의 식물한약재(연교, 소목, 형개, 황련, 소엽, 오매)의 에탄올(70%) 추출물 중에서 오매 추출물이 Helicobacter pylori의 urease 활성에 가장 강한 억제력을 나타내었다. 극성이 다른 용매를 사용한 회분식 용매추출과 칼럼 크로마토그래피를 이용한 3단계 분리공정을 통하여 오매 추출물에 함유된 유효성분을 분리·정제하였다. NMR 분석에 의해 정제된 오매 추출물에 함유된 활성성분이 ursolic acid로 확인되었다. 본 실험결과는 오매에 함유된 이 성분이 항생제를 대신하여 H. pylori 제거에 활용될 수 있음을 시사하였다. Urease activity of Helicobacter pylori was most strongly inhibited by extract of Mume Fructus among ethanol (70%, v/v) extract of 6 herbal materials selected from our previous work, database on traditional herbal materials, and literature data on Korean plant resources. Active compounds in the extract of Mume Fructus were separated by batch extraction, and further purified by chromatography in a silica gel column and an octadecyl silica gel column using solvents of different polarity. By NMR analysis of the last chromatographic fraction we identified ursolic acid as the active compound of urease inhibition. The result suggests that this component in Mume Fructus can possibly be used for the eradication of H. pylori.