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들깨 대실/잎들깨1호 재조합 자식계통(RILs)의 농업적 특성 및 품질 분석
박재은,이명희,오기원,김성업,오은영,하태정,조광수,정찬식,김정인,Park, Jae Eun,Lee, Myoung Hee,Oh, Ki Won,Kim, Sungup,Oh, Eunyoung,Ha, Tae Joung,Cho, Kwang-Soo,Jung, Chan Sik,Kim, Jung In 한국작물학회 2021 한국작물학회지 Vol.66 No.3
본 연구는 고품질의 들깨 신품종 육성을 위한 기초 자료로서 모본으로 종실용 품종인 '대실'과 부본으로 잎전용 품종인 '잎들깨1호'를 이용하여 교배된 재조합 집단(F<sub>1</sub>)을 양성하였고, F<sub>2</sub>세대부터 SSD법으로 계통을 전개한 고세대(F<sub>7</sub>) RIL집단 277계통들에 대해서 농업적 형질과 종실의 품질특성을 비교하였다. 재조합 집단의 주요 농업적 형질의 변이를 분석한 결과 경장은 66~150 cm, 유효분지수는 5~23개, 화방군장은 5.1~10.5 cm, 화방군수는 17~131개 및 화방군당삭수는 23~39개 등으로 분포하였다. 종실의 품질 특성을 분석한 결과 주요 지방산인 리놀렌산(C18:3)은 54.2~64.1%, 기능 성분인 rosmarinic acid는 869.5~3,508.1 ㎍/g, luteolin은 47.4~864.3 ㎍/g 및 apigenin은 57.1~296.7 ㎍/g 등으로 분포하였다. 조사된 대부분의 농업적 형질이 변이의 폭이 크면서 정규곡선 양상을 보였으며, 양친의 특성보다 우월한 특성을 가진 후대들이 많이 나타나는 초월분리 현상을 확인하였다. 이러한 결과는 F<sub>7</sub> RIL 집단이 향후 QTL 분석뿐만 아니라 우수 품종 육성을 위한 중간 모본 양성에도 유용하게 활용될 수 있을 것으로 판단된다. This study was conducted to obtain basal information for the development of perilla cultivars with improved quality. The F<sub>7</sub> population of recombinant inbred lines (RILs) from a cross between the parents of Daesil for seeds and Ipdeulkkae1 for vegetables was used as the material. We evaluated several agricultural characteristics and seed quality. Variations were observed in most of the measurements; for example, stem length (ranging from 66.0 to 150.0 cm), number of branches (from 5 to 23), flower cluster length (ranging from 5.1 to 10.5 cm), number of flower clusters (from 17 to 131), a-linolenic acid content (from 54.2 to 64.1%), and functional compound content (rosmarinic acid 869.5~3,508.1 ㎍/g; luteolin 47.4~864.3 ㎍/g; apigenin 57.1~296.7 ㎍/g) all showed variation. Significant correlations between stem length and the number of branches (0.561) and number of branches versus number of flower clusters (0.638) were detected in the RIL F<sub>7</sub> population. Most agricultural characteristics and seed qualities showed a normal distribution with large variation, and transgressive segregation was observed in many descendants with characteristics to those of their parents. Daesil/Ipdeulkkae1 RIL F<sub>7</sub> populations could be useful for future QTL analysis as well as for intermediate breeding lines for high-quality perilla cultivars.
체계적 문헌고찰 및 메타분석: 크론병 환자에서 Infliximab과 Adalimumab의 유효성 비교
박재은,정서일,서재경,강혜영 한국보건의료기술평가학회 2021 보건의료기술평가 Vol.9 No.1
Objectives: Infliximab and adalimumab are common biologic agents to induce remission state among patients with Crohn’s disease. Although, direct head-to-head studies comparing the clinical outcomes of the two treatments are sparse, several observational trials have been conducted recently. In this study, we performed systematic literature review and meta-analysis of cohort studies to compare the effectiveness of infliximab and adalimumab. Methods: We searched four databases, Ovid-Medline, Embase, PubMED, and Cochran Library. Observational studies comparing infliximab and adalimumab in patients with Crohn’s disease were selected. Quality of studies was assessed, and meta-analysis was conducted using a random effect model. In addition, subgroup analyses were performed based on the diagnostic criteria, biologics naïve/relapse and patients’ ethnicity. Results: Of the total 2,209 searched studies, 8 studies were included in the analysis. No significant difference in clinical remission between Infliximab and adalimumab was found [risk ratio (RR) 0.98, 95% confidence interval (CI) 0.90−1.07, heterogeneity: p=0.08, I2=45%]. In subgroup analysis, we found that the effectiveness of adalimumab was significantly better than infliximab (RR 0.77, 95% CI 0.61−0.98) in Asian population, however, due to the insufficient number of included studies for Asian population, careful interpretation is needed. Conclusion: The effectiveness of infliximab and adalimumab is comparable in observational studies. Follow-up studies are needed to find out treatment outcomes in different ethnicity.
박재은,한지숙 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.6
We examined the effects of HM-chromanone (HMC) on alleviating hyperglycemia and protecting pancreatic β-cells from streptozotocin (STZ)-induced damage in C57BL/6J mice. HMC was administered to STZ-induced diabetic mice at 10 or 30 mg/kg, for 14 days. Thereafter, changes in fasting blood glucose levels, insulin-secretion, histopathological examination of pancreas islet cell and apoptotic protein levels, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay were determined. The results revealed that HMC dose-dependently improved blood glucose concentrations and alleviated pancreatic islet cells damage. In diabetic mice, degeneration of the islet cells was observed wherein they appeared shrunken, with hyaline deterioration, nuclear dissolution, and condensation. However, morphology of the islet cell was restored, and nuclei were visibly rounded in the HMC (30 mg/kg)-administered diabetic mice. In addition, β-cell numbers were markedly increased in HMC mice compared to STZ-induced diabetic mice, and the number of cells stained with glucagon was decreased. HMC markedly decreased the expression of proapoptotic proteins and increased antiapoptotic proteins, and the number of apoptotic cells detected by TUNEL was elevated. HMC decreased expression of interleukin (IL)-1β, IL-6, and tumor necrosis factor-α in diabetic mice. Moreover, HMC increased antioxidant-enzymes activity, and decreased reactive oxygen species generation. In conclusion, the results demonstrate the potential of HMC to alleviate hyperglycemia by protecting the pancreatic β-cells in diabetic mice.