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항진균제로서 1,3- Dioxolane 유도체의 합성과 그의 생물학적 활성 평가
오정희,조훈,류성렬,장향동,유의경 한국공업화학회 1998 응용화학 Vol.2 No.1
In an effort the synthesis of new antifungal agent, We have synthesized two new cis-1- (N-cycloalkylcarbamoyl)-4-[4-[[2-(2,4-dichlorophenol)-2-(1H-imidazol-1-yl-methyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine derivatives ( R=cyclopropyl, cyclohexyl)were synthesized by the reaction of cis-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl-methyl)-1,3-dioxolan-4-y1]methoxy]phenyl]piperazine with N-cyc-loalkylcarbamoyl substituted derivatives and their in vitro antifungal activities will be presented.