Aminofusin L300의 비경구적 추여에 대한 임상적 고찰

나건영(KY Na),이명우(MW Lee) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.6

Aminofusin L300 (25% solution of essential amoni acids and non-essetial amino acids, carbohydrates, electrolytes and vitamins) has been tested in hyperemesis gravidarum patients at Seoul National Unviersity Hospital during the period from January 1974 to July 1975. The results obtained are as follows; 1. The body weight was initially decreased for 3 days but thereafter gardually increased and returned to normal weight. 2. The level of blood sugar BUN protein, and electrolytes were not changed sighnificantly and kept within normal ranges. 3. With infusion of aminofusin L300, positive nitrogen balance was obtaiend from the 4th day. 4. No unpleasant side effects were observed.

질트리코모나스질염의 Ornidazole 1gm 1일요법에 대한 임상적 평가

나건영(KY Na),강길전(KC kang) 대한산부인과학회 1977 Obstetrics & Gynecology Science Vol.20 No.10

1976년 5월부터 동년 7월까지 서울의과대학부속병원산부인과 외래환자중에서 질트리코모나스질염 35명에 대하여 Ornidazole(Tiberal) 1gm 1일요법으로 다음과 같은 성적을 얻었다. 1) 치료성적은 92.6%이었다. 2) 약의 부작용은 전연 인정할 수 없었다. 3) 약의 독성도 전연 인정할 수 없었다. 따라서 Ornidazole 1gm 1일요법은 질트리코모나스질염늬 치료에 있어서 안전하고 우수 한 약제로 판단되었다. Previously we had tested a single day therapy with Ornidazole 2 gm in vaginal trichomniasis, in which side effect of dizziness was somewhat troublesome. Hence it was suggested that a lower dose would have adequate trichomocidal effect, but minimal side effects. In this study, ornidazole 1gm was tested in 27 women with vaginal trichomoniasis at Seoul National university Hospital during the period from May to july, 1976. To all patients and their husbands, oridazole 0.5gm was ad,omostered twoce a somg;e dau amd a vagomal tablet 0.5gm was inserted in women. We used Roiron-pattner medium and obtained the following results. 1. The cure rate 1 week later after administration of the drug was 92.6%. 2. Side effects or toxicity of the drug was noticed in none of the patients. It was suggested that a single day tharapy with ornidazole 1gm was effective and well tolerated in the treatment of vaginal trichomoniases.

방사선이 자궁경암세포 염색체에 미치는 형태학적 변화

나건영(KY Na) 대한산부인과학회 1970 Obstetrics & Gynecology Science Vol.13 No.3

The author studied on the effects of radiation on the chromosome of the uterine cervix cancer by the method of tissue culture. As a result, followings were obtained. 1) 24 slices of the uterine cervix cancer tissue were tried to culture. But 5 in non-radiating group, 3 in radiating group by 200 rad, and 2 in radiating group by 400 rad were succeeded in culture. It was enought to study the chromosomal morphology. 2) The range of number of chromosomes of 236 cells in non-radiating group and 188 cell in radiating group, were varied from haploid to tetraploid, and furthermore they had stemline of hyperdiploid. The significant change of chromosome number caused by radiation was not recognized. 3) The breakage rate of chromosoma! morphology of non-radiating group was 15.4 percent and that od radiating group was 28.4 percent. It means that there was significant difference in the morphological change of chromosome by radiation.

자궁경의 Carcinoma in Situ 에 대하여

나건영(KY Na) 대한산부인과학회 1961 Obstetrics & Gynecology Science Vol.4 No.3

자궁경의 Carcinoma in situ는 암의 조기진단, 치료 및 발생기전에 관한 연구에 있어서 중요한 위치를 차지하고 있으므로 근대암학연구의 초점이 되어 있다. Carcinoma in situ는 Novak에 의하면 편평상피 전층이 침윤암세포와 현미경적으로 구별할 수 없는 세포로서 대치되어 있는 병변부위를 말하며 상피의 층장배열의 결여와 기저막의 침윤이 없음이 그의 특징이라고 하였다. 그러나 Carcinoma in situ의 정의는 물론 이형상피의 조직학적 분류법도 학자에 따라서 많은 논의가 있으며 특히 생체화학적, 면역조직학적 및 실험종양학적 연구가 거듭됨에 따라 새로운 지견도 발표된 바 있으므로 이에 부인과영역에 있어서의 Carcinoma in situ의 조직학적 연구의 발전과정, 이형상피의 분류법, 침윤암과의 관계성, 진단, 발생빈도, 제성상, 치료법 등의 현황의 일부를 기술하고저 한다.

산부인과 영역에 있어서의 Haemaccel ( 혈장증량제 ) 사용경험

나건영(KY Na),이동경(TK Lee),임원일(WI Im),오덕겸(DK Oh),엄익부(IB Um),고근익(KI Koh) 대한산부인과학회 1965 Obstetrics & Gynecology Science Vol.8 No.9

Thirteen gynecelogical and obstetrical patients with massive bleeding caused by various reasons were treated by infusion of "HAEMACCEL". a new plasma volume expender, manufactured by Hoechst Pharmaceutical Company in Germany. Results of the follow-up observation were as follows; 1) Patients in shock state following more than 1000cc of bleeding could be reversed to conscious state within I hour after rapid infusion of 1000 cc to 1500 cc of "HAEMACCEL". Recovery from hypotension was also coincident. 2) On Patients with less than 500cc of bleeding, safty operations were carried out without any fall in blood pressure by infusion of "HAEMCCEL" alone as a measure of replacement of the lost blood volume. 3) No overloading signs were noted with infusion of 500 to 1000 cc of "HAEMACCEL" and same amount of whole blood. 4) The value of hemoglobin was not decreased as a result of hemodilution which was expected on infusion of "HAEMACCEL". 5) Leucocytosis, which was thought caused in response to foreign body reaction, diminished sligtly in general. No significant side reactions such as fever, urticaria, bleeding tendency, etc. were noticed. 6) No sequelae of "HAEMACCEL" infusion was present.

자궁경암 발생과정에 있어서 핵용적 및 DNA양의 태도에 관한 현미광도법적 연구

나건영(KY Na) 대한산부인과학회 1962 Obstetrics & Gynecology Science Vol.5 No.1

자궁경암의 발생과정에 관한 많은 조직학적 연구의 결과, 뚜렷한 단계적 과정을 밟아서 발생한다는 사실이 명백히 되었다. 저자는 자궁경암 발생과정에 있어서의 핵용적 및 염색체수의 변동을 관찰하고저 220예의 자궁경원추절제술 및 생검법시행예중 조직학적으로 정형적소견을 가진 정상상피, 이상상피, 불온상피, 이형상피, 침윤전상피, 성숙암 각 2예를 선택하여 조직편을 Hamatoxylin-Eosin염색을 하여 기저세포, 방기저세포의 핵용적을 측정하고 Feulgen염색후 현미광도법으로 DNS량을 측정하였다. 정상상피의 기저세포, 방기저세포는 주로 배수염색체의 핵을 볼 수 있으나 방기저세포의 핵용적이 기저세포의 2배임은 방기저세포의 기능적 핵종창이라 할 수 있다. 이상상피 (abnomes Epithel)에 있어서는 DNS량에는 변동이 없으나 핵용적은 현저히 증가되어 있다. 불온상피(unruhiges Epithel)에 있어서는 방기저세포에 있어서 4배수염색체의 핵이 대부분임은 활발한 DNs합성을 의미한다. 이형상피(atypisches Epithel)인 상피내암(Carcinoma in situ)에 있어서는 기저세포에서도 대부분의 핵이 4배수 염색체이다.침윤전상피(prainvasives Epithel)에 있어서는 기저세포 뿐만이 아니라 방기저세포에 있어서도 염색체수가 반감되어 정상상피에 있어서와 같이 배수염색체의 핵을 가지고 있다. 이와같은 염색체수감소는 백서간암발생과정 있어서와 동일한 경향이다. 자궁경암 2예중 1예에 있어서는 초배수염색체 1예에 있어서는 주로 4배수염색체를 볼 수 있으나 보다 광범위한 분포를 볼 수 있음은 종양에 따라서 DNS량 즉 염색체수의 변동이 심하다는 사실과 일치된다. 발암과정에 있어서 볼 수 있다는 누진적 비배수성염색체는 핵용적측정과 현미광도법적으로는 인정할 수 없으므로 종양세포의 비배수성염색체는 급속한 증식에 기인 한다고 생각된다.

황체홀몬 작용 물질과 여아외음기형

나건영(KY Na) 대한산부인과학회 1963 Obstetrics & Gynecology Science Vol.6 No.1

임신중 특히 조기부터 Gestagen이 장기간 투여되는 경우에는 빈도는 높지 않으나 이와 관련이 있다고 추측되는 여성위반음양이 만출되는 수가 있다. 모체에 투여된 gestagen의 종류로서는 ethristerone, 19-norsteroid가 단연 많고 투여기간이 길수록 그 발생빈도가 높다. 그러므로 임부에 gestagen을 투여할 경우에는 잠재적인 남성화작용에 유의하여 투여량과 투여기간이 과다되지 않도록 주의할 것이며 특히 19-norsteroid를 사용할 경우에는 총량을 500mg이하로 한정함이 현명할 것이다. 만일 이러한 외음기형이 발생하였다 하더라도 간단한 수술로서 정형되며 생식기능에도 장해가 없으므로 gestagen사용에 있어서 공포을 가질 필요는 없다고 생각된다.

질트리코모나스질염의 Ornidazole 2gm 1일요법에 대한 임상적 평가

강길전(KC kang),나건영(KY Na) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.12

Ornidazole, a new antiprotozoal compund has been tested in 51 women with trichomonadal vaginitis at Seoul National Unviersity Hospital during the period from October to December 1975. In all patients and their husbands orinidazole 1 gm. was administered twice a single day and a vaginal tablet 500 mg. Was inserted in women. The results obtained are follows; 1. the cure rate ws 85.5% 2. side effects were noticed in 12.5% of patients, and it was of minor degree and transitory, but vertigo (6.2%) was somewhat troublesome. 3. Toxicity of the drug was negligible. It was suggested, that a single day therapy with ornidazole 2gm. was effective and well tolerated in the treatment of trichomonadal vaginitis.

임신빈혈에 대한 정주용철제 Fesin의 임상적 평가

김종우(CW Kim),이진용(JY Lee),나건영(KY Na) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.12

The purpose of this study was to confirm the effectiveness of intravenous saccharated iron oxide, fesin in 33 patients suffering from pregnancy anemia. The aim of this study can be summerized as follows 1. To inverstigate the safety, tolerance and rapidity of intravenous sacharated oxide of iron. 2. To determine the gain of hemoglobin depeding upon the dose and timing of treatment during gestation with intravenous saccharated iron oxid in all patients the following laboratory tests were carried out periodically serum iron hemoglobin and reticulocyte for evaluation fo drug effect at the same time any side effect wer abserved. 1. The results in all patients, were favorable with an average rise of 2.4+-0.87 gm of hemoglobin per patient within 3 weeks. 2. The degree of response is in general inversely proportional to the severity of the anemia before treatment. 3. The hematologic response showed more favorable response in late pregnancy than in mid-trimeseter 4. Delerious reactoins to the drug were few and negligible and were seen only following too rapid administration. On the basis of the above results it is concluded that not only the saccharated iron oxide is safe unless overdosage is administered but also the most reliable preparation for the treatment of pregnancy anemia. But this form of iron therapy should be reserved for patients not suitable for oral iro therapy.

질트리코모나스 질염의 Tinidazole 1회 대량투여법의 치료성적

신순철(SC Shin),박재일(JI Park),나건영(KY Na) 대한산부인과학회 1976 Obstetrics & Gynecology Science Vol.19 No.4

The purpose of this study was to access the effectiveness of single 2gm dose of Tinidazole a dertivative of imidazole, in 49 patients suffering from trichomonas vaginalis vaginitis. The aim of this study can be summarized as follows; 1. The inverstigate the safety and tolerance of tinidazole. 2. To determine the optimal dose and duration of therapy on trichomonas vaginalis vaginitis with tinidazole. In all patients the following laboratory tests were carried out ; SGOT, SGPT, alkaline phosphatase serum bilirubin, total and differential white cell count, and BUN for evaluation of drug toxicity. At the same time any side effect was observed. Results; In all patients and their husbands, tinidazole 2gm was administered at one time by mouth only, and wet smear and culture were conducted on 1wk and 4wks later for assesing the evidence of cure. 1. Side effects were appeared 11 cases (22.4%) such as abdominal discomfort, anorexia, dry mouth, verigo, and headache. But they were mild or moderate. 2. Toxicity ; only 2 cases (4.1%) were showed SGOT level increasing on post treatment 1wk, but they were returned normal level on post-treatment 4wks 3. Clinical symptoms and signs were imporved within post-treatment 1wk in 95%. 4. Cure rate ; post treatment 1wk ; 98% post treatment 4wks ; 92%