http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
정상치은열구액과 치주질환시 치은열구액의 단백질 조성비교에 관한 연구
김수아,이진용,김형섭,Kim, Soo-Ah,Lee, Jin-Young,Kim, Hyong-Seop 대한치주과학회 1993 Journal of Periodontal & Implant Science Vol.23 No.3
Gingival crevicular fluid (GCF) is a promising source for markers of destructive periodontal disease activity. This study was undertaken to evaluate the protein composition of GCF in varying stages of the gingival inflammatory response. GCF sampled from 26 people with clinically healthy gingiva and 18 people with periodontitis were examined via sodium dodecyl sulphate polyacrylamide gel electrophoresis(SDS/PAGE). The result were as follows. 1. Total amount of GCF protein of diseased group significantly different from that of normal group. But difference in protein concentration was not that significant. 2. In analyzing GCF with SDS/PAGE, it was suggested that albumin is used as indicator plasma protein leakage because of heavily staining bond of albumin in patients with periodontal disease. 3. In diseased group, overall bonds of protein and bands of high molecular weight protein were heavily stained. It was proved useful information on high molecular plasma protein leakage with increasing vascular permeability due to inflammation.
성인형 치주염에서 Chlorhexidine과 Tetracycline 양치액의 효과에 관한연구
서석란,곽정민,김형섭,Seo, Seok-Ran,Kwack, Jung-Minn,Kim, Hyong-Seop 대한치주과학회 1994 Journal of Periodontal & Implant Science Vol.24 No.2
Active treatment of periodontal disease consists of plaque control by the patient, with root planing and surgery perfomed by the dental practitioner. Chlorhexidine rinse has been the most effective antiplaque agent available today and tetracycline has been the most favored antibiotics. Therefore, the purpose of this study was compared the different effect among groups(saline mouthrinse[group I], 0.125% chlorhexidine mouthrinse [groupII], and 0.125% chlorhexidine mouthrinse containing tetracycline[groupIII]) during the immediate post periodontal therapy. We assessed plaque index, gingival index, papillary bleediing index, gingival crevicular volume, periodontal attachment loss, and periodontal pocket depth in 3 sites per subject. The assessment was made at baseline. At 1 week after scaling, and at 2 weeks after curettage. All groups were clinically and statistically reduced plaque score, gingival score, papillary bleeding score, and gingival crevicular volume at 2 weeks after curettage. Group II was significantly reduced periodontal pocket depth.(P<0.05) At 1 week after scaling, al clinical index scores were reduced but not singificantly difference between the groups.(p>0.05) At 2 weeks after curettage, plaque score, gingival score and papillary bleeding score were significantly difference between the groups.(P<0.05) During the experimental period, gingiva was not damaged and stain of the tongue or teeth were not noted in all groups.
Ni/Mo 합금분말(FLC-4608)의 소결경화 공정에서 유한요소법을 이용한 마르텐사이트 분율의 예측
박효욱,주수현,이언식,권기혁,김형섭,Park, Hyo Wook,Joo, Soo-Hyun,Lee, Eon Sik,Kwon, Ki Hyuk,Kim, Hyong Seop 한국분말야금학회 2015 한국분말재료학회지 (KPMI) Vol.22 No.1
In recent years, industrial demands for superior mechanical properties of powder metallurgy steel components with low cost are rapidly growing. Sinter hardening that combines sintering and heat treatment in continuous one step is cost-effective. The cooling rate during the sinter hardening process dominates material microstructures, which finally determine the mechanical properties of the parts. This research establishes a numerical model of the relation between various cooling rates and microstructures in a sinter hardenable material. The evolution of a martensitic phase in the treated microstructure during end quench tests using various cooling media of water, oil, and air is predicted from the cooling rate, which is influenced by cooling conditions, using the finite element method simulations. The effects of the cooling condition on the microstructure of the sinter hardening material are found. The obtained limiting size of the sinter hardening part is helpful to design complicate shaped components.
고압비틀림 성형 공정에 의한 Al 분말의 초미세결정 벌크화 및 특성 평가
주수현,윤승채,이종수,김형섭,Joo, Soo-Hyun,Yoon, Seung-Chae,Lee, Chong-Soo,Kim, Hyong-Seop 한국분말야금학회 2010 한국분말재료학회지 (KPMI) Vol.17 No.1
Bulk nanostructured metallic materials are generally synthesized by bottom-up processing which starts from powders for assembling bulk materials. In this study, the bottom-up powder metallurgy and High Pressure Torsion (HPT) approaches were combined to achieve both full density and grain refinement at the same time. After the HPT process at 473K, the disk samples reached a steady state condition when the microstructure and properties no longer evolve, and equilibrium boundaries with high angle grain boundaries (HAGBs) were dominant. The well dispersed alumina particles played important role of obstacles to dislocation glide and to grain growth, and thus, reduced the grain size at elevated temperature. The small grain size with HAGBs resulted in high strength and good ductility.
주수현(Soo-Hyun Joo),김형섭(Hyong Seop Kim) 한국소성가공학회 2010 한국소성가공학회 학술대회 논문집 Vol.2010 No.5
Carbon nanotubes (CNTs) are expected to be ideal reinforcements of composite materials used in aircraft and sports industries due to their high modulus and low density. In the present paper, severe plastic deformation by high pressure torsion (HPT) of powders at elevated temperature (473 K) was employed to achieve both powder consolidation and grain refinement of aluminum-matrix nanocomposites reinforced by 5 vol% CNTs. Before the HPT, the powders were ball milled using planetary ball mill in order to achieve molecular level mixing. Aluminum was treated by the same process for a reference. The HPT processed disk were composed of mostly equilibrium grain boundaries with high misorientation angles. The CNT reinforced ultrafine grained microstructural features resulted in high strength and good ductility.
면역세포의 cytokine 유리에 미치는 substance P의 영향
이진용,김수아,서석란,김형섭,Lee, Jin-Yong,Kim, Soo-Ah,Seo, Seok-Ran,Kim, Hyong-Seop 대한치주과학회 1997 Journal of Periodontal & Implant Science Vol.27 No.2
The neuropeptide substance P(SP) has been implicated in the mediation of inflammation and immune-mediated disease such as arthritis. Recently, it was reported that SP was markedly increased around the blood vessels in inflamed gingiva as well as in close association with the inflammatory cell infiltrate. These results support that SP may contribute to the pathophysiology of neuronal inflammation in human periodontal tissues. SP may regulate inflammatory/immune responses by stimulating the proliferation of human T cells, differentiation and antibody-secreting potential of B cells, macrophage respiratory burst, connective tissue proliferation, and the secretion of cytokines from monocytes and T cells. Here, I studied potential role of SP as a costimulatory chemical signal in inflammatory/immune responses, by determining the released proinflammatory cytokines such as $MIP-1{\alpha}$, $IL-1{\beta}$, and IL-6 from culture supernatants of homogeneous immune cell lines. Serum free cell supernatants were concentrated with TCA precipitation, fractionated with SDS-PAGE, and subjected into western blot analysis. Among 15 cell lines tested, macrophage/monocyte cell line RAW264.7 and WRl9m.1 showed the highest level of induction of $MIP-1{\alpha}$ when stimulated with LPS. Discrete IL-6 bands with multiple forms of molecular mass were detected from supernatants of B cell lines A20(32kDa), Daudi(32, 35kDa), and SKW6.4(29kDa), which were expressed constitutively. $IL-1{\beta}$ could not be detected by the method of western blot analysis from supernatants of all cell lines tested except RAW264.7, WRl9m.1, and erythroid cell line K562 which showed the least amount of $IL-{\beta}$ secretion. SP $10^{-9}M$ with suboptimal dose of LPS treatment showed synergistic induction of $MIP-1{\alpha}$ release from RAW264.7 or WR19m.1, and also IL-6 release from A20, but this synergism is not the case in costimulation of RAW264.7 or WRl9m.1 with SP $10^{-9}M$ and TPA. Although treatment of T cell line CTLL-R8 with SP $10^{-7}M$ or PHA+TPA induced modest level of $MIP-1{\alpha}$ secretion, synergism was not observed when they are applied together. These findings all together suggest the possibility of a regulatory role of SP in inflammatory/immune reaction through differential modulation of bioactivities of other chemical cosignals.
Core-shell 구조를 지니는 하모닉 분말의 성형거동 분석
주수현,박효욱,강수영,이언식,강희수,김형섭,Joo, Soo-Hyun,Park, Hyo Wook,Kang, Soo Young,Lee, Eon Sik,Kang, Hee-Soo,Kim, Hyong Seop 한국분말야금학회 2015 한국분말재료학회지 (KPMI) Vol.22 No.2
In this study, effect of core-shell structure on compaction behavior of harmonic powder is investigated. Harmonic powders are made by electroless plating method on Fe powders. Softer Cu shell encloses harder Fe core, and the average size of Fe core and thickness of Cu shell are $34.3{\mu}m$ and $3.2{\mu}m$, respectively. The powder compaction procedure is processed with pressure of 600 MPa in a cylindrical die. Due to the low strength of Cu shell regions, the harmonic powders show better densification behavior compared with pure Fe powders. Finite element method (FEM) is performed to understand the roll of core-shell structure. Based on stress and strain distributions of FEM results, it is concluded that the early stage of powder compaction of harmonic powders mainly occurs at the shell region. FEM results also well predict porosity of compacted materials.