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김운기,Jin-Soo Park,Ok-Ju Sul,Jae-Hee Seo,최범규,Hee-Young Park,Anne M. Latour,Beverly H. Koller,권병세,Choon-Soo Jeong 한국분자세포생물학회 2011 Molecules and cells Vol.31 No.2
Previous work has suggested that the LIGHT-TR2 costimulatory pathway plays a role in the acute and chronic stages of dextran sulfate sodium (DSS)-induced colitis [Steinberg et al. (2008); Wang et al. (2005)]. To clarify the role of TNFR-related 2 (TR2) signaling in the maintenance of intestinal homeostasis, we generated a TR2 knock-out (KO) mouse. Using DSS to induce colitis, we compared the colitic symptoms and pathological changes in wild type (WT) and TR2 KO mice, and the production of cytokines by the diseased colons. We also studied the role of TR2 in suppressing innate and adaptive immunity in the DSS model. TR2 deficient mice were characterized by reduced symptoms of intestinal inflammation compared with wildtype mice, and reduced production of cytokines. We therefore generated a monoclonal antibody against mouse TR2 which was specific to TR2 and capable of blocking TR2 signals. With this antibody, we demonstrated that antagonizing TR2 during the development of DSS-induced colitis reduced the symptoms of inflammation. Our findings suggest that TR2 is an important mediator in colitis, and may serve as a therapeutic target in inflammatory bowel disease.
김운기,Ok-Ju Sul,곽정숙,Hye-Young Hur,Anne M. Latour,Beverly H. Koller,권병세,Choon-Soo Jeong 생화학분자생물학회 2010 Experimental and molecular medicine Vol.42 No.12
Tumor necrosis factor receptor-related 2 (TR2, HVEM or TNFRSF-14) plays an important role in immune responses,however, the mechanisms regulating its expression are unclear. To understand the control of TR2gene expression, we studied the upstream region of the gene. Gel supershift assays revealed inducible binding of nuclear factor of activated T cells (NFAT)to a putative NFAT site within the TR2 promoter. Furthermore, cotransfection of a dominant negative NFAT construct, or siRNA for NFAT, resulted in increased expression of a TR2 reporter gene. Our findings demonstrate that NFAT negatively regulates TR2expression in activated T cells.
Platinum nanoparticles reduce ovariectomy-induced bone loss by decreasing osteoclastogenesis
김운기,김진천,박현정,설옥주,Mi-Hyun Lee,김지순,최혜선 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.7
Platinum nanoparticles (PtNP) exhibit remarkable antioxidant activity. There is growing evidence concerning a positive relationship between oxidative stress and bone loss, suggesting that PtNP could protect against bone loss by modulating oxidative stress. Intragastric administration of PtNP reduced ovariectomy (OVX)-induced bone loss with a decreased level of activity and number of osteoclast (OC) in vivo. PtNP inhibited OC formation by impairing the receptor activator of nuclear factor-κB ligand (RANKL) signaling. This impairment was due to a decreased activation of nuclear factor-κB and a reduced level of nuclear factor in activated T-cells, cytoplasmic 1 (NFAT2). PtNP lowered RANKL-induced long lasting reactive oxygen species as well as intracellular concentrations of Ca2+oscillation. Our data clearly highlight the potential of PtNP for the amelioration of bone loss after estrogen deficiency by attenuated OC formation.
SSD-Mobilenet과 ResNet을 이용한 모바일 기기용 자동차 번호판 인식시스템
김운기,Fatemeh Dehghan,조성원 (사)한국스마트미디어학회 2020 스마트미디어저널 Vol.9 No.2
This paper proposes a vehicle license plate recognition system using light weight deep learning models without high-end server. The proposed license plate recognition system consists of 3 steps: [license plate detection]-[character area segmentation]-[character recognition]. SSD-Mobilenet was used for license plate detection, ResNet with localization was used for character area segmentation, ResNet was used for character recognition. Experiemnts using Samsung Galaxy S7 and LG Q9, accuracy showed 85.3% accuracy and around 1.1 second running time. 본 논문은 고성능의 서버 없이 안드로이드 스마트폰 단독으로 동작할 수 있도록 경량화 딥러닝 모델을 사용하여 구현한 자동차 번호판 인식 시스템을 제안한다. 자동차 번호판 인식시스템은 [번호판검출]-[문자영역 분할]-[문자인식]으로 3단계의 과정으로 구성되며, 번호판검출은 SSD-Mobilenet, 문자영역 분할은 ResNet에 localization을 추가하여 사용하였고 문자인식은 ResNet을 이용하여 구현하였다. 테스트한 기기는 삼성 갤럭시 S7, LG Q9이며 정확도는 약 85.3%, 실행속도는 약 1.1초가 소요된다.
Ni-Fe bimetallic oxides 촉매의 CO, NO 가스상 오염물질 동시저감 특성
김운기,정재일,이명진,정보라,예보라,이희수,김홍대 대한금속·재료학회 2024 대한금속·재료학회지 Vol.62 No.2
Many studies have been conducted on methods to remove air pollutants. Among them, arepresentative commercial technology for reducing nitrogen oxides (NOX) is selective catalytic reduction (SCR)using NH3 as a reductant. However, the NH3-SCR technology has problems, such as the need for additionalNH3 gas (Active-SCR), the fact that unreacted NH3 (slipped-NH3) in the reaction process can be re-oxidizedto NOX, and the facility system cost according to the added NH3 gas. In order to solve these problems, COgas that is naturally generated in industrial processes can be used, and NO and CO can be removed at thesame time using passive-SCR technology that does not require a separate injection of a reductant. In thisstudy, transition metals Ni and Fe were used as catalytic materials to replace expensive precious metals. Theresults confirmed that both NOX and CO removal efficiencies were about 90% or more in the catalyst withcombined Ni-Fe, compared to the single catalyst. The addition of Ni to the Fe catalyst increased the catalyticreducing power, which also affected the increase in acid sites. Therefore, it is expected that this catalyst cansimultaneously remove NO and CO without the use of NH3 gas. These results could be explained throughXRD, FT-IR, TEM, BET, H2-TPR and CO-TPD analyses, and compared to single catalysts, it was confirmedthat the catalyst had higher low-temperature desorption ability for CO as a reductant and reducing capability.