내시경초음파 세침흡인술을 통한 전이성 미분화육종의 진단

김시영,이희승,정문재,박정엽,방승민,박승우,송시영,Si Young Kim,Hee Seung Lee,Moon Jae Chung,Jeong Youp Park,Seungmin Bang,Seung Woo Park,Si Young Song 대한소화기암연구학회 2017 Journal of digestive cancer reports Vol.5 No.2

A-49-year-old male patient with no specific medical history was admitted to the clinic because of persistent epigastric pain radiating to back for 4 months. He had multiple parenchymal tumors in body and tail of pancreas, para-spinal muscle, and mediastinum on abdomen CT image. Cytologic examination of the pancreas which was done by endoscopic ultrasound guided fine needle aspiration (EUS-FNA) showed adenocarcinoma, whereas histological examination of the para-spinal mass showed undifferentiated sarcoma. Histologic examination of the pancreatic mass was made through endoscopic ultrasound guided fine needle biopsy (EUS-FNB) for accurate diagnosis, and the histologic examination of both the pancreas and posterior mediastinal mass showed the same undifferentiated sarcoma. Therefore, we reviewed the cytopathic tissue obtained from the pancreas for the first time, and it was confirmed to be similar to histologic findings in the mediastinal mass.

폐쇄성 수면무호흡 증후군에서 앙와위 자세시간과 수면관련변인 간 상관관계 분석

김시영,박두흠,유재학,유승호,하지현,Kim, Si Young,Park, Doo-Heum,Yu, Jaehak,Ryu, Seung-Ho,Ha, Ji-Hyeon 대한수면의학회 2017 수면·정신생리 Vol.24 No.1

목 적 : 폐쇄성 수면무호흡 증후군(obstructive sleep apnea syndrome, OSAS)에서 앙와위는 비앙와위보다 수면무호흡을 증가시키는 것으로 알려져 있다. 앙와위 자세시간(supine position time, SPT)과 OSAS의 무호흡-저호흡 지수(apnea-hypopnea index, AHI)의 관련성에 대해서 많은 연구가 있었으나, SPT가 OSAS에서 어떤 변수의 영향을 받는지는 알려져 있지 않다. OSAS에서 수면다원검사상 어떤 변수가 SPT과 관련이 있는지를 평가하였다. 방 법 : 수면다원검사로 진단된 치료받지 않은 365 명의 OSAS 남자 환자를 선정하였다. SPT($276.4{\pm}92.3$ 분)가 인구 통계학적 데이터, 수면구조 관련변수, OSAS 관련변수 및 심박변이도(Heart rate variability, HRV)와 상관관계가 있는지 분석했다. SPT에 영향을 주는 요인을 알아보기 위해 SPT에 대해 다중회귀분석을 시행하였다. 결 과 : 전체 대상군의 상관분석에서 SPT는 총수면시간(total sleep time, TST) (r = 0.443, p < 0.001)과 수면 효율(r = 0.300, p < 0.001)과 가장 유의한 상관관계가 있었고, 코골이 시간(r = 0.238, p < 0.001), 산소포화도 90 % 미만시간(r = 0.188, p < 0.001), AHI (r = 0.180, p = 0.001), 산소탈포화지수(oxygen desaturation index, ODI), (r = 0.149, p = 0.004), NN50 count(r = 0.137, p = 0.036)와 SPT 간에 유의한 상관관계가 있었다. 다중회귀분석 결과 SPT에 유의한 영향을 끼치는 요인으로 TST (t = 7.781, p < 0.001), 코골이 시간(t = 3.794, p < 0.001), AHI (t = 3.768, p < 0.001), NN50 count (t = 1.993, p = 0.047)가 있었다. 결 론 : SPT는 OSAS 관련변수보다 수면구조 관련변수와 더 높은 상관관계를 보였다. 특히 SPT는 TST과 AHI 뿐만 아니라 NN50 count와도 밀접하게 관련되어 있었다. 이것은 SPT가 OSAS의 심각도뿐만 아니라 수면구조와 심박변이도에 의해서도 결정될 가능성이 있음을 시사한다. Objectives: A supine sleep position increases sleep apneas compared to non-supine positions in obstructive sleep apnea syndrome (OSAS). However, supine position time (SPT) is not highly associated with apnea-hypopnea index (AHI) in OSAS. We evaluated the correlation among sleep-related variables and SPT in OSAS. Methods: A total of 365 men with OSAS were enrolled in this study. We analyzed how SPT was correlated with demographic data, sleep structure-related variables, OSAS-related variables and heart rate variability (HRV). Multiple linear regression analysis was conducted to investigate the factors that affected SPT. Results: SPT had the most significant correlation with total sleep time (TST ; r = 0.443, p < 0.001), followed by sleep efficiency (SE ; r = 0.300, p < 0.001). Snoring time (r = 0.238, p < 0.001), time at < 90% SpO2 (r = 0.188, p < 0.001), apnea-hypopnea index (AHI ; r = 0.180, p = 0.001) and oxygen desaturation index (ODI ; r = 0.149, p = 0.004) were significantly correlated with SPT. Multiple regression analysis revealed that TST (t = 7.781, p < 0.001), snoring time (t = 3.794, p < 0.001), AHI (t = 3.768, p < 0.001) and NN50 count (t = 1.993, p = 0.047) were associated with SPT. Conclusion: SPT was more highly associated with sleep structure-related parameters than OSAS-related variables. SPT was correlated with TST, SE, AHI, snoring time and NN50 count. This suggests that SPT is likely to be determined by sleep structure, HRV and the severity of OSAS.

지방정부 공공서비스의 성과평가모형에 관한 소고

김시영,김규덕 ( Si Young Kim,Kyu Duk Kim ) 한국지방자치학회 1996 한국지방자치학회보 Vol.8 No.3

The performance evaluation of local government public service can improve decisions made by local government managers, and enhance accountability of local government to the citizens they citizens they serve, and elevate performance by using performance evaluation to improve resource allocation, analysis, planning. This study is intended to develop integrated model on performance evaluation of local government public service. Performance evaluation of local government public service is defined as a degree of the results or the impacts of the local government public service delivery on the citizens` needs, demands and expectations. So far, existing studies on performance evaluation are divided into two dimensions. One is evaluated by focusing on efficiency and effectiveness in the objective, economic, and quantitative aspects of suppliers, the other is evaluated by focusing on equity and responsiveness in the subjective, political, and qualitative aspects of recipients. But each of these two methods has strength and weakness. Therefore, integrated performance evaluation model of local government public service should be reflected a point of suppliers` and recipients`, simultaneously.

행정정보시스템의 도입에 따른 조직구조의 변화분석 - 대구광역시 남구청의 사례를 중심으로 -

김시영,정우열 ( Si Young Kim,Woo Youl Jung ) 한국지방자치학회 1997 한국지방자치학회보 Vol.9 No.3

대상포진 환자의 임상적 관찰 ( 1990 - 1994 )

김시영,조보현,김중환 ( Si Young Kim,Bo Hyun Cho,Joong Hwan Kim ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2

Background: Herpes zoster is an important and troublesome disease. Objective. The purpose of this study was the elucidation of the epidemiological and clinical characteristics of herpes zoster through patient assessrnent. Methods. During a 5- Year period, January 1990 to December 1994, 215 patients with herpes zoster were assessed with regard to annual and monthly frequency in occurrence, age and gender incidence. Associated conditions, dermatomic distributions, the relationship of onset of pain and skin lesions, Multi-CMI test and complications were also evaluated. Results : 1. The annual freguency of herpes zoster ranged from 0.88% to 1.78% (mean 1.23%) during the 5-year period. The highest number of herpes zoster patients was observed in winter (p<0. 001) especially in January. 2. Herpes zoster was found to most frequently afflict persons aged 50-59(27.9%). 71% of the patients were over 40 years of age. 3. In 76 patients(41.8%), neuralgia occurred several days(4 days mean) before the development of skin lesions. In 92 patients(50.5%), pain and skin lesions developed simultaneously while skin lesion development occurred before the onset of pain in 14 patients(7.7%). 4. Among the patients, 42.8% had associated conditions such as diabetes mellitus, hypertension, pulmonary tuberculosis, liver diseases, peptic ulcer, hypothyroidism, pharyngitis, fracture, etc. 5. The dermatomic invclvement of herpes zoster patients having one dermatome was most frequent in thoracic dermatome ca. es(52.6%). Others included cervical(16.7%), trigeminal(11.6%), sacral(6. 0%), lumbar(4.2%), facial(0.5%). Cases having two different dermatomes constituted 8.4%. 6. The most common complication of herpes zoster was postherpetic neuralgia although instance of ophthalmologic compiications, secondary bacterial infection, scar formation, Ramsay-Hunt syndrome, keloid formation, and urinary difficulty were also documented. 7. Multi-CMI(Cell-mediated immunity) tests were done on 88 herpes zoster patients. Thirteen of them(14.8%) were found to have comparatively depressed scores. Ten of the 79 single dermatome involvement patients(12.7%) and three of the 9 two dermatome involvement patients(33.3%) exhibited similar scores. Conclusion : These results are in accordance with those of previous reports with the exception of the higher incidence ot two different dermatome involvements and seasonal variation. (Kor J Dermatol 1997;35(2): 266-272)

수정체 방사선 방호에 관한 규제기준 및 기술기준 검토

김시영,황석주,김재성,손중권,Si Young Kim,Seok-Ju Hwang,Jae Seong Kim,Jung-Kwon Son 한국방사선산업학회 2024 방사선산업학회지 Vol.18 No.1

The International Commission on Radiological Protection (ICRP) lowered the annual equivalent dose limit of lens of the eye for radiation workers from 150 to 20 mSv in April 2011. This trend of lowering the equivalent dose limit for radiation workers has been observed worldwide, including international organizations such as the International Atomic Energy Agency (IAEA), International Organization for Standardization (ISO) and the European Commission (EC). In 2016, the Nuclear Safety and Security Commission of South Korea published research results that included a proposal for lowering the equivalent dose limit of lens of the eye for radiation workers in line with the ICRP recommendation. However, as of now, South Korea's Nuclear Safety Act and related regulations still specify an annual equivalent dose limit of lens of the eye as 150 mSv for radiation workers. The IAEA and ISO have issued guidelines regarding radiation protection for lens of the eye and recommended a dose level for the lens of the eye at 5 or 6 mSv per year for periodic monitoring of the equivalent dose for the lens of the eye.

지진취약도 곡선의 응답변수에 대한 상관계수 평가 및 변수별 조합

김시영,김정한,Kim, Si Young,Kim, Jung Han 한국전산구조공학회 2020 전산구조공학 Vol.33 No.6

확률론적 지진취약도 평가는 구조물 혹은 기기의 손상확률을 각 취약도 변수별 조합을 통해 이루어진다. 지진취약도로부터 구해지는 2개 이상 기기의 동시손상확률 계산은 기존에는 각 기기의 손상확률을 독립으로 가정해 왔다. 하지만 기기별 손상확률에 상관성이 있으며, 이를 평가한 결과 상관성에 따라 동시손상확률이 변화할 수 있는 결과를 보였다. 이 지진상관성을 무시하면 비보수적인 결과가 나오고 따라서 이를 고려해서 계산되어야 한다. 이 연구에서는 지진상관계수를 해석적으로 평가하기 위해 몇 가지 확률 변수를 선정하여 각 변수별로 혹은 통합하여 평가하고 그 차이를 비교했다. 그리고 단순화된 모델과, 복잡한 모델에 대한 상관계수 차이도 비교하였다. 이들 방법에 따른 상관계수의 결과와 차이를 분석했다. 그 결과 각 변수별로 평가하는 것과 통합하여 평가할 때 변수별 영향의 차이에 따라 상관성이 변화함을 확인하였고, 모델이 단순할수록 상관성이 높아짐을 확인하였다. Seismic fragility assessments include a procedure to combine the random variables of response and capacity to produce the relationship between failure probability and seismic intensity. The evaluation of the failure probability of simultaneous multiple failures of two or more components assumes that the failure probability of each component is independent of those of the others. However, a correlation is expected to exist because several random factors have the same cause. The multiple-failure probability can differ depending on this correlation and may be unconservative without considering the seismic correlation. Therefore, a practical methodology for fragility assessment should be evaluated using the seismic correlation and correlation coefficient for each random variable. In this study, several random variables were selected for numerical evaluation of the correlation coefficient. The correlation coefficient was then compared with each variable and the combined variables. The correlation coefficient using simplified and complex models were also compared to determine and analyze the differences between each of the approaches.

언어치료 전공학생의 임상실습만족도 및 교수효율성 연구

김시영(Si Young Kim),신명선(Myung Sun Shin) 한국언어치료학회 2015 言語治療硏究 Vol.24 No.4

점진적 언어 난이도 증가 프로그램을 이용한 말더듬 치료 효과

김시영(Si-Young Kim),권도하(Do-Ha Kwon) 한국언어치료학회 1994 言語治療硏究 Vol.4 No.-

장기간 운동이 마우스 조직별 heme oxygenase-1 발현에 미치는 영향

김시영 ( Si Young Kim ) 한국운동생리학회(구-한국운동과학회) 2010 운동과학 Vol.19 No.1

Heme oxygenase-1 (HO-1)은 산화적인 자극을 포함한 다양한 외부 스트레스에 대한 조직세포의 적응 및 방어에 중요한 역할을 담당하는 항산화효소이다. 본 연구의 목적은 마우스의 다양한 조직에서 HO-1의 발현 차이는 물론 장기간의 운동에 의한 조절 가능성을 알아보는데 있다. 연구에 사용된 24마리의 ICR계 마우스는 각각 8마리씩 세 그룹 [control group (CONT, n=8), low-intensity exercise group (LIE, n=8), high-intensity exercise group (HIE, n=8)]으로 나누어 졌으며, 16주간의 트레드밀 운동프로그램 후 골격근, 대장, 심장, 폐, 간 그리고 뇌를 분리하여 분석하였다. CONT에서 안정시 마우스 조직별 HO-1 발현량을 분석한 결과, 간 조직에서의 발현량이 가장 높았으며, 이어서 대장, 폐, 심장, 골격근 그리고 뇌 순으로 발현량의 유의한 차이가 나타났다. 16주간 트레이닝 후 비교그룹 (CONT)에 비해 트레이닝 그룹 (HIE, LIE)의 골격근, 대장 및 간에서 HO-1의 발현량이 유의하게 증가된 (p<.01, p<.001) 반면, 심장, 폐 그리고 뇌 조직에서는 그룹 간 발현차이가 나타나지 않았다. 이상의 결과를 바탕으로 결론을 내리면, 안정된 상태에서 마우스 조직에 따라 발현되는 HO-1 단백질량은 조직 사이에 유의한 차이가 있으며, 골격근, 대장 그리고 간 조직에서의 HO-1 발현량은 반복된 운동으로 증가시킬 수 있었다. Heme oxygenase (HO)-1, involved in the heme degradation process, is upregulated by a wide array of stimuli and has antioxidant, anti-inflammatory and other cytoprotective functions. The aim of this study was to investigate the difference and effect of long-term exercise on HO-1 expression among mouse tissues. The study carried out on twenty-four ICR mice. All mice participated in this study which consisted of three groups [control group (CONT, n=8), low-intensity exercise group (LIE, n=8), high-intensity exercise group (HIE, n=8)]. Mice were euthanized after 16 weeks of training periods and tissues (skeletal muscle, colon, heart, lung, liver, and brain) were removed. As a result of analyzed difference of HO-1 expression among tissues, liver topped the list, followed by colon, lung, heart, skeletal muscle, and brain (p<.001). In case of skeletal muscle, colon, and liver, after training for 16 weeks, HO-1 expression in HIE and/or LIE dramatically increased in comparison with CONT (p<.01, p<.001). On the other hand, no significant differences in the heart, lung, and brain were found between all groups. Taken together, we conclude that level of HO-1 expression is different between mouse tissues and long-term regular exercise can enhance the levels of HO-1 expression in skeletal muscle, colon, and liver.