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조성진,허택,김기선,이홍연 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.11
From March, 1986 to August, 1995, 67 patients who underwent a microsurgical reversal of the fallopian tubes which were followed-up for more than 6 months in the Department of Obstetrics and Gynecology, National medical Center were reviewed in order to determine the pregnancy rate and to evaluate the influencing factors. The results were as follows: 1. The mean age of the patients was 31.7 years and the mean age at sterilization and reversal was 5.74 years, the mean living children at tubal reversal was 1.3. 2. The reasons for requesting tubal reversal were desire for more children(42.2%), death of children(37.7%), and change in marital state(20.0%). 3. The kinds of previous tubal sterilization was performed, were laparoscoic cautery (53%), laparoscopic ring(28.9%), pomeroy method(15.6%), and minilap(2.2%). 4. The most common site of the anastomosis was isthmic-ampular portion(62.2%), the site of the highest pregnancy rate was cornual-isthmic portion(100%). 5. The postoperative tubal length was 6.6cm the average interval between tubal reversal and pregnancy was 3.9 months. 6. No statistical difference were found in pregnancy rate according to the method of previous sterilization. 7. The pregnancy rate according to the tubal length 3 or less, 3~4.9, 5~6.9, 7~8.9, 9 or more were 0%, 42.8%, 76.4%, 78.6%, 100% respectively. 8. The overall pregnancy rate after tubal reversal was 71.1%, and the outcome of the pregnancy was as follows; term pregnancy 62.3%, preterm-delivery 2.2%, spontaneous abortion 4.4%, ectopic pregnancy 2.2%.
시험관내에서 생쥐배아 발달에 대한 배양액의 용적 및 배아의 밀도가 미치는 영향
조성진,양회생,남미현,김기선,이홍연,임주형 대한산부인과학회 1996 Obstetrics & Gynecology Science Vol.39 No.11
The morphology, cleavage rate and viability of preimplantation embryos from F1 mice were associated after culture in different incubation fluid volumes and embryo desities. Decreasing the incubation fluid volume, from 5㎕ to 2ml, not increased morula cell number(p>0.05). Increasing the number of embryos incubated per drop from 1 to 16 significantly increased the number of two-cell embryos reaching the blastocyst stage in 5㎕, 20㎕ and 2 ml(p<0.05). The results of this study have implications for clinical in-vitro fertilization, where embryos are routinely cultured individualy in relatively large volume.
가토의 난관내 Methotrexate 주입시 수태력에 미치는 영향에 관한 연구
조성진,박찬용,박창서,배덕호,허택,김기선 대한산부인과학회 1995 Obstetrics & Gynecology Science Vol.38 No.10
우리는 본 예에서 가토 20마리를 이용하여 MTX의 난과주입후 수태력에 관한 연구를 한바, MTX의 난관주입으로 가토의 임신력에 영향을 주지 않았고 사람의 경우 파열되지 않은 자궁 외 임신에서 복강경을 이용한 MTX 주입이 기존의 수술에 의한 치료방법을 대체할 수있으리 라 사료된다. The effect of tubal injection of Methotrexate(MTX) on feritility was investigated in rabbits 10. Rabbits were injection with MTX(0.7mg/kg) in right tube and isotonic lactated Ringers solution(0.7ml) in left tube for control. Remaining 10 of rabbits were performed salpingotomy in right tube and salpingotomy in left tube . After 4 weeks later, 3 rabbits died and 17 female rabbits were left with 2 male rabbits, then they were killed 2 weeks later postoperatively . In these rabbits, the nidation index for the tube injected with MTX was 38 of 92 (0.413) and the control tube injected with Ringers solution was 32 of 102 (0.314). Also the nidation index in group with performed salpingotomy and salpingotomy was 20 of 68(0.295) and 22 of 68(0.324) respectively. The difference was not statistically significant and the tubal injection of MTX has no adverse effect on fertility of rabbits. It seems ethical to investigate tubal injection of MTX using pelviscopy as an alternative to surgical management of unruptured ectopic pregnancy in the human.