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剔出 白鼠 心臟에서 抗히스타민제인 Chlorpheniramine이 Norepinephrine效果에 미치는 影響
곽기철,최인선,김동수,곽용근,조규박 의과학연구소 1988 全北醫大論文集 Vol.12 No.2
Effects of chlorpheniramine on the contractile response of isolated rat auricle to norepine-phrine were studied in order to clarify the mechanisms of depressant and stimulant actions of chlorpheniramine. 1. Large dose of chlorpheniramine (10uM) potentiated the contractile action of norepi-nophrine but small dose of chlorpheniramine suppressed the action of norepinephrine. 2. Cocain did not affect the stimulant antion of chlorpheniramine, but reversed the depressant action of this drug. 3. Ouabain did not affect the excitory and inhibitory action of chlorpheniramine. 4. Verapamil did not change the excitory and inhibitroy action of chlorpheniramine. From the above results, it has appeared that chlorpheniramine has stmulant and depressant action on the contractile action of norepinephrine, and it is suggested that the potentiation of norepinephrine action by chlorpheniramine is due to inhibition of amine pump, but the inhibition of norepinephrine action by chlorpheniramine is not related to modification of amine pump or Ca flux.
백서에서 진통과 금단증상에 미치는 Enkephalinase Inhibitor의 영향
곽기철,조문환,김기원,채수완,조규박 의과학연구소 1991 全北醫大論文集 Vol.15 No.3
Analgesic effect and influence of 2 enkephalinase inhibitors, thiorphan and N-carboxyl-Phe Leu(CMPL) on the analgesia induced by centrally administered Leu-enkephalin, B-endorphin or morphine, and their influences on the withdrawal signs in chronic morphine-dependent rats were examined. Intracerebroventricular administration of thiorphan and CMPL induced short-lasting analgesia in a dose dependent manner, whereas CMPL was 3.5 time more potent than phiorphan. these analgesic effects were attrnuated by preteatment with naloxone. Subanalgesic doses of yhese inhibitors significantly enhanced the analgesic effect of :eu-enkephalin or B-endorphine However, neither of these inhibitors affecyed the analgrsic effect morphine. In chronic morphine-dependent rats, intraventricular thiorphan or CMPL significantly attenuated naxone-precipitated jumping, diarrhea, ptosis and teeth chattering, while wet-dog shaking sign was unaltered and penile licking sign was increased. These results showed that enkephalinase inhibitors can produce analgesia by themselves and that they can enchance the analgesic effects of ensogenous opioids. these data also suggest that enkephalinase inhibitors might be useful in attenuating opiate withdrawal symptoms.
剔出白鼠精管에서 Norepinephrine의 筋收縮效果에 미치는 Diphenhydramine의 影響
송태효,곽기철,곽용근,조규박,김용기 의과학연구소 1991 全北醫大論文集 Vol.14 No.4
Influences of H1-antihistaminics on the contractile response of isolated rat vas deferens to norepinephrine were studied in order to clarify the mechanisms of stimulant action of the drugs. 1. Lagre doses (10^-5M) of diphenhydramine and chlorpheniramine potentiated the contractile action of norepinephrine, but small deses (10^-7M) of them and the lage dose (10^-5M) of methdilazine suppressed the contractile action of norepinephrine. 2. Large dose (10^-5M) of diphenhydramine potentiated the contractile action of phenylephrine and isoproterenol. 3. The potentiating effect of diphenhydramine on contractile action of norepinephrine was partially inhibited by cocaine (3×10^-6M) or berapamil (10^-6M), and was completely blocked by KT362 (10^-4M). 4. Large dose of diphenhydramine inhibited the uptake of ^3H-norepinephrine, and increased the efflux of ^3H-norepinephrine. 5. Large dose of diphenhydramine increased the ^45Ca uptake. From the above results, it indicates that diphenhydramine has both potentiating and inhibiting effects on the contractile action of norepinephrine. And also, it is suggested that the potentiation of norepinephrine action by diphenhydramine is due to inhibition of amine pump as well as to increases of intracellular calcium both through increased Ca2+influx and release of calcium from intracellular storage site.
Poly(n - butyl methacrylate) 의 열분해에 관한 연구
손진언,설수덕,곽기철 한국고무학회 1988 엘라스토머 및 콤포지트 Vol.23 No.3
The thermal decomposition of poly(n-butyl methacrylate)(Pn-BMA) was studied using a dynamic and isothermal thermogravimetry in nitrogen gas with 50㎖/min at several heating rates from 1 to 20℃/min, and at several heating temperature from 320 to 370℃. The mathematical techniques used for calculation of activation energy were Kissinger, Anderson, Chatterjee-Conrad, Friedman, Fuoss, Ozawa and isolthermal method. The range of activation energies obtained using the several techniques was between 43 and 51 Kcal/㏖ except Chatterjee-Conrad and this range agreed with each other very well. The thermal degradation of Pn-BMA was considered to be carried out by main chain scission.