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        Distribution of Human Rotavirus Genotypes in a Tertiary Hospital, Seoul, Korea During 2009-2013

        한태희,박상훈,정주영,황응수 대한소아감염학회 2015 Pediatric Infection and Vaccine Vol.22 No.2

        Purpose: Group A rotavirus (RV) is most common etiologic agent of acute gastroenteritis (AGE) in children worldwide. Recently, vaccination has been introduced in several countries to reduce the disease burden caused by RV infections, but continuous surveillance of RV strains is necessary to detect the emergence of potential variants induced by vaccine-immune pressure. This study aimed to investigate the changing pattern of RV genotypes in children with AGE, following the introduction of vaccination in Korea. Methods: Genotyping of RVs by RT-PCR on the basis of VP7 and VP4 gene segment sequence was carried out on 201 rotavirus-positive stool samples, from children hospitalized with AGE between August 2009 and June 2013. We have directly sequenced PCR products and analyzed the phylogenetic tree. Results: The most prevalent G genotype was G9 (33.3%), followed by G1 (22.4%), G3 (15.9%), G2 (6.0%), G4 (3.0%), G10 (1.5%), and mixed G-type (15.4%), with some nontypeable cases (2.5%). The detected P genotypes were P[4] (45.3%), P[8] (43.8%), mixed P-type (10.4 %), and P[2] (0.5%). The G9P[4] genotype was predominantly observed in hospitalized cases in Seoul in 2010/2011, however G1P[8] has been re-emerged as the predominant genotype in the following season (P =0.004). Conclusions: It seems that the periodic fluctuation in predominance of the G1, G3, and G9 strains occurred in Korea during 2009-2013, following the introduction of RV vaccination.

      • KCI등재

        변압기 권선을 이용한 자속구속형 초전도 전류제한기의 전류제한 특성 분석

        한태희,임성훈,Han, Tae-Hee,Lim, Sung-Hun 한국전기전자재료학회 2011 전기전자재료학회논문지 Vol.24 No.2

        The fault current limiting characteristics of the flux-lock type superconducting fault current limiter (SFCL) using a transformer winding were investigated. The suggested flux-lock type SFCL consists of two parallel connected coils on an iron core and the transformer winding connected in series with one of two coils. In this SFCL, the high-TC superconducting (HTSC) element was connected with the secondary side of the transformer. The short-circuit experimental devices to analyze the fault current limiting characteristics of the flux-lock type SFCL using the transformer winding were constructed. Through the short-circuit tests, the flux-lock type SFCL using transformer winding was shown to perform more effective fault current limiting operation compared to the previous flux-lock type SFCL without the transformer winding from the viewpoint of the quench occurrence and the recovery time of the HTSC element.

      • KCI등재

        자속구속형 초전도전류제한기의 권선비 변화에 따른 전류제한 및 전압강하 보상 특성

        한태희,임성훈,Han, Tae-Hee,Lim, Sung-Hun 한국전기전자재료학회 2011 전기전자재료학회논문지 Vol.24 No.5

        In this paper, we investigated the fault current limiting and the load voltage sag suppressing characteristics of the flux-lock type SFCL, designed with the additive polarity winding, according to the variations of turn number's ratio and the comparative analysis between the resistive type and the flux-lock type SFCLs were performed as well. From the analysis for the short-circuit tests, the flux-lock type SFCL designed with the larger turn number's ratio was shown to perform more effective fault current limiting and load voltage sag suppressing operations compared to the flux-lock type SFCL designed with the lower turn number's ratio through the fast quench occurrence of the high-$T_C$ superconducting (HTSC) element comprising the flux-lock type SFCL. In addition, the recovery time of the flux-lock type SFCL after the fault removed could be confirmed to be shorter in case of the flux-lock type SFCL designed with the lower turn number ratio.

      • KCI등재

        피크전류제한 기능을 갖는 초전도한류기의 전류제한 특성분석

        한태희,임성훈,Han, Tae-Hee,Lim, Sung-Hun 한국전기전자재료학회 2011 전기전자재료학회논문지 Vol.24 No.1

        The superconducting fault current limiter (SFCL) with a peak current limiting function according to the initial fault current with the different amplitudes was suggested. The proposed SFCL, which consists of two limiting components, causes only the first superconducting element among two limiting components to be quenched in case that the initial fault current with the lower peak amplitude happens. On the other hand, the initial fault current with the higher peak amplitude makes both the superconducting elements of two limiting components to be quenched, which contributes to the peak current limiting function of the SFCL. To confirm the fault current limiting operation of the proposed SFCL, the short-circuit tests of the SFCL according to the fault angle were carried out and its effective fault current limiting operations could be discussed.

      • KCI등재

        Study on Current Limiting Characteristics of a Flux-locktype SFCL using Series Connected Two Coils with Twice Triggering Operation

        한태희,임성훈,고석철,이병준 대한전기학회 2014 Journal of Electrical Engineering & Technology Vol.9 No.3

        The current limiting characteristics of the flux-lock type superconducting fault currentlimiter (SFCL) using series connected two coils with twice triggering operation, which consists ofseries connected two coils and two superconducting (SC) modules with the inserting resistance, wasanalyzed. The feature of the suggested SFCL is that it can limit the fault current by triggering eitherone SC module or two SC modules comprising the SFCL depending on the amplitude of the faultcurrent. To verify the current limiting operation of the suggested SFCL, the short-circuits in the faultlocation with the different fault currents were tested and its useful operations were described throughthe analysis on the tested results.

      • KCI등재후보

        한국 임산부에서 Human Neutrophil Alloantigen-3a 동종면역

        한태희,한규섭 대한수혈학회 2015 大韓輸血學會誌 Vol.26 No.2

        Background: Alloantibodies against human neutrophil alloantigen (HNA)-3a are associated with severe and fatal transfusion related acute lung injury (TRALI). HNA-3 genotyping and HNA-3a antibody (Ab) identification are essential to diagnosis and prevention of TRALI caused by HNA-3a Ab. However there had been no laboratory for HNA-3a Ab identification in Korea. The aims of this study were to establish the HNA-3a Ab test in Korea and to estimate the incidence of HNA-3a alloimmunization among pregnant Korean women. Methods: HNA-3a homozygotes and HNA-3b homozygotes were identified by HNA-3 genotyping. Three HNA-3a homozygotes and three HNA-3b homozygotes are included in the granulocytes panel, which consisted of 10 donors for granulocytes. Sera from 650 pregnant Korean women were tested for granulocyte Ab using a mixed passive hemagglutination assay (MPHA). When a HNA-3a Ab was detected, the woman’s HNA-3 was typed to support her HNA-3a alloimmunization. Results: MPHA showed positive reactions in the sera from 26 women (4.0%, 26/650). HLA Abs were detected in 18 women (2.8%, 18/650), among whom HNA Abs were identified simultaneously in 7 women. Granulocyte Abs were detected in sera from 15 women (2.3%, 15/650). The incidence of HNA-3a, HNA-1b, HNA-1a, HNA-2a, and unidentified HNA Abs among pregnant Korean women was 0.77% (5/650), 0.77% (5/650), 0.62% (4/650), 0.15 (1/650), and 0.31% (2/650), respectively. Conclusion: In this study, we established the HNA-3a Ab test using MPHA for diagnosis and prevention of TRALI caused by HNA-3a Ab. The incidence of HNA-3a Ab in pregnant Korean women was 0.77% (5/650). 배경: HNA-3a 항체는 심각하고 치명적인 수혈관련급성폐손상의 원인이다. HNA-3 유전자검사와 HNA-3a 항체 동정검사는 HNA-3a 항체에 의해 발생하는 수혈관련급성폐손상을 진단하고 예방하는데 필수적인 검사이다. 하지만 한국에는아직 HNA-3a 항체를 동정하는 검사실이 없었다. 저자들은 이번 연구에서 HNA-3a 항체검사를 한국에서도 시행할 수 있게 하고 한국 임산부의HNA-3a 동종면역 발생률을 확인하고자 하였다. 방법: HNA-3a 동형접합자와 HNA-3b 동형접합자를 HNA-3 유전자검사로 확인하였다. 각각 3명의 HNA-3a 동형접합자와 HNA-3b 동형접합자를포함한 10인의 공혈자의 과립구로 제작한 과립구패널이 제조되었다. 혼합수동적혈구응집법(MPHA) 으로 650명의 임산부의 혈청을 이용하여 과립구항체 검사를 실시하였다. HNA-3a 항체가 검출되면 HNA-3a 동종면역을 확인하기 위해 HNA-3 유전자검사를 시행하였다. 결과: 혼합수동적혈구응집법을 이용하여 총26명(4.0%, 26/650)의 임산부의 혈청에서 양성반응을 확인하였다. HLA 항체를 18명(2.8%, 18/650) 의 혈청에서 검출하였다. 이 중 과립구항체와 HLA 항체가 동시에 검출된 경우가 7명이었다. 과립구항체는 15명(2.3%, 15/650)의 임산부의 혈청에서검출되었다. HNA-3a 항체, HNA-1b 항체, HNA-1a 항체, HNA-2a 항체, 특이성이 동정되지 않은 과립구항체가 각각 0.77% (5/650), 0.77% (5/650), 0.62% (4/650), 0.15 (1/650), 0.31% (2/650)로 확인되었다. 결론: 이번 연구에서 저자들은 HNA-3a 항체에의해 발생하는 수혈관련급성폐손상의 진단과 예방에 사용할 수 있는 혼합수동적혈구응집법을 이용한 HNA-3a 항체 검사를 확립하였다. 한국인 임산부에서 HNA-3a 항체발생률은 0.77% (5/650)이었다.

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