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정해원,최진영,이원영 대한보건협회 1988 대한보건연구 Vol.14 No.1
Drug resistance of P 815 mouse tumor cells after various drug treatment were studied "by scoring the changes of cell sizes. Percent of cells with abnormal large cell size (larger than 15㎛. in diameter) increased by treatment of anticancer drugs. When the cells were treated with adriamycin, cells larger than 15㎛ in diameter were observed at second day post-treatment and the percent of larger cells reached maximum at 9th day post-treatment. Similar trends were observed following the treatment with cisplatin, 5-Fu, or methotrexate. Inverse relationship between survival of tumor cell population and percent distribution of large cells was observed when cisplatin was treated. Thus it was suggested that co-existence of abnormal large cells and cells in original size in the tumor cell population after drug treatment might be a key to determine that the cell line is resistant which thereby indication for next drug of choice.
유리단자용 무연(Pb-Free) 솔더 소재 및 공정 개발
정해원(Haewon Jeong),이선명(Sunmyoung Lee),박민호(Minho Park) 한국자동차공학회 2012 한국자동차공학회 학술대회 및 전시회 Vol.2012 No.11
A new lead(Pb)-free solder material for automotive glass terminals is developed. In order to satisfy the regulation of EU ELV(End of Life Vehicle), the leaded solder in automotive glass should be replaced by lead-free solder. However, due to the unique property of the glass, it is easily broken with general electric lead-free solder material. As a result of the trying 120 types of solder material, we finally developed the excellent lead-free solder composition which has minimum Indium(In) contents. It is the optimized solder material against the wide range of thermal change environment. There is no glass crack with the developed lead-free solder. And it also shows good bonding strength enough to satisfy the automotive test standard.
3-Amino benzamide 및 Cytosine arabinoside가 방사선 조사된 림프구의 이동원 염색체 및 상호전좌 유발빈도에 미치는 영향
정해원(Hai Won Chung),김수영(Su Young Kim),조윤희(Yoon Hee Cho),김태환(Tae Hwan Kim),조철구(Chul Koo Cho),하성환(Sung Hwan Ha) 한국환경성돌연변이발암원학회 2002 한국환경성돌연변이·발암원학회지 Vol.22 No.3
In irradiated human lymphocytes, translocation of chromosome has been more frequently observed than dicentric chromosome. Differences in the misrepair process leading to translocation and dicentric chromosomes may explain the above observations. In order to find out whether dicentric and translocation are originated from different mechanism, the frequencies of radiation induced translocation and dicentric in lymphocytes were examined following treatment of irradiated lymphocytes with two DNA repair inhibitors, 3AB for inhibition of poly(ADP-ribose) synthesis and Ara C for inhibition of DNA-polymerase α. Ara C potentiated the frequencies of radiation induced dicentric and translocation. 3AB also potentiated the frequencies of radiation induced dicentric, but not translocation. These results suggest the potential differences in the mechanisms in the formation of translocation and dicentric chromosomes.