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항진균성항생물질 griseofulvin 유도체인 6' - phenylgriseofulvin 의 합성과 항균활성
고병섭,절곡융지,산하공평 한국농화학회 1992 Applied Biological Chemistry (Appl Biol Chem) Vol.35 No.5
In order to study the influence of a 6′-methyl group in ring C of griseofulvin (1_) on the fungicidal activity, 6′-methyl group was replaced with a larger phenyl group as (±)-6′-phenylgriseofulvin (3_), (±)-6′-epiphenylgriseofulvin (4_), synthesized by a Diels-Alder cycloaddition. Their biological activities were examined against Botrytis allii (IFO 9430) and B. cinerea (AHU 9573). (±)-6′-Phenylgriseofulvin (3_) showed high activity in 25 ㎍/disc.
( Daisuke Yamada ),( Tomoaki Nishikawa ),( Takuro Yoshikawa ),( Takayuki Kawai ),( Norihiro Kori ),( Mina Kobayashi ),( Masashi Kodan ),( Kohei Seto ),( Kumiko Yamashita ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
A heavy rainfall in July 2018 caused sediment disasters in West Japan. In this disaster, some debris flow were occured on slopes that were not recognized the potential of the occurence of sediment disasters. In this report, based on the results of the sediment disaster emergency survey conducted in several cities in West Japan, we will report the distribution and examples of slopes where these disasters occurred. In addition, regarding the occurrence of debris flow, the features related to topography and weather were examined. In Japan, the hazards of sediment disasters are recognized based on whether the topography of the slope has the same conditions as the topography of sediment disasters that occurred in the past. In this report, we focused on the debris flow occured on the slope that was not recognized as a valley where the debris flow occurs(the valley depth is wider than the valley width). As a result of this survey, we were able to understand the characteristics of the debris flow that occurred at a slope that was not recognized dangerous of sediment disaster. We believe that this report will help improve the warning and evacuation system for future sediment disasters in Japan.
Suzuki Yugo,Ochiai Yorinari,Hosoi Atsuko,Okamura Takayuki,Hayasaka Junnosuke,Mitsunaga Yutaka,Tanaka Masami,Odagiri Hiroyuki,Nomura Kosuke,Yamashita Satoshi,Matsui Akira,Kikuchi Daisuke,Ohashi Kenichi 거트앤리버 소화기연관학회협의회 2024 Gut and Liver Vol.18 No.1
Background/Aims: Asymptomatic esophageal eosinophilia (aEE) is considered to be a potential precursor of eosinophilic esophagitis (EoE). However, there are few clinical parameters that can be used to evaluate the disease. Therefore, we aimed to clarify the factors involved in the symptoms of EoE by examining the clinicopathological differences between aEE and EoE. Methods: We reviewed 41 patients with esophageal eosinophilia who underwent endoscopic ultrasonography and high-resolution manometry. They were divided into the aEE group (n=16) and the EoE group (n=25) using the Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease score. The patients’ clinicopathological findings were collected and examined. Results: The median Frequency Scale for the Symptoms of Gastroesophageal Reflux Disease score was 3.0 in the aEE group and 10.0 in the EoE group. There was no significant difference in patient characteristics, endoscopic findings and pathological findings. The cutoff value for wall thickening was 3.13 mm for the total esophageal wall thickness and 2.30 mm for the thickness from the surface to the muscular layer (total esophageal wall thickness: 84.0% sensitivity, 75.0% specificity; thickness from the surface to the muscular layer: 84.0% sensitivity, 68.7% specificity). The high-resolution manometry study was abnormal in seven patients (43.8%) in the aEE group and in 12 (48.0%) in the EoE group. The contractile front velocity was slower in the EoE group (p=0.026). Conclusions: The esophageal wall thickening in the lower portion of the esophagus is an important clinical factors related to the symptoms in patients with EoE.
Yoon, Jeong-Hwan,Jung, Su Myung,Park, Seok Hee,Kato, Mitsuyasu,Yamashita, Tadashi,Lee, In-Kyu,Sudo, Katsuko,Nakae, Susumu,Han, Jin Soo,Kim, Ok-Hee,Oh, Byung-Chul,Sumida, Takayuki,Kuroda, Masahiko,Ju, Blackwell Publishing Ltd 2013 EMBO molecular medicine Vol.5 No.11
<P>Varieties of transforming growth factor-β (TGF-β) antagonists have been developed to intervene with excessive TGF-β signalling activity in cancer. Activin receptor-like kinase5 (ALK5) inhibitors antagonize TGF-β signalling by blocking TGF-β receptor-activated Smad (R-Smad) phosphorylation. Here we report the novel mechanisms how ALK5 inhibitors exert a therapeutic effect on a mouse B16 melanoma model. Oral treatment with a novel ALK5 inhibitor, EW-7197 (2.5 mg/kg daily) or a representative ALK5 inhibitor, LY-2157299 (75 mg/kg bid) suppressed the progression of melanoma with enhanced cytotoxic T-lymphocyte (CTL) responses. Notably, ALK5 inhibitors not only blocked R-Smad phosphorylation, but also induced ubiquitin-mediated degradation of the common Smad, Smad4 mainly in CD8<SUP>+</SUP> T cells in melanoma-bearing mice. Accordingly, T-cell-specific deletion of Smad4 was sufficient to suppress the progression of melanoma. We further identified eomesodermin (Eomes), the T-box transcription factor regulating CTL functions, as a specific target repressed by TGF-β via Smad4 and Smad3 in CD8<SUP>+</SUP> T cells. Thus, ALK5 inhibition enhances anti-melanoma CTL responses through ubiquitin-mediated degradation of Smad4 in addition to the direct inhibitory effect on R-Smad phosphorylation.</P>