A case of pigmented condyloma acuminatum

( Yujin Jung ),( Ji Hong Lim ),( Yu Ri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Human papillomavirus (HPV) infection of the genital skin is a highly prevalent condition with a variety of presentations. HPV type 6 or 11 is usually detected in cases of Condyloma acuminatum (CA), while high-risk HPV type 16 is detected in cases of Bowenoid papulosis (BP). Also, p16 stain is a marker for HPV infection and associated neopalsia of the genital skin. A 29-year-old man presented with multiple bean-sized brownish verrucous papules on the genital area for 1 year. The lesions had been progressively increasing in size. He had no family or personal history of skin cancer or other medical diseases. Histopathological examination revealed parakeratosis, acanthosis, papillomatosis and atypical dyskeratotic keratinocytes with mitotic figures and loss of orderly maturation throughout the thickened epidermis. HPV DNA chip microarray analysis was used for the detection of HPV genotyping. HPV-6 was identified from the DNA extracted from the lesion. Based on the clinical and histological findings, a diagnosis of CA was made. After the lesions were diagnosed as a case of CA, it was successfully treated with electroablation. Two months later, no recurrence of the lesions had been observed. Because making the clinical diagnosis between pigmented CA, BP and seborrheic keratosis is difficult in certain cases, HPV DNA chip microarray and pattern of p16 staining are helpful for distinguishing pigmented papules of CA from those of BP.

Effect of Green Manure Crops Incorporation for Reduction of Ginger Rhizomes (Pythium zingiberum) in Ginger Continuous Cultivation

Yujin Jung,Inhye Lee,Myongduc Kim,Maral Tsevelkhoroloo,Hunkyo Seo,Kwonkyoo Kang 한국원예학회 2014 한국원예학회 학술발표요지 Vol.2014 No.10

Reduction of Charge Trapping in <tex> $\hbox{HfO}_{2}$</tex> Film on Ge Substrates by Atomic Layer Deposition of Various Passivating Interfacial Layers

Jung, Hyung-Suk,Yu, Il-Hyuk,Kim, Hyo Kyeom,Lee, Sang Young,Lee, Joohwi,Choi, Yujin,Chung, Yoon Jang,Lee, Nae-In,Park, Tae Joo,Choi, Jung-Hae,Hwang, Cheol Seong IEEE 2012 IEEE transactions on electron devices Vol.59 No.9

<P>The dielectric performance and charge trapping properties of <TEX>$ \hbox{HfO}_{2}$</TEX> on a Ge substrate with various passivating interfacial layers (PILs), such as <TEX>$\hbox{SiO}_{x}\hbox{N}_{y}$</TEX>, <TEX> $\hbox{AlO}_{x}\hbox{N}_{y}$</TEX>, <TEX>$\hbox{HfO}_{x}\hbox{N}_{y}$</TEX> , and <TEX>$\hbox{LaO}_{x}\hbox{N}_{y}$</TEX>, are investigated. The large capacitance–voltage (<TEX>$C$</TEX>– <TEX>$V$</TEX>) hysteresis of <TEX>$ \hbox{HfO}_{2}$</TEX> on a Ge substrate (<TEX>$\sim$</TEX>1500 mV) was not improved by inserting either <TEX>$\hbox{HfO}_{x}\hbox{N}_{y}$</TEX> or <TEX>$\hbox{LaO}_{x}\hbox{N}_{y}$</TEX> PIL between the <TEX>$\hbox{HfO}_{2}$</TEX> and Ge substrates, while both <TEX>$\hbox{SiO}_{x}\hbox{N}_{y}$</TEX> and <TEX>$\hbox{AlO}_{x}\hbox{N}_{y}$</TEX> PILs induced a noticeable reduction of <TEX>$C$</TEX>–<TEX>$V$</TEX> hysteresis. As the PILs' thicknesses increased, the <TEX>$C$</TEX>– <TEX>$V$</TEX> hysteresis of <TEX>$ \hbox{HfO}_{2}$</TEX> with <TEX>$\hbox{SiO}_{x}\hbox{N}_{y}$</TEX> PIL decreased to almost zero, while that of <TEX>$\hbox{HfO}_{2}$</TEX> with <TEX>$\hbox{AlO}_{x}\hbox{N}_{y}$</TEX> PIL decreased but was saturated at approximately 400 mV. Furthermore, the charge trapping property of <TEX>$ \hbox{HfO}_{2}$</TEX> with <TEX>$\hbox{SiO}_{x}\hbox{N}_{y}$</TEX> PIL on a Ge substrate is comparable to that of <TEX>$\hbox{HfO}_{2}$</TEX> grown on a Si substrate. Negligible <TEX>$C$</TEX>– <TEX>$V$</TEX> hysteresis and negligible charge trapping of <TEX>$\hbox{HfO}_{2}$</TEX> with <TEX>$ \hbox{SiO}_{x}\hbox{N}_{y}$</TEX> PIL were understood from the fact that <TEX>$\hbox{SiO}_{x}\hbox{N}_{y}$</TEX> is more resistant to react with a Ge substrate and defective Ge suboxides are efficiently suppressed during the formation of <TEX>$\hbox{SiO}_{x} \hbox{N}_{y}$</TEX> PIL and <TEX>$\hbox{HfO}_{2}$</TEX> layers.</P>

Protein Detection Based on The Target-induced DNA Polymerase Activity Modulation

Yujin JUNG,Chang Yeol LEE,Ki Soo PARK,Hyun Gyu PARK 한국생물공학회 2018 한국생물공학회 학술대회 Vol.2018 No.4

Change in quality of life in psoriasis patients after the treatment with ustekinumab

( Yujin Jung ),( Jong Sic Kim ),( Ji Hong Lim ),( Yu Ri Woo ),( Mi Ri Kim ),( Hyun Jeong Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Psoriasis is a relapsing, chronic condition that negatively influences a patient’s daily life, and quality of life (QOL) is increasingly emphasized in comprehensive treatment. There is limited evidence demonstrating the changes in QOL in Korean psoriasis patients treated with ustekinumab by using both dermatologic-specific and psoriasis-specific responder-based questionnaire. Objectives: To evaluate the effects of ustekinumab on quality of life in psoriasis patients Methods: Fifty two psoriasis patients treated with ustekinumab were asked to complete a questionnaire about the effect of ustekinumab on their QOL before and after the treatment. Psoriasis area and severity index (PASI) were assessed based on the clinical pictures taken at baseline and following visits. QOL was assessed using Dermatology Life Quality Index (DLQI) and Psoriasis Disability Index (PDI). Results: Total scores and all domain scores in DLQI and PDI increased after at least three administration of ustekinumab (p<0.05). Additionally, total scores showed a significant difference before and after the treatment depending on sex, age, comorbidity, and disease duration. PASI, which reflects the disease severity also showed a relative association with total QOL scores in DLQI and PDI in psoriasis patients. Conclusion: When treated with ustekinumab, quality of life significantly improved in psoriasis patients, suggesting the positive influence of the treatment in patient’s subjective perception.

A case of bullous fixed drug eruption

( Yujin Jung ),( Hyun Ji Lee ),( Yu Ri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Fixed drug eruption (FDE) is characterized by a well-defined erythematous patch, plaque, or bullous eruption that recurs at the same site as the result of systemic exposure to a causative drug, and resolves with or without hyperpigmentation. A 47-year-old woman presented with painful, solitary, 7㎝-sized blistering eruption with surrounding erythema affecting the right sole. 2 weeks before the appearance of the lesion, she was prescribed naproxen/esmeprazole from the orthopedics department for knee pain. After ingestion of the prescribed medicine, tense bulla was observed. She stopped taking the medication and after simple dressing, the lesion improved. One week later, after taking the same pills, the lesion was recurred. Skin biopsy was carried out at the peripheral side of the lesion. Histological examination revealed subepidermal blister formation and lymphohistiocytic, eosinophil infiltration at the epidermis, papillary and reticular dermis. The patient was treated with topical steroid for 1 week along with cessation of naproxen/esmeprazole. On follow-up, resolution of the lesions with surrounding hyperpigmentation was examined. The bullous FDE located on the soles can be confused with friction blister or bullous type tinea pedis. Herein we report a case of bullous fixed drug eruption on the sole. Clinicians must be aware of the possibility of bullous FDE if a patient has the corresponding drug history.

A case of unilateral vasculitis

( Yujin Jung ),( Jong Sic Kim ),( Yu Ri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Cutaneous small vessel vasculitis is generally manifested as palpable purpura on dependent areas of the body such as the lower extremities and sites covered by tight clothing. Classically involving both sides of the lower limb, cutaneous vasculitis with predominantly unilateral involvement have been rarely reported. A 77-year-old woman presented with painful, multiple, erythematous to purpuric papules on the left leg that appeared 2 days ago. The lesion had been rapidly progressed. The patient was consistently consuming oral warfarin to control the lymphedema of the left leg that occurred after surgery for cervical cancer 20 years ago. Laboratory findings showed mild elevation of liver enzyme, otherwise in normal range. Histological examination was consistent with leukocytoclastic vasculitis. The patient was diagnosed as cutaneous vasculitis, and was treated with oral methylprednisolone (0.5 mg/kg/day). This dose was maintained for 1 week and then was tapered over the next 3 weeks. A progressive resolution of the rash was observed. Unilateral vasculitis has been associated with underlying diseases such as infection, lymphedema, and immobilization. In this case, the patient developed chronic lymphedema, which is associated with hydrostatic pressure and stasis in the pathogenesis. Herein, we report a rare case of unilateral cutaneous small vessel vasculitis in the patient with chronic lymphedema.

A case of blue-red macules and pseudoatrophic macules: distinct cutaneous signs in neurofibromatosis 1

( Yujin Jung ),( Hyun Ji Lee ),( Yu Ri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

The cutaneous neurofibroma is typically characterized by dome-shaped, soft, fleshy, and brownish to skin-colored tumor. The blue-red macule (BRM) and pseudoatrophic macule (PAM) have been known as rare subtypes of neurofibromatosis (NF). A 26-year-old man presented with a 6-year history of asymptomatic numerous blue-red, atrophic skin-colored macules scattered over his trunk and lower leg. The skin lesions have increased numerically and in size. Numerous small (< 5mm) and more than ten large ( >5mm) cafe au lait macules could be examined. Additional dermatological, ophthalmological and neurological examination showed no abnormalities. Results of a routine analysis of the blood and urine stool were within the normal range. The patient’s grandfather had a history of NF type 1. Histologic findings of his back showed diffuse replacement by tumor-like neurogenic tissue throughout the dermis, an increase of thick-walled blood vessels. Histologic findings of leg showed reduction in collagen in the reticular dermis and increased perivascularly situated neuroid tissue. Mutation analysis of the NF1 gene’s coding region revealed frameshift mutation (p.Thr586Valfs^*18) in exon 16. Finally, the patient was diagnosed as NF type 1 presenting with BRM and PAM. Herein we report the first case of neurofibromatosis type 1 with a various clinical signs with blue red macule, and pseudoatrophic macule in a Korean patient.

A case of milia en plaque resulted from Stevens- Johnson Syndrome

( Yujin Jung ),( Ji Hing Lim ),( Yu Ri Woo ),( Miri Kim ),( Hyun Jeong Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Milia en plaque (MEP) is an uncommon cutaneous disorder characterized by multiple clustered milia, which are small keratin-containing epidermal cysts of 1-2 mm in diameter, placed over the inflammed plaques. MEP frequently appears on the periorbital, preauricular, and eyelid, and rarely regresses spontaneously, posing a cosmetic problem. We present a case of a 51-year-old male who developed multiple grouped whitish papules on the both forearms. This patient has a history of Steven-Johnson syndrome (SJS) after the use of beta-lactam antibiotics in order to manage postoperative wound infection of a tibiofibular fracture. After two months of the treatment for SJS, variable-sized grouped papules incidentally appeared on the forearms, which was histopathologically consistent with MEP. The involved area in this patient is relatively uncommon as MEP affects most often on the face. In addition, since only few cases involving MEP caused by SJS are introduced in both international and Korean dermatologic studies, this case emphasizes the necessity of a continuous follow-up on the affected lesions in a patient with SJS.

Overexpression of Pineapple BAA1 Gene Encoding Cysteine Protease in Transgenic Brassica rapa Plants Results in Enhanced Bacterial Disease Resistance

Yujin Jung,Jinheui Park,Illsup Nou,Kwonkyoo Kang 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-