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Identification of Homer1 as a Potential Prognostic Marker for Intrahepatic Cholangiocarcinoma
Wu, San-Yun,Yu, Ming-Xia,Li, Xiao-Gai,Xu, Shu-Fang,Shen, Ji,Sun, Zhen,Zhou, Xin,Chen, Xing-Zhen,Tu, Jian-Cheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Background: The aim of the present study was to analyze whether Homer1 is a potential prognostic marker for intrahepatic cholangiocarcinoma (ICC). Materials and Methods: The expression of Homer1 in ICC tissue was detected with immunohistochemistry and levels of protein in ICC and paratumor tissues were evaluated by Western blotting. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. Results: Homer1 expression was high in 67.4% (58/86) of ICC samples, and there was significant difference between ICC and adjacent noncancerous tissues (p<0.001); high expression was associated with poor histologic differentiation (p=0.019), TNM stage (p=0.014), lymph node metastasis (p=0.040), and lymphatic invasion (p=0.025). On Kaplan-Meier analysis, a comparison of survival curves of low versus high expressors of Homer1 revealed a highly significant difference in OS (p=0.001) and DFS (p=0.006), indicating that high expression of Homer1 was linked with a worse prognosis. Multivariate analyses showed that Homer1 expression was an independent risk factor predicting overall survival[Hazard ratio(HR), 7.52; 95% confidence interval (CI), 2.63-21.47; p=0.002] and disease-free survival (HR, 11.56; 95%CI, 5.17-25.96; p<0.001) in ICC. Conclusions: Homer1 promotes lymphatic invasion and associates with lymph node metastasis and poor prognosis of ICC. The current study shows that Homer1 may be an independent prognostic factor for ICC patients after curative resection, and it provides an important basis for screening/treating high-risk patients.
Genetic Analysis of Generalized S-Transform
Yun Lin,Xiaowan Yu,Chunguang Ma,Zheng Dou,Zhiqiang Wu,Zhiping Zhang 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.4
This text starts with the short time Fourier transform and continuous wavelet transform to deduce the generalized S-transformation. From the point of generation views, we analyzed a relative relationship between generalized S-transformation and the short time Fourier transform, and the other relative relationship between generalized S transform and continuous wavelet transform. The article gives the definition of “the gene mutation of formula” and “the genetic restructuring of formula”, and introduces the deriving process of the two core concept. Theoretical analyses show that generalized S-transformation inherited the desirable characteristics in short time Fourier transform which use the window function to select suitable signal. Through genome sequencing of specific parameters, generalized S-transformation has a stronger adaptation that the time-frequency window could make real-time adjusting of frequency. Moreover, generalized S-transformation breaks out limitation that the wavelet function has to content the admissible conditions. From the point of gene mutation, we give the definition of “the gene mutation of formula”. Based on the structure form of wavelet functions, we define the generalized S-transformation with a wider domain of definition. Generalized S-transformation inherited the desirable characteristics of the short time Fourier transform and continuous wavelet transform. It has great utility and flexibility in analyzing non-stationary signals.
Yun-Chieh Tsai,Yu-Chen Lin,Chun-Chih Huang,Oliver B. Villaflores,Tzong-Yuan Wu,Shih-Ming Huang,Ting-Yu Chin 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.5
Aging and lifestyle factors, including high-sugar and high-fat diets, promote a systemic metabolic imbalance that promotes neurodegeneration. Hericium erinaceus has long been used in traditional Chinese medicine. Recently, its functional activities, such as antimetabolic dysfunction, antineuroinflammatory activities, and stimulation of nerve growth factor (NGF) synthesis, have been revealed. This study demonstrated that Hericium erinaceus mycelium (HEM) and an isolated diterpenoid derivative, erinacine A (EA), may reverse spatial learning disabilities in aging mice (15 months old) fed with a high-fat and high-sucrose diet (HFSD). Aging mice were randomly assigned to one of four treatment groups: (1) a chow diet (control), (2) an HFSD, and an HFSD supplemented with either (3) HEM or (4) EA for 18 weeks. The Morris water maze (MWM) and Y-maze were used for behavioral assessments. Both HEM- and EA-treated mice had shorter mean daily escape latencies than HFSD-treated mice in the MWM. In addition, HEM-treated mice had a slightly increased exploratory time and frequency in the novel arm in the Y-maze. Quantitative PCR revealed that both HEM- and EA-treated mice exhibited reduced messenger RNA (mRNA) expression of tumor necrosis factor-α, interleukin-1β, and HEM-treated mice exhibited increased mRNA expression of NGF and NeuN in the hippocampus. Moreover, HEM and EA also decreased body weight, abdominal fat, plasma glucose, serum and liver total cholesterol, and liver triacylglycerol. Thus, HEM may be a potential health-promoting supplement for minimizing the progression of aging and obesity-induced neurodegeneration by reducing metabolic abnormalities and neuroinflammatory cytokines and increasing neurogenesis factors.
Effects of Ginsenosides Rg1 on Osteoblasts Cultured with Ti Particles
( Yu Lin ),( Yin Sheng Wu ),( Jia Cheng He ),( Yun Mei Huang ),( Yan Ping Lin ) 한국응용약물학회 2012 Biomolecules & Therapeutics(구 응용약물학회지) Vol.20 No.1
The aim of this study was to explore the role and effect of ginsenosides Rg1 on osteoblasts cultured with Ti particles. Osteoblasts from neonatal rats were cultured with particles and different doses of Rg1, the main active ingredient in ginsenosides Rg1. We found that the COX-2, PGE2, TNF-α, IL-1, and IL -6 concentrations in the medium of cells cultured with Ti particles significantly increased as compared with that of the control cells (p<0.05 or p<0.01). In addition, cells cultured with Ti particles alone exhibited the highest concentrations of these molecules. The PGE2, TNF-α, IL-1, and IL-6 levels in the medium of cells cultured with Rg1 were in between those of the control cells and the cells cultured with Ti particles alone. The IL-1ra level in the group cultured with Ti and medium-dose Rg1 was the highest followed by the cells cultured with Ti and high-dose Rg1 and those cultured with Ti and low-dose Rg1 (p<0.05). In conclusion, ginsenosides can reduce the levels of inflammatory cytokines produced by osteoblasts on induction with Ti particles and can prevent prosthesis loosening.
Thrust Ripples Suppression of Permanent Magnet Linear Synchronous Motor
Yu-wu Zhu,Yun-Hyun Cho IEEE 2007 IEEE transactions on magnetics Vol.43 No.6
<P>The thrust ripples in permanent magnet linear synchronous motor (PMLSM) are mainly generated by the distortion of the stator flux linkage distribution, reluctance force due to the relative position between the mover and stator, cogging force caused by the interaction between the permanent magnet (PM) and the iron core, and the end effects. This is the significant drawback which will deteriorate the performance of the drive system in high-precision applications. Comparing the complexity of the motor structure design to eliminate the thrust ripples, an optimal control method is more desirable. This paper focuses on thrust ripples reduction based on the predictive control algorithm. To minimize the thrust ripples and realize the high-precision control, the components of thrust ripples are extracted by finite element method (FEM) first and then compensated by injecting the instantaneous current to counteract the thrust ripples using the field-oriented control (FOC) method. The effectiveness of this proposed method is verified by the simulation using Simulink/Matlab according to the comparison between the compensation and noncompensation cases</P>
Control Based Reduction of Detent Force for Permanent Magnet Linear Synchronous Motor
Yu-wu Zhu(주옥오),Yun-hyun Cho(조윤현) 전력전자학회 2008 전력전자학술대회 논문집 Vol.- No.-
The detent force of the permanent magnet linear synchronous motor (PMLSM) is caused by the interaction between the permanent magnet and the iron core of the mover without input current. It is a function of the mover position relative to the stator. This paper proposes a control based method to reduce the detent force for the PMLSM. This detent force that can be predicted by finite element method (FEM) is compensated by injecting the instantaneous current using the field oriented control (FOC) method. Both the simulated and experimental results are reported to validate the effectiveness of this proposed method.