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( Si Shen ),( Guojiang Shen ),( Yang Shen ),( Duanyang Liu ),( Xi Yang ),( Xiangjie Kong ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.11
Advanced traffic signal timing method plays very important role in reducing road congestion and air pollution. Reinforcement learning is considered as superior approach to build traffic light timing scheme by many recent studies. It fulfills real adaptive control by the means of taking real-time traffic information as state, and adjusting traffic light scheme as action. However, existing works behave inefficient in complex intersections and they are lack of feasibility because most of them adopt traffic light scheme whose phase sequence is flexible. To address these issues, a novel adaptive traffic signal timing scheme is proposed. It's based on actor-critic reinforcement learning algorithm, and advanced techniques proximal policy optimization and generalized advantage estimation are integrated. In particular, a new kind of reward function and a simplified form of state representation are carefully defined, and they facilitate to improve the learning efficiency and reduce the computational complexity, respectively. Meanwhile, a fixed phase sequence signal scheme is derived, and constraint on the variations of successive phase durations is introduced, which enhances its feasibility and robustness in field applications. The proposed scheme is verified through field-data-based experiments in both medium and high traffic density scenarios. Simulation results exhibit remarkable improvement in traffic performance as well as the learning efficiency comparing with the existing reinforcement learning-based methods such as 3DQN and DDQN.
Yang Zhen,Xie Jiqin,Yang Yu,Sun Xiaohong,Jing Jie,Shen Yongmei,Yue Bisong,Zhang Xiuyue 한국곤충학회 2021 Entomological Research Vol.51 No.12
Thymosin is a physiologically active polypeptide hormone which has many functions involved in promoting wound healing, promoting hair growth, and accelerating tissue and organ regeneration. American cockroach (Periplaneta americana) has three subtypes thymosin (THY1, THY2, THY3) which are different splices from the same thymosin gene. Real-time PCR was used to detect and analyze the expression differences of THY1 and THY2 in different stages, sexes, tissues and after stimulation by bacteria. Thymosins were expressed in adult, eclosion, and ootheca, and their expression levels were significantly up-regulated during the eclosion period, showing the thymosin might be involved in the eclosion process. The expression levels of thymosins in females were higher than males, and the differences in eclosion stages were more significant (P < 0.01), indicating that they were closely related to development and female reproduction. The expressions of THY1 and THY2 in hemolymph were significantly higher (P < 0.01) than that in other tissues. The up-regulated expression of thymosin in two immune-related tissues (Hemolymph and adipose) after Escherichia coli stimulation further confirmed its involvement in the immune response. Our research would provide a basis for screening of novel pesticides target genes.
A New Furostanol Saponin from Asparagus cochinchinensis
Yang Shen,Hai-Sheng Chen,Cong-Li Xu,Wei-Dong Xuan,Hui-Liang Li,Run-Hui Liu,Xi-Ke Xu 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.10
A new furostanol saponin, (25S)-26-O-β-D-glucopyranosyl-5β-furost-20(22)-en-3β, 15β,26-triol-3-O-[α-L-rhamnopyranosyl-(1-4)]-β-D-glucopyranoside, namely, aspacochioside D (1) were isolated from Asparagus cochinchinensis (Lour.) Merr, along with three known saponins, aspacochioside C (2), (25S)-5β-spirostan-3β-yl-O-[O-α-L-rhamnopyranosyl-(1-4)]-β-D-glucopyranoside (3), and pseudoprotoneodioscin (4). The structure of 1 was elucidated on the basis of chemical reactions and spectral analysis (IR, GC, ESI-MS, ^1H-NMR, ^13C-NMR, DEPT, HMBC, HMQC and NOESY). The antiproliferative effects of 1-4 were evaluated in a cytotoxicity assay against the human tumor cell line, A549. Compound 2 (Aspacochioside C) exhibited moderate cytotoxicity against A-549, with an IC_50 value of 3.87 μg/mL.
Purposeless Groaning in Parkinson's Disease
Shen-Yang LIM,Ai Huey Tan,Jia Lun Lim,Azlina Ahmad Annuar 대한파킨슨병및이상운동질환학회 2018 Journal Of Movement Disorders Vol.11 No.2
Purposeless groaning has been reported in advanced progressive supranuclear palsy. We present a case of purposeless groaning occurring as a primary complaint in a patient with advanced Parkinson's disease. Purposeless groaning is thought to be a manifestation of disinhibition and perseveration, due to frontal-subcortical dysfunction. Proper recognition of this phenomenon will help clinicians to avoid unnecessary investigations and treatment. (e.g., prescription of opioid medications).
miR-182-5p Inhibits NKAPL Expression and Promotes the Proliferation of Osteosarcoma
Shen Yang,Kaixi Chen,Kun Cao,Shenglin Xu,Chengxiao Ma,Yongping Cai,Yong Hu,Yejin Zhou 한국생물공학회 2021 Biotechnology and Bioprocess Engineering Vol.26 No.5
Purpose Osteosarcoma, a malignant bone tumor, has the lowest survival rate among all pediatric cancers. NF-κB-activating protein-like (NKAPL) is highly homologous with NKAP. The expression of NKAPL is downregulated in primary liver cancer and breast cancer, and plays a role of tumor suppressor gene. However, the role of NKAPL in osteosarcoma has not been reported. Materials and Methods We explored the effect of NKAPL on the proliferation of osteosarcoma cells by immunohistochemical, RT-PCR, Western blot, and double luciferase reporter gene analysis. Results The low expression of NKAPL mRNA was correlated with distant metastasis (P = 0.017), tumor size (P = 0.023), and clinical stage (P < 0.001). The NKAPL expression level in MG63 and U2OS cells was lower than that in Nhost cells. Downregulation of NKAPL expression in Nhost cells could promote cell proliferation and upregulation of NKAPL expression in MG63 and U2OS cells could inhibit cell proliferation. miR-182-5p expression was negatively correlated with NKAPL mRNA expression (R2 = 0.1169, P = 0.0099). After upregulating NKAPL expression, the Notch1, hes1, hey2, and cyclin D1 expression levels were significantly decreased, with G0/G1 phase arrest and G2/M phase reduction. Conclusions miR-182-5p targeted NKAPL and inhibit NKAPL expression in osteosarcoma. miR-182- 5p could regulate cell cycle and promote tumor proliferation through upregulating Notch signaling pathway.
Shen-Yang LIM,Ai Huey Tan,Azlina Ahmad Annuar,Susanne A. Schneider,Ping Chong Bee,Jia Lun Lim,Norlisah Ramli,Mohamad Imran Idris 대한파킨슨병및이상운동질환학회 2018 Journal Of Movement Disorders Vol.11 No.2
We present a case of beta-propeller protein-associated neurodegeneration, a form of neurodegeneration with brain iron accumulation. The patient harbored a novel mutation in the WDR45 gene. A detailed video and description of her clinical condition are provided. Her movement disorder phenomenology was characterized primarily by limb stereotypies and gait dyspraxia. The patient’s disability was advanced by the time iron-chelating therapy with deferiprone was initiated, and no clinical response in terms of cognitive function, behavior, speech, or movements were observed after one year of treatment.
Yang Yang,Keyong Shen,Gholamreza Ghasemian Talkhunche,Mohammad Arefi 국제구조공학회 2021 Smart Structures and Systems, An International Jou Vol.28 No.3
This paper uses higher-order shear deformation theory and modified couple stress theory (MCST) to the electroelastic results of FG micro-shell integrated with piezoelectric thin sheets subjected to electrical and mechanical loads rested on Pasternak's foundation. Third-order shear deformation theory (TSDT) is used for the description of the displacement field. Effect of micro-size is applied using MCST with the introduction of one micro-length scale parameter. Governing equations are derived based on the principle of virtual work. Micro-shell is composed of a FG micro core and two piezoelectric hollow shells. The numerical results are obtained for the simply-supported boundary conditions. Longitudinal and radial displacements are presented in terms of important parameters such as applied electric potentials, micro length scale parameter, dimensionless geometric parameters and two parameters of Pasternak's foundation.
( Li-yang Sun ),( Jiong-jie Yu ),( Ju-dong Li ),( Xin-fei Xu ),( Jia-he Wang ),( Bing Quan ),( Wen-tao Yan ),( Feng Shen ),( Chao Li ),( Lei Liang ),( Tian Yang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Surgical site infection (SSI) is a common postoperative complication and associated with an increased morbidity, hospital stay, and overall cost. The aim of the present study was to identify risk factors for SSIs after hepatic resection based on a large single-center cohort. Methods: A retrospective study was conducted of 6,132 patients who underwent liver resection without concomitant biliary reconstruction or gastrointestinal procedures between 2014 and 2016 at the largest hepatic center in China. The occurrences of SSI, classified as incisional SSI and organ/space SSI within 30 days after operation were investigated. Patient- and surgical-related risk variables were collected using standardized data collection form. A likelihood ratio forward regression model was used to assess the independent association of risk factors with SSI. Results: SSI developed in 587 patients (9.6%), including superficial/deep incisional SSI in 357 patients (5.8 %), and organ/ space SSI in 304 patients (5.0 %). Multivariate logistic regression analysis showed that obesity, diabetes mellitus, ASA score ≥ 2, liver cirrhosis, re-hepatectomy, hepatoliathiasis, and intraoperative blood transfusion were independent risk factors of overall SSI. However, incisional and organ/space SSI differed from each other with respect to risk factors. Among a variety of risk factors, hepatolithiasis, liver cirrhosis, and intraoperative blood transfusion were consistently associated with both incisional and organ/space SSI. Conclusions: SSI is a common complication after liver resection, and more caution should be taken in patients with hepatolithiasis or liver cirrhosis. Prevention strategies focusing on factors associated with SSI is necessary in order to reduce SSI after liver resection.
( Tian Yang ),( Li-yang Sun ),( Lei Liang ),( Ya-hao Zhou ),( Wei-min Gu ),( Hong Wang ),( Ting-hao Chen ),( Yong-yi Zeng ),( Wan Yee Lau ),( Meng-chao Wu ),( Feng Shen ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Postoperative morbidity following hepatectomy remains high, and understanding its risk factors is important to improve perioperative outcomes. We aimed to identify the role of two non-invasive markers - albumin-bilirubin (ALBI) and aspartate transaminase to platelet ratio index (APRI) - in predicting postoperative morbidity following hepatectomy for hepatocellular carcinoma (HCC). Methods: A multicenter data of patients undergoing hepatectomy for HCC at 8 centers were retrospectively analyzed. These patients were divided into normal and high groups according to preoperative ALBI and APRI scores. ALBI and APRI’s predictive accuracy of postoperative 30-day overall and major morbidity were evaluated by the area under the receiver operating characteristic curve (AUC) and compared with two conventional scores: Child-Pugh grade and model for end-stage liver disease (MELD). Results: In 2,301 patients, 866 (37.6%) and 400 (17.4%) were in the high ALBI and APRI groups, respectively. There were significant differences of postoperative overall morbidity between the normal and high ALBI groups (26.2% vs. 40.1%, P<0.001), as well as between the normal and high APRI groups (29.2% vs. 42.4%, P<0.001). The AUCs of the ALBI and APRI scores for predicting overall morbidity are greater than those of Child- Pugh grade and MELD score. Multivariable analyses revealed that ALBI and APRI were independent predictors of overall morbidity in both preoperative and postoperative prediction models. Similar results existed in predicting postoperative major morbidity. Conclusions: Preoperative ALBI and APRI could predict postoperative 30-day overall and major morbidity following hepatectomy for HCC before or after surgery.