Congenital Malformations in Infants of Mothers Undergoing Assisted Reproductive Technologies: A Systematic Review and Meta-analysis Study

Hoorsan, Hayedeh,Mirmiran, Parvin,Chaichian, Shahla,Moradi, Yousef,Hoorsan, Roza,Jesmi, Fatemeh The Korean Society for Preventive Medicine 2017 Journal of Preventive Medicine and Public Health Vol.50 No.6

Objectives: This meta-analysis aimed to evaluate congenital malformations in infants conceived by assisted reproductive techniques (ART), compared with infants conceived spontaneously. Methods: In this study, available resources searched to find relevant articles included PubMed, ScienceDirect, Scopus, Google Scholar, Cochrane, ProQuest, Iranmedex, Magiran, and Scientific Information Database. After extracting the necessary information from evaluated articles, meta-analysis on the articles' data was performed using Stata version 11.2. Results: In this study, from a total of 339 articles, extracted from the initial investigation, ultimately 30 articles were selected for meta-analysis that assessed the use of ART on the risk of congenital abnormalities and some birth complications on 5 470 181 infants (315 402 cases and 5 154 779 controls). The odds ratio (95% confidence interval [CI]) for low birth weight was 1.89 (95% CI, 1.36 to 2.62), preterm labor 1.79 (95% CI, 1.21 to 2.63), cardiac abnormalities 1.43 (95% CI, 1.27 to 1.62), central nervous system abnormalities 1.36 (95% CI, 1.10 to 1.70), urogenital system abnormalities 1.58 (95% CI, 1.28 to 1.94), musculoskeletal disorders 1.35 (95% CI, 1.12 to 1.64), and chromosomal abnormalities in infants conceived by ART was 1.14 (95% CI, 0.90 to 1.44), which were all statistically significant, except chromosomal abnormalities. Conclusions: The risk of congenital abnormalities and some birth complications were significantly higher in ART than normal conception, while chromosomal abnormalities were not; therefore, the application of ART should be selected individually for patients by detailed assessment to reduce such risks in the population.

Congenital Malformations in Infants of Mothers Undergoing Assisted Reproductive Technologies: A Systematic Review and Meta-analysis Study

Hayedeh Hoorsan,Parvin Mirmiran,Shahla Chaichian,Yousef Moradi,Roza Hoorsan,Fatemeh Jesmi 대한예방의학회 2017 Journal of Preventive Medicine and Public Health Vol.50 No.6

Objectives: This meta-analysis aimed to evaluate congenital malformations in infants conceived by assisted reproductive techniques (ART), compared with infants conceived spontaneously. Methods: In this study, available resources searched to find relevant articles included PubMed, ScienceDirect, Scopus, Google Scholar, Cochrane, ProQuest, Iranmedex, Magiran, and Scientific Information Database. After extracting the necessary information from evaluated articles, meta-analysis on the articles’ data was performed using Stata version 11.2. Results: In this study, from a total of 339 articles, extracted from the initial investigation, ultimately 30 articles were selected for meta-analysis that assessed the use of ART on the risk of congenital abnormalities and some birth complications on 5 470 181 infants(315 402 cases and 5 154 779 controls). The odds ratio (95% confidence interval [CI]) for low birth weight was 1.89 (95% CI, 1.36 to 2.62), preterm labor 1.79 (95% CI, 1.21 to 2.63), cardiac abnormalities 1.43 (95% CI, 1.27 to 1.62), central nervous system abnormalities 1.36 (95% CI, 1.10 to 1.70), urogenital system abnormalities 1.58 (95% CI, 1.28 to 1.94), musculoskeletal disorders 1.35 (95% CI, 1.12 to 1.64), and chromosomal abnormalities in infants conceived by ART was 1.14 (95% CI, 0.90 to 1.44), which were all statistically significant, except chromosomal abnormalities. Conclusions: The risk of congenital abnormalities and some birth complications were significantly higher in ART than normal conception, while chromosomal abnormalities were not; therefore, the application of ART should be selected individually for patients by detailed assessment to reduce such risks in the population.

Ovarian cysts disappear after 14-day oral regimen of Korean red ginseng extract in letrozole-induced polycystic ovarian syndrome

Niknaz Moradi,Sepideh Arbabi Bidgoli,Shahla Chaichian 대한산부인과학회 2021 Obstetrics & Gynecology Science Vol.64 No.3

ObjectiveHormonal and inflammatory mechanisms are involved in the pathogenesis of polycystic ovarian syndrome (PCOS),which is a prevalent metabolic disorder among women of reproductive age. We aimed to evaluate the comparativeefficiency of short-term oral administration of Korean red ginseng extract (KRGE) and the standard treatmenton PCOS by focusing on the histopathological parameters and serum levels of luteinizing hormone (LH), folliclestimulatinghormone (FSH), testosterone, and nuclear factor kappa B (NF-κB). MethodsA PCOS rat model was established by oral gavage of letrozole (1 mg/kg) for 21 days. The serum levels of LH, FSH,testosterone, and NF-κB were measured, and the morphological features and differences of the ovaries wereexamined in each group using a light microscope before and after 14 days of treatment with oral regimens—KRGE,oral contraceptives (OCPs), KRGE+OCPs, and carboxymethyl cellulose (CMC). ResultsOCPs alone could not normalize the mean ovarian weights of PCOS rats despite the 14-day oral regimen, but theywere more effective in reducing the number and size of cysts compared to others. KRGE alone and in combinationwith OCPs was effective in normalizing abnormal ovarian weights, decreasing LH serum levels, and dissipating theovarian cysts in PCOS rats. However, when combined with the standard regimen, KRGE showed additional therapeuticeffects by efficiently reducing serum testosterone and NF-κB levels. ConclusionOur necropsy and histopathological evidence suggests the efficacy of KRGE as a novel integrative medicine againstabnormal multiple follicular cysts. However, antiandrogenic and anti-inflammatory effects were only seen in animalsthat were administered a combination of KRGE and the standard regimen.

Application of the World Health Organization Quality of Life Instrument, Short Form (WHOQOL-BREF) to patients with endometriosis

( Abolfazl Mehdizadeh Kashi ),( Yousef Moradi ),( Shahla Chaichian ),( Zahra Najmi ),( Kamyar Mansori ),( Forugh Salehin ),( Azade Rastgar ),( Sorour Khateri ) 대한산부인과학회 2018 Obstetrics & Gynecology Science Vol.61 No.5

Objective Endometriosis, a common hormone-dependent chronic inflammatory disease causes various symptoms including pelvic pain, which affect the physical and psychological quality of life in women of reproductive age. The present study aimed to assess the quality of life of Iranian women with endometriosis using the World Health Organization Quality of Life Instrument, Short Form (WHOQOL-BREF) questionnaire. Methods This cross-sectional study performed in Tehran between October 2014 and July 2016 included 70 Iranian women with endometriosis. The Iranian version of the WHOQOL-BREF questionnaire was used to measure quality of life in these women. The Pearson's correlation coefficient, the paired and the independent t-tests, and a linear regression model were used to statistically analyze the data using the SPSS software version 16.0. Results The total mean score of the WHOQOL-BREF questionnaire was 80.58. The highest and the lowest mean scores were observed in the environmental (28.15) and the physical health domains (10.59), respectively. A multiple linear regression model (backward method) showed that insurance coverage was associated with the total WHOQOL-BREF score, whereas age, insurance coverage, and income level were associated with domains 1 through 4, respectively (P<0.05). Conclusion Endometriosis affects various aspects of the quality of life of Iranian women who therefore require holistic management focused on both, the physical and psychological aspects of treatment.

The effect of diluted ropivacaine in distending fluid on cramping pain after hysteroscopic surgeries: a randomized clinical trial study

Kobra Tahermanesh,Abolfazl Mehdizadeh Kashi,Marziyeh Ajdary,Samaneh Rokhgireh,Masood Mohseni,Shahla Chaichian,Maryam Ahmadi 대한산부인과학회 2022 Obstetrics & Gynecology Science Vol.65 No.6

ObjectiveThe effect of ropivacaine on postoperative hysteroscopy has not yet been evaluated; this study investigated the effectof diluted ropivacaine in distending media during hysteroscopy on postoperative cramping pain. MethodsThis double-blind randomized clinical trial was conducted on 60 women who underwent hysteroscopy at a tertiaryhospital. Normal saline was used as the distending fluid in both groups. The intervention group received 10 mLof 2% ropivacaine in only one bottle of 1,000 mL normal saline as a distending fluid, while the control groupreceived 10 mL of normal saline in 1,000 mL normal saline during hysteroscopy. Patients’ pain scores wereevaluated before hysteroscopy and at 2, 6, 12, 24, and 48 hours after hysteroscopy. ResultsBased on the results, the pain measured by visual analog scale (VAS) score was significant at 6 and 12 hours after theintervention was significantly lower than that in the ropivacaine group (3.03±1.57 vs. 4±1.49, P=0.02 at 6 hours and1.28±1.36 vs. 2.4±1.43, P=0.003 at 12 hours). There were no significant differences in the VAS scores at 2, 24, and 48hours after the intervention between the two groups. ConclusionRopivacaine in the distending fluid during hysteroscopy is associated with a significant reduction in pain within a fewhours after hysteroscopy with no remarkable adverse effects.

Does transcutaneous electrical nerve stimulation reduce the laparoscopic related shoulder pain?

Abolfazl Mehdizadeh kashi,Sepideh Khodaverdi,Azam Govahi,Saeedeh Sarhadi,Mania Kaveh,Kambiz Sadegi,Roya Derakhshan,Marziyeh Ajdary,Shahla Chaichian 대한산부인과학회 2024 Obstetrics & Gynecology Science Vol.67 No.1

Objective Although laparoscopic surgery is a good substitute for laparotomy in reducing postsurgical pain, many patients complain of shoulder pain after laparoscopic surgery and require pain-relief. Post-operative pain management leads to increased patient satisfaction. Transcutaneous Electrical Nerve Stimulation (TENS) is a non-pharmacological, noninvasive modality that reduces pain by activating the descending inhibitory systems in the central nervous system. Given the importance of decreasing shoulder pain after gynecological laparoscopy, the current study aimed to investigate the management of shoulder pain in these patients using TENS. Methods This was a retrospective case-control study. A total of 112 women aged 18-45 years who experienced shoulder pain due to gynecologic laparoscopic surgery were included in the study. Patients were divided into TENS and control groups. In the TENS group, TENS was used twice for 20 minutes each, but in the control group, the patients received regular treatment. Patients were evaluated at intervals of 2, 4, 8, 24, 48, and 72 hours after laparoscopy for shoulder pain score. Results The results showed a significant decrease in visual analog scale scores at 2, 4, and 8-hour in the TENS group compared with the control group. At 24 hours evaluation, although the pain was reduced, the difference was not significant. At 48- and 72-hour assessment, all patients in each group reported zero score for severity of pain. Conclusion The findings suggest that TENS significantly reduces postoperative shoulder pain.