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Fertility-sparing treatment in women with endometrial cancer
Won, Seyeon,Kim, Mi Kyoung,Seong, Seok Ju The Korean Society for Reproductive Medicine 2020 Clinical and Experimental Reproductive Medicine Vol.47 No.4
Endometrial cancer (EC) in young women tends to be early-stage and low-grade; therefore, such cases have good prognoses. Fertility-sparing treatment with progestin is a potential alternative to definitive treatment (i.e., total hysterectomy, bilateral salpingo-oophorectomy, pelvic washing, and/or lymphadenectomy) for selected patients. However, no evidence-based consensus or guidelines yet exist, and this topic is subject to much debate. Generally, the ideal candidates for fertility-sparing treatment have been suggested to be young women with grade 1 endometrioid adenocarcinoma confined to the endometrium. Magnetic resonance imaging should be performed to rule out myometrial invasion and extrauterine disease before initiating fertility-sparing treatment. Although various fertility-sparing treatment methods exist, including the levonorgestrel-intrauterine system, metformin, gonadotropin-releasing hormone agonists, photodynamic therapy, and hysteroscopic resection, the most common method is high-dose oral progestin (medroxyprogesterone acetate at 500-600 mg daily or megestrol acetate at 160 mg daily). During treatment, re-evaluation of the endometrium with dilation and curettage at 3 months is recommended. Although no consensus exists regarding the ideal duration of maintenance treatment after achieving regression, it is reasonable to consider maintaining the progestin therapy until pregnancy with individualization. According to the literature, the ovarian stimulation drugs used for fertility treatments appear safe. Hysterectomy should be performed after childbearing, and hysterectomy without oophorectomy can also be considered for young women. The available evidence suggests that fertility-sparing treatment is effective and does not appear to worsen the prognosis. If an eligible patient strongly desires fertility despite the risk of recurrence, the clinician should consider fertility-sparing treatment with close follow-up.
Won-Jun Choi,Seyeon Jeong,Kiyoung Moon,Hyeseon Shin,Sijin Lee,Heon Heo,Sangjun Son,Gwangil Jung,신두철 물리치료재활과학회 2022 Physical therapy rehabilitation science Vol.11 No.3
Objective: The purpose of this study was to prepare evidence for the prevention and management of nonspecific chronic neck pain (NSCNP) by examining the correlation between activity of daily living and physical activities of office workers with NSCNP. Design: Crossed-sectional studyMethods: 89 patients with NSCNP were recruited for this study. But 2 subjects met the exclusion criteria and were dropped out, and 86 subjects finally participated. Numerical pain rating scale (NPRS) and neck disability index (NDI) were used to check the pain intensity and disability of patients with neck pain, respectively. For the activity of daily living, computer use time, sleep time, and driving time were used. To find out the physical activities of the subjects, International Physical Activity Questionnaires (IPAQ-SF) was used. Correlation analysis was performed to find out the correlation of each variable. Results: A clear positive correlation was established between computer use time and pain (p<0.05), and a clear positive correlation was established between computer use time and disability index (p<0.05). The correlation between NPRS and NDI and physical activity total time, high intensity activity score, moderate intensity activity score, and walking score were not statistically significant (p>0.05). Conclusions: In treating patients with NSCNP, it is necessary to reduce the computer usage time as a professional factor or to educate the proper posture. In addition, rather than emphasizing physically comprehensive physical activity, grafting therapeutic exercise directly related to neck pain could have a more positive effect on NSCNP patients.
Won Kim,Seyeon Bae,Hyemin Kim,Yejin Kim,Jiwon Choi,Sun Young Lim,Hei Jin Lee,Jihyuk Lee,Jiyea Choi,Mirim Jang,Kyoung Eun Lee,Sun G,Chung,Young-il Hwang,Jae Seung Kang,Wang Jae Lee 대한해부학회 2013 Anatomy & Cell Biology Vol.46 No.4
The L-gulono-γ-lactone oxidase gene (Gulo) encodes an essential enzyme in the synthesis of ascorbic acid from glucose. On the basis of previous findings of bone abnormalities in Gulo-/- mice under conditions of ascorbic acid insufficiency, we investigated the effect of ascorbic acid insufficiency on factors related to bone metabolism in Gulo-/- mice. Four groups of mice were raised for 4 weeks under differing conditions of ascorbic acid insufficiency, namely, wild type; ascorbic acid-sufficient Gulo-/- mice, 3-week ascorbic acid-insufficient Gulo-/- mice, and 4-week ascorbic acid-insufficient Gulo-/- mice. Four weeks of ascorbic acid insufficiency resulted in significant weight loss in Gulo-/- mice. Interestingly, average plasma osteocalcin levels were significantly decreased in Gulo-/- mice after 3 weeks of ascorbic acid insufficiency. In addition, the tibia weight in ascorbic acid-sufficient Gulo-/- mice was significantly higher than that in the other three groups. Moreover, significant decreases in trabecular bone volume near to the growth plate, as well as in trabecular bone attachment to the growth plate, were evident in 3- or 4-week ascorbic acid-insufficient Gulo-/-. In summary, ascorbic acid insufficiency in Gulo-/- mice results in severe defects in normal bone formation, which are closely related to a decrease in plasma osteocalcin levels.
Characteristics of an HTS Pancake Coil in Persistent Current Mode Using Wind-and-Flip Winding Method
Seyeon Lee,Woo-Seok Kim,Yungil Kim,Sang Ho Park,Ji-Kwang Lee,Jin-Ho Hahn,Gye-Won Hong,Il Han Park,Chan Park,Kyeongdal Choi IEEE 2013 IEEE transactions on applied superconductivity Vol.23 No.3
<P>It has been well known that a coated conductor (CC), 2G superconducting tape, shows a higher critical current and better performance than the 1G, BSCCO one. However, there has still been no way to make a superconducting joint with CC, so it has been almost impossible to build a CC superconducting magnet in persistent current mode. As a viable solution for this, we have proposed a special winding technology called the Wind-and-Flip method. It shows a new possibility for the generation of a persistent current mode in a magnet with CC. First, we partially cut a wide CC tape into two pieces along the tape except at both end parts like cutting the abdomen of a fish. Then we wind two pancake coils with the cut but connected CC tape. Finally, one of the two coils is turned over, and then the magnetic fields from both coils would have the same direction with each other. In this paper, we made two high-temperature superconducting double pancake windings by the Wind-and-Flip method. One has turn-to-turn insulation layers while the other does not. They both have oxygen-free copper bobbins for the conduction cooling. First, they were magnetized by field cooling within a fine background magnet, and operated in persistent current mode at 77 K. As a result of the experiment, we measured and compared temporal stabilities for both pancake windings to investigate the possible use of these windings for magnetic resonance imaging or nuclear magnetic resonance applications. We have future plans of measuring the temporal stabilities of similar windings under lower temperatures and confirm the possibility of a high-field high-temperature superconducting magnet, which will be fabricated by stacking these pancake coils with larger cold bore size.</P>
Persistent Current Mode Operation of A 2G HTS Coil With A Flux Pump
Seyeon Lee,Woo-Seok Kim,Yungil Kim,Ji-Yung Lee,Sang-Ho Park,Ji-Kwang Lee,Gye-Won Hong,Sungsoo Kim,Jinho Han,Young Jin Hwang,Kyeongdal Choi Institute of Electrical and Electronics Engineers 2016 IEEE transactions on applied superconductivity Vol.26 No.4
<P>A flux pump is a kind of power source that energizes superconducting magnets usually embedded in the cryogenic system. Therefore, heat loss through current leads is eliminated, allowing for more efficient cooling design. A winding technique, the so-called 'wind-and-flip,' had been proposed by the authors to realize a jointless HTS coil for a perfect resistanceless closed loop, which may enable to induce a persistent current in an HTS coil wound with second-generation HTS tape. In this paper, we investigated charging/discharging characteristics and a possibility of persistent current operation of a jointless HTS coil with a flux pump. Results are discussed with regard to current capacity and temporal stability with a prototype jointless HTS coil.</P>
Bae, Seyeon,Kim, Hyemin,Lee, Naeun,Won, Cheolhee,Kim, Hang-Rae,Hwang, Young-il,Song, Yeong Wook,Kang, Jae Seung,Lee, Wang Jae American Association of Immunologists 2012 Journal of Immunology Vol. No.
<P>α-Enolase (ENO1) is a multifunctional glycolytic enzyme expressed abundantly in the cytosol. It has been implicated in autoimmune and inflammatory diseases. Serum Abs against ENO1 were reported in rheumatoid arthritis (RA). Cell-surface expression of ENO1 has been found to be increased rapidly in response to inflammatory stimuli, but its expression and function has not been reported in RA. In this study, we show that cell-surface expression of ENO1 is increased on monocytes and macrophages isolated from RA patients but not on those from osteoarthritis patients, and Ab against ENO1 can stimulate these cells to produce higher amounts of proinflammatory mediators, such as TNF-α, IL-1 α/β, IFN-γ, and PGE(2) via p38 MAPK and NF-κB pathway. The frequency of ENO1-positive cells in synovial fluid mononuclear cells was higher than PBMCs. ENO1-positive cells were also found in the inflamed synovium from RA patients and arthritic ankle tissues of mice with collagen-induced arthritis. Taken together, these findings suggest that Abs against ENO1 present in RA sera may stimulate monocytes and macrophages expressing cell-surface ENO1 and contribute to production of proinflammatory mediators during the effector phase of synovial inflammation.</P>