The Effect of Gamma Radiation on Inintial Growth of Albizzia julibrissin in Heavy Metal Contaminated Soil

Seongmin Woo(우성민),Hyejin Kwon(권혜진),Jaehong Yim(임재홍),DongWook Kim(김동욱),Munho Jung(정문호),Taeheok Kim(김태혁),Tehryung Kim(김태령) 한국토양비료학회 2008 한국토양비료학회 학술발표회 초록집 Vol.2008 No.9

전기 히터 방식의 동결 우레아 해동 현상 및 상경계면 이동에 대한 수치해석

우성민(Seongmin Woo),최병철(Byungchul Choi) 한국자동차공학회 2014 한국 자동차공학회논문집 Vol.22 No.5

전기히터 방식에 의한 동결 우레아의 해동 시 상경계면 이동의 수치해석

우성민(Seongmin Woo),최병철(Byungchul Choi) 한국자동차공학회 2013 한국자동차공학회 부문종합 학술대회 Vol.2013 No.5

Urea-SCR system which is the selective catalytic reduction using urea as reducing system is a powerful technique for reducing nitrogen oxides(NOx) emitted from diesel vehicles. In this study, numerical analysis of 3-dimensional unsteady heating problems was conducted to predict the motion of phase interface between electric heater and frozen urea. It can be applied to determine the location of the urea suction pipe in storage tank. This study also includes the change of liquid volume fraction, temperature profiles and natural convection by using the commercial software STAR-CCM+(v7.06). The accuracy of the numerical analysis is assessed by comparisons with experimental data. After validation, a comparison with high power heaters is simulated to know effect of difference in velocity of phase changes interface.

습도 센서 부착형 고추 모종 이식기 개발

박예린 ( Yushin Ha ),이정화 ( Seungmin Woo ),김지은 ( Yerin Park ),김태원 ( Jeonghwa Lee ),우현지 ( Jieun Kim ),우승민 ( Taewon Kim ),하유신 ( Hyunji Woo ),( Seongmin Woo ),( Yushin Ha ) 한국농업기계학회 2020 한국농업기계학회 학술발표논문집 Vol.25 No.2

최근 농업 사회에서의 노동력 감소와 귀농·귀촌에 따른 청년 농부가 증가함에 따라 새로운 방식의 농업사회가 구성되고 있으며 이에 따라 정확한 계측 농업의 도입과 농업의 디지털화가 이루어지고 있다. 본 연구의 목적은 농촌 사회의 변화에 맞춰 편리함과 정확함을 목표로한 고추모종 이식기를 개발하는 것이다. 현재 농촌에서는 고추 정식 과정에서 물을 줄 때 눈대중으로 적당량의 수분을 공급해 주는 방식을 사용한다. 이런 방식은 농민의 경험에 의존한 방법이며 최적의 생산량을 도출해내기는 어렵기에 수분을 공급하는 적합한 습도 값을 조사해 이 습도 값만큼 물을 주도록 개발품을 설계하였다. 정식 시에 기존 토양의 물 주기 전의 습도 값을 측정하고 이에 따라 적합한 습도 값(85%)에 도달할 때까지 물을 공급하고 저절로 멈추도록 하는 장치의 개발이다. 또한 기존의 고추 정식 과정은 땅을 파고 모종을 심고 물을 주고 흙을 덮는 과정으로 이루어지는데 비닐 멀칭 구멍 뚫기, 모종심기, 필요한 수분 공급 등의 세분화된 과정들을 한 번에 수행함으로써 모종을 이식하는 과정을 하나의 기계로 한번의 공정을 통하여 수행할 수 있도록 설계하여 노동력과 경영비를 감소시키는데 그 목적이 있다. 이를 위해서는 토양 습도 측정을 위한 습도계, 수분 공급을 위한 워터 펌프, 습도 값을 읽고 워터 펌프로 내보낼 물의 양을 계산해 줄 아두이노를 사용하며,수분이 공급되는 분수호스를 적용하였다. 간편해진 모종 이식 방법으로 모종을 이식 할수 있기에 노인이 많은 농촌 사회에서 부족한 일손을 본 개발품을 통하여 일정부분 해소할수 있으며 불필요한 동작 및 위험요소가 사라짐에 따라 부상 위험을 감소시킬 것으로 기대되며 추후 개발품의 현장 실험을 통하여 능률을 분석하며, 수정 보완할 계획이다.

The evaluation of concordance of genomic alterations in cell-free DNA and tumor tissues via next-generation sequencing: A pilot study

( Seongmin Kim ),( Kyung Jin Min ),( Sanghoon Lee ),( Jin Hwa Hong ),( Jae Kwan Lee ),( Nak Woo Lee ),( Jae Yun Song ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: Genomic analysis of circulating tumor cell-free DNA (cfDNA) represents a non-invasive method of assessing genomic alterations using peripheral blood. But its efficacy of clinical use in patients with ovarian cancer is not established yet. We compared the concordance of genomic alterations between cfDNA and tissue biopsies in patients with advanced ovarian cancer. Methods: 7 patients with advanced epithelial ovarian cancers were included, The cfDNA biopsy was done just before surgery, and the tumor tissue was obtained during surgery. Both samples were analyzed by next-generation sequencing. Concordance was defined as the presence or absence of the identical genomic alteration(s) in a single gene on both molecular platforms. Results: The cfDNA amount was 107.3 in average, and showed positive correlation with advancing stage (p=0.029). Total 54 gene mutations were identified in both groups. the average number of alterations per patient for tissue and cfDNA analysis was 1.71 and 7.43, respectively. The overall concordance was 96.1% but the rate decreased to 16.6% when considering only genes with reported genomic alterations in both assays. 66.67% of mutations detected in tissue was found in cfDNA, and 16.56% of alterations detected in cfDNA was detected in tissue, indicating a potential complementary role of each assay. But the variant allele frequency (VAF) was significantly higher in concordant genes than discordant genes (p<0.001). Most frequently detected genes (TP53, BRCA1, MED12, PTCH1) showed sensitivity and specificity were 100% and 44% respectively. Conclusion: The cfDNA could detect critical mutations with high VAF in several patients. The discordancy between two samples could be explained by tumor heterogeneity, possible germline contamination of cfDNA, and difference in assay platform. The prospective studies to evaluate concordance of genomic alterations between two platforms would be necessary to determine clinical significance of cfDNA in ovarian cancer. Acknowledgements: This study was supported by Korea University Anam Hospital grant.

Optimal Strategy of Ovarian Cystectomy for Safety in Borderline Ovarian Tumors - A Retrospective Analysis and Review of the Literature

( Seongmin Kim ),( Sung Hye Jeon ),( Kyung Jin Min ),( Sanghoon Lee ),( Jin Hwa Hong ),( Jae Kwan Lee ),( Nak Woo Lee ),( Jae Yun Song ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: Borderline ovarian tumors (BOTs) occur in younger, fertile women, with a more favorable prognosis. This study aimed to evaluate the risk of recurrence according to the type of surgery in BOTs. Methods: This retrospective study included patients with BOTs treated between August 2007 and August 2017 at our institution. Patients were divided into two groups according to the type of surgery: cystectomy and oophorectomy with or without salpingectomy. The disease-free survival (DFS) was compared using KaplanMeier curves. Differences in surgical outcomes were also analyzed. Results: Of the 169 patients enrolled, 134 (79.3%) had an oophorectomy with or without salpingectomy and 35 (20.7%) had an ovarian cystectomy. Eight patients (4.7%) developed recurrence of disease: six (4.5%) patients in the oophorectomy group and two (5.7%) in the cystectomy group and one patient died. Median disease-free months were 30 months for oophorectomy patients and 40 months for cystectomy patients, while the two-year disease-free rate was 97.6% and 94.7%, respectively. DFS was not different between the groups (p=0.886). The surgical approach (minimally invasive surgery or laparotomy) was not associated with disease recurrence (p=0.881). None of the parameters increased risk of recurrence on univariate analysis. In patients with cystectomy, the cumulative recurrence was higher in subgroup with optimally removed tumor (p=0.025). Conclusion: Ovarian cystectomy in BOTs was not associated with an increased recurrence of disease. It can be considered a safe and effective option in surgical management of BOTs in young women who desire fertility preservation. Best effort to remove all visible cystic wall is necessary to prevent the recurrence of BOTs managed by ovarian cystectomy.

Analysis of Anticancer Activity and Chemical Sensitization Effects of Dendropanax morbifera and Commersonia bartramia Extracts

( Seongmin Kim ),( Kyung Jin Min ),( Jin Hwa Hong ),( Jae Yun Song ),( Jae Kwan Lee ),( Nak Woo Lee ),( Robert M. Hoffman ),( Sanghoon Lee ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: Dendropanax morbifera (DM) and Commersonia bartramia (CB) are possible candidates for immunotherapy. In this study, the cytotoxicity and chemical sensitization of DM and CB extracts on gynecologic and colon cancers were evaluated. Methods: The malignant cell lines were cultured and analyzed for cytotoxicity and chemical sensitization. A mouse model was also constructed to make the condition similar to in vivo. Reverse transcription-polymerase chain reaction was conducted to determine alterations in drug-resistant genes. Results: The extracts from DM and CB showed specific cytotoxicity to malignant cell lines. DM increased chemical sensitivity to cervical and ovarian cancer, while CB showed improved sensitization to endometrial cancer. The effects of the extracts were confirmed using a mouse model. The extracts induced differences in the expression levels of a number of genes related to drug resistance. Conclusion: DM and CB extracts could be novel agents for immunotherapy and chemical sensitization in gynecologic and colon cancers. Acknowledgements: This study was supported by Metibio, Inc.

A Slot-Loaded Composite Right/Left-Handed Transmission Line for a Zeroth-Order Resonant Antenna With Improved Efficiency

Seongmin Pyo,Sang-Min Han,Jung-Woo Baik,Young-Sik Kim IEEE 2009 IEEE transactions on microwave theory and techniqu Vol.57 No.11

<P>In this paper, a new composite right/left-handed transmission line (CRLH-TL) with equilateral slots is proposed for efficiency-improved zeroth-order resonant antennas. A 1-D infinitesimal equivalent transmission line circuit model is derived, and the characteristic impedance and dispersive relation are theoretically computed. Based on the isotropic arranged unit cells of the slot-loaded composite right/left-handed transmission line (SL CRLH-TL), 2-D zeroth-order resonators are designed for planar magnetic monopole antenna applications. The SL CRLH-TL provides the zeroth-order resonance with some degradation of the quality factor. Therefore, a highly efficient radiating resonator can be designed with higher gain at the zeroth-order frequency. The theoretical approach was verified by the experimental results. The radiation efficiency was improved by up to 45.6% for the nine-rectangular zeroth-order resonant antenna and 21.4% for the seven-hexagonal zeroth-order resonant antenna without degrading the radiating performance. Moreover, the antenna gains of these two antennas were enhanced by 7.56 and 6.31 dB, respectively, due to the increase of the radiation efficiency.</P>

Premature ovarian insufficiency could be related with exposure to environmental hormones: identification via next-generation sequencing of vaginal microbiome

( Seongmin Kim ),( Se Hee Lee ),( Kyung Jin Min ),( Jin Hwa Hong ),( Jae Kwan Lee ),( Nak Woo Lee ),( Jae Yun Song ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: The vaginal microbiome has been investigated widely because of its value for diagnosis of vaginitis or connection to other conditions. But its relation with premature ovarian insufficiency (POI) possibly associated with environmental pollutants was never been evaluated. In this study, we conducted next-generation sequencing of vaginal microbiome in patients with POI and analyzed its correlation with various environmental pollutants. Methods: The vaginal swabs were collected from 92 patients (22 with POI and 70 of healthy control). The vaginal microbiome of specimens were analyzed using next-generation sequencing. The reads of 16S rDNA were assembled by FLASH, and clustered by OTUs. Diversity analysis was performed using QIIME. The laboratory findings including hormonal status were measured in all patients. Results: The characteristics of patients were similar between two groups except the lower AMH and higher FSH in POI group (p<0.01 and p=0.04, respectively). The abundant taxa showed difference among several species, but only 2 species showed significant difference (P. acnes and P. copri). The composition of taxonomy showed different tendency of lactobacilli and enterococcus, but the heatmap could not define significant difference between groups. The canonical correlation analysis revealed that the more environmental pollutants showed correlation with the change of vaginal microbiome in POI group than control group (6 materials vs 2 materials), and the coefficient of determinations were higher in correlated species with POI group. Conclusion: The vaginal microbiome in patients with POI showed more sensitive tendency according to the change of various environmental pollutants. This implies that the considerable link of POI to the pollutants, and the POIs might be induced by exposure to the environmental pollutants. We could expect that the vaginal microbiome analysis could be used for anticipation of exposure to the pollutants and possibility of POI in reproductive females. Acknowledgements: This study was granted by the Korea Ministry of Environment (MOE) as The Environmental Health Action Program (2016001360007).

Concurrent chemoradiotherapy for cervical cancer in a single institution: high-dose rate brachytherapy vs helical tomotherapy

( Seongmin Kim ),( Kyung Jin Min ),( Sanghoon Lee ),( Jin Hwa Hong ),( Jae Kwan Lee ),( Nak Woo Lee ),( Young Je Park ),( Jae Yun Song ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: We reviewed our experience and evaluated the results of helical tomotherapy (HT) compared the disease outcome with that of high-dose rate brachytherapy in patients with cervical cancer. Methods: Total 114 patients who have been treated with concurrent chemoradiotherapy(CCRT) for newly diagnosed cervical cancer from 2008 to 2017 were retrospectively reviewed. Radiotherapy was given as a combination of whole pelvic external beam RT (EBRT) followed by high-dose rate brachytherapy(BT) or helical tomotherapy(HT). Results: We extracted selected population using propensity score matching with 1:1 ratio. After adjustment for age, BMI, radiation dose, prior surgery, clinical stage and histologic type, there was no significantly different parameter between two groups. The overall survival was poorer in BT group compared to HT group (median survival 17.5 months after BT vs 30 months after HT, log rank p=0. 034). 4-year survival rates were 74.2% in brachytherapy group and 100% in tomotherapy group. But the progression free survival was not different between two groups(p=0.270). 1-year and 2-year progression-free rates were 85.3% and 76.3% in BT group, but those were 87.0% and 58.9% in HT group. In univariate analysis, there was no significant risk factor for overall survival. But in PFS, stage was the only significant risk factor for recurrence. In multivariate analysis, clinical stage was still significant risk factor after adjusting for the other clinical parameters. Conclusion: HT could be a feasible option for CCRT in patients with cervical cancer with appropriate indications. Further studies with delicate design and larger number from multicenter with long follow up period are warranted to confirm the significance of benefit of HT in concurrent chemoradiotherapy in the field of cervical cancer.