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In vivo molecular and single cell imaging
( Seongje Hong ),( Siyeon Rhee ),( Kyung Oh Jung ) 생화학분자생물학회 2022 BMB Reports Vol.55 No.6
Molecular imaging is used to improve the disease diagnosis, prognosis, monitoring of treatment in living subjects. Numerous molecular targets have been developed for various cellular and molecular processes in genetic, metabolic, proteomic, and cellular biologic level. Molecular imaging modalities such as Optical Imaging, Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Computed Tomography (CT) can be used to visualize anatomic, genetic, biochemical, and physiologic changes in vivo. For in vivo cell imaging, certain cells such as cancer cells, immune cells, stem cells could be labeled by direct and indirect labeling methods to monitor cell migration, cell activity, and cell effects in cell-based therapy. In case of cancer, it could be used to investigate biological processes such as cancer metastasis and to analyze the drug treatment process. In addition, transplanted stem cells and immune cells in cell-based therapy could be visualized and tracked to confirm the fate, activity, and function of cells. In conventional molecular imaging, cells can be monitored in vivo in bulk non-invasively with optical imaging, MRI, PET, and SPECT imaging. However, single cell imaging in vivo has been a great challenge due to an extremely high sensitive detection of single cell. Recently, there has been great attention for in vivo single cell imaging due to the development of single cell study. In vivo single imaging could analyze the survival or death, movement direction, and characteristics of a single cell in live subjects. In this article, we reviewed basic principle of in vivo molecular imaging and introduced recent studies for in vivo single cell imaging based on the concept of in vivo molecular imaging. [BMB Reports 2022; 55(6): 267-274]
Compact Biocompatible Fiber Optic Temperature Microprobe Using DNA-Based Biopolymer
Hong, Seongjing,Jung, Woohyun,Kim, Taeoh,Oh, Kyunghwan IEEE 2018 Journal of lightwave technology Vol.36 No.4
<P>A highly compact biocompatible microprobe type fiber optic temperature sensor was experimentally demonstrated utilizing an inherently high thermo-optic coefficient of DNA biopolymer. The sensor was based on an all-fiber multimode interferometer (MMI) along a coreless silica fiber (CSF) spliced to an end of a single mode fiber. Au film was deposited the CSF end facet to provide a double path for MMI and it also worked as a probe terminal. The circumferential area of CSF was coated with DNA-cetyltrimethylammonium chloride (CTMA) thin solid film, which served as a temperature sensing head. We experimentally investigated thermo-optical properties of DNA-CTMA thin solid films to find its large negative thermo-optical coefficient −4.15 × 10<SUP>−4</SUP>/°C in the temperature range from 20 to 70 °C. DNA-CTMA coated fiber optic probe was immersed in a water bath to simulate the bio compatible environment whose temperature was varied in the range from 30 to 70 °C. The proposed sensor showed a high-temperature sensitivity of −0.22 nm/°C in the spectral shifts, and 0.085 dB/°C in the reflected optical power changes. The proposed probe can be readily applied in various types of <I>in vivo</I> point of care temperature monitoring.</P>
회전압축기형 스털링 냉동기의 열환경 성능시험에 관한 연구
박성제(SeongJe Park),홍용주(YongJu Hong),김효봉(HyoBong Kim),김대웅(Dae Woong Kim) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.5
This paper presents the results of a series of performance tests for the integral Stirling cryocooler. Infrared sensor systems incorporating cryocoolers are required to be qualified to the appropriate environmental specification. Integral Stirling cryocooler for thermal imaging system have matured to the stage of undergoing formal qualification test program. The thermal environmental test of the Stirling cryocooler is presented in this paper. We performed that low and high temperature keeping test from -40℃ to +71℃ and operating test at high and low temperature cyclic range with acceptance tests performed at scheduled intervals. Cooldown time to 80K and steady state input power at 80K were determined as a function of cooler components temperatures at the compressor, hot end and cold tip. Tests performed on this cooler have been successful with a measured cooldown time to 80K of less than 5 minutes 24seconds for 71℃ ambient temperature with input power of 11W.
열상장비용 스털링 극저온 냉동기의 최적화 실험에 관한 연구
박성제(SeongJe Park),홍용주(YongJu Hong),김효봉(HyoBong Kim),염한길(HanKil Yeom) 대한기계학회 2006 대한기계학회 춘추학술대회 Vol.2006 No.6
Stirling cryocoolers have been widely used for the cooling of infrared sensors and high temperature superconducting filters to the temperature of the liquid nitrogen. The Stirling cryocooler with the rotary compressor is applicable to the cooling device for the compact mobile htermal imaging system, because the cryocoolers have the compact structure and light weight. This paper presents design, manufacturing process and test results in the optimum design and operating condition for the rotary type Stirling cryocooler designed and manufactured by Korea Institute of Machinery & Materials(KIMM). The performance of rotary type Stirling cryocooler is evaluated as a function of charging pressure, piston diameter, and piston displacement. The prototype has achieved no load temperature of 50 K and cooling capacity of 0.6 W at 80 K for 20 W of input power.
박성제(SeongJe Park),홍용주(YongJu Hong),김효봉(HyoBong Kim),염한길(HanKil Yeom) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.11
Stirling cryocoolers have been widely used for the cooling of infrared sensors and high temperature superconducting filters to the temperature of the liquid nitrogen. The Stirling cryocooler with the rotary compressor is applicable to the cooling device for the compact mobile thermal imaging system, because the refrigerators have the compact structure and light weight. In this paper, integral Stirling cryocooler is designed, manufactured and fabricated, and performance characteristics are investigated. This cooler delivers approximately 0.6W cooling at 80K for 21W of input power from 24V DC power supply.
박성제(SeongJe Park),홍용주(YongJu Hong),김효봉(HyoBong Kim),김양훈(YangHun Kim),나종문(JongMoon Na) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5
A Stirling cryocooler is relatively compact, reliable, commercially available, and uses helium as a working fluid. Over the past decade and a half there has been rapid development of Stirling cryocoolers, mainly for military and space applications. Stirling cryocoolers have been widely used for the cooling of infrared sensors and high temperature superconducting filters to the temperature of the liquid nitrogen. The Stirling cryocooler with the rotary compressor is applicable to the cooling device for the compact mobile thermal imaging system, because the refrigerators have the compact structure and light weight. This paper presents design and operating process of the integral Stirling cryocooler and results obtained with the performance test for integral Stirling cryocooler. An experimental study will be carried out to develop the more efficient and reliable integral Stirling cryocooler.
LNG 및 극저온 기계기술 시험인증센터 구축 및 시험절차
박성제(Seongje Park),고준석(Junseok Ko),홍용주(Yongju Hong),김효봉(Hyobong Kim),고득용(Deukyong Koh),염한길(Hankil Yeom),김기덕(Kideok Kim) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
This paper describes some of the issues associated with LNG & cryogenic equipment test and evaluation center. The natural gas is stored and transported in a liquid state because its liquid density is 600 times greater than gas density. The storage and transportation of LNG (Liquified Natural Gas) are accompanied with cryogenic cooling processes which require various cryogenic equipments including compressor, pump, valve, heat exchanger and auxiliary components. LNG & cryogenic equipment test and evaluation center will fill the role of test and evaluation of these cryogenic equipments. In addition, its role will be extened to the cryogenic equipment for the other cryogenic field. LNG & cryogenic equipment test and evaluation center will be designed and established by KIMM (Korea Institute of Machinery & Materials) in cooperation with Gyeongnam Technopark, Gimhae city and Gyeongsangnam-do.