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역사적 도심지구내 거주동향에 관한 조사연구 : 청주시 성안동, 중앙동의 사례에서 In Case Seongan-dong and Jungang-dong in Cheongju City
정세림,원세용,이훈,김태영 대한건축학회 2003 대한건축학회논문집 Vol.19 No.1
This study aims to find out detailed status goes on movement of residents in traditional urban area focused the case of Seongan-dong, Juangang-dong in Cheongju City of Korea. As the result, the summaries of finding are as follows : 1. The short-term households usually inhabit in traditional urban area for a short while of less than 4 years. Approximately half(45%) of them are single persons. 2. The long-term households usually inhabit in the same area at here for a long while such as ten or twenty years and have become considerable portion in the district which could not be disregarded as family type. 3. The short-term households of more than 5 year's residence can be regarded as family type. How to improve residential context and housing type is demanded absolutely for households to promote the habitat in traditional residential urban area.
서희돈,이동원,손미정,최세곤 嶺南大學校 工業技術硏究所 1998 工業技術硏究所論文集 Vol.26 No.1
This paper describes structural characteristics of three kinds of piezoresistive pressure sensors, which include wheatstone-bridge type, center-boss type and single-element type, fabricated on one-chip by batch process. In order to optimize device dimensions with respect to the desired characteristics, analytical formula and finited-element modeling(FEM) are used in design process. In experiments the pressure sensitivity of wheatstone-bridge type is about 2.2㎷/V·㎪. The fabricated center-boss pressure sensor has improved in the characteristics as linearity at low pressure, and sensitivity is about 2.415㎷/V·㎪. In single-element type with a four-terminal gauge using shear stress, the maximum sensitivity about 0.4㎷/V·㎪ appeared at the center of the diaphragm with the 3:1 of the length : width ratio. this type is very appropriate method to minimize the temperature dependance of the offset voltage and sensitivity, because the fabricated sensors reduce the offset of themal stress and mismatch of piezoresistros as compared with the wheatstone-bridge type.
Factors Affecting Periprosthetic Bone Loss after Hip Arthroplasty
( Se-won Lee ),( Weon-yoo Kim ),( Joo-hyoun Song ),( Jae-hoon Kim ),( Hwan-hee Lee ) 대한고관절학회 2021 Hip and Pelvis Vol.33 No.2
Periprosthetic bone loss may lead to major complications in hip arthroplasty, including aseptic loosening, implant migration, and even periprosthetic fracture. Such a complication leads to revision surgeries, which are expensive, technically demanding, and result in a low satisfaction rate. Therefore, a study was conducted of the factors affecting the periprosthetic bone loss around the stem that caused these complications. Factors influencing periprosthetic bone loss include demographic factors such as age, sex, obesity, smoking, and comorbidity including diabetes and osteoporosis. The implant design and fixation method are also factors that are determined before surgery. In addition, there are surgical factors, such as surgical approach and surgical technique, and we wish to investigate the factors affecting periprosthetic bone loss around the stem by comparing the effects of postoperative rehabilitation protocols and osteoporosis drugs.
Lee, Su Jin,Lee, Seon Young,Lee, Weon Sup,Yoo, Jin San,Sun, Jong-Mu,Lee, Jeeyun,Park, Se Hoon,Park, Joon Oh,Ahn, Myung-Ju,Lim, Ho Yeong,Kang, Won Ki,Park, Young Suk Springer US 2017 Investigational new drugs Vol.35 No.6
<P><B>Summary</B></P><P><I>Background</I> Tanibirumab is a fully human monoclonal antibody to vascular endothelial growth factor receptor 2 (VEGFR-2). We conducted a first-in-human phase I study of tanibirumab in patients with solid tumors refractory to standard chemotherapy. Primary endpoints were evaluating safety, pharmacokinetics (PKs), estimating maximum-tolerated dose (MTD) and recommended phase II dose (RP2D). <I>Methods</I> We designed our study to escalate tanibirumab at 9 different dose levels with a 3 + 3 method and tanibirumab (1–28 mg/kg) was administered intravenously on D1, 8, 15 in 28-day courses. Dose limiting toxicities (DLTs) were only assessed during the first cycle of treatment and response evaluation was performed every 2 cycles. The effects of tanibirumab on several angiogenic factors were analyzed. <I>Results</I> From October 2011 to September 2013, a total of 26 patients with refractory solid tumors were enrolled. The median age was 58 years (range, 27–75) and 20 patients were male. The most common tumor type was colorectal cancer (<I>N</I> = 19) and seven patients had a history of previous bevacizumab treatment. As hemangioma continued to occur, the final dose level, 28 mg/kg, was not performed. DLTs were not found, and the MTD was confirmed to be 24 mg/kg. Hemangioma was observed in 16 patients (61.5%), but all were grade 1–2 and disappeared after discontinuation of the study drug. Among the 18 patients in the efficacy set, no objective response was observed, but 11 patients showed stable disease. PKs were characterized by dose-dependent linear exposure and the mean trough concentrations exceeded biologically relevant target levels at 12 mg/kg and above. Serum VEGF, soluble VEGFR-2, and PlGF increased at the 4 mg/kg dose level and above. <I>Conclusions</I> Treatment with tanibirumab showed a tolerable toxicity profile and modest clinical efficacy in patients with refractory solid tumors. A phase II trial of tanibirumab is ongoing now.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s10637-017-0463-y) contains supplementary material, which is available to authorized users.</P>
이국세(Lee Kook-Se),이장원(Lee Jang-Weon) 한국방송·미디어공학회 2012 한국방송공학회 학술발표대회 논문집 Vol.2012 No.11
이 논문은 LED 조명을 방송용 광원으로 실용화하는 과정에서 필수적으로 고려해야 할 기술적 측면에 대한 고찰이다. 방송용 LED 광원의 실용화를 위한 기술적 개발은 사실적이고 자연스러운 영상, 특히 방송 영상의 대부분을 차지하는 인물의 얼굴색을 사실적으로 재현하는 것을 목표로 한다. 이 목표를 달성하려면 LED 조명의 고효율과 분광분포 특성이 최대한으로 자연광에 가까워야 한다. LED를 스튜디오 방송조명의 광원으로 활용하기 위해서는 조도, 연색성, 색온도, 색공간, 디밍 커브, 배광곡선, 소음과 관계한 구체적인 기술적 특성이 요구되고 있다.