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Germ free mice are susceptible to gastric cancer induced by N-methyl-N-nitrosourea
Jiseon Kim,Chanyang Uhm,Buhyun Lee,Haengdueng Jeong,Kwan H Kim,Sung Hee Kim,Yura Lee,Sumin Hur,Donghun Jeon,Nakyum Lee,Yejin Cho,Yeseul Oh,Kyunghee Nam,Mina Lee,Ki Taek Nam 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.1
( Jee-hyun Hwang ),( Haengdueng Jeong ),( Nahyun Lee ),( Sumin Hur ),( Nakyum Lee ),( Jeong Jun Han ),( Hye Won Jang ),( Wang Keun Choi ),( Ki Taek Nam ),( Kyung-min Lim ) 한국피부장벽학회 2021 한국피부장벽학회지 Vol.23 No.2
Since the European Union (EU) announced their animal testing ban in 2013, all animal experiments related to cosmetics have been prohibited. Here, we investigated whether an ex vivo live porcine skin model can be employed to study the safety and skin barrier-improving effects of hydroxyacids widely used in cosmetics for keratolytic peels. Glycolic acid (1-10%), salicylic acid (0.2-2%), and lactobionic acid (1.2-12%) were used as representative substances for α-hydroxyacid (AHA), β-hydroxyacid (BHA), and polyhydroxyacid (PHA), respectively. When hydroxyacids were applied at high concentrations on the porcine skin every other day for 6 days, tissue viability was reduced to 50-80%, suggesting that the toxicity of cosmetic ingredients can be evaluated with this model. Based on tissue viability, the treatment scheme was changed to a single exposure for 20 min. The protective effects of a single exposure of hydroxyacids on skin barrier function were evaluated by examining rhodamine permeability and epidermal structural components of barrier function using immunohistochemistry (IHC) and immunofluorescence (IF) staining. Lactobionic acid (PHAs) improved skin barrier function most compared to other AHAs and BHAs. Most importantly, trans-epidermal water loss (TEWL), an important functional marker of skin barrier function, could be measured with this model, which confirmed the significant skin barrier-protective effects of PHAs. Collectively, we demonstrated that the ex vivo live full-thickness porcine skin model can be an excellent alternative to animal experiments for skin studies on the safety and efficacy of cosmetic ingredients. Funding: This study was funded by the Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant no. HP20C0061).
복합사고 경감을 위한 안전사업지구 선정지표 및 가중치 개발
신진동(Jindong Shin),손지현(Jeehyun Sohn),이향이(Hyangee Lee),유나겸(Nakyum Yoo),김윤태(Yuntae Kim) 한국방재학회 2024 한국방재학회논문집 Vol.24 No.4
안전사업지구는 공간 단위 안전관리의 한 방법으로, 지속성을 위해 유사제도와 차별성이 요구된다. 이에 본 연구는 브레인스토밍 과 계층분석기법(AHP)을 활용하여 안전사업지구 선정 시 우선적으로 고려되어야 할 사항을 중심으로 선정지표 및 가중치를 개발하였다. 연구결과 첫 번째, 복합사고의 경감 및 대응을 통해 기존 유사제도와의 명확한 차별성과 사업의 효율성도 높이는 방법이 제안되었다. 두 번째, 자율성, 실효성, 연계성 관점에서 6가지 차별화 방안이 도출되었다. 세 번째, 선정지표는 차별성과 연계된 4개 항목 8개 선정지표로 구성되고 지표별 가중치가 산출되어 중요도가 개발되었다. 이를 통하여 복합사고에 취약한 지구를 안전사업지구로 지정하고 위험성을 경감할 수 있을 것이다. This study aims to develop indicators for selecting safety project districts based on a safety index diagnosis. Safety project districts provide a method of space-level safety management that must be distinct from other similar systems for sustainability. Using brainstorming and AHP, the study recommends the following. First, an approach is proposed to clearly differentiate these districts from similar existing systems, enhancing the efficiency of the project by reducing and addressing complex accidents. Second, six differentiation measures are proposed, focusing on autonomy, effectiveness, and connectivity. Third, the selection index consists of eight detailed selection indicators for four items related to differentiation, analyzed based on the importance of each indicator. This framework will make it possible to designate districts vulnerable to complex accidents as safe business districts, thereby reducing risks.