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JPEG 이미지 압축정보를 이용한 이미지 유포 기기 특정 방안 연구
허욱(Uk Hur),김소람(Soram Kim),박은후(Eunhu Park),신수민(Sumin Shin),김종성(Jongsung Kim) 한국디지털포렌식학회 2020 디지털 포렌식 연구 Vol.14 No.1
모바일 인스턴트 메신저가 대중화되면서 별도의 사용요금 없이 사진 및 영상 파일의 공유가 가능하다. 이에 따라 인스턴트 메신저를 불법 촬영된 음란물 및 기밀자료 유출에 활용하는 사례가 다수 존재한다. 그러나 데이터 수집은 사용자의 개인정보보호를 위하여 사건과 관련이 있는 데이터만을 선별 후 수집해야 하므로 사건과의 관련성을 입증하지 못하면 압수수색영장이 발부되더라도 불가능하다. 따라서 사건과 직접적으로 관련된 미디어 파일 데이터로부터 유포 기기를 특정하는 기술은 메신저 데이터가 사건과 연관되어 있음을 증명할 수 있으므로 디지털 수사에 유용하게 활용할 수 있다. 본 논문에서는 가장 보편적으로 사용되는 이미지 압축 포맷인 JPEG의 압축정보를 이용하여 이미지 전송에 사용된 메신저를 특정하는 연구를 진행하였다. 또한, 메신저 외에도 MMS(Multimedia Message Service)로 전송된 이미지로부터 스마트폰의 제조사를 특정하는 연구를 추가로 진행하였다. With the popularization of mobile instant messenger, photo and video files can be shared without any additional fee. Therefore, a number of cases using instant messengers for spread of illegally pornography and leakage of confidential information are exists. However, in order to protect the personal information, only the selective acquisition related to the case should be required. Even if the seizure search warrant is issued, the data cannot be collected arbitrarily. Therefore, the technique of identifying the distribution device from the media file data that the messenger data is related to the case can be useful for digital investigation. In this paper, we analyze the MMS (Multimedia Message Service) as well as the messenger used for image transmission using compressed information of JPEG, the most commonly used image compression format. Based on experimental results, we propose the method to specify the manufacturer of the smartphone using transferred image.
A New Murine Liver Fibrosis Model Induced by Polyhexamethylene Guanidine-Phosphate
Kim Minjeong,Hur Sumin,김광휘,Cho Yejin,Kim Keunyoung,Kim Ha Ryong,남기택,Lim Kyung-Min 한국응용약물학회 2022 Biomolecules & Therapeutics(구 응용약물학회지) Vol.30 No.2
Liver fibrosis is part of the wound healing process to help the liver recover from the injuries caused by various liver-damaging insults. However, liver fibrosis often progresses to life-threatening cirrhosis and hepatocellular carcinoma. To overcome the limitations of current in vivo liver fibrosis models for studying the pathophysiology of liver fibrosis and establishing effective treatment strategies, we developed a new mouse model of liver fibrosis using polyhexamethylene guanidine phosphate (PHMG-p), a humidifier sterilizer known to induce lung fibrosis in humans. Male C57/BL6 mice were intraperitoneally injected with PHMG-p (0.03% and 0.1%) twice a week for 5 weeks. Subsequently, liver tissues were examined histologically and RNA-sequencing was performed to evaluate the expression of key genes and pathways affected by PHMG-p. PHMG-p injection resulted in body weight loss of ~15% and worsening of physical condition. Necropsy revealed diffuse fibrotic lesions in the liver with no effect on the lungs. Histology, collagen staining, immunohistochemistry for smooth muscle actin and collagen, and polymerase chain reaction analysis of fibrotic genes revealed that PHMG-p induced liver fibrosis in the peri-central, peri-portal, and capsule regions. RNA-sequencing revealed that PHMG-p affected several pathways associated with human liver fibrosis, especially with upregulation of lumican and IRAK3, and downregulation of GSTp1 and GSTp2, which are closely involved in liver fibrosis pathogenesis. Collectively we demonstrated that the PHMG-p-induced liver fibrosis model can be employed to study human liver fibrosis.
( Jee-hyun Hwang ),( Haengdueng Jeong ),( Nahyun Lee ),( Sumin Hur ),( Nakyum Lee ),( Jeong Jun Han ),( Hye Won Jang ),( Wang Keun Choi ),( Ki Taek Nam ),( Kyung-min Lim ) 한국피부장벽학회 2021 한국피부장벽학회지 Vol.23 No.2
Since the European Union (EU) announced their animal testing ban in 2013, all animal experiments related to cosmetics have been prohibited. Here, we investigated whether an ex vivo live porcine skin model can be employed to study the safety and skin barrier-improving effects of hydroxyacids widely used in cosmetics for keratolytic peels. Glycolic acid (1-10%), salicylic acid (0.2-2%), and lactobionic acid (1.2-12%) were used as representative substances for α-hydroxyacid (AHA), β-hydroxyacid (BHA), and polyhydroxyacid (PHA), respectively. When hydroxyacids were applied at high concentrations on the porcine skin every other day for 6 days, tissue viability was reduced to 50-80%, suggesting that the toxicity of cosmetic ingredients can be evaluated with this model. Based on tissue viability, the treatment scheme was changed to a single exposure for 20 min. The protective effects of a single exposure of hydroxyacids on skin barrier function were evaluated by examining rhodamine permeability and epidermal structural components of barrier function using immunohistochemistry (IHC) and immunofluorescence (IF) staining. Lactobionic acid (PHAs) improved skin barrier function most compared to other AHAs and BHAs. Most importantly, trans-epidermal water loss (TEWL), an important functional marker of skin barrier function, could be measured with this model, which confirmed the significant skin barrier-protective effects of PHAs. Collectively, we demonstrated that the ex vivo live full-thickness porcine skin model can be an excellent alternative to animal experiments for skin studies on the safety and efficacy of cosmetic ingredients. Funding: This study was funded by the Health Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant no. HP20C0061).
Germ free mice are susceptible to gastric cancer induced by N-methyl-N-nitrosourea
Jiseon Kim,Chanyang Uhm,Buhyun Lee,Haengdueng Jeong,Kwan H Kim,Sung Hee Kim,Yura Lee,Sumin Hur,Donghun Jeon,Nakyum Lee,Yejin Cho,Yeseul Oh,Kyunghee Nam,Mina Lee,Ki Taek Nam 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.1