수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력에 미치는 영향

김미경 ( Kim¸ Mikyung ),한혜숙 ( Han¸ Hyesook ) 한국수학교육학회 2021 수학교육논문집 Vol.35 No.3

본 연구는 수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력에 미치는 영향을 파악하기 위하여 대학 연계 자유학기제 융합수학탐구 수업에 신청한 49명의 학생들을 대상으로 단일집단 사전-사후 검사 설계를 통해 한 학기동안 이루어졌다. 본 연구의 주요 결과는 다음과 같다. 첫째, 사전, 사후 수학적 모델링 능력 검사 결과에 의하면, 사전 검사에 비해서 사후 수학적 모델링 검사의 평균 점수가 향상되었고, 사전, 사후 검사 간에 통계적으로 유의미한 차이가 있는 것으로 나타나 본 연구에서 제공한 수학교과 중심의 STEAM 수업 경험이 중학교 1학년 학생들의 수학적 모델링 능력을 향상시키는데 긍정적인 영향을 준다는 것을 확인하였다. 둘째, 각 문항별 분석 결과에 의하면 STEAM 수업 경험은 학생들의 창의적 사고 및 열린 사고를 요구하는 개방성이 높은 수학적 모델링 문항의 해결에 더욱 효과적인 것으로 나타났다. 셋째, 하위문항별 학생 응답 내용 분석 결과에 의하면, STEAM 수업 경험이 특히 학생들의 수학적 모델 구성 및 결과에 대한 타당성 검토 과정을 더욱 활성화시킨 것으로 나타났다. This study was conducted for one semester through one group pretest-posttest design with 49 first-year middle school students to explore the effects of mathematics-centered STEAM class experiences on students’ mathematical modeling abilities. The main results of this study are as follows: First, the results of the pre and post-mathematical modeling ability tests showed that the average score of posttest was improved compared to the pretest, and that the experiences of mathematics-centered STEAM classes provided in this study had a positive effect on improving the mathematical modeling ability of first-year middle school students. Second, STEAM classes were more effective in solving mathematical modeling problems that require students’ creative and divergent thinking. Third, the content analysis of student responses for each subquestion showed that STEAM classes were especially more helpful in activating students' mathematical model construction and validating steps.

Effect of fermented porcine placenta on physical fatigue in mice

Kim, Hee-Yun,Han, Na-Ra,Kim, Na-Rae,Lee, Mikyung,Kim, Jongbae,Kim, Chang-Ju,Jeong, Hyun-Ja,Kim, Hyung-Min SAGE Publications 2016 Experimental biology and medicine Vol.241 No.17

<P>The fatigue spreads among the people who live under stressful life and brings about a negative impact on physical function. Here we evaluated the anti-fatigue effects of fermented porcine placenta (FPP) and main constituents, lysine (Lys) and leucine (Leu) with treadmill stress test and forced swimming test (FST) in animal models. The mice were administrated with FPP, Lys, and Leu for 21 days. After treadmill exercise, FPP, Lys, and Leu significantly reduced fatigue-related biochemical parameters, including lactate, lactate dehydrogenase, glucose, creatine kinase, urea nitrogen, cortisol, and pro-inflammatory cytokines, whereas superoxide dismutase activity and glycogen levels were significantly increased by FPP, Lys, and Leu. In the FST, FPP, Lys, and Leu significantly decreased immobility times and up-regulated brain-derived neurotrophic factor expression in brain. Furthermore, FPP, Lys, and Leu significantly decreased production of tumor necrosis factor-kappa B, interleukin (IL)-6, IL-1, and IL-4 through blockade of caspase-1/nuclear factor-B pathway in stimulated splenocytes. In addition, FPP, Lys, and Leu significantly promoted proliferation of splenocytes. In conclusion, these findings suggest the potential of FPP as a novel functional food for the regulation of fatigue.</P>

A Profile of Serum Mineral Parameters in Korean CKD Patients on Maintenance Hemodialysis

( Gheunho Kim ),( Bumsoon Choi ),( Daeryong Cha ),( Eunah Hwang ),( Hyungwuk Kim ),( Jaehyun Chang ),( Joohak Lee ),( Joongkyung Kim ),( Kwonwook Joo ),( Mikyung Kim ),( Sangchoel Lee ),( Sangwoong Ha 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1

Efficacy and safety of initial combination therapy with gemigliptin and metformin compared with monotherapy with either drug in patients with type 2 diabetes: A double‐blind randomized controlled trial ( INICOM study)

Lim, Soo,Han, Kyung Ah,Yu, JaeMyung,Chamnan, Parinya,Kim, Eun Sook,Yoon, Kun‐,Ho,Kwon, Sam,Moon, Min Kyong,Lee, Kwan Woo,Kim, Dong‐,Jun,Kim, Mikyung,Wongtanate, Manaj,Kim, Eun Young,Kim, S Blackwell Publishing Ltd 2017 Diabetes, obesity & metabolism Vol.19 No.1

<P><B>Background</B></P><P>Gemigliptin is a new dipeptidyl peptidase‐IV inhibitor. We investigated the efficacy and safety of initial combination therapy with gemigliptin and metformin compared with monotherapy with either drug in patients with type 2 diabetes (T2D).</P><P><B>Methods</B></P><P>A total of 433 T2D patients with a glycosylated haemoglobin (HbA1c) level of 7.5% to 11.0% and a fasting plasma glucose (FPG) concentration <270 mg/dL were randomly assigned to 3 groups: (1) gemigliptin 50 mg qd + metformin 1000 to 2000 mg qd (titrated individually), (2) gemigliptin 50 mg qd, or (3) metformin 1000 to 2000 mg qd. The primary end‐point was the change in HbA1c level after 24 weeks. Secondary end‐points were the changes in FPG, insulin, proinsulin and C‐peptide levels. The percentages of responders who achieved an HbA1c level <7% (or <6.5%) were compared between treatment groups.</P><P><B>Results</B></P><P>Baseline HbA1c levels were 8.7% in all groups. The mean changes in HbA1c level from baseline to week 24 were −2.06%, −1.24% and −1.47% in the combination, gemigliptin monotherapy and metformin monotherapy groups, respectively. The 95% confidence intervals for between‐group differences in HbA1c changes were −1.02 to −0.63 in the combination group vs the gemigliptin group and −0.82 to −0.41 vs the metformin group, which confirmed the superiority of combination therapy. A significantly higher percentage of patients in the combination therapy group reached the target HbA1c level <7% (or <6.5%) compared with the monotherapy groups. No severe side effects were observed.</P><P><B>Conclusions</B></P><P>In T2D patients, the initial combination of gemigliptin and metformin had superior efficacy without safety concerns compared with monotherapy with either drug.</P>

NADPH Oxidase and the Cardiovascular Toxicity Associated with Smoking

Kim, Mikyung,Han, Chang-Ho,Lee, Moo-Yeol Korean Society of ToxicologyKorea Environmental Mu 2014 Toxicological Research Vol.30 No.3

Smoking is one of the most serious but preventable causes of cardiovascular disease (CVD). Key aspects of pathological process associated with smoking include endothelial dysfunction, a prothrombotic state, inflammation, altered lipid metabolism, and hypoxia. Multiple molecular events are involved in smoking-induced CVD. However, the dysregulations of reactive oxygen species (ROS) generation and metabolism mainly contribute to the development of diverse CVDs, and NADPH oxidase (NOX) has been established as a source of ROS responsible for the pathogenesis of CVD. NOX activation and resultant ROS production by cigarette smoke (CS) treatment have been widely observed in isolated blood vessels and cultured vascular cells, including endothelial and smooth muscle cells. NOX-mediated oxidative stress has also been demonstrated in animal studies. Of the various NOX isoforms, NOX2 has been reported to mediate ROS generation by CS, but other isoforms were not tested thoroughly. Of the many CS constituents, nicotine, methyl vinyl ketone, and ${\alpha}$,${\beta}$-unsaturated aldehydes, such as, acrolein and crotonaldehyde, appear to be primarily responsible for NOX-mediated cytotoxicity, but additional validation will be needed. Human epidemiological studies have reported relationships between polymorphisms in the CYBA gene encoding p22phox, a catalytic subunit of NOX and susceptibility to smoking-related CVDs. In particular, G allele carriers of A640G and $-930^{A/G}$ polymorphisms were found to be vulnerable to smoking-induced cardiovascular toxicity, but results for C242T studies are conflicting. On the whole, evidence implicates the etiological role of NOX in smoking-induced CVD, but the clinical relevance of NOX activation by smoking and its contribution to CVD require further validation in human studies. A detailed understanding of the role of NOX would be helpful to assess the risk of smoking to human health, to define high-risk subgroups, and to develop strategies to prevent or treat smoking-induced CVD.

Reply to “The discussion on the validity of sham controls and patient blinding in a sham-controlled acupuncture trial”

Kim Mikyung,Kwon O-Jin,Lee Jun-Hwan,Kim Joo-Hee 한국한의학연구원 2022 Integrative Medicine Research Vol.11 No.2

Role of Self-Control in Developing Self-Directed Christian Young Children

Mikyung Kim CHONGSHIN UNIVERSITY 2013 CHONGSHIN REVIEW Vol.18 No.-

Current status of the spontaneous reporting and classification/coding system for herbal and traditional medicine in pharmacovigilance

Mikyung Kim,Yeonju Woo,한창호 한국한의학연구원 2021 Integrative Medicine Research Vol.10 No.1

Background: While the use of herbal and traditional medicine (H&TM) has been extensive worldwide, the current status of H&TM management in pharmacovigilance remains to be investigated. To date, there is little information regarding the use of the classification/coding system (CCS) to detect signals for certain drugs within databases built on the basis of the spontaneous reporting system (SRS). The purpose of this study is to investigate the status of the SRS and CCS for H&TM in the pharmacovigilance systems of various countries around the world. Methods: An e-mail survey was performed from late December 2018 to early January 2019 with 54 experts in pharmacovigilance. The results based on the information provided by the respondents were summarized. Results: Fourteen experts from 13 countries responded to the survey. Eleven countries/regions were found to already include H&TM in their SRSs, managing only limited range of H&TM. Of the 9 countries/regions that provided the information on the status of CCS for H&TM in their domestic pharmacovigilance systems, only China had a separate CCS for H&TM. Conclusion: Revising the current pharmacovigilance systems to include or expand the range of H&TM, and developing an internationally harmonized system to classify and code H&TM suitable to the unique characteristics of H&TM are critical and overall beneficial.

NADPH Oxidase and the Cardiovascular Toxicity Associated with Smoking

Mikyung Kim,Chang-ho Han,Moo-Yeol Lee 한국독성학회 2014 Toxicological Research Vol.30 No.3

Smoking is one of the most serious but preventable causes of cardiovascular disease (CVD). Key aspects of pathological process associated with smoking include endothelial dysfunction, a prothrombotic state, inflammation, altered lipid metabolism, and hypoxia. Multiple molecular events are involved in smokinginduced CVD. However, the dysregulations of reactive oxygen species (ROS) generation and metabolism mainly contribute to the development of diverse CVDs, and NADPH oxidase (NOX) has been established as a source of ROS responsible for the pathogenesis of CVD. NOX activation and resultant ROS production by cigarette smoke (CS) treatment have been widely observed in isolated blood vessels and cultured vascular cells, including endothelial and smooth muscle cells. NOX-mediated oxidative stress has also been demonstrated in animal studies. Of the various NOX isoforms, NOX2 has been reported to mediate ROS generation by CS, but other isoforms were not tested thoroughly. Of the many CS constituents, nicotine, methyl vinyl ketone, and α,β-unsaturated aldehydes, such as, acrolein and crotonaldehyde, appear to be primarily responsible for NOX-mediated cytotoxicity, but additional validation will be needed. Human epidemiological studies have reported relationships between polymorphisms in the CYBA gene encoding p22phox, a catalytic subunit of NOX and susceptibility to smoking-related CVDs. In particular, G allele carriers of A640G and -930<SUP>A/G</SUP> polymorphisms were found to be vulnerable to smoking-induced cardiovascular toxicity, but results for C242T studies are conflicting. On the whole, evidence implicates the etiological role of NOX in smoking-induced CVD, but the clinical relevance of NOX activation by smoking and its contribution to CVD require further validation in human studies. A detailed understanding of the role of NOX would be helpful to assess the risk of smoking to human health, to define high-risk subgroups, and to develop strategies to prevent or treat smoking-induced CVD.

Effects of Abdominal Isolation and 20-Hydroxyecdysone During Development of Bombyx mori Ventral Nerve Cord

KIM, Mikyung,YUN, Chi-Young,KIM, Hak-Ryul 대전대학교 이과대학 기초과학연구소 1997 自然科學 Vol.- No.-

누에나방(Bombyx mori)의 각 신경절에 존재하는 신경세포의 분포를 toludine blue 염색법과 hematoxylin-eosin 염색법을 이용하여 확인하였다. 또한 신경계 발달과정에서각 복부 신경절에 존재하는 신경세포수의 변화를 조사해 본 결과, 유충에서 번데기로 전환되는 시기와 번데기 말기에서 성충으로 전환되는 시기에 뚜렷한 신경세포 소실시기가 관찰되었다. 이러한 신경세포 소실이 흉부 또는 뇌에서 기인되는 인자에 의해 조절되는가를 조사하기 위해 복부결절을 시행한 결과 신경세포소실이 현저히 억제된 것을 알수 있었다. 또한 신경세포 소실에서 steoid hormone의 효과를 조사하기 위해 B. mori의 흉부 측면에 주사한 결과 신경세포소실이 억제되었다. Total numbers of neuron from last instar larvae to adults in Bombyx mori abdominal ganglion were investigated to elucidate patterns of neuronal fluctuation during life cycle. Two periods in reduction of neuronal numbers were present; the larval- pupal transition and the pupal-adult transition. To eliminate the factor originating from thorax and head, abdominal isolation was conducted. Neuronal cell death on abdominal ganglion (A₃) was significantly delayed. To study the interaction between cell death and 20- hydroxyecdysone (20-HE), 20-HE was injected into lateral part of thorax every 12 hours for three days. Neuronal cell death was significantly delayed by 20-HE injection.