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( Sang Jik Lee ),( Toshitaka Nakamura ),( Hyung Ryul Kim ),( Masashige Suzuki ) 한국스포츠정책과학원(구 한국스포츠개발원) 2003 International Journal of Applied Sports Sciences Vol.15 No.1
Effects of strenuous resistance exercise training on hindlimb bone formation and resorption were studied in growing male rats. Fifty-three Sprague-Dawley rats, 5 weeks of age, were assigned to control and training groups. Resistance training consisted of squatting at 75% of one repetition maximum for 150 squat/day and 3 days/week for 8 weeks. Animals were sacrificed at 0 (start), 4, and 8 weeks of the training period. Bone mineral value was measured in the femur middiaphysis and the tibia proximal metaphysis by DXA(Dual energy X-ray absorptiometry). Using histomorphometric analysis, bone mass, structure and bone cellular parameters were estimated in secondary spongiosa of the tibial metaphysis and in periosteal and endocortical site of midfemur. As compared with the age-matched control group, significant increases in bone mineral content (BMC) and bone mineral density (BMD) in femur and tibia were apparent after 4 weeks of resistance training. In tibial proximal metaphysis, bone formation rate/bone volume (BFR/BV) significantly increased after 4 weeks of resistance training but the number of osteoclast number/bone surface (Oc.N/BS) and osteoclast surface/bone surface (Oc.S/BS) was significantly decreased. In femoral middiaphysis, endocortical mineral apposition rate (MAR) significantly decreased after 4 weeks of resistance training, leading to an enlargement of bone marrow area. On the contrary, periosteal MAR and BFR/BV were increased, resulting in increased cross-sectional and cortical bone area. In conclusion, resistance training in young growing rats (1) increased bone formation and decreased bone resorption in the tibial metaphysis, and (2) enhanced the exercise-induced cortical modeling drift in midfemur.
성장기 수컷 흰쥐의 레지스턴스 운동에 의한 골형성증가 및 피질골 형태변화를 유도
이상직 ( Sang Jik Lee ),김형렬 ( Hyung Ryul Kim ),토시타카나카무라 ( Toshitaka Nakamura ),마사시게스즈키 ( Masashige Suzuki ) 한국스포츠정책과학원(구 한국스포츠개발원) 2002 체육과학연구 Vol.13 No.3
본 연구는 격렬한 레지스턴스 운동이 성장기 수컷 흰쥐의 하지 골형성 및 골흡수에 미치는 영향에 관해서 검토되었다. 5주령된 SD계 수컷 흰쥐 53마리를 이용하여 대조군과 운동군으로 구분하였다. 레지스턴스 운동은 최대근력의 75%강도, 주 3회, 8주 동안의 트레이닝을 흰쥐에 부하 하였다. 실험 전, 실험시작 4주, 8주 후에 흰쥐를 도살하여 대퇴골 및 경골을 적출 한 후 대퇴골의 골간부 및 경골단면의 골밀도는 DXA로서 측정하였다. 형태계측법을 통하여 경골단면의 2차 스폰자상 및 대퇴골 골간부 내막과 외막의 골량, 미세구조, 골세포관련 항목을 분석하였다. 그 결과 4주간의 레지스턴스 운동에 의해 대퇴골 및 경골의 골미네랄 및 골밀도는 대조군에 비해 유의한 증가를 가져왔다. 또한 경골단면의 골형성률이 4주간의 레지스턴스 운동에 의해 유의하게 증가하였으나 파골세포의 활성(Oc.N/BS. Oc.S/BS)은 유의한 감소를 나타내었다. 대퇴골 골간부의 내막에서는 4주간의 레지스턴스 운동에 의해 골미네랄 침착률이 감소하여 골수공(내경)이 확장하는 결과를 보였다. 그러나 외막에서는 골미네랄 침착률, 골형성률의 증가로 인하여 골횡단면적 및 피질골 면적이 넓어지는 결과(외경의 확대)를 나타내었다. 결론적으로 (1) 성장기 흰쥐의 레지스턴스 운동은 경골단면의 골형성 증가 및 골흡수 감소를 유도하고 (2) 대퇴골 골간부의 운동유발성 피질골 형태변화를 유도하였다. Effects of a strenuous resistance exercise training on hindlimb bone formation and resorption were studied in growing male rats. Fifty-three Sprague-Dawley rats, 5 weeks of age, were assigned to control and training group. Resistance training consisted of squatting at 75% of one repetition maximum for 150 squat/day and 3 days/week for 8 weeks. Animals were sacrificed at 0 (start), 4, and 8 weeks of the training period. Bone mineral value was measured in the femur middiaphysis and the tibia proximal metaphysis by DXA(Dual energy X-ray absorptiometry). Using histomorphometric analysis, bone mass, structure and bone cellular parameters were estimated in secondary spongiosa of the tibial metaphysis and in periosteal and endocortical site of midfemur. As compared with the age-matched control group, significant increases in bone mineral content (BMC) and bone mineral density (BMD) in femur and tibia were apparent after 4 weeks of resistance training. In tibial proximal metaphysis, bone formation rate/bone volume (BFR/BV) significantly increased after 4 weeks of resistance training but the number of osteoclast number/bone surface (Oc.N/BS) and osteoclast surface/bone surface (Oc.S/BS) was significantly decreased. In femoral middiaphysis, endocortical mineral apposition rate (MAR) significantly decreased after 4 weeks of resistance training, leading to an enlargement of bone marrow area. On the contrary, periosteal MAR and BFR/BV were increased resulting in increased cross-sectional and cortical bone area. In conclusion, resistance training in young growing rats (1) increased bone formation and decreased bone resorption in the tibial metaphysis, and (2) enhanced the exercise-induced cortical modeling drift in midfemur.
자연과학편 : Capsaicin의 투여가 안정시 및 운동시의 에너지 기질 이용에 미치는 영향
임기원(KiWonLim),김규완(DewWanKim),서혜정(HeaJungSuh),이수천(SooChunLee),( Mayumi Yoshioka ),( Shinichi Saitoh ),( Masashige Suzuki ) 한국체육학회 1995 한국체육학회지 Vol.34 No.3
본 연구는 capsaicin의 투여가 안정시 및 운동시의 에너지 기질 이용에 미치는 영향을 검토하기 위하여 Sprague-Dawley계 수컷 45마리의 rat을 이용하여 수행되었다. 3주간의 예비사육 기간 중 실험동물용 treadmill을 이용하여 running 운동에 적응시킨다.실험 최종일에 비처리군(non-treatment), 안정대조군(sedentary control), 운동대조군(exercise control), 안정CAP군(sedentary-CAP), 안정CAP군(exercise-CAP) 등 5개군으로 나누었다. CAP군에는 체중 ㎏ 당 6㎎의 capsaicin을 복강내주사하였고, 대조군에는 僞藥을 주사하였다. 운둥군은 주사직후 27m/min의 강도로 running운동을 부하하여 운동 1시간 후 및 2시간 후에 도살하여 분석에 이용하였고, 안정군은 동일시간에 사육상자에서 안정을 취한 후 도살하였다.운동 1시간 후 및 2시간 후의 혈장포도당의 농도는 exercise-control군에 비하여 exercise-capsaicin군에서 높았으나, 유의한 차는 없었다. 혈장유리지방산과 간 및 가자미근의 글리코겐함량은 각 군간의 유의차는 없었다. 한편, 운동 2시간 후의 비복근 글리코겐 함량은 대조군(exercise-control)에 비하며 CAP군(exercise-capsaicin)에서 유의하게 높았다.운동시의 capsaicin의 주사는 basal lipolytic activity는 증가시켰으나, epinephrine-stimulate activeity에는 capsaicin의 투여효과가 나타나지 않았다.이상의 결과에서, 실험쥐에 있어서 capsaicin의 투여는 운동시의 에너지원으로 지방 동원을 증가시켜 근육의 글리코겐 절약효과(glycogen-sparing effect) 가 있는 것으로 시사되었다. This study investigated the effect of capsaicin on carbohydrate and lipid metabolism at rest and during exercise in rats. Forty-five male Sprague-Dawley rats were trained by treadmill running for 3 wk. On the final day of the experiment, the rats were divided into 5 groups: non-treatment, sedentary-control, sedentary-capsaicin, exercise-control, and exercise-capsaicin. Rats were kept sedentary or given a treadmill-running for 1 or 2 h after the intraperitoneally injection of capsaicin or vehicle. Plasma glucose concentration tended to be higher in exercise-capsaicin group than in exercise-control group, but no significant difference was found. In the plasma free fatty acid concentration and the glycogen levels in the liver and the soleus muscle, there was no significant capsaicin effect. The glycogen levels in the red and white gastrocnemius muscles tended to be higher in the capsaicin groups than in control groups, and this tendency wasy observed only in exercised groups at 2 h after the injection. The basal lipolysis in epididymal adipose tissue at 1 h after the injection was significantly higher in the exercise-capsaicin group than in the exercise-control group. These results indicate that capsaicin might have a glycogen-sparing effect to promote the utilization of lipid from adipose tissue during exercise and that the effect of capsaicin during exercise seems to be different from those at rest.