A SIMPLE END CRINE DISRUPTING CHEMICALS MONITORING SYSTEM FOR A LANDFILL SITE BY MEDAKA (Oryzias latipes) FOR COEXISTENCE WITH THE LOCAL COMMUNITY

( Makiko Tanaka ),( Kazuhiko Fukatsu ),( Ryota Shinohara ),( Koji Arizono ),( Hiroshi Ishibashi ),( Masataka Hanashima ),( Sotarou Higuchi ),( Keijirou Tomoda ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.1

Our study aims to establish a practical monitoring system by using Japanese Medaka (Oryzias latipes) for drainage from a landfill site and the environment around it. The monitoring system consists of 2 phases. The first phase is water testes, and the second phase is ecological monitoring. In this paper, we reported the first phase. We carried out the first phase experiment using untreated leachate and treated leachate processed by 3 types of advanced processes (Electric dialysis, RO, and DT module system). Untreated and treated leachate from the processing plant, Wakamatsu-ku, Kitakyushu city, Japan was used. The test items were acute toxicity of embryo, juvenile and adult, fecundity, and vitellogenesis as an estrogenic activity. Toxicity of leachate increased according to TOC concentration. Juvenile of Medaka was a very useful indicator of the toxicity of the leachate. No vitellogenin was induced after 2 weeks exposure to untreated leachate, although suspected EDCs were detected by GC/MS or targeted analysis. HSI increased in the case of exposure to diluted leachate (TOC concentration, 107, 214 mg/1). As the leachate has strong complex toxicities, it is difficult to evaluate the leachate by vitellogenin inducing only. Fecundity and vitellogenesis ware not effected by exposure to 2% concentration of leachate for 1 and 2 weeks exposure. Advanced treated leachate induced no acute toxicity, vitelogenesis, and reproduction.

송사리(Oryzias latipes)를 이용한 매립지에서의 내분비 교란물질 모니터링 시스템

( Makiko Tanaka ),( Kazuhiko Fukatsu ),( Ryota Shinohara ),( Koji Arizono ),( Hiroshi Ishibashi ),( Masataka Hanashima ),( Sotarou Higuchi ),( Keijirou Tomoda ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.2

본 논문의 목적은 매립지와 매립지 주변환경에 대해서 송사리를 사용하여 실제 내분비교란물질에 대한 모니터링 시스템을 수립하는데 있으며, 그 모니터링 시스템은 2개phase 구성되어 있다. 첫번째 phase는 물에 대한 실험이며, 두번째 phase는 생태적 모니터링이다. 본 논문에서는 첫번째 phase에 관해서 나타내었으며, 이 실험에서는 처리되지 않는 침출수와 고도 처리된3가지(전기투석, 역삼투압, DT module system)의 침출수를 사용하여 실험을 실시하였다. 이때의 침출수는 일본의 若 松區北九州市에 위치한 매립지의 침출수를 이용하였다. 실험항목은 송사리의 태아, 치어, 성어의 급성 독성, 송사리의 생산성, 에스트로젠 활성도로써의 vitellogenesis 실험을 실시하였으며, 침출수의 의독성은 TOC농도에 따라 증가하였다. 송사리의 치어는 침출수의 독성 지표로 유용하였다. 비록, GC/MS를 이용하여 EDCs로 의심되는 물질이 검출될지라도, 처리되지 않은 침출수로부터의 2주간 노출시 vitellogenin는 유도되지 않았다. HIS는 희석된 침출수 (TOC 농도 107, 214mg/l)에 노출시 증가하였다. 침출수는 강한 복합독성을 가지고 있으므로, 오직 vitellogenin 변형만으로 침출수를 평가하기에는 어려움을 가지고 있으며, 생상성과 vitellogenesis는 2%농도에서 1-2주일간의 노출시 어떤 영향도 없었다. 고도처리된 침출수는 급성독성, 생산성과 vitellogenesis의 변화가 없었다. Our study aims to establish a practical monitoring system by using Japanese Medaka (Oryzias latipes) for drainage from a landfill site and the environment around k. The monitoring system consists of 2 phases. The first phase is water testes, and the second phase is ecological monitoring. In this paper, we reported the first phase. We carried out the first phase experiment using untreated leachate and treated leachate processed by 3 types of advanced processes (Electric dialysis, RO, and DT module system). Untreated and treated leachate from the processing plant, Wakamatsu-ku, Kitakyushu city, Japan was used. The test items were acute toxicity of embryo, juvenile and adult, fecundity, and vitellogenesis as an estrogenic activity. Toxicity of leachate increased according to TOC concentration. Juvenile of Medaka was a very useful indicator of the toxicity of the leachate. No vitellogenin was induced after 2 weeks exposure to untreated leachate, although suspected EDCs were detected by GC/MS or targeted analysis. HSI increased in the case of exposure to diluted leachate (TOC concentration, 107, 214 mg/l). As the leachate has strong complex toxicities, it is difficult to evaluate the leachate by vitellogenin inducing only. Fecundity and vitellogenesis ware not effected by exposure to 2% concentration of leachate for 1 and 2 weeks exposure. Advanced treated leachate induced no acute toxicity, vitellogenesis, and reproduction.

Service Interaction Prediction Methods for Customized Specifications

Makiko Tomioka,Yukari Tanaka,Osamu Mizuno 한국통신학회 1995 Asia-Pacific Conference on Communications Vol.1 No.1

日米のspecial schoolにおける進路指導と Supported Employmentの制度 : 學校敎育におけるジョブコ一チ的支援の必要性 Needs for Skills of Job Coach in Special Schools

下地眞希子,田中敦士,韓昌完,知名靑子 우송대학교 2004 우송대학교 논문집 Vol.9 No.-

"Supported Employment" is a model for a partnership strategy, which will enable people with disabilities to achieve sustainable long-term employment and businesses to employ valuable workers. "Supported Employment" affords the public the opportunity to see the person for who they are rather than seeing the disability. A specialized trainer known as a job coach or employment specialist provides individualized training for the supported employee. Job coaches work with supervisors and coworkers to assure a successful job match. Once a supported employee is trained, the job coach slowly reduces their frequency of contact and presence in the workplace. Recently, job coach system established in Japan. However, it is for only person who graduated from school in Japan. We considered the present conditions and problems of "Supported Employment"

Folate-Related Nutrients, Genetic Polymorphisms, and Colorectal Cancer Risk: the Fukuoka Colorectal Cancer Study

Morita, Makiko,Yin, Guang,Yoshimitsu, Shin-Ichiro,Ohnaka, Keizo,Toyomura, Kengo,Kono, Suminori,Ueki, Takashi,Tanaka, Masao,Kakeji, Yoshihiro,Maehara, Yoshihiko,Okamura, Takeshi,Ikejiri, Koji,Futami, K Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11

One-carbon metabolism plays an important role in colorectal carcinogenesis. Meta-analyses have suggested protective associations of folate and vitamin $B_6$ intakes with colorectal cancer primarily based on studies in Caucasians, and genetic polymorphisms pertaining to the folate metabolism have been a matter of interest. Less investigated are the roles of methionine synthase (MTR) and thymidylate synthetase (TS) polymorphisms in colorectal carcinogenesis. In a study of 816 cases and 815 community controls in Japan, we investigated associations of dietary intakes of folate, methionine, vitamin $B_2$, vitamin $B_6$, and vitamin $B_{12}$ with colorectal cancer risk. The associations with MTR 2756A>G, MTRR 66A>G, and TSER repeat polymorphism were examined in 685 cases and 778 controls. Methionine and vitamin $B_{12}$ intakes were inversely associated with colorectal cancer risk, but the associations were totally confounded by dietary calcium and n-3 fatty acids. The other nutrients showed no association with the risk even without adjustment for calcium and n-3 fatty acids. The TSER 2R allele was dose-dependently associated with an increased risk. The MTR and MTRR polymorphisms were unrelated to colorectal cancer risk. There was no measurable gene-gene or gene-nutrient interaction, but increased risk associated with the TSER 2R allele seemed to be confined to individuals with high folate status. This study does not support protective associations for folate and vitamin $B_6$. The TSER 2R allele may confer an increased risk of colorectal cancer. The role of the TSER polymorphism in colorectal carcinogenesis may differ by ethnicity.

매립지 침출수 특성별 생분해 플라스틱의 분해작용

( Yasushi Matsufuji ),( Ayako Tachifuji ),( Makiko Tanaka ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.2

최근에 소각장은 다이옥신 최소배출가스를 고비용으로 처리하고 있다. 그러므로 지방정부는 플라스틱 소각장 대신에 경제적인 또한 안전한 처리체계가 필요하다. 이 연구는 생분해 플라스틱을 포함한 도시고형폐기물을 플라스틱에서 생분해플라스틱(BP)으로 대부분 전환한 후 매립지로 처분한 경우 이것의 해결책과 문제를 제기한다. 이 결과로부터 (1)BP의 증가로 매립지의 오염부하 (2) 이문제는 준호기성 매립형태와 예를들면 PLA로서 BP 가스화로서 해결한다. Recently, the incineration plant was integrated to satisfy the limit levels of Dioxins in emission and get more expensive. Therefore local government needs an economical and safety treatment system instead of incinerating waste plastics. This study provides the problems and its solutions in case that municipal solid waste including biodegradable plastics (BP) was disposed of in landfill after converting most of plastics to BP. From this result, it was clarified (i) the pollutant load in landfill increase by receiving BP, (ii) this problem is solved by selecting the semiaerobic landfill type and BP with high in gasification rate such as PLA.

INFLUENCE OF THE DECOMPOSITION OF BIODEGRADABLE PLASTIC ON LEACHATE QUALITY IN LANDFILLS

( Yasushi Matsutuji ),( Ayako Tachifuji ),( Makiko Tanaka ) 한국폐기물자원순환학회 2002 APLAS Vol.2002 No.1

Recently, the incineration plant was integrated to satisfy the limit levels of Dioxins in emission and get more expensive. Therefore local government needs an economical and safety treatment system instead of incinerating waste plastics. This study provides the problems and its solutions in case that municipal solid waste including biodegradable plastics (BP) was disposed of in landfill after converting most of plastics to BP. From this result, it was clarified (i) the pollutant load in landfill increase by receiving BP, (ii) this problem is solved by selecting the semiaerobic landfill type and BP with high in gasification rate such as PLA.

Effects of Sulfur Dioxide on Fractional Exhaled Nitric Oxide Concentration in the Child Residents of Miyakejima Island

Satoko Iwasawa,Tazuru Tsuboi,Makiko Nakano,Aya Hirata,Noriyuki Yoshioka,Satoko Suzuki,Shigeru Tanaka,Kazuyuki Omae 한국대기환경학회 2019 Asian Journal of Atmospheric Environment (AJAE) Vol.13 No.2

The island of Miyakejima in Japan is subject to ongoing emissions of volcanic gases, including high concentrations of sulfur dioxide (SO2). Annual health checkups on the island, therefore, include the examination of respiratory system parameters. Here, we aimed to investigate the relationship between SO2 exposure and fractional exhaled nitric oxide (FeNO) concentration among children who received health checkups from 2008 to 2014. The subjects were 83 and 31 second-year junior high school students aged 13-14 years who resided on Miyakejima island and an SO2-free reference island, respectively. SO2 concentration in the air was measured at 6 fixed-point monitoring stations. FeNO was examined according to the American Thoracic Society guideline and European Respiratory Society recommendations for standardized procedures. Average concentrations of SO2 on Miyakejima over a period of 3 months prior to each health checkup from 2008 to 2014 were 22.2, 20.6, 8.9, 10.5, 10.7, 4.4 and 8.0 ppb, respectively. Among the Miyakejima students, geometric mean (GM) FeNO concentrations measured at each health checkup from 2008 to 2014 were 28.2, 18.2, 23.6, 35.5, 36.9, 28.1, and 32.1 ppb. The GM FeNO concentration measured from all Miyakejima students across the study period was 28.3 ppb. No clear dose-response relationship was observed. The GM FeNO concentration among the students from the reference island was 27.7 ppb in 2017. No significant difference was observed between the two populations, even when the data was stratified by sex and sensitivity. There was no clear significant difference in GM of FeNO concentration between Miyakejima and control students, when the average concentration of SO2 over a period of 3 months was 22 ppb or less.