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(Yutaka Tochihara),(Tadakatsu Ohnaka) 한국의류산업학회 2000 한국의류산업학회지 Vol.2 No.5
To be able to work safely and efficiency, the Threshold Limit Values (TLV) for work in the heat are widely used. Since these TLV are only applicable to workers in regular clothing, TLV should be adjusted when applied to the asbestos removal workers who wear extra impermeable protective clothing. Although abbreviated guidelines for heat stress exposure have been proposed, literature advocating their use in the asbestos removal industry is limited. Therefore, we planed a survey to evaluate the workload of asbestos abatement workers in summer, and an experiment with climatic chambers to evaluate the effects of resting in a cool environment between work periods. From these studies, we got following conclusions. There is a high risk of suffering from heat illness by asbestos abatement work in summer in Japan. It is proposed to create a cool room inside the workplace of asbestos abatement work to reduce thermal stress.
Takeshige, Nobuyuki,Yin, Guang,Ohnaka, Keizo,Kono, Suminori,Ueki, Takashi,Tanaka, Masao,Maehara, Yoshihiko,Okamura, Takeshi,Ikejiri, Koji,Maekawa, Takafumi,Yasunami, Yohichi,Takenaka, Kenji,Ichimiya, Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5
Much interest has been drawn to possible associations between vitamin D receptor (VDR) gene polymorphisms and colorectal cancer risk in conjunction with potentially protective effects of calcium and vitamin D. In a study of 685 cases of colorectal cancer and 778 community controls in Japan, we examined the associations of the FokI, BsmI, ApaI, and TaqI polymorphisms with colorectal cancer risk and effect modification by dietary calcium and vitamin D. Genotypes were determined by the PCR-RFLP method. The ApaI polymorphism seemed to be associated with a decreased risk of colorectal cancer, particularly of rectal cancer. The adjusted odds ratio of colorectal cancer for the ApaI AA and Aa genotypes combined versus the aa genotype was 0.83 (95% confidence interval [CI] 0.67-1.02), and the corresponding value for rectal cancer was 0.75 (95%CI 0.56-0.99). A decreased risk of colorectal cancer for the ApaI AA and Aa genotypes combined was more evident in individuals with high calcium intake (interaction p=0.055). The FokI polymorphism seemed to be associated with a decreased risk of colon cancer among those with high vitamin D intake (interaction p=0.09). The BsmI and TaqI polymorphisms were unrelated to colorectal cancer risk, and the null associations were not modified by calcium or vitamin D intake. In conclusion, the ApaI polymorphism may be associated with a decreased risk of colorectal cancer in Japanese, dependent on dietary calcium intake.
Morita, Makiko,Yin, Guang,Yoshimitsu, Shin-Ichiro,Ohnaka, Keizo,Toyomura, Kengo,Kono, Suminori,Ueki, Takashi,Tanaka, Masao,Kakeji, Yoshihiro,Maehara, Yoshihiko,Okamura, Takeshi,Ikejiri, Koji,Futami, K Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.11
One-carbon metabolism plays an important role in colorectal carcinogenesis. Meta-analyses have suggested protective associations of folate and vitamin $B_6$ intakes with colorectal cancer primarily based on studies in Caucasians, and genetic polymorphisms pertaining to the folate metabolism have been a matter of interest. Less investigated are the roles of methionine synthase (MTR) and thymidylate synthetase (TS) polymorphisms in colorectal carcinogenesis. In a study of 816 cases and 815 community controls in Japan, we investigated associations of dietary intakes of folate, methionine, vitamin $B_2$, vitamin $B_6$, and vitamin $B_{12}$ with colorectal cancer risk. The associations with MTR 2756A>G, MTRR 66A>G, and TSER repeat polymorphism were examined in 685 cases and 778 controls. Methionine and vitamin $B_{12}$ intakes were inversely associated with colorectal cancer risk, but the associations were totally confounded by dietary calcium and n-3 fatty acids. The other nutrients showed no association with the risk even without adjustment for calcium and n-3 fatty acids. The TSER 2R allele was dose-dependently associated with an increased risk. The MTR and MTRR polymorphisms were unrelated to colorectal cancer risk. There was no measurable gene-gene or gene-nutrient interaction, but increased risk associated with the TSER 2R allele seemed to be confined to individuals with high folate status. This study does not support protective associations for folate and vitamin $B_6$. The TSER 2R allele may confer an increased risk of colorectal cancer. The role of the TSER polymorphism in colorectal carcinogenesis may differ by ethnicity.
Cellular Automaton 법을 이용한 주물의 응고조직 시뮬레이션에의 적용
조인성(In Sung Cho),(Itsuo Ohnaka) 한국주조공학회 2001 한국주조공학회지 Vol.21 No.1
Computer simulation of the solidification grain structure was applied to the casting process by using CA-DFDM. The Direct Finite Difference Method (DFDM) for temperature field calculation and latent heat treatment was coupled with Cellular Automaton (CA) method for the grain growth. 2-dimensional simulation of the solidification grain structures and calculation of the concentration fields were carried out and the calculated concentration distributions were compared with exact solution. Castings having complex geometries such as turbine blades were applied for 3-dimensional CA-DFDM. Effects of grain selector and mold extraction speed on the solidification grain structures in the turbine blade were examined.
Nisa, Hoirun,Hirata, Akie,Kohno, Michiko,Kiyohara, Chikako,Ohnaka, Keizo Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.5
Background: High-sensitivity C-reactive protein (hsCRP) levels are lower in Japanese compared with Western subjects. Since it is uncertain whether hsCRP is a potent predictor of mortality at low CRP concentrations, the present study examined associations with all-cause and cause-specific mortality in a large population of Japanese. Materials and Methods: Subjects were 4,737 men and 6,343 women aged 49-76 years participating in the baseline survey of an ongoing cohort study of lifestyle-related diseases between February 2004 and July 2006. Hazard ratios for all-cause and cause-specific mortality associated with hsCRP levels were estimated using Cox proportional hazards regression. Results: A total of 436 all-cause deaths occurred during a median follow-up of 8 years. The main cause of death was cancer. In men, hsCRP levels were positively associated with the risk of all-cause mortality as well as deaths from cancer and cardiovascular disease (CVD). All-cause mortality hazards for the 2nd (0.34-0.84 mg/L) and the 3rd (${\geq}0.85mg/L$) tertiles of hsCRP were 1.27 (95% confidence interval [CI], 0.93-1.73) and 1.75 (1.30-2.37), respectively (p for trend=0.001). In women, increased risk of all-cause and cause-specific mortality associated with elevated hsCRP levels was observed, but the associations were not statistically significant. Conclusions: HsCRP may be an independent predictor of all-cause, cancer and CVD mortality in apparently healthy Japanese men, but not women. The differential effect of hsCRP in predicting mortality risk by sex warrants further investigation.