A case of lichen amyloidosis in an adult

( Jee Yon Shin ),( Myeong Heon Chae ),( Ji Yeoun Lee ),( Tae Young Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Lichen amyloidosis is a type of primary localized cutaneous amyloidosis clinically characterized by persistent pruritic, hyperkeratotic papules commonly distributed on the shins. Histopathologically, amyloid deposition in the papillary dermis is the characteristic finding. It appears to be more common in males and most often occurs in people 50-60 years of age. A 49-year-old woman presented with brownish papuloplaques on the both lower legs. Itching sense was severe and the lesion was occurred 2 years ago. Histopatholgic findings showed amyloid deposit in the papillary dermis. D-PAS staining was negative. Based on these findings, a diagnosis of lichen amyloidosis was made. We think this case has typical chracteristics of lichen amyloidosis. Therefore we report a case of lichen amyloidosis for educational purposes.

Treatment of Hidradenitis Suppurativa Patient with Klinefelter Syndrome by Adalimumab

( Ji Yeoun Shin ),( Jung Yeon Hong ),( Ho Jung Lee ),( Chang Yoon Sim ),( Young Lip Park ),( Jong Suk Lee ),( Sung Yul Lee ),( Jung Eun Kim ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.4

Hidradenitis suppurativa (HS) is a chronic, inflammatory and painful skin disease with recurrent nodules and tracts involving the intertriginous regions. It is known that the patient with HS shows an increased risk of metabolic disorders such as diabetes, metabolic syndrome and autoimmune diseases. Klinefelter syndrome (KS) is a sex chromosomal disorder occurring in males due to an abnormality of sexual differentiation, characterized by 47, XXY karyotype. Also, KS is related with somatic comorbidities such as metabolic syndrome, autoimmune and rheumatologic disorders as HS is. We report a HS patient with KS who shows a big improvement while on tumor necrosis factor-alpha inhibitor treatment. (Ann Dermatol 31(4) 446∼449, 2019)

[P139] Pemphigus vegetans induced by aceclofenac

( Ji Yeoun Shin ),( Chang Yoon Sim ),( Sun Bum Kwon ),( Ye Seul Kim ),( Jong Suk Lee ),( Kyu Uang Whang ),( Sang Hoon Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1

Pemphigus is an autoimmune bullous disease that may be influenced by genetic and exogenous factors. Pemphigus vegetans is one of the rare form of pemphigus, accounting for 1~2% of total pemphigus cases. Pemphigus vegetans is characterized by granulation formation in the bullous lesions while the wound healed. Many kinds of drugs have been reported to the causes of the onset of exacerbation of these disease. The NSAIDs triggering pemphigus can be categorized into the drug-induced pemphigus. Diclofenac, one of the NSAIDS widely used, was implicated to trigger pemphigus through the two reported cases. Aceclofenac is chemically related with diclofenac in the way that diclofenac is metabolized to aceclofenac in the body. Here in, We report a rare case of aceclofenac-induced pemphigus vegetans in the English literature.

Research of public perceptions and behaviors for skin health: results of survey from the skin health expo in Korea

( Ji Yeoun Shin ),( A Young Park ),( Woo Il Kim ),( Sung Yul Lee ),( Moon Kyun Cho ),( Sang Hoon Lee ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2

Background: Healthy skin is an important factor for the quality of life and physical and mental well-being. The demand for dermatological information is increasing not only in patients with skin diseases, but also in the publics with normal skin. However, the public’s perception and behaviors for skin health in Korea is unknown. Objectives: To examine public’s perception and behaviors for skin health in Koreans visiting Skin Health Expo 2017. Methods: A total of 597 participants completed a questionnaire. The questionnaire regarding demographics, status and behavior for skin health and expo satisfaction. Results: Respondents with higher stress level, and history of skin diseases had lower satisfaction with self-skin health. Most subjects responded with sleep and water intake as important factor for healthy skin. One-on-one consultation with dermatologists was the most satisfactory among the Expo. Conclusion: To provide proper information for improving public skin health and emphasize the importance and expertise of dermatologists in skin disorders with social burden, educational efforts using mass media and education program such as Expo planned by dermatologists and government are necessary.

A randomized controlled split-body trial of efficacy and safety of balneotherapy as an adjuvant treatment for atopic dermatitis at samsan spa, Korea

( Ji Yeoun Shin ),( Jeong Yeon Hong ),( Tae Heum Park ),( Soo Young Kim ),( Sung Yul Lee ),( Young Lip Park ),( Sang Hoon Lee ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.2

Background: Atopic dermatitis is chronic inflammatory diseases associated with long-term use of topical and systemic treatment. Several articles have been described the use of balneotherapy as an adjuvant treatment for atopic dermatitis in many countries including Korea. Objectives: The goal of this study was to investigate the therapeutic efficacy and safety of balneotherapy in the adjuvant treatment of atopic dermatitis. Methods: Ten patients with concurrent atopic dermatitis were enrolled in this study and each patient served as their own control. Testing was conducted on the anterior cubital fossa of the arm. A priori binary randomization was completed to determine which arm would receive balneotherapy or tap water. They visited clinics three times per week for 2 weeks and had a forearm bath for 15 minutes. Assessment was performed at baseline, and after 1 and 2 weeks of treatment. Results: At the last visit, the balneotherapy group showed improvement in their local eczema area and severity index score and the value of transepidermal water loss. The physician’s global assessment, patient’s self global assessement and skin hydration was increased in the both groups. Conclusion: Our study suggests that balneotherapy is safe and considerable adjuvant therapy of atopic dermatitis, although more studies should be performed to demonstrate scientific basis.

Treatment of hidradenitis suppurativa patient with klinefelter syndrome using adalimumab

( Ji Yeoun Shin ),( Ho Jung Lee ),( Sung Yul Lee ),( Young Lip Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.1

Hidradenitis suppurativa (HS) is a chronic recurrent suppurative skin disease of unknown etiology, frequently involves axillae, inguinal area, buttock, and perineum, and is more frequent in women. Klinefelter syndrome, known as 47,XXY or XXY, is the set of symptoms that result from two or more X chromosomes in males. There have been reported many cases of autoimmune disease in patients with Kleinfelter syndrome, but no case has been reported with HS. We reported at a 30-year-old man with Klinefelter syndrome presenting suppurative nodules around the anus. We found that multiple purulent nodules with tenderness and odor was present around the anus and perineum, accompanied by scar and sinus on the periphery through physical examination. We diagnosed him as HS, based on clinical findings. When serum testosterone level was low (e.g, Klinefelter syndrome), level of tumor necrosis factor-α (TNF-α) was significantly increased. TNF-α is overexpressed in intact skin as well as lesions in patients with HS, which correlates with the severity of the disease. Although the exact mechanism is unknown, low male hormone level in Klinefelter syndrome associated with increased TNF-α, may have contributed to worsening the patient's disease. We reported that biologics were more effective than primary treatment such as antibiotics in patients with autoimmune or genetic diseases, which may be accompanied by increased TNF-α in patients with HS.

Multiple Eruptive Milia and Milia En Plaque in a 21-Year-Old Man

Ji Yeoun Shin,Sung Yul Lee,Young Lip Park,Kyu Uang Whang,Jung Eun Kim 순천향대학교 순천향의학연구소 2017 Journal of Soonchunhyang Medical Science Vol.23 No.2

Milia are benign primary or secondary keratinous cysts. Multiple eruptive milia (MEM) and milia en plaque (MEP) are rarely reported. A 21-year-old male presented with multiple skin-colored papules on the abdomen and both acral regions, and erythematous plaques featuring similar papules on the wrist and the dorsa of the feet. A biopsy confirmed MEP and he was diagnosed with both MEM and MEP. We thus report a rare case of simultaneous MEM and MEP.

피부 건강 박람회 방문자를 대상으로 한 피부 건강에 대한 인식과 행태에 관한 조사 연구

신지연 ( Ji Yeoun Shin ),강훈 ( Hoon Kang ),김문범 ( Moon Bum Kim ),김유찬 ( You Chan Kim ),박미연 ( Mi Youn Park ),박천욱 ( Chun Wook Park ),손상욱 ( Sang Wook Son ),유박린 ( Bark Lynn Lew ),이동윤 ( Dong Youn Lee ),이동훈 ( Don 대한피부과학회 2018 대한피부과학회지 Vol.56 No.8

Background: Healthy skin is an important determinant of the quality of life and physical and mental well-being. The demand for dermatological information is increasing not only in patients with skin diseases, but also in the general population with normal/healthy skin. However, public perception and behavior with regard to skin health among Koreans are not known. Objective: To examine public perception and behaviors with regard to skin health in Koreans visiting the Skin Health Expo 2017. Methods: A total of 597 participants completed a questionnaire that assessed demographics, status, and behavior for skin health and Expo satisfaction. Results: Respondents with higher stress levels and a history of skin diseases showed lower satisfaction with self-skin health. Most participants considered adequate sleep and water intake to be important factors associated with healthy skin. One-on-one consultation with dermatologists was the most satisfactory among participants at the Expo. Conclusion: Educational tools using mass media and informative activities such as the Expo planned by dermatologists and the government are necessary to spread awareness and provide proper information to improve skin health in thegeneral population and to emphasize the key role of dermatologists in skin disorders with a social burden. (Korean J Dermatol 2018;56(8):475∼484)

Long-term endocrine outcome of suprasellar arachnoid cysts

Lee, Ji Yeoun,Lee, Young Ah,Jung, Hae Woon,Chong, Sangjoon,Phi, Ji Hoon,Kim, Seung-Ki,Shin, Choong-Ho,Wang, Kyu-Chang Journal of Neurosurgery Publishing Group 2017 Journal of neurosurgery. Pediatrics Vol.19 No.6

<B>OBJECTIVE</B><P>Due to their distinct location, suprasellar arachnoid cysts are known to cause a wide variety of problems, such as hydrocephalus, endocrine symptoms, and visual abnormalities. The long-term outcome of these cysts has not been elucidated. To find out the long-term outcome of suprasellar arachnoid cysts, a retrospective review of the patients was performed. The neurological and endocrine symptoms were thoroughly reviewed.</P><B>METHODS</B><P>Forty-five patients with suprasellar arachnoid cysts, with an average follow-up duration of 9.7 years, were enrolled in the study. A comprehensive review was performed of the results of follow-up regarding not only neurological symptoms but also endocrine status. The outcomes of 8 patients who did not undergo operations and were asymptomatic or had symptoms unrelated to the cyst were included in the series.</P><B>RESULTS</B><P>Surgery was most effective for the symptoms related to hydrocephalus (improvement in 32 of 32), but endocrine symptoms persisted after surgery (4 of 4) and required further medical management. More surprisingly, a fairly large number of patients (14 of 40; 1 was excluded because no pre- or postoperative endocrine evaluation was available) who had not shown endocrine symptoms at the time of the initial diagnosis and treatment later developed endocrine abnormalities such as precocious puberty and growth hormone deficiency. The patients with endocrine symptoms detected during the follow-up included those in both the operated (n = 12 of 32) and nonoperated (n = 2 of 8) groups who had been stable during follow-up since the initial diagnosis.</P><B>CONCLUSIONS</B><P>This study implies that patients with suprasellar arachnoid cysts can develop late endocrine problems during follow-up, even if other symptoms related to the cyst have been successfully treated. Hence, patients with these cysts need long-term follow-up for not only neurological symptoms but also endocrine abnormalities.</P>

아토피 피부염에서 강화 삼산 온천수 보조치료의 효과 및 안전성에 대한 연구

신지연 ( Ji Yeoun Shin ),홍규락 ( Kyu Rak Hong ),권륭 ( Ryung Kwon ),김예슬 ( Ye Seul Kim ),이설희 ( Sul Hee Lee ),박영립 ( Young Lip Park ),이상훈 ( Sang Hoon Lee ) 대한피부과학회 2019 대한피부과학회지 Vol.57 No.10

Background: Atopic dermatitis is a chronic inflammatory disease associated with long-term use of topical and systemic medications. Several articles have described the use of balneotherapy as an adjuvant treatment for atopic dermatitis in many countries, including Korea. Objective: The goal of this study was to investigate the therapeutic efficacy and safety of balneotherapy as an adjuvant treatment of atopic dermatitis. Methods: Ten patients with atopic dermatitis were enrolled in this study and each patient served as their own control. Testing was conducted on the anterior cubital fossa of the arm. A priori binary randomization was completed to determine which arm would receive balneotherapy or tap water. Patients visited clinics 3 times per week for 2 weeks and had a forearm bath for 15 minutes. Assessment was performed at baseline, and after 1 and 2 weeks of treatment. Results: At the last visit, the balneotherapy group showed improvements in their local eczema area, severity index score, and the degree transepidermal water loss. The physician’s global assessment, patient’s self-global assessment, and skin hydration was increased in both groups. Conclusion: Our study suggests that balneotherapy is a safe adjuvant therapy that could be considered for the treatment of atopic dermatitis. However, more studies are required to demonstrate scientific basis for this treatment. (Korean J Dermatol 2019;57(10):594∼599)