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        클로자핀 반응의 임상적 예측인자 : 치료 저항성 정신분열증 환자군 중 반응군과 비반응군간의 차이 Comparison between Clozapine Responders and Non-Responders in Treatment-Refractory Schizophrenic Patients

        곽경필,이양현,강병조 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.1

        요 약치료 저항성 정신분열증 환자의 클로자핀반응의 임상적 예측인자를 알아보고자 70명의 환자를 대상으로 개방 연구를 실시하였다. 기존의 항정신병 약물을 중지하고 7일간의 배설기간을 가진 후 기초평가를 실시하였고 최종 12주까지 임상적 평가를 실시하였다.최종평가시 PANSS 전체점수가 기초평가에 비해 20%이상 호전되었을 때를 반응군이라 하였을 때 78.5%가 반 응군에 속하였다. 치료 전 평가한 PANSS 세부항목상 환각행동, 흥분, 적개심, 빈약한 신뢰감, 비협조성, 판단과 병식의 결여, 충동조절장애 등의 소항목들이 반응-비반응군간에 유의한 차이가 있었다. 그리하여 이런 항목들이 있는 환자들이 클로자핀에 의하여 좋은 예후를 가져온다고 볼 수 있다.비록 본 연구가 대조군이 없는 개방연구라는 점을 감안해 볼 때 본 연구의 결과에 대한 추후 보완된 이중맹검 대조군 연구가 필요할 것으로 생각된다. In order to find the clinical predictors of clozapine response in patients with refractory schizophrenia, the clinical responses of 70 schizophrenic inpatients with treatment-refractory illness were examined in open trial. After all previous antipsychotic medications had been withdrawn for 1 week, the patients were treated with clozapine according to a standardized titration and dosage schedule. Patients who tolerated and responded to treatment were maintained on a regimen(100-600mg/day) of clozapine for up to 12 weeks. The psycho- pathologic severity and functioning status of the patients were assessed by PANSS, CGI, GAF at baseline and weeks 4, 12 of treatment. Clinical improvement as defined by a 20% or more reduction in total PANSS score at end point, was shown by 77.1% of the patients. The predictors of response to clozapine were associated with hallucinatory behavior, excitement, hostility, poor rapport, uncooperativeness, lack of judgement and insight, poor impulse control subscale of PANSS. These findings have important implications for the use of clozapine and our understanding of the pathophysiology of treatment-resistant schizophrenia.

      • 레이저를 이용한 얇은 원통형 튜브에서의 유도초음파 발생

        김현묵,정경일,장경영,안형근,곽노권,이창목 한국비파괴검사학회 2003 학술대회 논문집 Vol.- No.1

        레이저를 이용하여 두께가 얇은 원통형 튜브에 유도초음파를 발생하고, 공기-결합 트랜스듀서를 이용하여 비접촉식으로 수신하였다. 원통형 튜브는 발전설비의 열교환기 및 증기발생기 튜브에 사용되는 인코넬(Inconnel)튜브이다. 레이저의 조사 경로에 선 배열 슬릿을 삽입하여 유도 초음파의 파장을 조절하였다. 파장이 일정할 때 발생되는 모드를 이론적인 분산선도로부터 예측하고, 예측된 위상속도로부터 공기-결합 트랜스듀서의 경사각을 결정하였다. 원통형 튜브에는 축대칭 모드가 지배적으로 발생하는 것으로 나타났다. 이러한 결과는 웨이블렛 변환에 의한 시간-주파수 선도와 이론적인 분산선도를 비교한 결과 증명되었다.

      • 휘안광의 부선특성에 관하여

        박경호,오재현,곽창섭,심원석 연세대학교 산업기술연구소 1980 논문집 Vol.12 No.2

        The authors investigated thoroughly the flotation characteristics of stibnite. The flotation behavior of this mineral was carried out by using modified hallimond tube with various xanthates as a collector and modifying agents such as copper sulphate, lead acetate, sodium sulfide, zinc sulphate, sodium cyanide, sodium sulfite and potassium dichromate. The main results obtained in this experiments are summarized as follows; (1) Stibnite shows that it has maximum floatability in pH range 4.0 to 8.0. (2) Stibnite is activated by copper sulphate and lead acetate. (3) Potassium dichromate is an effective depressing agents in stibnite-xanthate system in pH range 4.0 to 6.0. (4) In the pH range in which the zinc sulphate is preciptated by hydroxide, stibnite is depressed effectively (5) Stibnite is depressed by sodium sulfide in alkaline solution.

      • W(110) 표면에 CO의 흡착

        이경희,유위량,한현석,부진효,이순보,곽현태 성균관대학교 기초과학연구소 1998 論文集 Vol.49 No.-

        The interaction of CO with W(110) surface was investigated through LEED, TDS, and photoelectron spectroscopy using synchrotron radiation under UHV condition. After CO saturation at RT, two desorption states, called α and β , were observed at about 400 and 1150 K in thermal desorption spectra, respectively. The kinetics of 3-CO followed the first order kinetics, indicating the existence of molecular CO on W(110) surface. This is contrary to the previous results. The O 1s BE(binding energy) of CO adsorbed on W(110) surface at room temperature was 529.9 eV. On the other hand, the O 1s BE of β-CO after heating to 900 K was different from that of oxygen adsorbed W(110) surface, suggesting a different adsorption state. According to the UP valence band spectra, we observed two peaks at near -10.7 eV (4σ) and -7.0 eV (5σ+1π), indicating the molecular adsorption of CO at room temperature. Furthermore we could see the 4σ peak at the various photon energy and elevated temperatures. Comparing the energy separation, Δ(4σ-1π) , between 4σ and 1π UP peaks of chemisorbed CO, we found that an increased separation reflects an decreased C-O bond strength. Therefore on the basis of TDS and photoelectron spectroscopy, we could suggest that β state of CO on W(110) may not be dissociated and has an adsorption geometry of lying-down mode.

      • 동양사상을 통한 태권도정신 정립을 위한 연구

        김경지,곽정현 慶熙大學校 社會體育硏究所 1998 體育科學論叢 Vol.- No.11

        Taekwondo which is a traditional martial art native to Korea, is well-Known throughout the world at present. And our nation to is now wielding the power as a suzerain state of Taekwondo. Consequently, in Korea, the suzerain state of Taewondo among the world, the study for the thesis of the theoretical background has been doing continually and steadily but the most fundamental fields of cultural society, especially the study in the side of philosophy among them has been very insufficient in fact. Taewondo is a martial arts to defeat the enemy by hardering the hand and the foot methodically, and Taewondo spirits, which is a spirits every person to learn Taewondo should have most fundamentally, is a mental ability to control the upright human acts, thinking or emotions through training andalsois the behavior ideas, expressed as mental power or will, to be the basis of moral deeds. In Taewondo, the mind is considered to be the driving force to plan the solution of problems caused by violent degradation and material-oriented tendency and the education of Taewondo is to stressed as the basis of desirable idea and behavior needed in the scene of games. Therefore, in order for the philosophical thesis of the spirits of Taewondo, we should generalize all these ideas to establish proper for the emotions of our nation, and in addition, should do both comprehensive and microscopic study and mental philosophy for Taewondo systematically and continually.

      • 무선 애드 혹 기반 액티브네트워크상에서 QoS지원에 관한 연구

        李基源,裵振勝,丁燦赫,金玄郁,李光培,姜景仁,朴京培,文泰洙,郭承郁,河載承 明知大學校 産業技術硏究所 2003 産業技術硏究所論文集 Vol.22 No.-

        Abstract - In this thesis, we propose a QoS supporting method on wireless ad hoc-based active network for improving reliability. On the loss of route path, the existing DSR routing protocol has several problems with wireless network communication because of decease of data reception rate and increase of network load. The proposed method improves reliability of data transfer by using functions of active network. That is, by using functions of active nodes and active packets, the proposed method supports QoS with reservation transfer method that saves data packets on transfer at intermediate nodes with lost path and then re-transmit the packets after route reconfiguration.

      • 급성기 뇌경색환자를 대상으로 한양방 병행치료군과 양방 단독치료군간 기능회복도 비교연구

        우수경,현상호,이은찬,곽승혁,박주영,정우상,문상관,조기호,김영석,Woo, Su-kyung,Hyun, Sang-ho,Lee, Eun-chan,Kwak, Seung-hyuk,Park, Joo-young,Jung, Woo-sang,Moon, Sang-kwan,Cho, Ki-ho,Kim, Young-suk 대한중풍순환신경학회 2012 대한중풍.순환신경학회지 Vol.13 No.1

        Object : This is a study of ischemic stroke patients designed for comparison Combination therapy of western medical treatment and oriental medical treatment. and western medical treatments alone. Methods : 45 patients were diagnosed by Br-MRI scan as having suffered ischemic stroke. They had entered Kyung-Hee Medical hospital within ten days of attack, between March 2011 and October 2012. Patients were divided into two groups; a group treated with Combination therapy of western medical treatment and oriental medical treatment and other group treated with Western medical treatments. Scandinavian stroke scale and Motricity Index score was checked at admission, 2 weeks or 3 weeks later to assess neurologic improvement and motor function recovery. Results : Comparing the Scandinavian stroke scale and Motricity Index score between baseline and 2 or 3 weeks later, the combination therapy group and western medical treatment group had improved but there was no significance. Conclusions : Combination therapy have more beneficial effect on acute stage of stroke.

      • 급성기 뇌경색 환자에 있어 변증형별 유의한 임상지표의 분석

        이은찬,현상호,곽승혁,우수경,박주영,정우상,문상관,조기호,박성욱,고창남,Lee, Eun-chan,Hyun, Sang-ho,Kwak, Seung-hyuk,Woo, Su-kyung,Park, Ju-young,Jung, Woo-sang,Moon, Sang-kwan,Cho, Ki-ho,Park, Sung-wook,Ko, Chang-nam 대한중풍순환신경학회 2012 대한중풍.순환신경학회지 Vol.13 No.1

        Object : The aim of this study was to assess the clinical indicators related to Pattern-Identification(PI) in acute cerebral infarction patients. Methods : We studied hospitalized patients within 30days after ictus, who admitted at Korean Medicine Center of Kyung-Hee University from January 2010 to October 2012.(n=290) Two Traditional Korean Medicine(TKM) physicians evaluated the patients independently and diagnosed PI. Inter-rater reliability was measured using simple percentage agreement and the Cohen's kappa(κ) coefficient. To assess the clinical indicators closely related to each PI, we analysed average score of each indicator in each group. Results : Simple percentage agreement of PI between raters was 64.83% and Cohen's kappa(κ) coefficient was 0.526(95% CI: 0.451-0.600). Inter-rater reliability level was fair to good. We analysed the clinical indicators in each group. Significant indicators for Fire-Heat Pattern(FHP) were reddened complexion and strong pulse power, and meaningful indicators for FHP were halitosis and thick tongue fur. Significant indicator for Dampness-Phlegm Pattern(DPP) was overweight and there was no meaningful indicator. Significant indicator for Yin-Deficiency Pattern(YDP) was dry tongue fur and meaningful indicator for YDP was thirst. There was no significant indicator for Qi-Deficiency Pattern(QDP) and pale complexion and faint low voice were meaningful indicators for QDP. Conclusions : This study reveals the significant and meaningful clinical indicators related to each Pattern-Identification in acute cerebral infarction patients. It will contribute to standardization of Korean Medical Diagnosis and Treatment in acute cerebral infarction patients.

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