Mulligan 치료법과 고유수용성 신경근 촉진법이 동결견 환자의 치료에 미친 효과

양정애,윤홍일,박현식,신영일,전범수 대한정형도수치료학회 2006 대한정형도수물리치료학회지 Vol.12 No.1

The purpose of this study was to compare the effects of Mulligan method and PNF method on the pain and limitation of range of motion in patients with frozen shoulder. The subjects of this study were 20 patients, 10(50%) males and 10(50%) females. They visited clinic for physical treatment within 6 months after onset of shoulder pain and limitation of range of motion with frozen shoulder. One group was applied with Mulligan method and other group was with PNF method . The patient were treated 5 times session weekly for 6 weeks from March 4th, 2002. And each treatment session was 15min. with physiotherapy. The pain was measured by visual analogue scale (VAS) and rage of motion (ROM) of flexion, abduction, external rotation, internal rotation were measured by goniometer. The data was analysed by paired T-test and independent T-test. The results of this study were summarized as follow : 1. The ROM of Mulligan method group increase in after treatment in comparison with ROM in before treatment, it is significant increase. Although the VAS of MMG decrease in before than after treatment, it is significant difference. 2. There is significant difference in before and after treatment of ROM of shoulder flexion, abduction, internal rotation, external rotation between PNF method group. The VAS of PMG is decreasing in before than after treatment, it is significant difference. 3. There is significant difference in before movement and after movement ROM of flexion, abduction, internal rotation, external rotation and VAS between Mulligan method session and PNF method session then the scale which measured by Mulligan method was more increased than that of PNF method. The results showed that both Mulligan method and PNF method were effective in pain reduce and ROM increase, but Mulligan method was superior to PNF method in ROM increase and pain reduce.

돼지에서 정맥, 근육 그리고 경구 투여시의 enrofloxacin의 약물동태학

윤효인,김무열,박승춘,조준형,박병권,이내경,노상석,장범수,신광순,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-

In order to characterize pharmacokinetic profiles according to route of a new enrofloxacin salt form (Enrotil®), it was given to 4 healthy pigs via oral (p.o.), intramuscular (i.m.) or intravenous (i.v.) administrations at a dose rate of 5 ㎎/㎏ body weight. Enrofloxacin (ENFX) in serum was detected by bioassay using E. coli BE1186 as a test organism. The biological elimination half-lives (t_1/2(β)) of ENFX were 6.76±0.99 h (i.v.), 7.16±2.30 h (i.m.) and 11.45±3.90 h (p.o.), Volume of distribution (Vd) of enrofloxacin was 2.20±0.31 L/㎏ (i.v.), 2.52±0.60 L/㎏ (i.m.) and 1.88±0.33 L/㎏ (i.m.). Mean residence time (MRT) was 8.77±1.26 h after i.v. injection and the maximal concentration time (Tmax) following p.o. and i.m. administration was 0.76±0.09 h and 0.60±0.12 h, indicating a rapid absorption from these routes. Bioavailibility (F) was calculated as 64.1% for p.o. administration and 59.71% for i.m. injections. In summary, the newly formulated enrofloxacin salt form has shown a high water solubility, rapid absorption and large tissue distribution, suggesting a potential antibacterials for oral application on a large scale in veterinary sectors.

Maximizing biogas production by pretreatment and by optimizing the mixture ratio of co-digestion with organic wastes

Beom Lee,Jun-Gyu Park,Won-Beom Shin,Beom-Soo Kim,Byoung-su Byun,Hang-Bae Jun 대한환경공학회 2019 Environmental Engineering Research Vol.24 No.4

Anaerobic digestion is a popular sewage sludge (Ss) treatment method as it provides significant pollution control and energy recovery. However, the low C/N ratio and poor biodegradability of Ss necessitate pretreatment methods that improve solubilization under anaerobic conditions in addition to anaerobic co-digestion with other substrates to improve the process efficiency. In this study, three pretreatment methods, namely microwave irradiation, ultrasonication, and heat treatment, were investigated, and the corresponding improvement in methane production was assessed. Additionally, the simplex centroid design method was utilized to determine the optimum mixture ratio of food waste (Fw), livestock manure (Lm), and Ss for maximum methane yield. Microwave irradiation at 700 W for 6 min yielded the highest biodegradability (62.0%), solubilization efficiency (59.7%), and methane production (329 mL/g VS). The optimum mixture ratio following pretreatment was 61.3% pretreated Ss, 28.6% Fw, and 10.1% Lm. The optimum mixture ratio without pretreatment was 33.6% un-pretreated Ss, 46.0% Fw, and 20.4% Lm. These results indicate that the choice of pretreatment method plays an important role in efficient anaerobic digestion and can be applied in operational plants to enhance methane production. Co-digestion of Ss with Fw and Lm was also beneficial.

Silicone implants capable of the local, controlled delivery of triamcinolone for the prevention of fibrosis with minimized drug side effects

Jeon, Beom Su,Shin, Byung Ho,Huh, Beom Kang,Kim, Byung Hwi,Kim, Se-Na,Ji, Han Bi,Lee, Seung Ho,Kang, Soo Im,Shim, Jung Hee,Kang, So Min,Lee, Jae Chul,Lee, Kyu Sang,Heo, Chan Yeong,Choy, Young Bin Elsevier 2018 Journal of industrial and engineering chemistry Vol.63 No.-

<P><B>Abstract</B></P> <P>We propose silicone implants capable of the local, controlled release of a glucocorticoid drug, triamcinolone acetonide (TA), for the prevention of fibrosis. The shells of these silicone implants were coated with two different loading amounts of TA, which could release the drug in a sustained manner for 12 weeks. The drug-loaded implants were inserted into the subcutaneous space in living rats, and the tissues were biopsied at scheduled times during 12 weeks. For the drug-coated implants, the capsule thickness and collagen density decreased compared with those of the non-coated implant. Because of the effect of TA, inflammation and the expression of pro-inflammatory cytokines were downregulated, thereby decreasing the number of monocytes during acute inflammation. This effect in turn decreased the number of macrophages at the later stage of inflammation, leading to the expression of less TGF-β and consequently fewer fibroblasts and myofibroblasts. Our findings also revealed that with an appropriate dose control, skin and muscle atrophy, major side effects of TA, could be avoided while still effectively reducing fibrosis. Therefore, we conclude that the local, sustained release of an appropriate dose of a glucocorticoid drug can be a promising strategy for safely preventing fibrosis around silicone implants.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

기업의 브랜드 웹 사이트 활용 전략에 관한 실증 연구

신수범(Su-beom Shin),안현철(Hyun-chul Ahn) 경희사이버대학교 미래고등교육연구소 2010 사이버사회문화 Vol.1 No.1

브랜드 웹 사이트란 웹에서의 체험을 브랜드와 연결시켜 온/오프라인 브랜드를 보다 강화할 수 있도록 설계된 웹 사이트를 의미한다. 인터넷 환경의 발전으로 브랜드 웹 사이트는 광고, 홍보, 개인화를 모두 포괄하는 온라인 마케팅 커뮤니케이션 도구로서 그 중요성이 부각되고 있다. 이에 따라 오늘날 기업들은 고객과의 접점으로서 브랜드 웹 사이트의 중요성을 인식하고, 마케팅을 위한 전략적 도구로 활용하고자 노력하고 있다. 브랜드 웹 사이트는 크게 비즈니스 연계형, 이벤트형, 정보습득형, 그리고 친목도모형의 4가지 유형으로 구분될 수 있다. 본 연구에서는 이러한 4가지 유형으로 브랜드 웹 사이트를 분류하여 웹어워드 코리아에서 제시한 평가항목인 디자인, 사용자 인터페이스, 기술, 컨텐츠, 브랜드, 프로모션, 마케팅, 서비스 등 8가지의 설계요소에 대한 우선순위를 분석함으로써, 유형별 브랜드 웹 사이트 활용 전략에 가장 우선시 되는 요소가 어떤 것들인지 살펴보았다. 연구방법으로는 분석적 계층 프로세스(AHP: Analytic Hierarchy Process)를 이용하였으며, 주요 SI 및 웹 에이전시에 근무하는 웹 기획자를 대상으로 설문조사를 실시하여 이를 AHP로 분석하였다. 분석 결과 비즈니스 연계형에서는 서비스가, 이벤트형에서는 마케팅이, 그리고 정보습득형과 커 뮤니티형에서는 컨텐츠가 브랜드 웹 사이트 기획에 있어 가장 중요한 요인으로 나타났다. Brand web‐sites are web‐sites designed to reinforce online/offline brands by combining them with experiences on the web. Through brand web‐sites, companies can provide their customers with special brand experiences using the multimedia features of web technology. With the rapid enhancement of the Internet environment, brand web sites play a role as an online marketing communication tool that covers advertising, promotion and personalization. As a result, companies try to use them as the direct communication channel to their customers as well as a strategic tool for marketing. In general, brand web sites can be classified into four types: (1) business‐related brand web‐sites, such as 'iNavi (www.inavi.com)' and 'Anycall (www.anycall.com)'; (2) event‐oriented brand web sites like 'Chungjungwon (www.chungjungwon.co.kr)'; (3) information‐oriented brand web sites like 'Hackers TOEIC (www.hackers.co.kr)'; and (4) community‐oriented brand web sites like 'Lock&Lock (www.locknlock.com)'. Under this background, our study explores the relative importance of eight design factors ‐ graphic design, user interface (UI), technology, contents, brand, promotion, marketing, and service ‐ that are suggested by Web Award Korea. Our study is designed to present the relative importance of these factors for each type of brand web‐sites. As an analysis method, we adopt AHP (analytic hierarchy process). We collected the survey data from the industry experts and professionals in web agencies and system integrators, and we analyzed that using AHP. As a result, 'service' for business‐related, 'marketing' for event‐oriented, and 'contents' for information-oriented and community‐oriented brand web sites were found to be the most important design factors.

L - shape 채널 배선 알고리즘

신찬수(Chan-Su Shin),권오흠(Oh-Heum Kwon),신성용(Sung Yoog Shin),김정범(Jung Beom Kim),좌경룡(Kyung-Yong Chwa) 한국정보과학회 1993 한국정보과학회 학술발표논문집 Vol.20 No.1

본 논문에서는 빌딩블록 레이아웃 설계의 배치단계에서 발생하는 L-shape 채널의 gridless 배선알고리즘을 제시한다. 본 배선 알고리즘은 L-shape 채널을 구석부분과 두개의 채널로 나누어 구석부분부터 배선하고 랜덤데이타를 이용하여 성능을 평가한다.

Molecular mechanisms of immunomodulatory activity by polysaccharide isolated from the peels of <i>Citrus unshiu</i>

Shin, Myoung-Sook,Park, Su Beom,Shin, Kwang-Soon Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.112 No.-

<P><B>Abstract</B></P> <P>The extracts of the <I>Citrus unshiu</I> fruit induce numerous biological activities such as anticancer, anti-adipogenic, and antimicrobial effects. Furthermore, its peel has been used as a Chinese medicine for centuries and is consumed as a tea in China, Japan, and Korea. We investigated the effects of the polysaccharide isolated from <I>C. unshiu</I> peel (CPE-II) on cytokine and inflammatory mediator production in RAW 264.7 macrophages and performed signal transduction experiments to identify the pathways involved in its actions. CPE-II exhibited macrophage-stimulatory activity by inducing the production of interleukin (IL)-6, tumor necrosis factor (TNF)-α and nitric oxide (NO) in RAW 264.7 macrophages. Signal transduction experiments showed that CPE-II phosphorylated mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-κB in RAW 264.7 cells in a concentration-dependent manner. The effects of CPE-II on IL-6/IL-12 and TNF-α production were completely suppressed by a specific inhibitor of c-Jun N-terminal kinase (JNK). Moreover, experiments with neutralizing antibodies showed that Toll-like receptor 2 (TLR2) and TLR4 were involved in the stimulation of IL-6 and NO production by CPE-II in RAW 264.7 cells. Collectively, these results suggest that the TLR2/4 and JNK pathways are essential for the CPE-II immune activity in RAW 264.7 cells.</P>

Biodistribution of <SUP>99m</SUP>Tc Labeled Integrin Antagonist

Beom-Su Jang,Seung-Hee Park,In Soo Shin,Jin-Soo Maeng,Chang H. Paik 한국독성학회 2013 Toxicological Research Vol.29 No.1

The selective targeting of an integrin αvβ3 receptor using radioligands may enable the assessment of angiogenesis and integrin αvβ3 receptor status in tumors. The aim of this research was to label a peptidomimetic integrin αvβ3 antagonist (PIA) with <SUP>99m</SUP>Tc(CO)3 and to test its receptor targeting properties in nude mice bearing receptor-positive tumors. PIA was reacted with tris-succinimidyl aminotriacetate (TSAT) (20 mM) as a PIA per TSAT. The product, PIA-aminodiacetic acid (ADA), was radiolabeled with [<SUP>99m</SUP>Tc(CO)3(H2O)3]<SUP>+1</SUP>, and purified sequentially on a Sep-Pak C-18 cartridge followed by a Sep-Pak QMA anion exchange cartridge. Using gradient C-18 reverse-phase HPLC, the radiochemical purity of <SUP>99m</SUP>Tc(CO)3-ADA-PIA (retention time, 10.5 min) was confirmed to be > 95%. Biodistribution analysis was performed in nude mice (n = 5 per time point) bearing receptor-positive M21 human melanoma xenografts. The mice were administered <SUP>99m</SUP>Tc(CO)3-ADA-PIA intravenously. The animals were euthanized at 0.33, 1, and 2 hr after injection for the biodistribution study. A separate group of mice were also co-injected with 200 μg of PIA and euthanized at 1 hr to quantify tumor uptake. <SUP>99m</SUP>Tc(CO)3-ADA-PIA was stable in phosphate buffer for 21 hr, but at 3 and 6 hr, 7.9 and 11.5% of the radioactivity was lost as histidine, respectively. In tumor bearing mice, <SUP>99m</SUP>Tc(CO)3-ADA-PIA accumulated rapidly in a receptor-positive tumor with a peak uptake at 20 min, and rapid clearance from blood occurring primarily through the hepatobiliary system. At 20 min, the tumor-toblood ratio was 1.8. At 1 hr, the tumor uptake was 0.47% injected dose (ID)/g, but decreased to 0.12% ID/g when co-injected with an excess amount of PIA, indicating that accumulation was receptor mediated. These results demonstrate successful <SUP>99m</SUP>Tc labeling of a peptidomimetic integrin antagonist that accumulated in a tumor via receptor-specific binding. However, tumor uptake was very low because of low blood concentrations that likely resulted from rapid uptake of the agent into the hepatobiliary system. This study suggests that for <SUP>99m</SUP>Tc(CO)3-ADA-PIA to be useful as a tumor detection agent, it will be necessary to improve receptor binding affinity and increase the hydrophilicity of the product to minimize rapid hepatobiliary uptake.

Functional Expression of NAD<SUP>+</SUP>-Dependent Fungal Formate Dehydrogenase from Phanerochaete sordida

Beom Soo SHIN,Seokyoon JANG,Ye-Rin JU,Hye Bin KIM,Su-Yeon LEE,Tae-Jip KIM 한국생물공학회 2022 한국생물공학회 학술대회 Vol.2022 No.9

A Study on the Application of Artificial Intelligence (AI) in the Field of Nuclear Export Control

Beom Seok Shin,Su Jeong Kim 한국방사성폐기물학회 2020 한국방사성폐기물학회 학술논문요약집 Vol.2020 No.07