Hormons 및 弗素가 ergocalciferol에 依한 血中數種成分의 變動에 미치는 影響

이상신 서울大學校 大學院 1974 국내박사

Changes and associated factors in psychological distress of patients with early beast cancer : 1 year follow-up study : 조기 유방암 환자에서 심리적 불편감의 변화 및 연관된 요인들 : 1년 추적연구

이상신 경북대학교 대학원 2017 국내박사

Objective: The purpose of this study is to investigate the prevalence and its changes of psychological distress in patients with early breast cancer during 1 year follow-up and to evaluate associated factors with the psychological distress. Methods: A total of 114 post-operative early breast cancer patients were recruited. Psychological distress was assessed by the Hospital Anxiety and Depression Scale (HADS) within a week (baseline) and 1 year after surgical treatment. Moreover, a series of questionnaires also were completed at both assessment: the Body Image Scale (K-BIS), Rosenberg Self-Esteem Scale (RSES), and Experiences in Close Relationship (ECR-M36). Participants were categorized into distress or non-distress group based on a cut-off 13 of HADS total score. Additionally, participants at baseline were also categorized into four groups according to HADS subscale. Descriptive data about prevalence and changes of psychological distress were demonstrated. Logistic analyses revealed significant factors to predict psychological distress at 1 year follow-up in the distress, non-distress group and overall participants at baseline assessment. Results: In baseline assessment, 62 (54.4%) of participants showed psychological distress. Although the degree of psychological distress decreased over 1 year significantly (p=0.003 in HADS total), 52 (45.6%) of participants were found to be distressed at 1 year follow-up. In the overall participants (n=114), ECR-M36 (OR=1.038, 95% CI=1.011-1.065) and HADS-total at baseline (OR=1.157 95% CI=1.064-1.257) could predict psychological distress at 1 year follow-up. In the distress group at baseline (n=62), younger age (OR=0.912, 95% CI=0.839-0.991) and ECR-M36 (OR=1.044, 95% CI= 1.012-1.077) were found to be significant factors. In the non-distress group at baseline (n=52), HADS depression subscore at baseline (OR=1.621, 95% CI=1.008-2.609) was found as a predictive factor for psychological distress at 1 year follow-up. There were no cancer related variables which showed predictive ability to psychological distress at 1 year follow-up assessment. Conclusions: Although the degree of psychological distress in patients with early breast cancer decreases, substantial proportion of patients suffer emotional distress at 1 year follow-up. Psychological distress within a week after cancer surgery could be one of risk factors for persistent distress over 1 year. Attachment insecurity might be an important therapeutic issue in managing the emotional distress of patient with early breast cancer. 목적: 본 연구는 1년 추적 연구를 통하여 조기 유방암 환자에서 심리적 불편감의 유병률과 유병률의 변화를 조사하고, 수술 1년 후의 시기에 심리적 불편감과 연관된 요인들을 탐색하는 것이다. 방법: 조기유방암으로 진단 받고 수술을 받은 114명이 대상이었다. 심리적 불편감은 수술 후 일주일 이내 (기준선)와 1년 후의 두 시기에 병원불안우울척도(Hospital anxiety and depression scale, HADS)로 평가되었다. 이 두 평가시기에 대상자들은 한국판 신체상 척도 (Korean version of Body Image Scale: K-BIS), 로젠버그 자존감 척도 (Rosenberg Self-Esteem Scale: RSES)와 애착척도인 Experiences in Close Relationship (ECR-M36)도 작성하였다. 기준선에서 HADS 총점 13점 이상인 환자들을 심리적 불편감이 있다고 분류하였다. 추가적인 분석에서 기준선에서의 HADS 하위척도 (불안 및 우울)점수에 따라 대상군을 정상군, 불안군, 우울군 그리고 불안-우울군의 네 군으로 구분하기도 하였다. 각 군들의 심리적 불편감의 유병률과 1년 동안의 변화를 기술하였다. 로지스틱 회귀분석을 통하여 기준선에서의 심리적 불편감이 있는 군과 없는 군 그리고 전체 대상자를 대상으로 1년 후의 심리적 불편감을 예측할 수 있는 요인들을 탐색하였다. 결과: 기준선에서 114명 중 62명 (54.4%)의 대상군이 심리적 불편감이 있는 것으로 조사되었다. 1년 추적 연구기간 동안에 심리적 불편감의 정도는 유의하게 감소하였으나 (p=0.003, HADS 총점) 44.7%에 해당하는 51명의 환자들이 1년 추적 시기에도 심리적 불편감이 있었다. 전체 대상군 (n=114)에서 수술 후 1년 후에 심리적 불편감을 예측할 수 있는 요인들은 ECR-M36 (OR=1.038, 95% CI=1.011-1.065)과 기준선에서의 HADS 총점(OR=1.157 95% CI=1.064-1.257) 이었다. 기준선에서 심리적 불편감을 보였던 62명의 환자들을 대상으로 했을 때는 젊은 나이(OR=0.912, 95% CI=0.839-0.991)와 ECR-M36 (OR=1.044, 95% CI= 1.012-1.077)이 1년 후의 심리적 불편감과 유의하게 연관되어 있었다. 기준선에서 심리적 불편감을 나타내지 않는 환자 52명 중 11명 (21.9%)이 1년 추적 평가시에는 심리적 불편감이 있는 군으로 분류되었는데, 이를 예측할 수 있는 인자는 기준선에서의 HADS 우울하위 척도 점수였다 (OR=1.621, 95% CI=1.008-2.609). 어떠한 군에서도 암 관련 변수는 예측인자로 조사되지 않았다. 결론: 조기 유방암 환자의 심리적 불편감은 수술 후 1년의 시간이 경과하면서 그 정도가 유의하게 감소하기는 하지만 상당수의 환자들이 1년 뒤에도 불안 혹은 우울과 같은 심리적 어려움을 겪고 있다. 수술 후 일주일 이내에 보이는 심리적 불편감은 1년 뒤의 심리적 불편감의 위험요소일 수 있으므로 암 치료 초기부터 정신의학적 평가 및 개입이 요구된다. 이러한 심리적 어려움의 치료적 개입에 있어서 애착 불안정성이 중요한 주제일 수 있다. 중심단어: 심리적 고통, 유방암, 추적, 유병률, 예측인자.

공공조직내 공무원의 유형별 규모 변화와 분화에 관한 연구

이상신 강원대학교 정보과학·행정대학원 2010 국내석사

조직을 구성하는 다양한 변수들 상호간의 적절한 조화와 균형은 조직 전체에 영향을 주어 조직 목표의 달성에 기여하게 된다. 본 연구는 조직구조에 있어 상황변수(규모)의 변화가 기본변수(분화)에도 일정수준까지 영향을 미친다는 긍정적 영향에 대한 이론을 바탕으로 실증적으로 경찰 등 공공조직에서 공무원의 유형별(특정직:일반직) 규모변화와 분화와의 관계를 분석하였다. 이를 통해 경찰조직 내에서 공무원의 유형별, 특히 일반직에 대한 규모의 증가에 따른 분화의 필요성과 분화의 방법에 대한 시사점을 제공하는 것을 목적으로 한다. 연구를 위해 본 논문은 조작적 정의를 통하여 공공조직의 규모는 공무원의 정원으로, 분화는 각 공공조직 내에서 보직(직위)의 수 및 직무 관련 규정으로 하였다. 또한 대상기관은 일반직보다는 특정직 중심의 조직으로, 조직구조적 특성(복잡성, 공식화, 집권화)이 유사한 경찰, 해양경찰, 검찰조직을 대상으로 하였다. 본 연구의 결과를 요약하면 해양경찰조직은 특정직과 일반직, 그리고 검찰조직은 특정직에서 각각 규모의 증가가 나타났으며 이러한 변화는 분화의 증가에도 어느 수준까지 영향을 미친 것으로 분석되었다. 그러나 경찰조직은 일반직에 대한 규모의 증가는 매우 높았으나 그 변화가 분화까지 이어지지 못하고 있으며 조직 내에서 일반직에 대한 분화 자체가 부재한 것으로 나타나 규모의 변화가 기본변수인 분화까지 연결되지 못하고 있는 것으로 나타났다. 따라서 경찰조직 내에서 일반직에 대한 규모의 증가에 따른 분화의 발생 및 일정수준까지 분화의 증가가 필요하며 분화의 방법으로는 해양경찰과 검찰조직에서 시사점을 얻을 수 있다. 이들 조직 내에서는 특정직과 일반직에 대한 직무를 규정하고 직위를 형성하는 직무전문화의 방법을 사용하고 있다. 이를 통하여 공무원의 유형별(특정직: 일반직) 규모의 증가가 발생하면, 관련 직무에 대한 분화의 증가가 일정 수준까지 이루어지고 있는 것으로 나타났다. 이상의 연구결과를 바탕으로 경찰조직에 시사점 제공 및 연구의 한계를 논의하고 향후 연구방향을 제시하였다. The proper harmony and balance between the various variables which configures organization have effects on the entire organization so it contributes to the achievement of goals. This study analyzed correlation between the changes in the size and differentiation by the public official types(special service: general service) in the public organization such as police positively through the theory about the positive effects of the situational variables(size) on the basic variables(differentiation) at certain level in organizational structure. This will allow this study aims to provide implication about necessity and methods of differentiation according to the increase in size of the public officials, especially of the general service public official. To achieve this goal, this study stipulated the size of public organization as the fixed number and differentiation as the number of the post(position) within each public organization related duty through the operational definition. In addition, the police, maritime police, prosecutor organization which has similar degree of complexity, formalization, centralization as the indicator of the organizational structure for the public organization. In the summary of the results of this study, the maritime police organization showed increase in the size in each special service, general service and prosecutor organization special service, and it is analyzed that this change had certain degrees of effect on the increase in differentiation. But the police organization showed very high increase in size in the general service, however that change can't be connected to differentiation, and it is analyzed that there is no differentiation about general service within the organization, so the change of size as the situational variables can't be connected to differentiation as the basic variables. Thus, the occurrence and increase in differentiation according to the increase in size in the general service within the police organization is necessary to a certain level, and the implications can be obtained from the maritime police and prosecutor organization as the methods of differentiation. The method of job specialization which provides and forms duty about the special service and the general service was used within the organization. This allows size of the public official increases by the type(special service: general service) and differentiation about related duties increase to a certain level. Based on the result of research above, this study discussed providing implications to the police organization and the limitations of this study and suggested the directions for the next research.

(The) influence of physioloic lipid containing moisturizer on normal skin barrier

이상신 충남대학교 대학원 2010 국내석사

Moisturizers are commonly used for management of many skin problems or sometimes maintain the healthy skin. Previous studies on short-term treatment have shown that moisturizers can weaken or strengthen skin barrier function. We evaluated the effect of long-term treatment with physiologic lipid containing moisturizer on the barrier function of normal skin. 39 healthy volunteers applied the moisturizer on one forearm 3 times daily for 8 weeks and 2 weeks were followed ?up for the next 2 weeks of regression. The other forearm was spared as a control. TEWL, skin capacitance, skin lipid contents were evaluated weekly during 8 weeks of treatment period, and daily during 2 weeks of regression period. During the treatment period, skin capacitance and lipid contents values of treated side were significantly higher than that of control side and TEWL values of treated side were significantly lower than that of control side. During regression period, all values of treated side steadily got closer to that of control side. These results suggest that long term treatment moisturizer does not deteriorate skin barrier function. In conclusion, long-term treatment with physiologic containing lipid moisturizer not only enhances the normal skin barrier, but also does not suppress the endogenous lipid synthesis of the skin.

인덴일리덴 말로노나이트릴 유도체의 합성과 pH 또는 수분센서로의 응용

이상신 전남대학교 대학원 2012 국내석사

염료의 형광 현상을 이용한 화학센서는 10-9 M 농도에서도 신호를 관찰할 수 있는 아주 뛰어난 감도, 비교적 간단한 측정방법 등의 장점을 지니고 있어서 최근 많은 관심을 받고 있다. 본 연구에서는 수용액의pH 또는 유기용매 내의 수분 함유량의 변화에 따라 형광의 특성이 변하는 새로운 형광 염료를 개발하기 위해 amino-styryl 그룹을 갖는 indenylidene malononitrile 유도체 화합물들을 합성하였다. 이 화합물들은 그 구조적인 특징 때문에 산성, 중성, 염기성 영역에서 protonation /deprotonation 되면서 형광세기의 변화를 가져온다. 뿐만 아니라, malononitrile을 치환함으로써 수분 함량변화에 따라 형광의 세기가 변화하는 indenylidene malononitrile 유도체를 합성하였다. 15a, 15b, 15c, 15e등은 산성 영역에서 용액의 pH가 증가함에 따라 형광의 세기가 증가하는 현상을 보여 주었으며, 15d는 정제된 CH3CN용매 내에서 375nm영역의 빛을 흡수하여 여기되고 585nm에서 최대 발광한다. CH3CN 내 수분 함유량에 변화를 주며 관찰한 결과 최대 10%의 수분 함유에 전체 형광의 85%까지 소광되는 성질을 나타내어 수분센서로 유용함을 보여주었다.

가토에서 임계 크기 안와골 결손에 있어서 BMP-2의 골화 효과 및 유효용량에 대한 분석

이상신 울산대학교 대학원 2015 국내석사

Although bone morphogenetic protein-2 (BMP-2) is a potent growth factor known to induce bone formation, the appropriate and effective BMP-2 dosages for ideal bone formation according to defect size and type remain to be established. This study was designed to quantitatively measure the effects of BMP-2 on critically sized orbital wall defects in an animal model, that of the New Zealand Rabbit, via 3D CT imaging. Upon institutional approval, twenty four rabbits of equal age and weight were divided into one control and three experimental groups. After creating two round-shaped defects in each animal, a silk/hydroxyapatitie scaffolding mixture with varying concentrations of BMP-2 (0, 1, 10, and 100 μg/ml) was introduced into the defects. The defect filling response was assessed at 0, 8 and 16 weeks by 3D CT imaging-based measurement of the thickness and surface area of the regenerating bone. A linear mixed model was used for statistical analysis. All animals survived through the experimental period. Statistically significant responses to BMP-2 were observed with regard to the volume of regenerated bone. The mean thicknesses of the regenerated bone on 16 weeks were 0.59 mm for the control group (0 μg/ml of BMP-2), and 0.60, 0.85, and 1.18 mm for 1, 10, and 100 μg/ml BMP-2, respectively. As the original mean thickness of the orbital wall in the rabbits was 1.78 mm, a 100 μg/ml quantity of BMP-2 proved to be best of above for the defect. The mean surface area increase of the regenerated bone on 16 weeks were 2.863 mm2 for the control group, and 3.135, 13.802, and 30.523 mm2 for 1, 10, and 100 μg/ml BMP-2, respectively. This research introduces the rabbit as a useful animal model for the study of bone regeneration. BMP-2 promotes anatomically significant bone regeneration in critically sized orbital wall defects in this model, with an optimal dose-response at 100 μg/ml and without hyper- or hypoosteogenesis.

구강암세포 cDNA library cloning에서 구강암 발생에 관여하는 유전자의 검색

이상신 江陵大學校 大學院 2001 국내석사

structure . 지난 3년 동안 실험의 기초부터 논문을 쓰는 지금까지 전반적인 지도를 아끼지 않으신 이석근 교수님께 감사드리며 또한 논문을 쓰는데 있어서 부족한 점을 지적해주신 박영욱 교수님과 최영님 교수님께 감사드립니다. 또한 병리학 실험실에서 실험을 하는데 도움을 주신 김연숙 선생님과 송인선 선생님 그리고 (이후원문누락) In order to detect novel genes related to the carcinogenesis of oral cancer the cDNA of oral squamous cell carcinoma tissue was subtracted with the cDNA of RHEK cells, and the remaining cDNA was used to make a cDNA library for molecular cloning. Totally 135 clones were obtained from the library and their sequences were analyzed by automatic sequencer. 74 clones appeared to be non-redundant genes and the other genes were homologous to the known genes, i.e., heat shock protein, human ADP/ATP translocase mRNA, ubiquitin -conjugating enzyme 1, glutathione reductase, cyclophilin, human poly(rC)-binding protein, human gastrointestinal tumor-associated antigen, human tumor-associated calcium signal transducer 2, etc. Firstly, the 74 non-redundant genes were directly examined by RNA in situ hybridization in the sections of squamous cell carcinoma tissues. C79-47, C79-56, C79-74, and C79-124 clones were markedly expressed in the well differentiated tumor cells, but weak in the moderately differentiated and poorly differentiated tumor cells. C79-8 clone was intensely expressed in the poorly differentiated tumor cells, while it was almost negative in the well differentiated tumor cells. These stage- and spacial specific expressions in the tumor cells may suggest that these clones are novel ones probably playing certain roles in the carcinogenesis and tumor invasion. The selected genes were also translated and simulated for their protein structure. In the analysis of putative protein structure, C79-8 showed typical helix pattern, C79-47 and C79-74 showed the pattern of globular condensation, and other clones of C79-56, C79-93, and C79-124 showed characteristic motif structures in C-terminal region. Taken together, the selected 6 clones are supposed to be an important novel genes which are highly recommended to investigate their biological functions in the processes of carcinogenesis and tumor invasion.

대규모 무선센서네트워크를 위한 링크 품질과 클러스터 기반의 네트워크 프로토콜

이상신 韓國外國語大學校 大學院 2012 국내박사

Large-scale wireless sensor networks (WSNs) have attracted significant attention over the past few years. Large-scale applications such as battle field monitoring, environment monitoring, and industrial facility monitoring need a large number of sensors to build an entire system. Most WSN nodes use batteries as their power sources. Due to these limited power sources, it is difficult to implement a large-scale WSN systems without specialized network protocol which reflects characteristics from large-scale and battery-based WSNs. There are two major requirements when we design large-scale WSN systems. The first one is short set-up time to build an entire network. And, the second one is reliable data delivery. To achieve these requirements we need efficient network formation and routing path set-up methods. This paper presents a novel network protocol for large-scale WSNs based on link quality assessment and clustering, named LQCNP (Link Quality and Cluster-based Network Protocol). Link quality assessment is a crucial part of sensor network formation to stably operate large-scale WSNs. A stability of a path consisting of several nodes strongly depends on link quality between every pair of consecutive nodes. Thus, it is very important to assess the link quality on the stage of building a routing path. In this paper, we present a link quality assessment method, hybrid link quality metric (HQLM), which uses both of LQI and RSSI from RF chip of sensor nodes to minimize set-up time and energy consumption for network formation. The HQLM not only reduces the time and energy consumption, but also provides complementary cooperation of LQI and RSSI. We also propose link quality-based clustering method (LQCM) in order to efficiently manage a WSN which is made up with a large number of nodes because it is very difficult to manage a lot of node without hierarchical manner. The LQCM uses the HQLM in order to find a link which has the highest link quality. To minimize set-up time and energy consumption we should perform both of network formation and routing set-up simultaneously. By using of HQLM and LQCM, the LQCNP can offer a light and fast way to build networks. The routing method of the LQCNP has intra-cluster, inter-cluster and cross-layer routing methods. And, the LQCNP introduces a robust route recovery method as well. In order to evaluate the validity and efficiency of the proposed LQCNP, we examine the validity of the HQLM, the efficiency of the LQCM and the efficiency of the proposed routing method. For the evaluation of the HQLM, we measure PDR (Packet Delivery Rate) by exchanging multiple messages and then, compare PDR to the result of HQLM for evaluation. From the research being carried out, we can conclude that the HQLM performs better than either LQI- or RSSI-based metric in terms of recall, precision, and matching on link quality. For the evaluation of the LQCM, we compare the result of N-hop distance-based clustering, address space-based cluster, and LQCM. As the result of the simulation, it was found that the LQCM was relatively outperformed compared to other methods. For the evaluation of the LQCNP, we deployed 50 nodes which load whole LQCNP stack and we measure the data delivery rate. As the result of the experiment, the throughput of the LQCNP was relatively better than hop-based routing. Our LQCNP can offer an efficient and light way to construct reliable large-scale wireless sensor networks. And, it could be applied to various large-scale wireless sensor network systems such as disaster management, battle field reconnaissance, border protection and security surveillance.

長水地域語의 音韻論的 硏究

이상신 全北大學校 大學院 1983 국내석사

Jangsoo areal dialect is contained in the West-Southern dialect of Korean. However, since Jangsoo district is in contact with the Kyengsangnamdo vertically, at eastern area of Jangsoo appears some of the characteristics of contact dialect. But in this paper the author researched an areal dialect with regarding it as a linguistic system with independant adequancy. Because it is possible to have a grasp of the system of dialect-major unit, and compare a areal dialect with another one only after having a thorough grasp of a sub-dialect-minor unit. In phoneme catalogue of Jangsoo areal dialect are true consonant 17, liquid 1, true vowel 10, glide 3 registered ◁수식 삽입▷(원문을 참조하세요) In the catalogue of prosodic phoneme of this areal dialect are length and intonation. Examining the aspect of phoneme distribution, the onlv two /□,1/ of consonantal phonemes is never pronounced at the wordinitial position in parallel with other areal dialects. Glide is not pronounced in front of consonant and word· finally. Without the essential restriction of phonolosical conbination, /y/ and /w/ come together with the phoneme with 〔-cons, +voc〕, and so diphthongs /ye, yε, ya, yu, yo, y□, we, wε, w□, wa/ are formed. The distribution of dipthong at back of consonant is restricted according to the feature of theirs. For example consonants with 〔+ant, -cor〕 can not be followed by diphthong. (As for the phonological rules which summarize synchronically the phonological processes of Jangsoo areal dialect, see Chapter Ⅳ.)

전력선 통신을 위한 CPFSK 모뎀에 관한 연구

이상신 서울大學校 大學院 2001 국내석사